 Lens, Crystalline
"Lens, Crystalline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
| Descriptor ID |
D007908
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| MeSH Number(s) |
A09.371.060.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lens, Crystalline".
Below are MeSH descriptors whose meaning is more specific than "Lens, Crystalline".
This graph shows the total number of publications written about "Lens, Crystalline" by people in this website by year, and whether "Lens, Crystalline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 1 | 0 | 1 | | 1984 | 1 | 0 | 1 | | 1985 | 2 | 0 | 2 | | 1986 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 | | 1991 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 4 | 0 | 4 | | 1996 | 3 | 0 | 3 | | 1997 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 2 | 3 | | 2012 | 0 | 2 | 2 | | 2013 | 3 | 0 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 1 | 3 | | 2017 | 3 | 0 | 3 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2020 | 3 | 0 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Lens, Crystalline" by people in Profiles.
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Hieromnimon HM, Pearson AT. Ovarian cancer through a multi-modal lens. Nat Cancer. 2022 Jun; 3(6):662-664.
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Minogue PJ, Tong JJ, Wichmann K, Mysliwiec H, Ebihara L, Beyer EC, Berthoud VM. Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673.
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Tong JJ, Khan U, Haddad BG, Minogue PJ, Beyer EC, Berthoud VM, Reichow SL, Ebihara L. Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021 12 21; 120(24):5644-5656.
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Jara O, Minogue PJ, Berthoud VM, Beyer EC. Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens? Biomolecules. 2020 10 07; 10(10).
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Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization. Int J Mol Sci. 2020 Aug 13; 21(16).
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Jara O, Mysliwiec H, Minogue PJ, Berthoud VM, Beyer EC. p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency. Mol Vis. 2020; 26:204-215.
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Minogue PJ, Beyer EC, Berthoud VM. CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice. Mol Vis. 2019; 25:535-545.
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Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):2336-2346.
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Jara O, Minogue PJ, Berthoud VM, Beyer EC. Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses. Exp Eye Res. 2018 10; 175:192-198.
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Gao J, Minogue PJ, Beyer EC, Mathias RT, Berthoud VM. Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C492-C503.
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