Willard W. Sharp
Title | Associate Professor |
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Institution | University of Chicago |
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Department | Medicine-Emergency Medicine |
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Address | Chicago IL 60637
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vCard | Download vCard |
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Biography Wofford College, Spartanburg, SC | BS | 08/1989 | Biology and History | University of South Carolina, Columbia, SC | PhD | 12/1994 | Biomedical Science | University of South Carolina, Columbia, SC | MD | 05/2003 | Medicine | University of Illinois at Chicago, Chicago, IL | Post-Doctoral Work | 05/1998 | |
2014 | SAEM Young Investigator Award, Society for Academic Emergency Medicine | 2013 | Best Resuscitation Abstract Award, Scientific Sessions, Amercian Heart Association | 2008 - 2010 | Resuscitation Science Young Investigator Award, American Heart Association | 2007 | Civilian Citation for Cardiac Arrest Assistance, Canton, Michigan Fire Department | 1985 | Eagle Scout, Boy Scouts of America | 2016 | Best Abstract Award (Translational Medicine), Department of Medicine Janet Rowley Research Day, University of Chicago | 2017 | Best Abstract Award (Basic Science), Department of Medicine Janet Rowley Research Day, University of Chicago |
Research K08HL103901 (SHARP, WILLARD WILLIAM)Jun 10, 2011 - Mar 31, 2016 NIH Hypothermia in Cardiac Arrest: Akt Preservation of Mitochondrial Integrity Role: Principal Investigator |
| R03HL110826 (SHARP, WILLARD WILLIAM)Aug 1, 2012 - Jun 30, 2014 NIH Mitochondrial dynamics in human pulmonary hypertension: a new therapeutic target Role: Principal Investigator |
| R01HL133675 (SHARP, WILLARD WILLIAM)Jul 1, 2016 - Apr 30, 2021 NIH Pharmacological Induced Torpor/Hypothermia As A Novel Therapy for Improving Post Cardiac Arrest Resuscitation Outcomes Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Woods PS, Kimmig LM, Sun KA, Meliton AY, Shamaa OR, Tian Y, Cetin-Atalay R, Sharp WW, Hamanaka RB, Mutlu GM. HIF-1a induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife. 2022 07 13; 11. PMID: 35822617.
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Moore AB, Puskarich M, Vogel JA, Brown J, Sharp WW. Emergency medicine faculty serving on standing NIH and AHRQ study sections from 2019 to 2020. Acad Emerg Med. 2022 01; 29(1):118-122. PMID: 34250678.
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Jarou ZJ, Beiser DG, Sharp WW, Chacko R, Goode D, Rubin DS, Kurian D, Dalton A, Estime SR, O'Connor M, Patel BK, Kress JP, Spiegel TF. Emergency Department-initiated High-flow Nasal Cannula for COVID-19 Respiratory Distress. West J Emerg Med. 2021 Jul 20; 22(4):979-987. PMID: 35354003.
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Ousta A, Piao L, Fang YH, Vera A, Nallamothu T, Garcia AJ, Sharp WW. Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest. Neurocrit Care. 2022 02; 36(1):61-70. PMID: 34268646.
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Zhang HJ, Mitchell S, Fang YH, Tsai HM, Piao L, Ousta A, Leoni L, Chen CT, Sharp WW. Assessment of Brain Glucose Metabolism Following Cardiac Arrest by [18F]FDG Positron Emission Tomography. Neurocrit Care. 2021 02; 34(1):64-72. PMID: 32358767.
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Zaidi HQ, Li S, Beiser DG, Tataris KL, Sharp WW. The utility of computed tomography to evaluate thoracic complications after cardiopulmonary resuscitation. Resusc Plus. 2020 Sep; 3:100017. PMID: 34223300.
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Archer SL, Sharp WW, Weir EK. Differentiating COVID-19 Pneumonia From Acute Respiratory Distress Syndrome and High Altitude Pulmonary Edema: Therapeutic Implications. Circulation. 2020 07 14; 142(2):101-104. PMID: 32369390.
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Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2020 02; 48(2):e133-e140. PMID: 31939812.
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Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2019 Nov 13. PMID: 31725436.
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Bharmal MI, Venturini JM, Chua RFM, Sharp WW, Beiser DG, Tabit CE, Hirai T, Rosenberg JR, Friant J, Blair JEA, Paul JD, Nathan S, Shah AP. Cost-utility of extracorporeal cardiopulmonary resuscitation in patients with cardiac arrest. Resuscitation. 2019 03; 136:126-130. PMID: 30716427.
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Piao L, Fang YH, Kubler MM, Donnino MW, Sharp WW. Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest. PLoS One. 2017; 12(9):e0185046. PMID: 28934276.
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Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP. Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice. Oncotarget. 2017 May 23; 8(21):34082-34098. PMID: 28423723.
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Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 04; 95(4):381-393. PMID: 28265681.
