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Proinsulin

"Proinsulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.


expand / collapse publications
This graph shows the total number of publications written about "Proinsulin" by people in this website by year, and whether "Proinsulin" was a major or minor topic of these publications.
Bar chart showing 91 publications over 35 distinct years, with a maximum of 6 publications in 1987
To see the data from this visualization as text, click here.