 Second Messenger Systems
"Second Messenger Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
| Descriptor ID |
D015290
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| MeSH Number(s) |
G02.111.087.800.800 G02.149.115.800.800 G04.299.880.800
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| Concept/Terms |
Second Messenger Systems- Second Messenger Systems
- Second Messenger System
- System, Second Messenger
- Systems, Second Messenger
- Second Messengers
- Messenger, Second
- Messengers, Second
- Second Messenger
- Intracellular Second Messengers
- Intracellular Second Messenger
- Messengers, Intracellular Second
- Second Messenger, Intracellular
- Second Messengers, Intracellular
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Below are MeSH descriptors whose meaning is more general than "Second Messenger Systems".
Below are MeSH descriptors whose meaning is more specific than "Second Messenger Systems".
This graph shows the total number of publications written about "Second Messenger Systems" by people in this website by year, and whether "Second Messenger Systems" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1988 | 0 | 1 | 1 | | 1989 | 1 | 1 | 2 | | 1991 | 1 | 2 | 3 | | 1992 | 0 | 2 | 2 | | 1993 | 1 | 1 | 2 | | 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1998 | 0 | 2 | 2 | | 1999 | 0 | 3 | 3 | | 2002 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Second Messenger Systems" by people in Profiles.
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Jani MS, Veetil AT, Krishnan Y. Controlled release of bioactive signaling molecules. Methods Enzymol. 2020; 638:129-138.
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French AR, Sosnick TR, Rock RS. Investigations of human myosin VI targeting using optogenetically controlled cargo loading. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1607-E1616.
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Fridlyand LE, Philipson LH. Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One. 2016; 11(5):e0152869.
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Menon KP, Carrillo RA, Zinn K. The translational regulator Cup controls NMJ presynaptic terminal morphology. Mol Cell Neurosci. 2015 Jul; 67:126-36.
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Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev. 2015; 67(2):338-67.
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Evans-Molina C, Mirmira RG. Achieving "PeaK-A" insulin secretion. Diabetes. 2013 May; 62(5):1389-90.
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Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B. ß-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Diabetes. 2013 May; 62(5):1527-36.
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Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. J Mol Med (Berl). 2012 Mar; 90(3):265-72.
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Fridlyand LE, Philipson LH. Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis. Prog Biophys Mol Biol. 2011 Nov; 107(2):293-303.
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Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR. Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L879-87.
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