 Connexins
"Connexins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.
| Descriptor ID |
D017630
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| MeSH Number(s) |
D12.776.543.585.250
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| Concept/Terms |
Connexins- Connexins
- Gap Junction Protein
- Junction Protein, Gap
- Gap Junction Proteins
- Junction Proteins, Gap
- Gap Junction Channel Proteins
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Below are MeSH descriptors whose meaning is more general than "Connexins".
Below are MeSH descriptors whose meaning is more specific than "Connexins".
This graph shows the total number of publications written about "Connexins" by people in this website by year, and whether "Connexins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1989 | 0 | 5 | 5 | | 1990 | 0 | 6 | 6 | | 1991 | 0 | 6 | 6 | | 1992 | 0 | 4 | 4 | | 1993 | 2 | 7 | 9 | | 1994 | 10 | 2 | 12 | | 1995 | 10 | 1 | 11 | | 1996 | 2 | 0 | 2 | | 1997 | 4 | 0 | 4 | | 1998 | 0 | 2 | 2 | | 1999 | 3 | 1 | 4 | | 2000 | 9 | 1 | 10 | | 2001 | 5 | 0 | 5 | | 2002 | 4 | 2 | 6 | | 2003 | 2 | 1 | 3 | | 2004 | 7 | 2 | 9 | | 2005 | 1 | 1 | 2 | | 2006 | 2 | 0 | 2 | | 2007 | 3 | 1 | 4 | | 2008 | 5 | 0 | 5 | | 2009 | 4 | 0 | 4 | | 2011 | 5 | 0 | 5 | | 2012 | 4 | 1 | 5 | | 2013 | 2 | 1 | 3 | | 2014 | 6 | 0 | 6 | | 2015 | 1 | 1 | 2 | | 2016 | 2 | 0 | 2 | | 2017 | 6 | 0 | 6 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Connexins" by people in Profiles.
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Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization. Int J Mol Sci. 2020 Aug 13; 21(16).
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Jara O, Mysliwiec H, Minogue PJ, Berthoud VM, Beyer EC. p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency. Mol Vis. 2020; 26:204-215.
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Minogue PJ, Beyer EC, Berthoud VM. CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice. Mol Vis. 2019; 25:535-545.
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Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):2336-2346.
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Jara O, Minogue PJ, Berthoud VM, Beyer EC. Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses. Exp Eye Res. 2018 10; 175:192-198.
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Gao J, Minogue PJ, Beyer EC, Mathias RT, Berthoud VM. Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice. . 2018 04 01; 314(4):C492-C503.
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Leybaert L, Lampe PD, Dhein S, Kwak BR, Ferdinandy P, Beyer EC, Laird DW, Naus CC, Green CR, Schulz R. Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev. 2017 10; 69(4):396-478.
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Kuo DS, Sokol JT, Minogue PJ, Berthoud VM, Slavotinek AM, Beyer EC, Gould DB. Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract. PLoS One. 2017; 12(8):e0183438.
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Minogue PJ, Gao J, Zoltoski RK, Novak LA, Mathias RT, Beyer EC, Berthoud VM. Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4366–4374.
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Beyer EC, Berthoud VM. Gap junction gene and protein families: Connexins, innexins, and pannexins. Biochim Biophys Acta Biomembr. 2018 Jan; 1860(1):5-8.
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