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Nickolai Dulin

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
Phone+1 (773) 702-5198
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    Collapse Overview 
    Collapse overview
    Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT.

    Dr. Dulin's NIH Commons ID is NDULIN

    Collapse Research 
    Collapse research activities and funding
    R01HL149993     (DULIN, NICKOLAI O)Aug 15, 2020 - Jul 31, 2024
    Fibroblast Biology and Pulmonary Fibrosis
    Role: Principal Investigator

    R56HL127395     (DULIN, NICKOLAI O)Sep 15, 2015 - Aug 31, 2017
    Control of myofibroblast activation and pulmonary fibrosis by Na/K-ATPase
    Role: Principal Investigator

    R01GM085058     (DULIN, NICKOLAI O)May 1, 2009 - Apr 30, 2013
    Novel functions of RGS3
    Role: Principal Investigator

    R01HL071755     (DULIN, NICKOLAI O)May 1, 2005 - Apr 30, 2011
    Activation of protein kinase A by endothelin-1
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reed EB, Sitikov A, Hamanaka RB, Cetin-Atalay R, Mutlu GM, Mongin AA, Dulin NO. Critical role of Ga12 and Ga13 proteins in TGF-ß-induced myofibroblast differentiation. bioRxiv. 2024 May 30. PMID: 38854083; PMCID: PMC11160726.
    2. Reed EB, Orbeta S, Miao BA, Sitikov A, Chen B, Levitan I, Solway J, Mutlu GM, Fang Y, Mongin AA, Dulin NO. Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2024 01 01; 326(1):L111-L123. PMID: 38084409.
      Citations:    Fields:    Translation:HumansCells
    3. Reed EB, Orbeta S, Sitikov A, Levitan I, Mutlu GM, Dulin NO, Miao BA, Chen B, Solway J, Fang Y, Mongin AA. Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation. bioRxiv. 2023 Nov 09. PMID: 37333255; PMCID: PMC10274757.
    4. O'Sullivan JA, Kohlhapp FJ, Zloza A, Plaza-Rojas L, Burke B, Dulin NO, Guevara-Patiño JA. Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß. Int J Mol Sci. 2023 Feb 15; 24(4). PMID: 36835342; PMCID: PMC9966622.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Eid S, Zerbes T, Williams D, Wang X, Sackmann C, Meier S, Dulin NO, Nagorny P, Schmitt-Ulms G. Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein. Int J Mol Sci. 2022 Nov 26; 23(23). PMID: 36499150; PMCID: PMC9736291.
      Citations: 3     Fields:    Translation:Humans
    6. Dulin NO. Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling. Front Physiol. 2020; 11:590262. PMID: 33250781; PMCID: PMC7674831.
      Citations: 12     
    7. Orlov SN, Tverskoi AM, Sidorenko SV, Smolyaninova LV, Lopina OD, Dulin NO, Klimanova EA. Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence? Genes Dis. 2021 May; 8(3):259-271. PMID: 33997173; PMCID: PMC8093582.
      Citations: 13     
    8. Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Meliton AY, Dulin NO, Gökalp GA, Mutlu GM. Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 11; 61(5):597-606. PMID: 30973753; PMCID: PMC6827066.
      Citations: 54     Fields:    Translation:HumansCells
    9. Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Dulin NO, Mutlu GM. Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling. Respir Res. 2019 Jul 29; 20(1):168. PMID: 31358001; PMCID: PMC6664561.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    10. Ard S, Reed EB, Smolyaninova LV, Orlov SN, Guzy RD, Dulin NO, Mutlu GM. Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-ß. Am J Respir Cell Mol Biol. 2019 03; 60(3):367-369. PMID: 30821500; PMCID: PMC6397974.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    11. Dulin NO, Smolyaninova LV, Orlov SN. Control of lung myofibroblast transformation by monovalent ion transporters. Curr Top Membr. 2019; 83:15-43. PMID: 31196603.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L. P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation. Am J Respir Cell Mol Biol. 2019 02; 60(2):221-231. PMID: 30230348; PMCID: PMC6376409.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Orlov SN, La J, Smolyaninova LV, Dulin NO. Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis. Curr Med Chem. 2019; 26(3):564-575. PMID: 28625151.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    14. Koo HY, El-Baz LM, House S, Cilvik SN, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol. 2018 09; 246(1):54-66. PMID: 29873400; PMCID: PMC6175645.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    15. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 05; 58(5):585-593. PMID: 29019702; PMCID: PMC5946329.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    16. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 02; 32(2):862-874. PMID: 29042451; PMCID: PMC5888400.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    17. La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Orlov SN, Dulin NO, Mutlu GM. Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 2016; 11(12):e0168363. PMID: 28006004; PMCID: PMC5179089.
