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Dominique Missiakas

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMicrobiology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Dr. Missiakas’s research program examines the Gram-positive pathogens Staphylococcus aureus and Bacillus anthracis. This program seeks to appreciate the biogenesis of the envelope of these microorganisms as well as the secretion of their virulence factors and host pathways targeted by these pathogens.
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    Collapse Biography 
    Collapse education and training
    Université of Paris XI, Orsay, FrancePh.D.1991Biochemistry

    Collapse Research 
    Collapse research activities and funding
    UC7AI180312     (MISSIAKAS, DOMINIQUE M.)Aug 18, 2023 - Jul 31, 2028
    NIH
    BSL3 management and practice of infectious disease research at HTRL
    Role: Principal Investigator
    75N93022C00057     (MISSIAKAS, DOMINIQUE)Sep 22, 2022 - Apr 21, 2026
    NIH
    Advanced development of a vaccine candidate for Staphylococcus aureus infection and colonization
    Role: Principal Investigator
    R01AI148543     (MISSIAKAS, DOMINIQUE M. ;WANG, LAI-XI)Dec 13, 2019 - Nov 30, 2024
    NIH
    Antibody therapy of MRSA colonization and infection
    Role: Principal Investigator
    R01AI069227     (MISSIAKAS, DOMINIQUE)Apr 1, 2006 - Jun 30, 2027
    NIH
    Surface proteins of Bacillus anthracis
    Role: Principal Investigator
    R01AI038897     (MISSIAKAS, DOMINIQUE M.)Feb 1, 1996 - Dec 31, 2024
    NIH
    Surface Proteins of Gram-Positive Bacteria
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cullum E, Perez-Betancourt Y, Shi M, Gkika E, Schneewind O, Missiakas D, Golovkina T. Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice. PLoS Pathog. 2024 Jun; 20(6):e1012306. PMID: 38843309; PMCID: PMC11185455.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Ibrahim AM, Azam MS, Schneewind O, Missiakas D. Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls. mBio. 2024 Feb 14; 15(2):e0285223. PMID: 38174934; PMCID: PMC10865820.
      Citations:    Fields:    Translation:HumansCells
    3. Ramos-León F, Anjuwon-Foster BR, Anantharaman V, Ferreira CN, Ibrahim AM, Tai CH, Missiakas DM, Camberg JL, Aravind L, Ramamurthi KS. Protein coopted from a phage restriction system dictates orthogonal cell division plane selection in Staphylococcus aureus. bioRxiv. 2023 Sep 03. PMID: 37886572; PMCID: PMC10602043.
      Citations:    
    4. Bernardino PN, Bhattacharya M, Chen X, Jenkins J, Missiakas D, Thammavongsa V. A humanized monoclonal antibody targeting protein a promotes opsonophagocytosis of Staphylococcus aureus in human umbilical cord blood. Vaccine. 2023 08 07; 41(35):5079-5084. PMID: 37455161; PMCID: PMC10412981.
      Citations: 1     Fields:    Translation:HumansCells
    5. Nicolaescu V, Tomatsidou A, Gula H, Randall G, Missiakas D, Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Cianfarini C, Forster P, Khurram N, Singer BD, Henkin J, Batlle D. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection. Life Sci Alliance. 2023 07; 6(7). PMID: 37041017; PMCID: PMC10098141.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Bobrovskyy M, Chen X, Missiakas D. The Type 7b Secretion System of S. aureus and Its Role in Colonization and Systemic Infection. Infect Immun. 2023 05 16; 91(5):e0001523. PMID: 37039657; PMCID: PMC10187124.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Vilgalys TP, Klunk J, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LB. Reply to Barton et al: signatures of natural selection during the Black Death. bioRxiv. 2023 Apr 07. PMID: 37066254; PMCID: PMC10104142.
      Citations:    
    8. Chen X, Gula H, Pius T, Ou C, Gomozkova M, Wang LX, Schneewind O, Missiakas D. Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2220765120. PMID: 36972444; PMCID: PMC10083571.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Elli D, Gula H, Schneewind O, Missiakas D, Oh SY, Château A, Tomatsidou A. Modeling gastrointestinal anthrax disease. Res Microbiol. 2023 Jul-Aug; 174(6):104026. PMID: 36646261; PMCID: PMC10338639.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Meyers S, Lox M, Kraisin S, Liesenborghs L, Martens CP, Frederix L, Van Bruggen S, Crescente M, Missiakas D, Baatsen P, Vanassche T, Verhamme P, Martinod K. Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release. Arterioscler Thromb Vasc Biol. 2023 02; 43(2):267-285. PMID: 36453281; PMCID: PMC9869964.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Eaton K, Golding GB, Devault A, Rouillard JM, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Poinar HN, Barreiro LB, Beau R, Varlik N, Grenier JC, Yotova V, Sindeaux R, Rouleau GA, Steinrücken M, Pizarro-Cerdá J. Evolution of immune genes is associated with the Black Death. Nature. 2022 Nov; 611(7935):312-319. PMID: 36261521; PMCID: PMC9580435.
      Citations: 43     Fields:    Translation:HumansCells
    12. Tomatsidou A, Krunic M, Missiakas D. Contribution of TagA-Like Glycosyltransferases to the Assembly of the Secondary Cell Wall Polysaccharide in Bacillus anthracis. J Bacteriol. 2022 Sep 20; 204(9):e0025322. PMID: 35997505; PMCID: PMC9487633.
      Citations: 1     Fields:    Translation:Cells
    13. Bobrovskyy M, Oh SY, Missiakas D. Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus. J Biol Chem. 2022 09; 298(9):102318. PMID: 35921891; PMCID: PMC9436818.
      Citations: 3     Fields:    Translation:Cells
    14. Malachowa N, McGuinness W, Kobayashi SD, Porter AR, Shaia C, Lovaglio J, Smith B, Rungelrath V, Saturday G, Scott DP, Falugi F, Missiakas D, Schneewind O, DeLeo FR. Toward Optimization of a Rabbit Model of Staphylococcus aureus (USA300) Skin and Soft Tissue Infection. Microbiol Spectr. 2022 04 27; 10(2):e0271621. PMID: 35389241; PMCID: PMC9045089.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Teplensky MH, Distler ME, Kusmierz CD, Evangelopoulos M, Gula H, Elli D, Tomatsidou A, Nicolaescu V, Gelarden I, Yeldandi A, Batlle D, Missiakas D, Mirkin CA. Spherical nucleic acids as an infectious disease vaccine platform. Proc Natl Acad Sci U S A. 2022 04 05; 119(14):e2119093119. PMID: 35312341; PMCID: PMC9168922.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Hassler L, Wysocki J, Gelarden I, Sharma I, Tomatsidou A, Ye M, Gula H, Nicoleascu V, Randall G, Pshenychnyi S, Khurram N, Kanwar Y, Missiakas D, Henkin J, Yeldandi A, Batlle D. A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection. J Am Soc Nephrol. 2022 07; 33(7):1293-1307. PMID: 35236774; PMCID: PMC9257820.
