"Poly(A)-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that bind to the 3' polyadenylated region of MRNA. When complexed with RNA the proteins serve an array of functions such as stabilizing the 3' end of RNA, promoting poly(A) synthesis and stimulating mRNA translation.
| Descriptor ID |
D039102
|
| MeSH Number(s) |
D12.776.157.725.452 D12.776.664.962.452
|
| Concept/Terms |
Poly(A)-Binding Proteins- Poly(A)-Binding Proteins
- Poly(A)-Binding Protein
- Poly A-Binding Proteins
- Poly A Binding Proteins
- Poly(A)+ mRNA Binding Protein
- Poly A-Binding Protein
- Poly A Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Poly(A)-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Poly(A)-Binding Proteins".
This graph shows the total number of publications written about "Poly(A)-Binding Proteins" by people in this website by year, and whether "Poly(A)-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2017 | 2 | 0 | 2 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Poly(A)-Binding Proteins" by people in Profiles.
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An adaptive biomolecular condensation response is conserved across environmentally divergent species. Nat Commun. 2024 Apr 11; 15(1):3127.
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HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker. Proc Natl Acad Sci U S A. 2024 Mar 26; 121(13):e2321606121.
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Chaperones directly and efficiently disperse stress-triggered biomolecular condensates. Mol Cell. 2022 02 17; 82(4):741-755.e11.
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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017 Aug 16; 95(4):808-816.e9.
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Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response. Cell. 2017 03 09; 168(6):1028-1040.e19.
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Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells. Biochem Soc Trans. 2004 Nov; 32(Pt 5):697-701.
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Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. J Virol. 2004 Aug; 78(16):8582-92.
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Cytotoxicity and apoptosis in human renal allografts: identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA. Lab Invest. 1997 May; 76(5):639-49.