      Citations: 11     Fields:    Translation:HumansCells
    18. Sandbo N, Smolyaninova LV, Orlov SN, Dulin NO. Control of Myofibroblast Differentiation and Function by Cytoskeletal Signaling. Biochemistry (Mosc). 2016 Dec; 81(13):1698-1708. PMID: 28260491.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    19. Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016 12 30; 291(53):27239-27251. PMID: 27836973; PMCID: PMC5207151.
      Citations: 66     Fields:    Translation:HumansCells
    20. Bindu S, Pillai VB, Kanwal A, Samant S, Verdin E, Dulin N, Gupta MP, Mutlu GM. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L68-L78. PMID: 27815257; PMCID: PMC5283928.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    21. La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Orlov SN, Dulin NO, Mutlu GM. Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23. PMID: 26851261; PMCID: PMC4867347.
      Citations: 14     Fields:    Translation:HumansCells
    22. Kapilevich LV, Kironenko TA, Zaharova AN, Kotelevtsev YV, Dulin NO, Orlov SN. Skeletal muscle as an endocrine organ: Role of [Na+]i/[K+]i-mediated excitation-transcription coupling. Genes Dis. 2015 Dec; 2(4):328-336. PMID: 27610402; PMCID: PMC5012537.
      Citations: 6     
    23. Akimova OA, Tverskoi AM, Smolyaninova LV, Mongin AA, Lopina OD, La J, Dulin NO, Orlov SN. Critical role of the a1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain. Apoptosis. 2015 Sep; 20(9):1200-10. PMID: 26067145; PMCID: PMC4677477.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Orlov SN, Koltsova SV, Kapilevich LV, Gusakova SV, Dulin NO. NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension. Genes Dis. 2015 Jun; 2(2):186-196. PMID: 26114157; PMCID: PMC4477834.
      Citations: 25     
    25. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. PMID: 26034042; PMCID: PMC4522239.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    26. Bernau K, Ngam C, Torr EE, Acton B, Kach J, Dulin NO, Sandbo N. Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis. Respir Res. 2015 Mar 27; 16:45. PMID: 25885656; PMCID: PMC4392778.
      Citations: 16     Fields:    Translation:AnimalsCells
    27. Mayorova T, Kosevich I, Dulin N, Savina E, Kraus Y. Organizer regions in marine colonial hydrozoans. Zoology (Jena). 2015 Apr; 118(2):89-101. PMID: 25749284.
      Citations: 2     Fields:    Translation:Animals
    28. Orlov SN, Koltsova SV, Kapilevich LV, Dulin NO, Gusakova SV. Cation-chloride cotransporters: regulation, physiological significance, and role in pathogenesis of arterial hypertension. Biochemistry (Mosc). 2014 Dec; 79(13):1546-61. PMID: 25749164.
      Citations: 5     Fields:    Translation:Humans
    29. Kach J, Sandbo N, La J, Denner D, Reed EB, Akimova O, Koltsova S, Orlov SN, Dulin NO. Antifibrotic effects of noscapine through activation of prostaglandin E2 receptors and protein kinase A. J Biol Chem. 2014 Mar 14; 289(11):7505-13. PMID: 24492608; PMCID: PMC3953264.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    30. Williams JW, Yau D, Sethakorn N, Kach J, Reed EB, Moore TV, Cannon J, Jin X, Xing H, Muslin AJ, Sperling AI, Dulin NO. RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L693-701. PMID: 24077945; PMCID: PMC3840273.