      Citations: 22     Fields:    Translation:AnimalsCells
    17. Chen X, Schneewind O, Missiakas D. Engineered human antibodies for the opsonization and killing of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2022 01 25; 119(4). PMID: 35058363; PMCID: PMC8795526.
      Citations: 13     Fields:    Translation:HumansCells
    18. El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. Nat Commun. 2022 01 20; 13(1):405. PMID: 35058437; PMCID: PMC8776790.
      Citations: 67     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    19. Chen X, Sun Y, Missiakas D, Schneewind O. Corrigendum to: Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A. J Infect Dis. 2022 Jan 18; 225(2):358. PMID: 34888665; PMCID: PMC8764223.
      Citations:    Fields:    
    20. Cai X, Chen M, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Nguyen M, Shi J, Tomatsidou A, Randall G, Missiakas D, Fung J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2. Adv Sci (Weinh). 2022 01; 9(2):e2103240. PMID: 34761549; PMCID: PMC8646742.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S, Muñoz-Alía MÁ. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936. PMID: 34285133; PMCID: PMC8809056.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    22. Shi M, Chen X, Sun Y, Kim HK, Schneewind O, Missiakas D. A protein A based Staphylococcus aureus vaccine with improved safety. Vaccine. 2021 06 29; 39(29):3907-3915. PMID: 34088508; PMCID: PMC8259053.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Shi M, Willing SE, Kim HK, Schneewind O, Missiakas D. Peptidoglycan Contribution to the B Cell Superantigen Activity of Staphylococcal Protein A. mBio. 2021 04 20; 12(2). PMID: 33879590; PMCID: PMC8092194.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Viljoen A, Viela F, Missiakas D, Pietrocola G, Speziale P, Mathelié-Guinlet M, Dufrêne YF. Staphylococcus aureus vWF-binding protein triggers a strong interaction between clumping factor A and host vWF. Commun Biol. 2021 04 12; 4(1):453. PMID: 33846500; PMCID: PMC8041789.
      Citations: 9     Translation:Cells
    25. Willing S, Schneewind O, Missiakas D. Regulated cleavage of glycan strands by the murein hydrolase SagB in S. aureus involves a direct interaction with LyrA (SpdC). J Bacteriol. 2021 05 01; 203(9). PMID: 33593946; PMCID: PMC8092163.
      Citations: 7     Fields:    
    26. Missiakas D, Winstel V. Selective Host Cell Death by Staphylococcus aureus: A Strategy for Bacterial Persistence. Front Immunol. 2020; 11:621733. PMID: 33552085; PMCID: PMC7859115.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    27. Na M, Hu Z, Mohammad M, Stroparo MDN, Ali A, Fei Y, Jarneborn A, Verhamme P, Schneewind O, Missiakas D, Jin T. The Expression of von Willebrand Factor-Binding Protein Determines Joint-Invading Capacity of Staphylococcus aureus, a Core Mechanism of Septic Arthritis. mBio. 2020 11 17; 11(6). PMID: 33203754; PMCID: PMC7683397.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    28. Chen X, Shi M, Tong X, Kim HK, Wang LX, Schneewind O, Missiakas D. Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies. Proc Natl Acad Sci U S A. 2020 09 15; 117(37):22992-23000. PMID: 32855300; PMCID: PMC7502815.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Willing S, Dyer E, Schneewind O, Missiakas D. FmhA and FmhC of Staphylococcus aureus incorporate serine residues into peptidoglycan cross-bridges. J Biol Chem. 2020 09 25; 295(39):13664-13676. PMID: 32759309; PMCID: PMC7521636.
      Citations: 9     Fields:    Translation:Cells
    30. Chateau A, Oh SY, Tomatsidou A, Brockhausen I, Schneewind O, Missiakas D. Distinct Pathways Carry Out a and ß Galactosylation of Secondary Cell Wall Polysaccharide in Bacillus anthracis. J Bacteriol. 2020 07 09; 202(15). PMID: 32457049; PMCID: PMC7348550.
      Citations: 3     Fields:    Translation:HumansCells
    31. Chun LY, Dolle-Molle L, Bethel C, Dimitroyannis RC, Williams BL, Schechet SA, Hariprasad SM, Missiakas D, Schneewind O, Beavis KG, Skondra D. Rapid pathogen identification and antimicrobial susceptibility testing in in vitro endophthalmitis with matrix assisted laser desorption-ionization Time-of-Flight Mass Spectrometry and VITEK 2 without prior culture. PLoS One. 2019; 14(12):e0227071. PMID: 31887220; PMCID: PMC6936829.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    32. Winstel V, Schneewind O, Missiakas D. Staphylococcus aureus Exploits the Host Apoptotic Pathway To Persist during Infection. mBio. 2019 11 12; 10(6). PMID: 31719177; PMCID: PMC6851280.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    33. Liesenborghs L, Meyers S, Lox M, Criel M, Claes J, Peetermans M, Trenson S, Vande Velde G, Vanden Berghe P, Baatsen P, Missiakas D, Schneewind O, Peetermans WE, Hoylaerts MF, Vanassche T, Verhamme P. Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves. Eur Heart J. 2019 10 14; 40(39):3248-3259. PMID: 30945735; PMCID: PMC7963134.
      Citations: 45     Fields:    Translation:AnimalsCells
    34. Osei-Owusu P, Charlton TM, Kim HK, Missiakas D, Schneewind O. FPR1 is the plague receptor on host immune cells. Nature. 2019 10; 574(7776):57-62. PMID: 31534221; PMCID: PMC6776691.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    35. Kim HK, Premaratna R, Missiakas DM, Schneewind O. Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies. Proc Natl Acad Sci U S A. 2019 09 24; 116(39):19659-19664. PMID: 31413191; PMCID: PMC6765297.
