 Trypsin Inhibitor, Kazal Pancreatic
"Trypsin Inhibitor, Kazal Pancreatic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic trypsin inhibitor common to all mammals. It is secreted with the zymogens into the pancreatic juice. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ).
| Descriptor ID |
D014359
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| MeSH Number(s) |
D12.776.124.050.850
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| Concept/Terms |
Tumor-Associated Trypsin Inhibitor- Tumor-Associated Trypsin Inhibitor
- Tumor Associated Trypsin Inhibitor
- Inhibitor, Tumor-Associated Trypsin
- Inhibitor, Tumor Associated Trypsin
- Trypsin Inhibitor, Tumor-Associated
- Trypsin Inhibitor, Tumor Associated
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Below are MeSH descriptors whose meaning is more general than "Trypsin Inhibitor, Kazal Pancreatic".
Below are MeSH descriptors whose meaning is more specific than "Trypsin Inhibitor, Kazal Pancreatic".
This graph shows the total number of publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in this website by year, and whether "Trypsin Inhibitor, Kazal Pancreatic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2008 | 0 | 2 | 2 |
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Below are the most recent publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in Profiles.
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Schneider A, Larusch J, Sun X, Aloe A, Lamb J, Hawes R, Cotton P, Brand RE, Anderson MA, Money ME, Banks PA, Lewis MD, Baillie J, Sherman S, Disario J, Burton FR, Gardner TB, Amann ST, Gelrud A, George R, Rockacy MJ, Kassabian S, Martinson J, Slivka A, Yadav D, Oruc N, Barmada MM, Frizzell R, Whitcomb DC. Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology. 2011 Jan; 140(1):162-71.
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O'Reilly DA, Witt H, Rahman SH, Schulz HU, Sargen K, Kage A, Cartmell MT, Landt O, Larvin M, Demaine AG, McMahon MJ, Becker M, Kingsnorth AN. The SPINK1 N34S variant is associated with acute pancreatitis. Eur J Gastroenterol Hepatol. 2008 Aug; 20(8):726-31.
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Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A, Gerald WL, Lilja H, Reuter VE, Kantoff PW, Scardino PT, Rubin MA, Bjartell AS, Chinnaiyan AM. The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell. 2008 Jun; 13(6):519-28.
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Kim B, Young T, Harder E, Friesner RA, Berne BJ. Structure and dynamics of the solvation of bovine pancreatic trypsin inhibitor in explicit water: a comparative study of the effects of solvent and protein polarizability. J Phys Chem B. 2005 Sep 01; 109(34):16529-38.
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Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002 Oct; 123(4):1020-5.
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Truninger K, Witt H, Köck J, Kage A, Seifert B, Ammann RW, Blum HE, Becker M. Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol. 2002 May; 97(5):1133-7.
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