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Chin-Tu Chen

TitleProfessor
InstitutionUniversity of Chicago
DepartmentRadiology-Basic Sciences
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Dr. Chen's research interests, primarily in integrative multi-modality molecular imaging, cover a broad spectrum of imaging-centered topics including imaging physics and instrumentation, image reconstruction and processing, imaging tracers and probes development, physiological modeling, quantitative and intelligent image analysis, as well as applications of molecular imaging methods in a wide spectrum of biological and medical investigations, especially in cancer, brain disorders, cardiopulmonary diseases, and diabetes.

    Collapse Biography 
    Collapse education and training
    National Tsing-Hua University, Hsinchu, TaiwanBS06/1974Physics
    Northwester University, Evanston, IllinoisMS06/1978Physics
    The University of Chicago, Chicago, IllinoisPhD12/1986Medical Physics

    Collapse Research 
    Collapse research activities and funding
    R01CA236385     (CHEN, CHIN-TU ;HALPERN, HOWARD J)Jan 1, 2020 - Dec 31, 2024
    NIH
    Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
    Role: Principal Investigator
    S10OD025265     (CHEN, CHIN-TU)Apr 3, 2018 - Apr 2, 2019
    NIH
    Integrating Preclinical and Translational Imaging Resources for Animal Research
    Role: Principal Investigator
    R01DA044760     (GREEN, WILLIAM)Jul 1, 2017 - Apr 30, 2022
    NIH
    PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
    Role: Co-Principal Investigator
    R01EB022388     (MENG, LING-JIAN)Sep 15, 2016 - Jun 30, 2021
    NIH
    An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras
    Role: Co-Principal Investigator
    R01EB011640     (MENG, LING-JIAN)Sep 1, 2011 - Jun 30, 2017
    NIH
    An Ultra High Resolution SPECT System Integrated with a High-Field MRI Scanner
    Role: Co-Principal Investigator
    S10RR022520     (CHEN, CHIN-TU)Mar 1, 2008 - Feb 28, 2010
    NIH
    Hybrid MicroSPECT/MicroCT for Quantitative Imaging
    Role: Principal Investigator
    R01NS034069     (CHEN, CHIN-TU)Jul 25, 1996 - Apr 30, 2000
    NIH
    DETECTABILITY IN BRAIN ACTIVATION STUDIES
    Role: Principal Investigator
    R01CA052101     (CHEN, CHIN-TU)Jul 1, 1993 - Jun 30, 1997
    NIH
    STATISTICAL METHODS FOR MEDICAL IMAGE RECONSTRUCTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brugarolas P, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B, Sánchez-Rodríguez JE. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607. PMID: 29330383; PMCID: PMC5766510.
      Citations: 19     Fields:    Translation:HumansAnimals
    2. Quigley BP, Smith CD, Cheng SH, Souris JS, Pelizzari CA, Chen CT, Lo LW, Reft CS, Wiersma RD, La Riviere PJ. Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging. Med Phys. 2017 Oct; 44(10):5367-5377. PMID: 28703922; PMCID: PMC5646227.
      Citations: 5     Fields:    
    3. Chen NT, Souris JS, Cheng SH, Chu CH, Wang YC, Konda V, Dougherty U, Bissonnette M, Mou CY, Chen CT, Lo LW. Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions. Nanomedicine. 2017 Aug; 13(6):1941-1952. PMID: 28363770; PMCID: PMC5673680.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    4. Cheng SH, Yu D, Tsai HM, Morshed RA, Kanojia D, Lo LW, Leoni L, Govind Y, Zhang L, Aboody KS, Lesniak MS, Chen CT, Balyasnikova IV. Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2016 Feb; 57(2):279-84. PMID: 26564318; PMCID: PMC5831675.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    5. Lennon FE, Cianci GC, Cipriani NA, Hensing TA, Zhang HJ, Chen CT, Murgu SD, Vokes EE, Vannier MW, Salgia R. Lung cancer-a fractal viewpoint. Nat Rev Clin Oncol. 2015 Nov; 12(11):664-75. PMID: 26169924; PMCID: PMC4989864.
      Citations: 64     Fields:    Translation:Humans
    6. Souris JS, Cheng SH, Pelizzari C, Chen NT, La Riviere P, Chen CT, Lo LW. Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy. Appl Phys Lett. 2014 Nov 17; 105(20):203110. PMID: 25425747; PMCID: PMC4240777.
      Citations: 6     
    7. Makinen MW, Bamba R, Ikejimba L, Wietholt C, Chen CT, Conzen SD. The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells. Dalton Trans. 2013 Sep 07; 42(33):11862-7. PMID: 23644715; PMCID: PMC3733664.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS. Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 2013 Dec 20; 9(24):4123-9. PMID: 23873826; PMCID: PMC3879136.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    9. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78. PMID: 23449689; PMCID: PMC3707374.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    10. Souris JS, Hickson JA, Msezane L, Rinker-Schaeffer CW, Chen CT. Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging. Mol Imaging. 2013 Jan-Feb; 12(1):28-38. PMID: 23348789.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL. Lung ¹8F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):670-9. PMID: 22246173; PMCID: PMC3326289.
      Citations: 97     Fields:    Translation:Animals
    12. Liao S, Penney BC, Wroblewski K, Zhang H, Simon CA, Kampalath R, Shih MC, Shimada N, Chen S, Salgia R, Appelbaum DE, Suzuki K, Chen CT, Pu Y. Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2012 Jan; 39(1):27-38. PMID: 21946983.
      Citations: 139     Fields:    Translation:Humans
    13. Mathew B, Lennon FE, Siegler J, Mirzapoiazova T, Mambetsariev N, Sammani S, Gerhold LM, LaRiviere PJ, Chen CT, Garcia JG, Salgia R, Moss J, Singleton PA. The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg. 2011 Mar; 112(3):558-67. PMID: 21156980; PMCID: PMC4327979.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    14. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen CT, LaRiviere PJ, Mauceri H, Sammani S, Husain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JG. Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):415-22. PMID: 20508068; PMCID: PMC3095940.
      Citations: 37     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Souris JS, Lee CH, Cheng SH, Chen CT, Yang CS, Ho JA, Mou CY, Lo LW. Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles. Biomaterials. 2010 Jul; 31(21):5564-74. PMID: 20417962; PMCID: PMC2875342.
      Citations: 78     Fields:    Translation:AnimalsCells
    16. Cho S, Bian J, Pelizzari CA, Chen CT, He TC, Pan X. Region-of-interest image reconstruction in circular cone-beam microCT. Med Phys. 2007 Dec; 34(12):4923-33. PMID: 18196817.
      Citations: 13     Fields:    Translation:HumansAnimals
    17. Kao CM, Pan X, Chen CT. An exact Fourier rebinning algorithm for 3D PET imaging using panel detectors. Phys Med Biol. 2004 Jun 07; 49(11):2407-23. PMID: 15248586.
      Citations: 3     Fields:    
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