      Citations: 17     Fields:    Translation:Cells
    36. Schneewind O, Missiakas DM. Staphylococcal Protein Secretion and Envelope Assembly. Microbiol Spectr. 2019 07; 7(4). PMID: 31267890; PMCID: PMC7028390.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    37. Putra I, Rabiee B, Anwar KN, Gidfar S, Shen X, Babalooee M, Ghassemi M, Afsharkhamseh N, Bakhsh S, Missiakas D, Nezamabadi A, Milani B, Eslani M, Djalilian AR. Staphylococcus aureus alpha-hemolysin impairs corneal epithelial wound healing and promotes intracellular bacterial invasion. Exp Eye Res. 2019 04; 181:263-270. PMID: 30822400; PMCID: PMC6447303.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    38. Chen X, Sun Y, Missiakas D, Schneewind O. Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A. J Infect Dis. 2019 02 23; 219(6):884-888. PMID: 30551184; PMCID: PMC7184913.
      Citations: 25     Fields:    Translation:AnimalsCells
    39. Missiakas D. Staphylococcus aureus TarP: A Brick in the Wall or Rosetta Stone? Cell Host Microbe. 2019 02 13; 25(2):182-183. PMID: 30763532; PMCID: PMC6724547.
      Citations: 1     Fields:    Translation:HumansCells
    40. Chateau A, Schneewind O, Missiakas D. Extraction and Purification of Wall-Bound Polymers of Gram-Positive Bacteria. Methods Mol Biol. 2019; 1954:47-57. PMID: 30864123; PMCID: PMC7206762.
      Citations: 3     Fields:    Translation:HumansCells
    41. Schneewind O, Missiakas D. Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development. Microbiol Spectr. 2019 01; 7(1). PMID: 30737913; PMCID: PMC6386163.
      Citations: 27     Fields:    Translation:HumansCells
    42. Bobrovskyy M, Willing SE, Schneewind O, Missiakas D. EssH Peptidoglycan Hydrolase Enables Staphylococcus aureus Type VII Secretion across the Bacterial Cell Wall Envelope. J Bacteriol. 2018 10 15; 200(20). PMID: 30082459; PMCID: PMC6153663.
      Citations: 10     Fields:    Translation:Cells
    43. Missiakas D, Dos Santos RW, Lobosco M, Pigozzo AB, Alonso S. Development of a Computational Model of Abscess Formation. Front Microbiol. 2018; 9:1355. PMID: 29997587; PMCID: PMC6029511.
      Citations: 2     
    44. Winstel V, Missiakas D, Schneewind O. Staphylococcus aureus targets the purine salvage pathway to kill phagocytes. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6846-6851. PMID: 29891696; PMCID: PMC6042115.
      Citations: 21     Fields:    Translation:HumansCells
    45. Yu W, Missiakas D, Schneewind O. Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis. Elife. 2018 05 14; 7. PMID: 29757141; PMCID: PMC5962339.
      Citations: 14     Fields:    Translation:Cells
    46. Ahmed MM, Aboshanab KM, Ragab YM, Missiakas DM, Aly KA. The transmembrane domain of the Staphylococcus aureus ESAT-6 component EssB mediates interaction with the integral membrane protein EsaA, facilitating partially regulated secretion in a heterologous host. Arch Microbiol. 2018 Sep; 200(7):1075-1086. PMID: 29737367; PMCID: PMC9704473.
      Citations: 2     Fields:    Translation:HumansCells
    47. Sun Y, Emolo C, Holtfreter S, Wiles S, Kreiswirth B, Missiakas D, Schneewind O. Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus. J Bacteriol. 2018 05 01; 200(9). PMID: 29440258; PMCID: PMC5892116.
      Citations: 27     Fields:    Translation:AnimalsCells
    48. Chateau A, Lunderberg JM, Oh SY, Abshire T, Friedlander A, Quinn CP, Missiakas DM, Schneewind O. Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax Pathogenesis. J Bacteriol. 2018 03 01; 200(5). PMID: 29229702; PMCID: PMC5809694.
      Citations: 9     Fields:    Translation:AnimalsCells
    49. Mancini S, Oechslin F, Menzi C, Que YA, Claes J, Heying R, Veloso TR, Vanassche T, Missiakas D, Schneewind O, Moreillon P, Entenza JM. Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations. Virulence. 2018; 9(1):1615-1624. PMID: 30280967; PMCID: PMC7000203.
      Citations: 7     Fields:    Translation:AnimalsCells
    50. Aly KA, Anderson M, Ohr RJ, Missiakas D. Isolation of a Membrane Protein Complex for Type VII Secretion in Staphylococcus aureus. J Bacteriol. 2017 12 01; 199(23). PMID: 28874412; PMCID: PMC5686593.
      Citations: 15     Fields:    Translation:Cells
    51. Missiakas D, Schneewind O. Assembly and Function of the Bacillus anthracis S-Layer. Annu Rev Microbiol. 2017 09 08; 71:79-98. PMID: 28622090; PMCID: PMC6190687.
      Citations: 25     Fields:    Translation:Cells
    52. Kant S, Asthana S, Missiakas D, Pancholi V. A novel STK1-targeted small-molecule as an "antibiotic resistance breaker" against multidrug-resistant Staphylococcus aureus. Sci Rep. 2017 07 11; 7(1):5067. PMID: 28698584; PMCID: PMC5505960.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    53. Claes J, Liesenborghs L, Peetermans M, Veloso TR, Missiakas D, Schneewind O, Mancini S, Entenza JM, Hoylaerts MF, Heying R, Verhamme P, Vanassche T. Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall. J Thromb Haemost. 2017 05; 15(5):1009-1019. PMID: 28182324; PMCID: PMC6232194.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    54. Yu W, Kim HK, Rauch S, Schneewind O, Missiakas D. Pathogenic conversion of coagulase-negative staphylococci. Microbes Infect. 2017 02; 19(2):101-109. PMID: 28012900; PMCID: PMC5274588.
      Citations: 11     Fields:    Translation:AnimalsCells
    55. Ohr RJ, Anderson M, Shi M, Schneewind O, Missiakas D. EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway. J Bacteriol. 2017 01 01; 199(1). PMID: 27795323; PMCID: PMC5165103.
      Citations: 33     Fields:    Translation:AnimalsCells
    56. Anderson M, Ohr RJ, Aly KA, Nocadello S, Kim HK, Schneewind CE, Schneewind O, Missiakas D. EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To Modify Host Immune Responses during Infection. J Bacteriol. 2017 01 01; 199(1). PMID: 27795322; PMCID: PMC5165088.
