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Willard W. Sharp

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Wofford College, Spartanburg, SCBS08/1989Biology and History
    University of South Carolina, Columbia, SCPhD12/1994Biomedical Science
    University of South Carolina, Columbia, SCMD05/2003Medicine
    University of Illinois at Chicago, Chicago, ILPost-Doctoral Work05/1998
    Collapse awards and honors
    2014SAEM Young Investigator Award, Society for Academic Emergency Medicine
    2013Best Resuscitation Abstract Award, Scientific Sessions, Amercian Heart Association
    2008 - 2010Resuscitation Science Young Investigator Award, American Heart Association
    2007Civilian Citation for Cardiac Arrest Assistance, Canton, Michigan Fire Department
    1985Eagle Scout, Boy Scouts of America
    2016Best Abstract Award (Translational Medicine), Department of Medicine Janet Rowley Research Day, University of Chicago
    2017Best Abstract Award (Basic Science), Department of Medicine Janet Rowley Research Day, University of Chicago

    Collapse Research 
    Collapse research activities and funding
    K08HL103901     (SHARP, WILLARD WILLIAM)Jun 10, 2011 - Mar 31, 2016
    NIH
    Hypothermia in Cardiac Arrest: Akt Preservation of Mitochondrial Integrity
    Role: Principal Investigator
    R03HL110826     (SHARP, WILLARD WILLIAM)Aug 1, 2012 - Jun 30, 2014
    NIH
    Mitochondrial dynamics in human pulmonary hypertension: a new therapeutic target
    Role: Principal Investigator
    R01HL133675     (SHARP, WILLARD WILLIAM)Jul 1, 2016 - Apr 30, 2021
    NIH
    Pharmacological Induced Torpor/Hypothermia As A Novel Therapy for Improving Post Cardiac Arrest Resuscitation Outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Archer SL, Sharp WW, Weir EK. Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications. Circulation. 2020 07 14; 142(2):101-104. PMID: 32369390.
      View in: PubMed
    2. Zhang HJ, Mitchell S, Fang YH, Tsai HM, Piao L, Ousta A, Leoni L, Chen CT, Sharp WW. Assessment of Brain Glucose Metabolism Following Cardiac Arrest by [18F]FDG Positron Emission Tomography. Neurocrit Care. 2020 May 01. PMID: 32358767.
      View in: PubMed
    3. Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2020 02; 48(2):e133-e140. PMID: 31939812.
      View in: PubMed
    4. Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2019 Nov 13. PMID: 31725436.
      View in: PubMed
    5. Bharmal MI, Venturini JM, Chua RFM, Sharp WW, Beiser DG, Tabit CE, Hirai T, Rosenberg JR, Friant J, Blair JEA, Paul JD, Nathan S, Shah AP. Cost-utility of extracorporeal cardiopulmonary resuscitation in patients with cardiac arrest. Resuscitation. 2019 03; 136:126-130. PMID: 30716427.
      View in: PubMed
    6. Piao L, Fang YH, Kubler MM, Donnino MW, Sharp WW. Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest. PLoS One. 2017; 12(9):e0185046. PMID: 28934276.
      View in: PubMed
    7. Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP. Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. Oncotarget. 2017 May 23; 8(21):34082-34098. PMID: 28423723.
      View in: PubMed
    8. Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 04; 95(4):381-393. PMID: 28265681.
      View in: PubMed
    9. Pillai VB, Bindu S, Sharp W, Fang YH, Kim G, Gupta M, Samant S, Gupta MP. Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice. . 2016 Apr 15; 310(8):H962-72. PMID: 26873966.
      View in: PubMed
    10. Sharp WW. EM:RAP Commentaries in the Annals of Emergency Medicine: Peer Review and Financial Disclosure Needed. Ann Emerg Med. 2015 Jul; 66(1):90-1. PMID: 26097029.
      View in: PubMed
    11. Sharp WW, Davis C, McQueen A. Images in emergency medicine. Neonate with pustular rash. Neonatal methicillin-resistant staphylococcal (MRSA) pustulosis. Ann Emerg Med. 2015 Apr; 65(4):464, 469. PMID: 25805031.
