 Osteocalcin
"Osteocalcin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
| Descriptor ID |
D015675
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| MeSH Number(s) |
D12.776.157.125.700
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| Concept/Terms |
Osteocalcin- Osteocalcin
- Bone gamma-Carboxyglutamic Acid Protein
- Bone gamma Carboxyglutamic Acid Protein
- Vitamin K-Dependent Bone Protein
- Vitamin K Dependent Bone Protein
- Calcium-Binding Protein, Vitamin K-Dependent
- Calcium Binding Protein, Vitamin K Dependent
- Gla Protein, Bone
- 4-Carboxyglutamic Protein, Bone
- 4 Carboxyglutamic Protein, Bone
- Bone 4-Carboxyglutamic Protein
- Protein, Bone 4-Carboxyglutamic
- Bone Gla Protein
- Protein, Bone Gla
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Below are MeSH descriptors whose meaning is more general than "Osteocalcin".
Below are MeSH descriptors whose meaning is more specific than "Osteocalcin".
This graph shows the total number of publications written about "Osteocalcin" by people in this website by year, and whether "Osteocalcin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2015 | 0 | 3 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Osteocalcin" by people in Profiles.
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Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017 12 01; 358(6367).
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Jain RK, Bennet B, Vokes T. Ethnic Differences in Osteoporosis After Cardiac Transplantation. J Clin Densitom. 2017 Apr - Jun; 20(2):164-171.
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Rozental TD, Herder LM, Walley KC, Zurakowski D, Coyle K, Bouxsein ML, Wolf JM. 25-Hydroxyvitamin-D and Bone Turnover Marker Levels in Patients with Distal Radial Fracture. J Bone Joint Surg Am. 2015 Oct 21; 97(20):1685-93.
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Poon CC, Li RW, Seto SW, Kong SK, Ho HP, Hoi MP, Lee SM, Ngai SM, Chan SW, Leung GP, Kwan YW. In vitro vitamin K(2) and 1a,25-dihydroxyvitamin D(3) combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol. 2015 Nov 15; 767:30-40.
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Uy GL, Hsu YM, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC. Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia. Leuk Res. 2015 Dec; 39(12):1437-42.
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Li RD, Deng ZL, Hu N, Liang X, Liu B, Luo J, Chen L, Yin L, Luo X, Shui W, He TC, Huang W. Biphasic effects of TGFß1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells. BMB Rep. 2012 Sep; 45(9):509-14.
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Teven CM, Greives M, Natale RB, Su Y, Luo Q, He BC, Shenaq D, He TC, Reid RR. Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields. J Craniofac Surg. 2012 Mar; 23(2):586-93.
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Mahalingam CD, Datta T, Patil RV, Kreider J, Bonfil RD, Kirkwood KL, Goldstein SA, Abou-Samra AB, Datta NS. Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone. J Endocrinol. 2011 Nov; 211(2):145-56.
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Krishnan V, Shuman LA, Sosnoski DM, Dhurjati R, Vogler EA, Mastro AM. Dynamic interaction between breast cancer cells and osteoblastic tissue: comparison of two- and three-dimensional cultures. J Cell Physiol. 2011 Aug; 226(8):2150-8.
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Shu A, Yin MT, Stein E, Cremers S, Dworakowski E, Ives R, Rubin MR. Bone structure and turnover in type 2 diabetes mellitus. Osteoporos Int. 2012 Feb; 23(2):635-41.
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