 Agouti-Related Protein
"Agouti-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. It is expressed primarily in the HYPOTHALAMUS and the ADRENAL GLAND. As a paracrine signaling molecule, AGRP is known to regulate food intake and body weight. Elevated AGRP has been associated with OBESITY.
| Descriptor ID |
D054369
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| MeSH Number(s) |
D12.644.276.074 D12.776.467.074 D23.529.074
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Agouti-Related Protein".
Below are MeSH descriptors whose meaning is more specific than "Agouti-Related Protein".
This graph shows the total number of publications written about "Agouti-Related Protein" by people in this website by year, and whether "Agouti-Related Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Agouti-Related Protein" by people in Profiles.
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Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Strohbehn G, Trevaskis J, Rhodes CJ, Olson DP, Myers MG. Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.
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Yilmaz Z, Kaplan AS, Tiwari AK, Levitan RD, Piran S, Bergen AW, Kaye WH, Hakonarson H, Wang K, Berrettini WH, Brandt HA, Bulik CM, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson CL, Keel PK, Klump KL, Magistretti P, Mitchell JE, Strober M, Thornton LM, Treasure J, Woodside DB, Knight J, Kennedy JL. The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa. J Psychiatr Res. 2014 Aug; 55:77-86.
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Peng CY, Mukhopadhyay A, Jarrett JC, Yoshikawa K, Kessler JA. BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior. J Neurosci. 2012 Nov 28; 32(48):17211-24.
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Sánchez E, Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM. Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology. 2008 Sep; 149(9):4329-35.
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Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Lechan RM. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 2002 Oct; 143(10):3846-53.
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