      View in: PubMed
    12. Sharp WW. Change of shift. It's the Ebola. Ann Emerg Med. 2015 Apr; 65(4):457. PMID: 25805029.
      View in: PubMed
    13. Sharp WW. The crisis in the emergency medicine physician scientist workforce. Acad Emerg Med. 2015 Apr; 22(4):492. PMID: 25773995.
      View in: PubMed
    14. Sharp WW, Archer SL. Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function. J Mol Med (Berl). 2015 Mar; 93(3):225-8. PMID: 25669447.
      View in: PubMed
    15. Sharp WW. Dynamin-related protein 1 as a therapeutic target in cardiac arrest. J Mol Med (Berl). 2015 Mar; 93(3):243-52. PMID: 25659608.
      View in: PubMed
    16. Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb; 43(2):e38-47. PMID: 25599491.
      View in: PubMed
    17. Deal NS, Sharp WW, Orbelyan GA, Borak MH, Friant J, Shah AP, Beiser DG. The emergency cardiac arrest response team (eCART): a novel strategy for improving therapeutic hypothermia utilization following out-of-hospital cardiac arrest. Resuscitation. 2014 Dec; 85(12):1775-8. PMID: 25449348.
      View in: PubMed
    18. Sharp WW, Chan W. Images in emergency medicine. Infant with projectile vomiting. Peristaltic abdominal waves associated with infantile hypertrophic pyloric stenosis. Ann Emerg Med. 2014 Mar; 63(3):289,308. PMID: 24528943.
      View in: PubMed
    19. Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, Morrow E, Ryan JJ, Archer SL. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014 Jan; 28(1):316-26. PMID: 24076965.
      View in: PubMed
    20. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78. PMID: 23449689.
      View in: PubMed
    21. Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL. Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res. 2013 Mar 01; 112(5):802-15. PMID: 23334860.
      View in: PubMed
    22. Chang WT, Li J, Haung HH, Liu H, Han M, Ramachandran S, Li CQ, Sharp WW, Hamann KJ, Yuan CS, Hoek TL, Shao ZH. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. J Cell Biochem. 2011 Oct; 112(10):2873-81. PMID: 21618589.
      View in: PubMed
    23. Shao ZH, Sharp WW, Wojcik KR, Li CQ, Han M, Chang WT, Ramachandran S, Li J, Hamann KJ, Vanden Hoek TL. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. . 2010 Jun; 298(6):H2164-73. PMID: 20382860.
      View in: PubMed
    24. Shao ZH, Wojcik KR, Dossumbekova A, Hsu C, Mehendale SR, Li CQ, Qin Y, Sharp WW, Chang WT, Hamann KJ, Yuan CS, Hoek TL. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. 2009 Jul 01; 107(4):697-705. PMID: 19388003.
      View in: PubMed
    25. Perhonen M, Sharp WW, Russell B. Microtubules are needed for dispersal of alpha-myosin heavy chain mRNA in rat neonatal cardiac myocytes. J Mol Cell Cardiol. 1998 Sep; 30(9):1713-22. PMID: 9769227.
      View in: PubMed
    26. Goldspink P, Sharp W, Russell B. Localization of cardiac (alpha)-myosin heavy chain mRNA is regulated by its 3' untranslated region via mechanical activity and translational block. J Cell Sci. 1997 Dec; 110 ( Pt 23):2969-78. PMID: 9359883.
      View in: PubMed
    27. Sharp WW, Simpson DG, Borg TK, Samarel AM, Terracio L. Mechanical forces regulate focal adhesion and costamere assembly in cardiac myocytes. Am J Physiol. 1997 Aug; 273(2 Pt 2):H546-56. PMID: 9277468.
      View in: PubMed
    28. Simpson DG, Sharp WW, Borg TK, Price RL, Terracio L, Samarel AM. Mechanical regulation of cardiac myocyte protein turnover and myofibrillar structure. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1075-87. PMID: 8928735.
      View in: PubMed
    29. Simpson DG, Sharp WW, Borg TK, Price RL, Samarel AM, Terracio L. Mechanical regulation of cardiac myofibrillar structure. Ann N Y Acad Sci. 1995 Mar 27; 752:131-40. PMID: 7755252.
      View in: PubMed
    30. Sharp WW, Terracio L, Borg TK, Samarel AM. Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circ Res. 1993 Jul; 73(1):172-83. PMID: 8508528.
      View in: PubMed
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