      Citations: 9     Fields:    Translation:AnimalsCells
    31. Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L757-64. PMID: 23585227; PMCID: PMC3680759.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    32. Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin N. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2. J Biol Chem. 2013 May 31; 288(22):15466-73. PMID: 23580645; PMCID: PMC3668708.
      Citations: 35     Fields:    Translation:HumansCells
    33. Sethakorn N, Dulin NO. RGS expression in cancer: oncomining the cancer microarray data. J Recept Signal Transduct Res. 2013 Jun; 33(3):166-71. PMID: 23464602.
      Citations: 24     Fields:    Translation:HumansCells
    34. Kach J, Sethakorn N, Dulin NO. A finer tuning of G-protein signaling through regulated control of RGS proteins. Am J Physiol Heart Circ Physiol. 2012 Jul; 303(1):H19-35. PMID: 22542620; PMCID: PMC3404647.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    35. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. PMID: 21918105; PMCID: PMC3329869.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    36. Sandbo N, Lau A, Kach J, Ngam C, Yau D, Dulin NO. Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-ß. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L656-66. PMID: 21856814; PMCID: PMC3213993.
      Citations: 66     Fields:    Translation:HumansCells
    37. Sandbo N, Dulin N. Actin cytoskeleton in myofibroblast differentiation: ultrastructure defining form and driving function. Transl Res. 2011 Oct; 158(4):181-96. PMID: 21925115; PMCID: PMC3324184.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    38. O'Sullivan JA, Zloza A, Kohlhapp FJ, Moore TV, Lacek AT, Dulin NO, Guevara-Patiño JA. Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)ß-mediated suppression. Cancer Immunol Immunother. 2011 Nov; 60(11):1543-51. PMID: 21681376; PMCID: PMC3327162.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    39. Ma L, Brown M, Kogut P, Serban K, Li X, McConville J, Chen B, Bentley JK, Hershenson MB, Dulin N, Solway J, Camoretti-Mercado B. Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011 May; 300(5):L701-9. PMID: 21378028; PMCID: PMC3094029.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    40. Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011 Apr; 22(7):954-63. PMID: 21289089; PMCID: PMC3069020.
      Citations: 19     Fields:    Translation:AnimalsCells
    41. McConville JF, Fernandes DJ, Churchill J, Dewundara S, Kogut P, Shah S, Fuchs G, Kedainis D, Bellam SK, Patel NM, McCauley J, Dulin NO, Gupta MP, Adam S, Yoneda Y, Camoretti-Mercado B, Solway J. Nuclear import of serum response factor in airway smooth muscle. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):453-8. PMID: 21131446; PMCID: PMC3175573.
      Citations: 2     Fields:    Translation:HumansCells
    42. Sethakorn N, Yau DM, Dulin NO. Non-canonical functions of RGS proteins. Cell Signal. 2010 Sep; 22(9):1274-81. PMID: 20363320; PMCID: PMC2893250.
      Citations: 42     Fields:    Translation:Cells
    43. Kwon IK, Wang R, Thangaraju M, Shuang H, Liu K, Dashwood R, Dulin N, Ganapathy V, Browning DD. PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4. Oncogene. 2010 Jun 10; 29(23):3423-34. PMID: 20348951; PMCID: PMC3114416.
      Citations: 33     Fields:    Translation:HumansCells
    44. Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Mitchell RW, Solway J. MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J. 2010 Sep; 36(3):630-7. PMID: 20110395; PMCID: PMC3918254.
      Citations: 8     Fields:    Translation:AnimalsCells
    45. Taurin S, Sandbo N, Yau DM, Sethakorn N, Kach J, Dulin NO. Phosphorylation of myocardin by extracellular signal-regulated kinase. J Biol Chem. 2009 Dec 04; 284(49):33789-94. PMID: 19776005; PMCID: PMC2797148.
      Citations: 16     Fields:    Translation:AnimalsCells
    46. Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009 Nov 20; 284(47):32582-90. PMID: 19797053; PMCID: PMC2781672.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    47. Sandbo N, Kregel S, Taurin S, Bhorade S, Dulin NO. Critical role of serum response factor in pulmonary myofibroblast differentiation induced by TGF-beta. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):332-8. PMID: 19151320; PMCID: PMC2742753.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    48. Lakser OJ, Dowell ML, Hoyte FL, Chen B, Lavoie TL, Ferreira C, Pinto LH, Dulin NO, Kogut P, Churchill J, Mitchell RW, Solway J. Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma. Eur Respir J. 2008 Nov; 32(5):1224-30. PMID: 18768574; PMCID: PMC2582388.
