T Cell Transcription Factor 1
"T Cell Transcription Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TCF transcription factor that was originally identified as a DNA-binding protein that interacts with the enhancers of T-CELL RECEPTOR ALPHA GENES. It plays a role in T-LYMPHOCYTE development.
| Descriptor ID |
D051822
|
| MeSH Number(s) |
D12.776.260.730.750 D12.776.660.235.400.800.750 D12.776.664.235.400.800.750 D12.776.930.875.750
|
| Concept/Terms |
T Cell Transcription Factor 1- T Cell Transcription Factor 1
- TCF-1 Transcription Factor
- TCF 1 Transcription Factor
- Transcription Factor, TCF-1
- Transcription Factor 7
- T Cell Factor 1
|
Below are MeSH descriptors whose meaning is more general than "T Cell Transcription Factor 1".
Below are MeSH descriptors whose meaning is more specific than "T Cell Transcription Factor 1".
This graph shows the total number of publications written about "T Cell Transcription Factor 1" by people in this website by year, and whether "T Cell Transcription Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "T Cell Transcription Factor 1" by people in Profiles.
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Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction. Cancer Immunol Immunother. 2022 Dec; 71(12):2881-2898.
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Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484.
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TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med. 2016 Jan; 22(1):84-90.
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ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28.
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ß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6.
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T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5.
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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med. 2011 May 09; 208(5):1001-13.
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Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development. 2010 Feb; 137(3):507-18.
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Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol. 2009 Sep 15; 183(6):3873-84.