"Pro-Opiomelanocortin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
| Descriptor ID |
D011333
|
| MeSH Number(s) |
D06.472.699.327.935 D06.472.699.631.525.600 D12.644.400.400.935 D12.644.548.365.935 D12.644.548.691.525.690 D12.776.631.650.405.935 D12.776.811.800
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| Concept/Terms |
Pro-Opiomelanocortin- Pro-Opiomelanocortin
- Pro Opiomelanocortin
- ACTH-Endorphin Precursor
- ACTH Endorphin Precursor
- Endorphin-ACTH Precursor
- Endorphin ACTH Precursor
- Corticotropin-beta-Lipotropin Precursor
- Corticotropin beta Lipotropin Precursor
- POMC
- Proopiomelanocortin
- Pro-Opiocortin
- Pro Opiocortin
- Pro-Opio-Melanocortin
- Pro Opio Melanocortin
- Proopiocortin
- ACTH-beta-Lipotropin Precursor
- ACTH beta Lipotropin Precursor
- Pro-ACTH-Endorphin
- Pro ACTH Endorphin
|
Below are MeSH descriptors whose meaning is more general than "Pro-Opiomelanocortin".
Below are MeSH descriptors whose meaning is more specific than "Pro-Opiomelanocortin".
This graph shows the total number of publications written about "Pro-Opiomelanocortin" by people in this website by year, and whether "Pro-Opiomelanocortin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pro-Opiomelanocortin" by people in Profiles.
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Glycyl-l-glutamine attenuates NPY-induced hyperphagia via the melanocortin system. Neurosci Lett. 2020 09 25; 736:135303.
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Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13116-13121.
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Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.
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POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. Int J Cancer. 2017 06 01; 140(11):2517-2525.
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Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):7024-9.
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol. 2010 Mar; 298(3):R720-8.
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Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse. Regul Pept. 2004 Nov 15; 122(3):169-72.
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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest. 2003 Nov; 112(10):1550-60.
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Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10293-8.
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Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8595-600.