      Citations: 14     Fields:    Translation:AnimalsCells
    49. Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer. 2008 Apr 01; 112(7):1462-70. PMID: 18260092.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    50. Taurin S, Sandbo N, Yau DM, Sethakorn N, Dulin NO. Phosphorylation of beta-catenin by PKA promotes ATP-induced proliferation of vascular smooth muscle cells. Am J Physiol Cell Physiol. 2008 May; 294(5):C1169-74. PMID: 18353896; PMCID: PMC3327159.
      Citations: 32     Fields:    Translation:AnimalsCells
    51. Yau DM, Sethakorn N, Taurin S, Kregel S, Sandbo N, Camoretti-Mercado B, Sperling AI, Dulin NO. Regulation of Smad-mediated gene transcription by RGS3. Mol Pharmacol. 2008 May; 73(5):1356-61. PMID: 18287247; PMCID: PMC3329871.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    52. Taurin S, Dulin NO, Orlov SN, Akimova OA. Purinergic inhibition of Na?,K?,Cl? cotransport in C11-MDCK cells: Role of stress-activated protein kinases. Purinergic Signal. 2008 Jun; 4(2):183-91. PMID: 18368525; PMCID: PMC2377324.
      Citations: 4     Fields:    
    53. Haloui M, Taurin S, Akimova OA, Guo DF, Tremblay J, Dulin NO, Hamet P, Orlov SN. [Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements. FEBS J. 2007 Jul; 274(14):3557-3567. PMID: 17565602.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    54. Taurin S, Hogarth K, Sandbo N, Yau DM, Dulin NO. Gbetagamma-mediated prostacyclin production and cAMP-dependent protein kinase activation by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3. J Biol Chem. 2007 Jul 06; 282(27):19518-25. PMID: 17513863.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Sandbo N, Taurin S, Yau DM, Kregel S, Mitchell R, Dulin NO. Downregulation of smooth muscle alpha-actin expression by bacterial lipopolysaccharide. Cardiovasc Res. 2007 May 01; 74(2):262-9. PMID: 17303098.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    56. Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J Biol Chem. 2006 Apr 14; 281(15):9971-6. PMID: 16476742.
      Citations: 218     Fields:    Translation:HumansAnimalsCells
    57. Camoretti-Mercado B, Dulin NO, Solway J. SRF function in vascular smooth muscle: when less is more? Circ Res. 2005 Sep 02; 97(5):409-10. PMID: 16141114.
      Citations: 1     Fields:    Translation:Animals
    58. Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN, Akimova AO. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. J Physiol. 2005 Nov 01; 568(Pt 3):789-801. PMID: 16109726; PMCID: PMC1464179.
      Citations: 4     Fields:    Translation:AnimalsCells
    59. Sandbo N, Qin Y, Taurin S, Hogarth DK, Kreutz B, Dulin NO. Regulation of serum response factor-dependent gene expression by proteasome inhibitors. Mol Pharmacol. 2005 Mar; 67(3):789-97. PMID: 15550677.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    60. Anfinogenova YJ, Baskakov MB, Kovalev IV, Kilin AA, Dulin NO, Orlov SN. Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels. Pflugers Arch. 2004 Oct; 449(1):42-55. PMID: 15293051.
      Citations: 15     Fields:    Translation:AnimalsCells
    61. Yamaguchi K, Uzzo R, Dulin N, Finke JH, Kolenko V. Renal carcinoma cells undergo apoptosis without oligonucleosomal DNA fragmentation. Biochem Biophys Res Commun. 2004 Jun 04; 318(3):710-3. PMID: 15144896.
      Citations: 9     Fields:    Translation:HumansCells
    62. Hogarth DK, Sandbo N, Taurin S, Kolenko V, Miano JM, Dulin NO. Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C449-56. PMID: 15238360.