      Citations: 18     Fields:    Translation:AnimalsCells
    57. Oh SY, Lunderberg JM, Chateau A, Schneewind O, Missiakas D. Genes Required for Bacillus anthracis Secondary Cell Wall Polysaccharide Synthesis. J Bacteriol. 2017 01 01; 199(1). PMID: 27795328; PMCID: PMC5165087.
      Citations: 13     Fields:    Translation:Cells
    58. Missiakas D, Schneewind O. Staphylococcus aureus vaccines: Deviating from the carol. J Exp Med. 2016 08 22; 213(9):1645-53. PMID: 27526714; PMCID: PMC4995089.
      Citations: 43     Fields:    Translation:HumansCells
    59. Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, DeLeo FR. Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection. PLoS One. 2016; 11(6):e0158293. PMID: 27336691; PMCID: PMC4918888.
      Citations: 19     Fields:    Translation:AnimalsCells
    60. Kim HK, Falugi F, Missiakas DM, Schneewind O. Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5718-23. PMID: 27140614; PMCID: PMC4878465.
      Citations: 27     Fields:    Translation:AnimalsCells
    61. Thomer L, Schneewind O, Missiakas D. Pathogenesis of Staphylococcus aureus Bloodstream Infections. Annu Rev Pathol. 2016 05 23; 11:343-64. PMID: 26925499; PMCID: PMC5068359.
      Citations: 119     Fields:    Translation:HumansCells
    62. Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. J Exp Med. 2016 Mar 07; 213(3):293-301. PMID: 26880578; PMCID: PMC4813671.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    63. Chan YG, Frankel MB, Missiakas D, Schneewind O. SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion. J Bacteriol. 2016 Jan 25; 198(7):1123-36. PMID: 26811319; PMCID: PMC4800868.
      Citations: 23     Fields:    Translation:Cells
    64. Liszewski Zilla M, Lunderberg JM, Schneewind O, Missiakas D. Bacillus anthracis lcp Genes Support Vegetative Growth, Envelope Assembly, and Spore Formation. J Bacteriol. 2015 Dec; 197(23):3731-41. PMID: 26391207; PMCID: PMC4626891.
      Citations: 11     Fields:    Translation:Cells
    65. Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Staphylococcal manipulation of host immune responses. Nat Rev Microbiol. 2015 Sep; 13(9):529-43. PMID: 26272408; PMCID: PMC4625792.
      Citations: 271     Fields:    Translation:HumansCells
    66. Lunderberg JM, Liszewski Zilla M, Missiakas D, Schneewind O. Bacillus anthracis tagO Is Required for Vegetative Growth and Secondary Cell Wall Polysaccharide Synthesis. J Bacteriol. 2015 Nov; 197(22):3511-20. PMID: 26324447; PMCID: PMC4621081.
      Citations: 15     Fields:    Translation:Cells
    67. Nguyen-Mau SM, Oh SY, Schneewind DI, Missiakas D, Schneewind O. Bacillus anthracis SlaQ Promotes S-Layer Protein Assembly. J Bacteriol. 2015 Oct; 197(19):3216-27. PMID: 26216847; PMCID: PMC4560277.
      Citations: 7     Fields:    Translation:AnimalsCells
    68. Fan Y, Tan K, Chhor G, Butler EK, Jedrzejczak RP, Missiakas D, Joachimiak A. EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles. Protein Sci. 2015 Sep; 24(9):1389-400. PMID: 26032645; PMCID: PMC4570534.
      Citations: 7     Fields:    Translation:Cells
    69. Oh SY, Richter SG, Missiakas DM, Schneewind O. Glutamate Racemase Mutants of Bacillus anthracis. J Bacteriol. 2015 Jun; 197(11):1854-61. PMID: 25777674; PMCID: PMC4420906.
      Citations: 6     Fields:    Translation:Cells
    70. Kim HK, Falugi F, Thomer L, Missiakas DM, Schneewind O. Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs. mBio. 2015 Jan 06; 6(1). PMID: 25564466; PMCID: PMC4313907.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    71. Thammavongsa V, Rauch S, Kim HK, Missiakas DM, Schneewind O. Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus. Vaccine. 2015 Jan 15; 33(4):523-6. PMID: 25488332; PMCID: PMC4378561.
      Citations: 31     Fields:    Translation:AnimalsCells
    72. Liszewski Zilla M, Chan YG, Lunderberg JM, Schneewind O, Missiakas D. LytR-CpsA-Psr enzymes as determinants of Bacillus anthracis secondary cell wall polysaccharide assembly. J Bacteriol. 2015 Jan; 197(2):343-53. PMID: 25384480; PMCID: PMC4272586.
      Citations: 24     Fields:    Translation:Cells
    73. Rauch S, Gough P, Kim HK, Schneewind O, Missiakas D. Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection. Infect Immun. 2014 Nov; 82(11):4889-98. PMID: 25183728; PMCID: PMC4249340.
      Citations: 18     Fields:    Translation:AnimalsCells
    74. Claes J, Vanassche T, Peetermans M, Liesenborghs L, Vandenbriele C, Vanhoorelbeke K, Missiakas D, Schneewind O, Hoylaerts MF, Heying R, Verhamme P. Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein. Blood. 2014 Sep 04; 124(10):1669-76. PMID: 24951431; PMCID: PMC7025350.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    75. Wang YT, Missiakas D, Schneewind O. GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol. 2014 Aug 15; 196(16):2969-78. PMID: 24914184; PMCID: PMC4135639.
      Citations: 12     Fields:    Translation:Cells
    76. Kim HK, Missiakas D, Schneewind O. Mouse models for infectious diseases caused by Staphylococcus aureus. J Immunol Methods. 2014 Aug; 410:88-99. PMID: 24769066; PMCID: PMC6211302.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    77. Chan YG, Kim HK, Schneewind O, Missiakas D. The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes. J Biol Chem. 2014 May 30; 289(22):15680-90. PMID: 24753256; PMCID: PMC4140922.
      Citations: 56     Fields:    Translation:AnimalsCells
    78. Schneewind O, Missiakas D. Genetic manipulation of Staphylococcus aureus. Curr Protoc Microbiol. 2014 Feb 06; 32:Unit 9C.3.. PMID: 24510849; PMCID: PMC6249557.
      Citations: 19     Fields:    Translation:HumansCells
    79. Becker S, Frankel MB, Schneewind O, Missiakas D. Release of protein A from the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1574-9. PMID: 24434550; PMCID: PMC3910568.
