 Presenilins
"Presenilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.
| Descriptor ID |
D053763
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| MeSH Number(s) |
D12.776.543.696
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Presenilins".
Below are MeSH descriptors whose meaning is more specific than "Presenilins".
This graph shows the total number of publications written about "Presenilins" by people in this website by year, and whether "Presenilins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Presenilins" by people in Profiles.
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Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity. J Biol Chem. 2016 Mar 25; 291(13):6748-53.
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Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18; 51(37):7209-11.
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Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci. 2012 Jun 20; 32(25):8633-48.
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Buggia-Prevot V, Sevalle J, Rossner S, Checler F. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. J Biol Chem. 2008 Apr 11; 283(15):10037-47.
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Thinakaran G, Sisodia SS. Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci. 2006 Nov; 9(11):1354-5.
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