      Citations: 22     Fields:    Translation:AnimalsCells
    63. Camoretti-Mercado B, Dulin NO, Solway J. Serum response factor function and dysfunction in smooth muscle. Respir Physiol Neurobiol. 2003 Sep 16; 137(2-3):223-35. PMID: 14516728.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    64. Chandrasekar B, Mummidi S, Perla RP, Bysani S, Dulin NO, Liu F, Melby PC. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Biochem J. 2003 Jul 15; 373(Pt 2):547-58. PMID: 12729461; PMCID: PMC1223517.
      Citations: 59     Fields:    Translation:AnimalsCells
    65. Davis A, Hogarth K, Fernandes D, Solway J, Niu J, Kolenko V, Browning D, Miano JM, Orlov SN, Dulin NO. Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA. Cell Signal. 2003 Jun; 15(6):597-604. PMID: 12681447.
      Citations: 17     Fields:    Translation:AnimalsCells
    66. Solway J, Bellam S, Dowell M, Camoretti-Mercado B, Dulin N, Fernandes D, Halayko A, Kocieniewski P, Kogut P, Lakser O, Liu HW, McCauley J, McConville J, Mitchell R. Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Parker B. Francis lecture. Chest. 2003 Mar; 123(3 Suppl):392S-8S. PMID: 12629000.
      Citations: 5     Fields:    Translation:Humans
    67. Hou Y, Lascola J, Dulin NO, Ye RD, Browning DD. Activation of cGMP-dependent protein kinase by protein kinase C. J Biol Chem. 2003 May 09; 278(19):16706-12. PMID: 12609995.
      Citations: 10     Fields:    Translation:HumansCells
    68. Dulin NO, Fernandes DJ, Dowell M, Bellam S, McConville J, Lakser O, Mitchell R, Camoretti-Mercado B, Kogut P, Solway J. What evidence implicates airway smooth muscle in the cause of BHR? Clin Rev Allergy Immunol. 2003 Feb; 24(1):73-84. PMID: 12644719.
      Citations: 12     Fields:    Translation:HumansAnimals
    69. Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, Marelli-Berg FM, Dulin NO, Singh IS. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem. 2003 Feb 14; 278(7):4675-86. PMID: 12468547.
      Citations: 44     Fields:    Translation:AnimalsCells
    70. Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N, Kolenko VM, Uzzo RG, Leavis P, Hatch W, Gabai VL, Dulin N, Zvartau N, Kolenko VM. Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res. 2002 Nov; 8(11):3579-83. PMID: 12429649.
      Citations: 38     Fields:    Translation:HumansCells
    71. Dulin NO, Pchejetski D, Grygorczyk R, Tremblay J, Hamet P, Orlov SN, Taurin S. c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism. J Physiol. 2002 Sep 15; 543(Pt 3):835-47. PMID: 12231642; PMCID: PMC2290551.
      Citations: 18     Fields:    Translation:AnimalsCells
    72. Niu J, Scheschonka A, Druey KM, Davis A, Reed E, Kolenko V, Bodnar R, Voyno-Yasenetskaya T, Du X, Kehrl J, Dulin NO. RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain. Biochem J. 2002 Aug 01; 365(Pt 3):677-84. PMID: 11985497; PMCID: PMC1222729.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    73. Kolenko VM, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH, Kolenko VM, Uzzo RG, Dulin N, Hauzman E, Bukowski R, Finke JH. Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis. 2001 Dec; 6(6):419-29. PMID: 11595831.
      Citations: 15     Fields:    Translation:HumansCells
    74. Niu J, Vaiskunaite R, Suzuki N, Kozasa T, Carr DW, Dulin N, Voyno-Yasenetskaya TA. Interaction of heterotrimeric G13 protein with an A-kinase-anchoring protein 110 (AKAP110) mediates cAMP-independent PKA activation. Curr Biol. 2001 Oct 30; 11(21):1686-90. PMID: 11696326.
      Citations: 25     Fields:    Translation:HumansCells
    75. Uzzo RG, Dulin N, Bloom T, Bukowski R, Finke JH, Kolenko V, Uzzo RG, Dulin N, Bloom T, Bukowski R, Finke JH, Kolenko V. Inhibition of NFkappaB induces caspase-independent cell death in human T lymphocytes. Biochem Biophys Res Commun. 2001 Oct 05; 287(4):895-9. PMID: 11573949.
