"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
| Descriptor ID |
D016335
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985
|
| Concept/Terms |
Zinc Fingers- Zinc Fingers
- Finger, Zinc
- Fingers, Zinc
- Zinc Finger
- Zinc Finger Motifs
- Motif, Zinc Finger
- Motifs, Zinc Finger
- Zinc Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".
This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 1 | 2 | 3 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 2 | 2 |
| 2000 | 1 | 3 | 4 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 3 | 5 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Zinc Fingers" by people in Profiles.
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Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. J Clin Invest. 2023 04 03; 133(7).
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Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid. PLoS One. 2023; 18(1):e0274716.
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Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun. 2021 01 05; 12(1):121.
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Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome. Leukemia. 2021 01; 35(1):264-268.
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The octopus genome and the evolution of cephalopod neural and morphological novelties. Nature. 2015 Aug 13; 524(7564):220-4.
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Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis. Development. 2014 May; 141(10):2024-34.
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Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. J Allergy Clin Immunol. 2014 Mar; 133(3):723-8.e3.
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Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Neuropharmacology. 2014 Jan; 76 Pt B:250-8.
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BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012 Nov 22; 491(7425):618-21.
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The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. PLoS Biol. 2011 Dec; 9(12):e1001211.