      Citations: 69     Fields:    Translation:Cells
    80. Schneewind O, Missiakas D. Lipoteichoic acids, phosphate-containing polymers in the envelope of gram-positive bacteria. J Bacteriol. 2014 Mar; 196(6):1133-42. PMID: 24415723; PMCID: PMC3957714.
      Citations: 60     Fields:    Translation:Cells
    81. Cheng AG, Missiakas D, Schneewind O. The giant protein Ebh is a determinant of Staphylococcus aureus cell size and complement resistance. J Bacteriol. 2014 Mar; 196(5):971-81. PMID: 24363342; PMCID: PMC3957702.
      Citations: 29     Fields:    Translation:AnimalsCells
    82. Thomer L, Becker S, Emolo C, Quach A, Kim HK, Rauch S, Anderson M, Leblanc JF, Schneewind O, Faull KF, Missiakas D. N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection. J Biol Chem. 2014 Feb 07; 289(6):3478-86. PMID: 24344128; PMCID: PMC3916549.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    83. Kim HK, Emolo C, Missiakas D, Schneewind O. A monoclonal antibody that recognizes the E domain of staphylococcal protein A. Vaccine. 2014 Jan 16; 32(4):464-9. PMID: 24291195; PMCID: PMC6211298.
      Citations: 6     Fields:    Translation:AnimalsCells
    84. Schneewind O, Missiakas D. Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria. Biochim Biophys Acta. 2014 Aug; 1843(8):1687-97. PMID: 24269844; PMCID: PMC4031296.
      Citations: 63     Fields:    Translation:Cells
    85. Thammavongsa V, Missiakas DM, Schneewind O. Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science. 2013 Nov 15; 342(6160):863-6. PMID: 24233725; PMCID: PMC4026193.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    86. Anderson M, Aly KA, Chen YH, Missiakas D. Secretion of atypical protein substrates by the ESAT-6 secretion system of Staphylococcus aureus. Mol Microbiol. 2013 Nov; 90(4):734-43. PMID: 24033479; PMCID: PMC3951145.
      Citations: 43     Fields:    Translation:Cells
    87. Falugi F, Kim HK, Missiakas DM, Schneewind O. Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. mBio. 2013 Aug 27; 4(5):e00575-13. PMID: 23982075; PMCID: PMC3760252.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    88. Thomer L, Schneewind O, Missiakas D. Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma. J Biol Chem. 2013 Sep 27; 288(39):28283-92. PMID: 23960083; PMCID: PMC3784736.
      Citations: 38     Fields:    Translation:HumansCells
    89. Chan YG, Frankel MB, Dengler V, Schneewind O, Missiakas D. Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium. J Bacteriol. 2013 Oct; 195(20):4650-9. PMID: 23935043; PMCID: PMC3807444.
      Citations: 66     Fields:    Translation:Cells
    90. Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P. The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections. J Infect Dis. 2013 Jul; 208(1):92-100. PMID: 23532100; PMCID: PMC6281407.
      Citations: 30     Fields:    Translation:Animals
    91. Richter SG, Elli D, Kim HK, Hendrickx AP, Sorg JA, Schneewind O, Missiakas D. Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3531-6. PMID: 23401520; PMCID: PMC3587227.
      Citations: 53     Fields:    Translation:AnimalsCells
    92. Missiakas DM, Schneewind O. Growth and laboratory maintenance of Staphylococcus aureus. Curr Protoc Microbiol. 2013 Feb; Chapter 9:Unit 9C.1. PMID: 23408134; PMCID: PMC6211185.
      Citations: 34     Fields:    Translation:Cells
    93. Oh SY, Maier H, Schroeder J, Richter GS, Elli D, Musser JM, Quenee LE, Missiakas DM, Schneewind O. Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice. Infect Immun. 2013 Mar; 81(3):1008-17. PMID: 23319564; PMCID: PMC3584855.
      Citations: 6     Fields:    Translation:AnimalsCells
    94. Lunderberg JM, Nguyen-Mau SM, Richter GS, Wang YT, Dworkin J, Missiakas DM, Schneewind O. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol. 2013 Mar; 195(5):977-89. PMID: 23243307; PMCID: PMC3571321.
      Citations: 20     Fields:    Translation:Cells
    95. Chen YH, Anderson M, Hendrickx AP, Missiakas D. Characterization of EssB, a protein required for secretion of ESAT-6 like proteins in Staphylococcus aureus. BMC Microbiol. 2012 Sep 25; 12:219. PMID: 23006124; PMCID: PMC3489787.
      Citations: 18     Fields:    Translation:Cells
    96. Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O. Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice. Infect Immun. 2012 Oct; 80(10):3460-70. PMID: 22825452; PMCID: PMC3457578.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    97. McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as determinants of protective immune responses against Staphylococcus aureus. Infect Immun. 2012 Oct; 80(10):3389-98. PMID: 22825443; PMCID: PMC3457572.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    98. Rauch S, DeDent AC, Kim HK, Bubeck Wardenburg J, Missiakas DM, Schneewind O. Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection. Infect Immun. 2012 Oct; 80(10):3721-32. PMID: 22802349; PMCID: PMC3457571.
      Citations: 55     Fields:    Translation:AnimalsCells
    99. Garufi G, Hendrickx AP, Beeri K, Kern JW, Sharma A, Richter SG, Schneewind O, Missiakas D. Synthesis of lipoteichoic acids in Bacillus anthracis. J Bacteriol. 2012 Aug; 194(16):4312-21. PMID: 22685279; PMCID: PMC3416223.
      Citations: 16     Fields:    Translation:Cells
    100. Kern VJ, Kern JW, Theriot JA, Schneewind O, Missiakas D. Surface-layer (S-layer) proteins sap and EA1 govern the binding of the S-layer-associated protein BslO at the cell septa of Bacillus anthracis. J Bacteriol. 2012 Aug; 194(15):3833-40. PMID: 22609927; PMCID: PMC3416523.
      Citations: 30     Fields:    Translation:Cells
    101. Nguyen-Mau SM, Oh SY, Kern VJ, Missiakas DM, Schneewind O. Secretion genes as determinants of Bacillus anthracis chain length. J Bacteriol. 2012 Aug; 194(15):3841-50. PMID: 22609926; PMCID: PMC3416568.
      Citations: 27     Fields:    Translation:Cells
    102. Schneewind O, Missiakas DM. Protein secretion and surface display in Gram-positive bacteria. Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19; 367(1592):1123-39. PMID: 22411983; PMCID: PMC3297441.