      Citations: 1     Fields:    Translation:HumansCells
    76. Dulin NO, Orlov SN, Kitchen CM, Voyno-Yasenetskaya TA, Miano JM. G-protein-coupled-receptor activation of the smooth muscle calponin gene. Biochem J. 2001 Jul 15; 357(Pt 2):587-92. PMID: 11439113; PMCID: PMC1221990.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    77. Orlov SN, Taurin S, Dulin NO, Allen BG, deBlois D, Tremblay J, Pshezhetsky AV, Hamet P, Thorin-Trescases N. Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A. Can J Physiol Pharmacol. 2001 Jun; 79(6):471-80. PMID: 11430584.
      Citations: 1     Fields:    Translation:AnimalsCells
    78. Dulin NO, Niu J, Browning DD, Ye RD, Voyno-Yasenetskaya T. Cyclic AMP-independent activation of protein kinase A by vasoactive peptides. J Biol Chem. 2001 Jun 15; 276(24):20827-30. PMID: 11331270.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    79. Chen ZJ, Miao ZH, Vetter M, Dulin N, Liu S, Che D, Hughes B, Murad F, Douglas J, Chang CH. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Biochem Biophys Res Commun. 2000 Nov 11; 278(1):106-11. PMID: 11071862.
      Citations:    Fields:    Translation:AnimalsCells
    80. Dulin NO, Pratt P, Tiruppathi C, Niu J, Voyno-Yasenetskaya T, Dunn MJ. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J Biol Chem. 2000 Jul 14; 275(28):21317-23. PMID: 10749886.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    81. Taurin S, Thorin-Trescases N, Dulin NO, Tremblay J, Hamet P, Orlov SN. Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis. Hypertension. 2000 May; 35(5):1062-8. PMID: 10818065.
      Citations: 11     Fields:    Translation:AnimalsCells
    82. Orlov SN, Dulin NO, Gagnon F, Gekle M, Douglas JG, Schwartz JH, Hamet P. Purinergic modulation of Na(+),K(+),Cl(-) cotransport and MAP kinases is limited to C11-MDCK cells resembling intercalated cells from collecting ducts. J Membr Biol. 1999 Dec 01; 172(3):225-34. PMID: 10568792.
      Citations: 4     Fields:    Translation:AnimalsCells
    83. Orlov SN, Thorin-Trescases N, Dulin NO, Dam TV, Fortuno MA, Tremblay J, Hamet P. Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3. Cell Death Differ. 1999 Jul; 6(7):661-72. PMID: 10453077.
      Citations: 17     Fields:    Translation:AnimalsCells
    84. Gagnon F, Dulin NO, Tremblay J, Hamet P, Orlov SN. ATP-induced inhibition of Na+, K+, Cl- cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways. J Membr Biol. 1999 Jan 15; 167(2):193-204. PMID: 9916150.
      Citations: 8     Fields:    Translation:AnimalsCells
    85. Dulin NO, Sorokin A, Reed E, Elliott S, Kehrl JH, Dunn MJ. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. Mol Cell Biol. 1999 Jan; 19(1):714-23. PMID: 9858594; PMCID: PMC83928.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    86. Dulin NO, Sorokin A, Douglas JG. Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association. Hypertension. 1998 Dec; 32(6):1089-93. PMID: 9856979.
      Citations: 9     Fields:    Translation:AnimalsCells
    87. Dulin NO, Alexander LD, Harwalkar S, Falck JR, Douglas JG. Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin II. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8098-102. PMID: 9653146; PMCID: PMC20935.
      Citations: 9     Fields:    Translation:AnimalsCells
    88. Sorokin A, Reed E, Nnkemere N, Dulin NO, Schlessinger J. Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways. Oncogene. 1998 May 14; 16(19):2425-34. PMID: 9627109.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    89. Harwalkar S, Chang CH, Dulin NO, Douglas JG. Role of phospholipase A2 isozymes in agonist-mediated signaling in proximal tubular epithelium. Hypertension. 1998 Mar; 31(3):809-14. PMID: 9495265.
