"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
|
| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 5 | 0 | 5 |
| 2004 | 3 | 6 | 9 |
| 2005 | 4 | 9 | 13 |
| 2006 | 4 | 10 | 14 |
| 2007 | 4 | 14 | 18 |
| 2008 | 0 | 14 | 14 |
| 2009 | 3 | 15 | 18 |
| 2010 | 3 | 20 | 23 |
| 2011 | 1 | 17 | 18 |
| 2012 | 1 | 21 | 22 |
| 2013 | 1 | 16 | 17 |
| 2014 | 1 | 20 | 21 |
| 2015 | 0 | 20 | 20 |
| 2016 | 1 | 11 | 12 |
| 2017 | 1 | 19 | 20 |
| 2018 | 1 | 7 | 8 |
| 2019 | 2 | 6 | 8 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 6 | 6 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial. JAMA. 2024 03 05; 331(9):740-749.
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging. Nat Commun. 2024 Jan 18; 15(1):264.
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Zilebesiran for Hypertension. Reply. N Engl J Med. 2023 Oct 12; 389(15):1439-1440.
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Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension. N Engl J Med. 2023 Jul 20; 389(3):228-238.
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Autocrine signaling by receptor tyrosine kinases in urothelial carcinoma of the bladder. PLoS One. 2021; 16(7):e0241766.
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Programmable technologies to manipulate gene expression at the RNA level. Curr Opin Chem Biol. 2021 10; 64:27-37.
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Hypoxia Preconditioning Promotes the Proliferation and Migration of Human Urine-Derived Stem Cells in Chronically Injured Liver of Mice by Upregulating CXCR4. Stem Cells Dev. 2021 05 15; 30(10):526-536.
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RNA-based therapies: A cog in the wheel of lung cancer defense. Mol Cancer. 2021 03 19; 20(1):54.
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RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila. PLoS Genet. 2021 02; 17(2):e1009396.
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Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 2021 03 02; 33(3):499-512.e6.