      Citations: 113     Fields:    Translation:Cells
    103. Garufi G, Wang YT, Oh SY, Maier H, Missiakas DM, Schneewind O. Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracis. Vaccine. 2012 May 14; 30(23):3435-44. PMID: 22449424; PMCID: PMC3538850.
      Citations: 10     Fields:    Translation:AnimalsCells
    104. Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C. Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol. 2012 Apr; 194(7):1753-62. PMID: 22267518; PMCID: PMC3302473.
      Citations: 41     Fields:    Translation:Cells
    105. McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun. 2012; 4(2):141-8. PMID: 22222316; PMCID: PMC3388267.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    106. DeDent A, Kim HK, Missiakas D, Schneewind O. Exploring Staphylococcus aureus pathways to disease for vaccine development. Semin Immunopathol. 2012 Mar; 34(2):317-33. PMID: 22130613; PMCID: PMC3539746.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    107. Kim HK, Thammavongsa V, Schneewind O, Missiakas D. Recurrent infections and immune evasion strategies of Staphylococcus aureus. Curr Opin Microbiol. 2012 Feb; 15(1):92-9. PMID: 22088393; PMCID: PMC3538788.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    108. Thammavongsa V, Schneewind O, Missiakas DM. Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA). BMC Biochem. 2011 Oct 28; 12:56. PMID: 22035583; PMCID: PMC3213008.
      Citations: 31     Fields:    Translation:Cells
    109. McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog. 2011 Oct; 7(10):e1002307. PMID: 22028651; PMCID: PMC3197598.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    110. Frankel MB, Hendrickx AP, Missiakas DM, Schneewind O. LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly. J Biol Chem. 2011 Sep 16; 286(37):32593-605. PMID: 21784864; PMCID: PMC3173183.
      Citations: 41     Fields:    Translation:Cells
    111. Kim HK, Kim HY, Schneewind O, Missiakas D. Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses. FASEB J. 2011 Oct; 25(10):3605-12. PMID: 21753082; PMCID: PMC3177580.
      Citations: 40     Fields:    Translation:AnimalsCells
    112. Schneewind O, Missiakas D. Structural vaccinology to thwart antigenic variation in microbial pathogens. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10029-30. PMID: 21670300; PMCID: PMC3121818.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    113. Anderson VJ, Kern JW, McCool JW, Schneewind O, Missiakas D. The SLH-domain protein BslO is a determinant of Bacillus anthracis chain length. Mol Microbiol. 2011 Jul; 81(1):192-205. PMID: 21585566; PMCID: PMC3124567.
      Citations: 28     Fields:    Translation:Cells
    114. Cheng AG, DeDent AC, Schneewind O, Missiakas D. A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol. 2011 May; 19(5):225-32. PMID: 21353779; PMCID: PMC3087859.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    115. Anderson M, Chen YH, Butler EK, Missiakas DM. EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus. J Bacteriol. 2011 Apr; 193(7):1583-9. PMID: 21278286; PMCID: PMC3067666.
      Citations: 42     Fields:    Translation:AnimalsCells
    116. Frankel MB, Wojcik BM, DeDent AC, Missiakas DM, Schneewind O. ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus. Mol Microbiol. 2010 Oct; 78(1):238-52. PMID: 20923422; PMCID: PMC3538852.
      Citations: 23     Fields:    Translation:Cells
    117. Kim HK, Cheng AG, Kim HY, Missiakas DM, Schneewind O. Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice. J Exp Med. 2010 Aug 30; 207(9):1863-70. PMID: 20713595; PMCID: PMC2931167.
      Citations: 122     Fields:    Translation:AnimalsCells
    118. Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog. 2010 Aug 05; 6(8):e1001036. PMID: 20700445; PMCID: PMC2916881.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    119. Lan L, Cheng A, Dunman PM, Missiakas D, He C. Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus. J Bacteriol. 2010 Jun; 192(12):3068-77. PMID: 20400547; PMCID: PMC2901709.
      Citations: 68     Fields:    Translation:AnimalsCells
    120. Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine. 2010 Aug 31; 28(38):6382-92. PMID: 20226248; PMCID: PMC3095377.
      Citations: 89     Fields:    Translation:HumansAnimals
    121. Thammavongsa V, Kern JW, Missiakas DM, Schneewind O. Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med. 2009 Oct 26; 206(11):2417-27. PMID: 19808256; PMCID: PMC2768845.
      Citations: 124     Fields:    Translation:AnimalsCells
    122. Wu R, Richter S, Zhang RG, Anderson VJ, Missiakas D, Joachimiak A. Crystal structure of Bacillus anthracis transpeptidase enzyme CapD. J Biol Chem. 2009 Sep 04; 284(36):24406-14. PMID: 19535342; PMCID: PMC2782033.
      Citations: 8     Fields:    Translation:Cells
    123. Cheng AG, Kim HK, Burts ML, Krausz T, Schneewind O, Missiakas DM. Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J. 2009 Oct; 23(10):3393-404. PMID: 19525403; PMCID: PMC2747682.
      Citations: 248     Fields:    Translation:AnimalsCells
    124. Richter S, Anderson VJ, Garufi G, Lu L, Budzik JM, Joachimiak A, He C, Schneewind O, Missiakas D. Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol Microbiol. 2009 Jan; 71(2):404-20. PMID: 19017271; PMCID: PMC2770442.
      Citations: 33     Fields:    Translation:AnimalsCells
    125. Chen PR, Nishida S, Poor CB, Cheng A, Bae T, Kuechenmeister L, Dunman PM, Missiakas D, He C. A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus. Mol Microbiol. 2009 Jan; 71(1):198-211. PMID: 19007410; PMCID: PMC2698432.
      Citations: 65     Fields:    Translation:AnimalsCells
    126. DeDent A, Bae T, Missiakas DM, Schneewind O. Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus. EMBO J. 2008 Oct 22; 27(20):2656-68. PMID: 18800056; PMCID: PMC2572169.
      Citations: 65     Fields:    Translation:Cells
    127. Garufi G, Butler E, Missiakas D. ESAT-6-like protein secretion in Bacillus anthracis. J Bacteriol. 2008 Nov; 190(21):7004-11. PMID: 18723613; PMCID: PMC2580693.
      Citations: 45     Fields:    Translation:AnimalsCells
    128. Burts ML, DeDent AC, Missiakas DM. EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus. Mol Microbiol. 2008 Aug; 69(3):736-46. PMID: 18554323; PMCID: PMC2597432.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    129. Bae T, Glass EM, Schneewind O, Missiakas D. Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis. Methods Mol Biol. 2008; 416:103-16. PMID: 18392963.