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Pillai VB, Bindu S, Sharp W, Fang YH, Kim G, Gupta M, Samant S, Gupta MP. Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice. Am J Physiol Heart Circ Physiol. 2016 Apr 15; 310(8):H962-72. PMID: 26873966.
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Sharp WW. EM:RAP Commentaries in the Annals of Emergency Medicine: Peer Review and Financial Disclosure Needed. Ann Emerg Med. 2015 Jul; 66(1):90-1. PMID: 26097029.
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Sharp WW. Change of shift. It's the Ebola. Ann Emerg Med. 2015 Apr; 65(4):457. PMID: 25805029.
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Sharp WW, Davis C, McQueen A. Images in emergency medicine. Neonate with pustular rash. Neonatal methicillin-resistant staphylococcal (MRSA) pustulosis. Ann Emerg Med. 2015 Apr; 65(4):464, 469. PMID: 25805031.
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Sharp WW. The crisis in the emergency medicine physician scientist workforce. Acad Emerg Med. 2015 Apr; 22(4):492. PMID: 25773995.
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Sharp WW, Archer SL. Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function. J Mol Med (Berl). 2015 Mar; 93(3):225-8. PMID: 25669447.
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Sharp WW. Dynamin-related protein 1 as a therapeutic target in cardiac arrest. J Mol Med (Berl). 2015 Mar; 93(3):243-52. PMID: 25659608.
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Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb; 43(2):e38-47. PMID: 25599491.
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Deal NS, Sharp WW, Orbelyan GA, Borak MH, Friant J, Shah AP, Beiser DG. The emergency cardiac arrest response team (eCART): a novel strategy for improving therapeutic hypothermia utilization following out-of-hospital cardiac arrest. Resuscitation. 2014 Dec; 85(12):1775-8. PMID: 25449348.
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Sharp WW, Chan W. Images in emergency medicine. Infant with projectile vomiting. Peristaltic abdominal waves associated with infantile hypertrophic pyloric stenosis. Ann Emerg Med. 2014 Mar; 63(3):289,308. PMID: 24528943.
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Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, Morrow E, Ryan JJ, Archer SL. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014 Jan; 28(1):316-26. PMID: 24076965.
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Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78. PMID: 23449689.
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Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL. Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res. 2013 Mar 01; 112(5):802-15. PMID: 23334860.
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Chang WT, Li J, Haung HH, Liu H, Han M, Ramachandran S, Li CQ, Sharp WW, Hamann KJ, Yuan CS, Hoek TL, Shao ZH. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. J Cell Biochem. 2011 Oct; 112(10):2873-81. PMID: 21618589.
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Shao ZH, Sharp WW, Wojcik KR, Li CQ, Han M, Chang WT, Ramachandran S, Li J, Hamann KJ, Vanden Hoek TL. Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2164-73. PMID: 20382860.
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Shao ZH, Wojcik KR, Dossumbekova A, Hsu C, Mehendale SR, Li CQ, Qin Y, Sharp WW, Chang WT, Hamann KJ, Yuan CS, Hoek TL. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. 2009 Jul 01; 107(4):697-705. PMID: 19388003.
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Perhonen M, Sharp WW, Russell B. Microtubules are needed for dispersal of alpha-myosin heavy chain mRNA in rat neonatal cardiac myocytes. J Mol Cell Cardiol. 1998 Sep; 30(9):1713-22. PMID: 9769227.
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Goldspink P, Sharp W, Russell B. Localization of cardiac (alpha)-myosin heavy chain mRNA is regulated by its 3' untranslated region via mechanical activity and translational block. J Cell Sci. 1997 Dec; 110 ( Pt 23):2969-78. PMID: 9359883.
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Sharp WW, Simpson DG, Borg TK, Samarel AM, Terracio L. Mechanical forces regulate focal adhesion and costamere assembly in cardiac myocytes. Am J Physiol. 1997 Aug; 273(2 Pt 2):H546-56. PMID: 9277468.
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Simpson DG, Sharp WW, Borg TK, Price RL, Terracio L, Samarel AM. Mechanical regulation of cardiac myocyte protein turnover and myofibrillar structure. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1075-87. PMID: 8928735.
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Simpson DG, Sharp WW, Borg TK, Price RL, Samarel AM, Terracio L. Mechanical regulation of cardiac myofibrillar structure. Ann N Y Acad Sci. 1995 Mar 27; 752:131-40. PMID: 7755252.
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Sharp WW, Terracio L, Borg TK, Samarel AM. Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells. Circ Res. 1993 Jul; 73(1):172-83. PMID: 8508528.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1993 | 1 | 1995 | 1 | 1996 | 1 | 1997 | 2 | 1998 | 1 | 2009 | 1 | 2010 | 1 | 2011 | 1 | 2013 | 3 | 2014 | 2 | 2015 | 7 | 2016 | 1 | 2017 | 3 | 2019 | 2 | 2020 | 3 | 2021 | 4 | 2022 | 1 |
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