      Citations: 3     Fields:    Translation:AnimalsCells
    90. Thibonnier M, Berti-Mattera LN, Dulin N, Conarty DM, Mattera R. Signal transduction pathways of the human V1-vascular, V2-renal, V3-pituitary vasopressin and oxytocin receptors. Prog Brain Res. 1998; 119:147-61. PMID: 10074787.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    91. Thibonnier M, Preston JA, Dulin N, Wilkins PL, Berti-Mattera LN, Mattera R. The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways. Endocrinology. 1997 Oct; 138(10):4109-22. PMID: 9322919.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    92. Dulin N, Madhun ZT, Chang CH, Berti-Mattera L, Dickens D, Douglas JG. Angiotensin IV receptors and signaling in opossum kidney cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):F644-52. PMID: 7503230.
      Citations: 7     Fields:    Translation:AnimalsCells
    93. Dulin NO, Ernsberger P, Suciu DJ, Douglas JG. Rabbit renal epithelial angiotensin II receptors. Am J Physiol. 1994 Nov; 267(5 Pt 2):F776-82. PMID: 7977780.
      Citations: 6     Fields:    Translation:AnimalsCells
    94. Kravtsov GM, Dulin NO, Postnov YV. A mechanism of calcium binding by the erythrocyte skeleton: some features in primary hypertension. J Hypertens Suppl. 1991 Dec; 9(6):S300-1. PMID: 1818977.
      Citations:    Fields:    Translation:AnimalsCells
    95. Kravtsov GM, Dulin NO, Postnov IuV. [Calcium binding to the erythrocyte cytoskeleton in spontaneously hypertensive rats]. Kardiologiia. 1991 Oct; 31(10):77-81. PMID: 1753592.
      Citations:    Fields:    Translation:AnimalsCells
    96. Dulin NO, Kravtsov GM, Graevskaia EE, Kudriashov IuB. [Protein phosphorylation during mast cell secretion in radioprophylaxis]. Radiobiologiia. 1990 Jan-Feb; 30(1):32-5. PMID: 2315457.
      Citations:    Fields:    Translation:AnimalsCells
    97. Kravtsov GM, Dulin NO, Orlov SN, Pokudin NI. Protein kinase C activity in erythrocytes in primary hypertension: regulation of cell shape and cation transport. Physiol Bohemoslov. 1990; 39(1):27-36. PMID: 2165267.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    98. Dulin NO, Goncharenko EN, Kudriashov IuB, Graevskaia EE, Kravtsov GM. [The role of protein phosphorylation in mast cell secretion, stimulated by concanavalin A. Connection to the cytoskeleton]. Biokhimiia. 1989 Sep; 54(9):1428-33. PMID: 2590681.
      Citations:    Fields:    Translation:AnimalsCells
    99. Kravtsov GM, Dulin NO, Postnov IuV. [Protein kinase C activity in the brain tissue of spontaneously hypertensive rats]. Biull Eksp Biol Med. 1989 Jul; 108(7):42-4. PMID: 2804296.
      Citations:    Fields:    Translation:AnimalsCells
    100. Kravtsov GM, Dulin NO, Postnov YV. Activity of protein kinase C in erythrocytes in primary hypertension. J Hypertens. 1988 Nov; 6(11):853-7. PMID: 3235834.
      Citations:    Fields:    Translation:HumansAnimalsCells
    101. Kravtsov GM, Dulin NO, Kotelevtsev IuV, Postnov IuV. [Regulation of the shape and size of human erythrocytes by protein kinases A and C]. Biokhimiia. 1988 Aug; 53(8):1296-303. PMID: 2847816.
      Citations:    Fields:    Translation:HumansCells
    102. Kravtsov GM, Dulin NO, Postnov IuV. [Protein kinase A and C activity of erythrocytes in patients with essential hypertension]. Kardiologiia. 1988 May; 28(5):96-8. PMID: 3411869.
      Citations:    Fields:    Translation:HumansCells
    103. Postnov IuV, Kravtsov GM, Kotelevtsev IuV, Dulin NO, Postnov IIu. [Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C]. Kardiologiia. 1987 Aug; 27(8):60-5. PMID: 3682579.
      Citations:    Fields:    Translation:HumansCells
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