      Citations: 46     Fields:    Translation:Cells
    130. Maresso AW, Wu R, Kern JW, Zhang R, Janik D, Missiakas DM, Duban ME, Joachimiak A, Schneewind O. Activation of inhibitors by sortase triggers irreversible modification of the active site. J Biol Chem. 2007 Aug 10; 282(32):23129-39. PMID: 17545669; PMCID: PMC3366505.
      Citations: 39     Fields:    Translation:Cells
    131. Bubeck Wardenburg J, Williams WA, Missiakas D. Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13831-6. PMID: 16954184; PMCID: PMC1564215.
      Citations: 127     Fields:    Translation:AnimalsCells
    132. Missiakas DM, Schneewind O, Gründling A. Staphylococcus aureus mutants with increased lysostaphin resistance. J Bacteriol. 2006 Sep; 188(17):6286-97. PMID: 16923896; PMCID: PMC1595375.
      Citations: 57     Fields:    Translation:Cells
    133. Blaylock B, Riordan KE, Missiakas DM, Schneewind O. Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL. J Bacteriol. 2006 May; 188(10):3525-34. PMID: 16672607; PMCID: PMC1482870.
      Citations: 47     Fields:    Translation:Cells
    134. Tam C, Glass EM, Anderson DM, Missiakas D. Transposon mutagenesis of Bacillus anthracis strain Sterne using Bursa aurealis. Plasmid. 2006 Jul; 56(1):74-7. PMID: 16530833.
      Citations: 25     Fields:    Translation:Cells
    135. Tam C, Missiakas D. Changes in lipopolysaccharide structure induce the sigma(E)-dependent response of Escherichia coli. Mol Microbiol. 2005 Mar; 55(5):1403-12. PMID: 15720549.
      Citations: 41     Fields:    Translation:Cells
    136. Burts ML, Williams WA, DeBord K, Missiakas DM. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1169-74. PMID: 15657139; PMCID: PMC545836.
      Citations: 173     Fields:    Translation:AnimalsCells
    137. Williams WA, Zhang RG, Zhou M, Joachimiak G, Gornicki P, Missiakas D, Joachimiak A. The membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus binds the dipeptide GlyMet via side chain interactions. Biochemistry. 2004 Dec 28; 43(51):16193-202. PMID: 15610013; PMCID: PMC2792005.
      Citations: 13     Fields:    Translation:Cells
    138. Bae T, Banger AK, Wallace A, Glass EM, Aslund F, Schneewind O, Missiakas DM. Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12312-7. PMID: 15304642; PMCID: PMC514475.
      Citations: 181     Fields:    Translation:AnimalsCells
    139. Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A. Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site. Structure. 2004 Jul; 12(7):1147-56. PMID: 15242591; PMCID: PMC2792001.
      Citations: 39     Fields:    Translation:Cells
    140. Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Passage of heme-iron across the envelope of Staphylococcus aureus. Science. 2003 Feb 07; 299(5608):906-9. PMID: 12574635.
      Citations: 285     Fields:    Translation:Cells
    141. Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D. Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry. 2002 Jun 04; 41(22):6920-7. PMID: 12033924.
      Citations: 23     Fields:    Translation:Cells
    142. Tam C, Collinet B, Lau G, Raina S, Missiakas D. Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor. J Biol Chem. 2002 Jul 26; 277(30):27282-7. PMID: 12016219.
      Citations: 10     Fields:    Translation:Cells
    143. Missiakas D, Raina S, Dartigalongue C. Characterization of the Escherichia coli sigma E regulon. J Biol Chem. 2001 Jun 15; 276(24):20866-75. PMID: 11274153.
      Citations: 169     Fields:    Translation:Cells
    144. Krupp R, Chan C, Missiakas D. DsbD-catalyzed transport of electrons across the membrane of Escherichia coli. J Biol Chem. 2001 Feb 02; 276(5):3696-701. PMID: 11085993.
      Citations: 17     Fields:    Translation:Cells
    145. Collinet B, Yuzawa H, Chen T, Herrera C, Missiakas D. RseB binding to the periplasmic domain of RseA modulates the RseA:sigmaE interaction in the cytoplasm and the availability of sigmaE.RNA polymerase. J Biol Chem. 2000 Oct 27; 275(43):33898-904. PMID: 11777003.
      Citations: 27     Fields:    Translation:Cells
    146. Chung J, Chen T, Missiakas D. Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol Microbiol. 2000 Mar; 35(5):1099-109. PMID: 10712691.
      Citations: 21     Fields:    Translation:Cells
    147. Missiakas D, Raina S. The extracytoplasmic function sigma factors: role and regulation. Mol Microbiol. 1998 Jun; 28(6):1059-66. PMID: 9680198.
      Citations: 108     Fields:    Translation:Cells
    148. van Straaten M, Missiakas D, Raina S, Darby NJ. The functional properties of DsbG, a thiol-disulfide oxidoreductase from the periplasm of Escherichia coli. FEBS Lett. 1998 May 29; 428(3):255-8. PMID: 9654144.
      Citations: 6     Fields:    Translation:Cells
    149. Matthey-Dupraz A, Missiakas D, Raina S, Andersen CL. A new Escherichia coli gene, dsbG, encodes a periplasmic protein involved in disulphide bond formation, required for recycling DsbA/DsbB and DsbC redox proteins. Mol Microbiol. 1997 Oct; 26(1):121-32. PMID: 9383195.
      Citations: 29     Fields:    Translation:Cells
    150. Missiakas D, Raina S. Protein folding in the bacterial periplasm. J Bacteriol. 1997 Apr; 179(8):2465-71. PMID: 9098040; PMCID: PMC178991.
      Citations: 69     Fields:    Translation:Cells
    151. Missiakas D, Raina S. Signal transduction pathways in response to protein misfolding in the extracytoplasmic compartments of E. coli: role of two new phosphoprotein phosphatases PrpA and PrpB. EMBO J. 1997 Apr 01; 16(7):1670-85. PMID: 9130712; PMCID: PMC1169771.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    152. Missiakas D, Mayer MP, Lemaire M, Georgopoulos C, Raina S. Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins. Mol Microbiol. 1997 Apr; 24(2):355-71. PMID: 9159522.
