Trypsin Inhibitor, Kazal Pancreatic
"Trypsin Inhibitor, Kazal Pancreatic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premataure activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.
| Descriptor ID |
D014359
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| MeSH Number(s) |
D12.644.822.750.500 D12.776.124.050.850 D12.776.645.688.500
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| Concept/Terms |
Trypsin Inhibitor, Kazal Pancreatic- Trypsin Inhibitor, Kazal Pancreatic
- Serine Protease Inhibitor Kazal-Type 1
- Serine Protease Inhibitor Kazal Type 1
- Pancreatic Secretory Trypsin Inhibitor
- SPINK1
- Trypsin Inhibitor Kazal Pancreatic
- Pancreatic Trypsin Secretory Inhibitor, Kazal
- Inhibitor, Tumor-Associated Trypsin
- Inhibitor, Tumor Associated Trypsin
- Trypsin Inhibitor, Tumor-Associated
- Trypsin Inhibitor, Tumor Associated
- Tumor-Associated Trypsin Inhibitor
- Tumor Associated Trypsin Inhibitor
- Acidic Pancreatic Trypsin Inhibitor
- Pancreatic Secretory Trypsin Inhibitor, Kazal
- Serine Peptidase Inhibitor, Kazal-Type 1
- Serine Peptidase Inhibitor, Kazal Type 1
- Kazal Pancreatic Trypsin Inhibitor
|
Below are MeSH descriptors whose meaning is more general than "Trypsin Inhibitor, Kazal Pancreatic".
Below are MeSH descriptors whose meaning is more specific than "Trypsin Inhibitor, Kazal Pancreatic".
This graph shows the total number of publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in this website by year, and whether "Trypsin Inhibitor, Kazal Pancreatic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 2 | 2 |
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Below are the most recent publications written about "Trypsin Inhibitor, Kazal Pancreatic" by people in Profiles.
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Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis. Gastroenterology. 2011 Jan; 140(1):162-71.
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The SPINK1 N34S variant is associated with acute pancreatitis. Eur J Gastroenterol Hepatol. 2008 Aug; 20(8):726-31.
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The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell. 2008 Jun; 13(6):519-28.
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Structure and dynamics of the solvation of bovine pancreatic trypsin inhibitor in explicit water: a comparative study of the effects of solvent and protein polarizability. J Phys Chem B. 2005 Sep 01; 109(34):16529-38.
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Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002 Oct; 123(4):1020-5.
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Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis. Am J Gastroenterol. 2002 May; 97(5):1133-7.