 Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
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| MeSH Number(s) |
D12.776.543.695
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 6 | 6 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 5 | 5 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 3 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 2 | 1 | 3 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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Herrera A, Kim Y, Chen J, Jedrzejczak R, Shukla S, Maltseva N, Joachimiak G, Welk L, Wiersum G, Jaroszewski L, Godzik A, Joachimiak A, Satchell KJF. A Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins. J Bacteriol. 2022 May 17; 204(5):e0055521.
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Osei-Owusu P, Charlton TM, Kim HK, Missiakas D, Schneewind O. FPR1 is the plague receptor on host immune cells. Nature. 2019 10; 574(7776):57-62.
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Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze LJ, Wang J, Ghobrial RM, Xia J, Sciammas R, Li XC, Chen W. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017 12 19; 47(6):1114-1128.e6.
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Mitchell A, Tam C, Elli D, Charlton T, Osei-Owusu P, Fazlollahi F, Faull KF, Schneewind O. Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. mBio. 2017 05 16; 8(3).
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Catalán E, Jaime-Sánchez P, Aguiló N, Simon MM, Froelich CJ, Pardo J. Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
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Gilbert RJ, Dalla Serra M, Froelich CJ, Wallace MI, Anderluh G. Membrane pore formation at protein-lipid interfaces. Trends Biochem Sci. 2014 Nov; 39(11):510-6.
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Ligtenberg KG, Miller NC, Mitchell A, Plano GV, Schneewind O. LcrV mutants that abolish Yersinia type III injectisome function. J Bacteriol. 2013 Feb; 195(4):777-87.
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Varanasi V, Avanesyan L, Schumann DM, Chervonsky AV. Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic ß-cells. Diabetes. 2012 Nov; 61(11):2862-70.
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Miller NC, Quenee LE, Elli D, Ciletti NA, Schneewind O. Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity. Infect Immun. 2012 Apr; 80(4):1572-82.
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Praper T, Besenicar MP, Istinic H, Podlesek Z, Metkar SS, Froelich CJ, Anderluh G. Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH. Mol Immunol. 2010 Sep; 47(15):2492-504.
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