      Citations: 152     Fields:    Translation:Cells
    153. Missiakas D, Raina S. Protein misfolding in the cell envelope of Escherichia coli: new signaling pathways. Trends Biochem Sci. 1997 Feb; 22(2):59-63. PMID: 9048484.
      Citations: 16     Fields:    Translation:Cells
    154. Missiakas D, Raina S. Making and breaking disulfide bonds. Annu Rev Microbiol. 1997; 51:179-202. PMID: 9343348.
      Citations: 52     Fields:    Translation:Cells
    155. Missiakas D, Schwager F, Betton JM, Georgopoulos C, Raina S. Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli. EMBO J. 1996 Dec 16; 15(24):6899-909. PMID: 9003766; PMCID: PMC452516.
      Citations: 51     Fields:    Translation:Cells
    156. Metheringham R, Tyson KL, Crooke H, Missiakas D, Raina S, Cole JA. Effects of mutations in genes for proteins involved in disulphide bond formation in the periplasm on the activities of anaerobically induced electron transfer chains in Escherichia coli K12. Mol Gen Genet. 1996 Nov 27; 253(1-2):95-102. PMID: 9003292.
      Citations: 26     Fields:    Translation:Cells
    157. Rybin V, Zapun A, Raina S, Missiakas D, Creighton TE, Metcalf P, Törrönen A. Crystallization of DsbC, the disulfide bond isomerase of Escherichia coli. Acta Crystallogr D Biol Crystallogr. 1996 Nov 01; 52(Pt 6):1219-21. PMID: 15299592.
      Citations: 1     Fields:    
    158. Boscus D, Missiakas D, Raina S, Hofnung M, Betton JM. Probing the structural role of an alpha beta loop of maltose-binding protein by mutagenesis: heat-shock induction by loop variants of the maltose-binding protein that form periplasmic inclusion bodies. J Mol Biol. 1996 Sep 20; 262(2):140-50. PMID: 8831785.
      Citations: 16     Fields:    Translation:Cells
    159. Betton JM, Raina S, Missiakas D. New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH. Mol Microbiol. 1996 Aug; 21(4):871-84. PMID: 8878048.
      Citations: 128     Fields:    Translation:Cells
    160. Schwager F, Raina S, Missiakas D. Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J. 1995 Jul 17; 14(14):3415-24. PMID: 7628442; PMCID: PMC394408.
      Citations: 61     Fields:    Translation:Cells
    161. Zapun A, Missiakas D, Raina S, Creighton TE. Structural and functional characterization of DsbC, a protein involved in disulfide bond formation in Escherichia coli. Biochemistry. 1995 Apr 18; 34(15):5075-89. PMID: 7536035.
      Citations: 81     Fields:    Translation:Cells
    162. Missiakas D, Georgopoulos C, Raina S. The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli. EMBO J. 1995 Mar 01; 14(5):1043-55. PMID: 7889935; PMCID: PMC398177.
      Citations: 116     Fields:    Translation:Cells
    163. Georgopoulos C, Raina S, Missiakas D. The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation. EMBO J. 1994 Apr 15; 13(8):2013-20. PMID: 8168498; PMCID: PMC395044.
      Citations: 73     Fields:    Translation:Cells
    164. Raina S, Missiakas D, Baird L, Kumar S, Georgopoulos C. Identification and transcriptional analysis of the Escherichia coli htrE operon which is homologous to pap and related pilin operons. J Bacteriol. 1993 Aug; 175(16):5009-21. PMID: 8102362; PMCID: PMC204966.
      Citations: 22     Fields:    Translation:Cells
    165. Missiakas D, Georgopoulos C, Raina S. Identification and characterization of the Escherichia coli gene dsbB, whose product is involved in the formation of disulfide bonds in vivo. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7084-8. PMID: 7688471; PMCID: PMC47080.
      Citations: 92     Fields:    Translation:Cells
    166. Georgopoulos C, Raina S, Missiakas D. The Escherichia coli heat shock gene htpY: mutational analysis, cloning, sequencing, and transcriptional regulation. J Bacteriol. 1993 May; 175(9):2613-24. PMID: 8478327; PMCID: PMC204563.
      Citations: 18     Fields:    Translation:Cells
    167. Betton JM, Chaffotte A, Minard P, Yon JM, Missiakas D. Kinetic studies of the refolding of yeast phosphoglycerate kinase: comparison with the isolated engineered domains. Protein Sci. 1992 Nov; 1(11):1485-93. PMID: 1303767; PMCID: PMC2142125.
      Citations: 5     Fields:    Translation:AnimalsCells
    168. Missiakas D, Yon JM, Betton JM. The slow-refolding step of phosphoglycerate kinase as monitored by pulse proteolysis. Arch Biochem Biophys. 1992 Jul; 296(1):95-101. PMID: 1605649.
      Citations: 2     Fields:    Translation:AnimalsCells
    169. Betton JM, Minard P, Yon JM, Missiakas D. Unfolding-refolding of the domains in yeast phosphoglycerate kinase: comparison with the isolated engineered domains. Biochemistry. 1990 Sep 18; 29(37):8683-9. PMID: 2271549.
      Citations: 11     Fields:    Translation:AnimalsCells
    170. Desmadril M, Betton JM, Minard P, Ballery N, Missiakas D, Gaillard-Miran S, Perahia D, Mouawad L, Yon JM. Flexibility and folding of phosphoglycerate kinase. Biochimie. 1990 Jun-Jul; 72(6-7):417-29. PMID: 2124145.
      Citations: 6     Fields:    Translation:AnimalsCells
    171. Fairbrother WJ, Minard P, Hall L, Betton JM, Missiakas D, Yon JM, Williams RJ. Nuclear magnetic resonance studies of isolated structural domains of yeast phosphoglycerate kinase. Protein Eng. 1989 Oct; 3(1):5-11. PMID: 2682611.
      Citations: 3     Fields:    Translation:AnimalsCells
    172. Hall L, Betton JM, Missiakas D, Yon JM, Minard P. Efficient expression and characterization of isolated structural domains of yeast phosphoglycerate kinase generated by site-directed mutagenesis. Protein Eng. 1989 Oct; 3(1):55-60. PMID: 2682612.
      Citations: 7     Fields:    Translation:AnimalsCells
    173. Betton JM, Desmadril M, Mitraki A, Minard P, Gaillard S, Ballery N, Missiakas D, Yon JM. Survey of the folding pathway of a two-domain protein phosphoglycerate kinase. J Chromatogr. 1988 May 25; 440:421-37. PMID: 3165382.
      Citations:    Fields:    Translation:AnimalsCells
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