 Aprotinin
"Aprotinin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
| Descriptor ID |
D007611
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| MeSH Number(s) |
D12.776.083
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| Concept/Terms |
Aprotinin- Aprotinin
- Bovine Kunitz Pancreatic Trypsin Inhibitor
- Bovine Pancreatic Trypsin Inhibitor
- Trypsin Inhibitor, Kunitz, Pancreatic
- Kallikrein-Trypsin Inactivator
- Inactivator, Kallikrein-Trypsin
- Kallikrein Trypsin Inactivator
- Kunitz Pancreatic Trypsin Inhibitor
- Trypsin Inhibitor, Basic, Pancreatic
- Basic Pancreatic Trypsin Inhibitor
- BPTI, Basic Pancreatic Trypsin Inhibitor
Contrykal- Contrykal
- Kontrykal
- Kontrikal
- Arzneimittelwerk Dresden Brand of Aprotinin
- Contrical
Iniprol- Iniprol
- Sanofi Winthrop Brand of Aprotinin
Trasylol- Trasylol
- Bayer Brand of Aprotinin
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Below are MeSH descriptors whose meaning is more general than "Aprotinin".
Below are MeSH descriptors whose meaning is more specific than "Aprotinin".
This graph shows the total number of publications written about "Aprotinin" by people in this website by year, and whether "Aprotinin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 0 | 2 | 2 | | 1990 | 2 | 0 | 2 | | 1992 | 4 | 0 | 4 | | 1993 | 1 | 0 | 1 | | 1994 | 2 | 0 | 2 | | 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 3 | 0 | 3 | | 2010 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aprotinin" by people in Profiles.
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Briquez PS, Lorentz KM, Larsson HM, Frey P, Hubbell JA. Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials. Biomaterials. 2017 Aug; 135:1-9.
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DeSantis SM, Lazaridis C. Aprotinin revisited. Intensive Care Med. 2014 Jan; 40(1):142.
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Lorentz KM, Kontos S, Frey P, Hubbell JA. Engineered aprotinin for improved stability of fibrin biomaterials. Biomaterials. 2011 Jan; 32(2):430-8.
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Avlonitis VS, Wigfield CH, Kirby JA, Dark JH. Treatment of the brain-dead lung donor with aprotinin and nitric oxide. J Heart Lung Transplant. 2010 Oct; 29(10):1177-84.
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Desai PH, Kurian D, Thirumavalavan N, Desai SP, Ziu P, Grant M, White C, Landis RC, Poston RS. A randomized clinical trial investigating the relationship between aprotinin and hypercoagulability in off-pump coronary surgery. Anesth Analg. 2009 Nov; 109(5):1387-94.
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Strouch ZY, Drum ML, Chaney MA. Aprotinin use during cardiac surgery: recent alterations and effects on blood product utilization. J Clin Anesth. 2009 Nov; 21(7):502-7.
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Siehr S, Stuth E, Tweddell J, Hoffman G, Troshynski T, Jones D, Mitchell M, Ghanayem N. Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery. Eur J Cardiothorac Surg. 2010 Feb; 37(2):307-11.
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Castillo JG, Filsoufi F, Adams DH, Raikhelkar J, Zaku B, Fischer GW. Management of patients undergoing multivalvular surgery for carcinoid heart disease: the role of the anaesthetist. Br J Anaesth. 2008 Nov; 101(5):618-26.
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Kober BJ, Scheule AM, Voth V, Deschner N, Schmid E, Ziemer G. Anaphylactic reaction after systemic application of aprotinin triggered by aprotinin-containing fibrin sealant. Anesth Analg. 2008 Aug; 107(2):406-9.
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Bail DH, Ziemer G. Brain natriuretic peptide in cardiac surgery--influence of aprotinin. Int J Cardiol. 2009 Aug 14; 136(2):227-8.
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