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Ying-Jie Peng

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang N, Peng YJ, Su X, Prabhakar NR, Nanduri J. Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure. Front Physiol. 2021; 12:688322. PMID: 34079475.
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    2. Peng YJ, Su X, Wang B, Matthews T, Nanduri J, Prabhakar NR. Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia. J Neurophysiol. 2021 06 01; 125(6):2054-2067. PMID: 33909496.
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    3. Gridina A, Su X, Khan SA, Peng YJ, Wang B, Nanduri J, Fox AP, Prabhakar NR. Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. J Neurophysiol. 2021 05 01; 125(5):1533-1542. PMID: 33729866.
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    4. Wang B, Peng YJ, Su X, Zhang C, Nagati JS, Garcia JA, Prabhakar NR. Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia. J Appl Physiol (1985). 2021 04 01; 130(4):1122-1132. PMID: 33539264.
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    5. Prabhakar NR, Peng YJ, Nanduri J. Hypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. 2020 10 01; 130(10):5042-5051. PMID: 32730232.
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    6. Peng YJ, Gridina A, Wang B, Nanduri J, Fox AP, Prabhakar NR. Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia. J Neurophysiol. 2020 05 01; 123(5):1886-1895. PMID: 32208891.
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    7. Makarenko VV, Peng YJ, Khan SA, Nanduri J, Fox AP, Prabhakar NR. Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019 11 01; 122(5):1874-1883. PMID: 31483699.
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    8. Prabhakar NR, Peng YJ, Nanduri J. Recent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 2018; 7. PMID: 30631432.
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    9. Nanduri J, Peng YJ, Wang N, Prabhakar NR. Neural Activation of Molecular Circuitry in Intermittent Hypoxia. Curr Opin Physiol. 2019 Feb; 7:9-14. PMID: 31544168.
      View in: PubMed
    10. Peng YJ, Makarenko VV, Gridina A, Chupikova I, Zhang X, Kumar GK, Fox AP, Prabhakar NR. H2S mediates carotid body response to hypoxia but not anoxia. Respir Physiol Neurobiol. 2019 01; 259:75-85. PMID: 30086385.
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    11. Prabhakar NR, Peng YJ, Yuan G, Nanduri J. Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 2018 05; 372(2):427-431. PMID: 29470646.
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    12. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity. J Physiol. 2018 08; 596(15):3087-3100. PMID: 29148180.
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    13. Peng YJ, Prabhakar NR. Measurement of Sensory Nerve Activity from the Carotid Body. Methods Mol Biol. 2018; 1742:115-124. PMID: 29330795.
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    14. Peng YJ, Zhang X, Nanduri J, Prabhakar NR. Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model. Adv Exp Med Biol. 2018; 1071:109-114. PMID: 30357741.
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    15. Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418. PMID: 28115703.
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    16. Prabhakar NR, Peng YJ. Oxygen Sensing by the Carotid Body: Past and Present. Adv Exp Med Biol. 2017; 977:3-8. PMID: 28685420.
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    17. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. J Physiol. 2017 01 01; 595(1):63-77. PMID: 27506145.
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    18. Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016 08 16; 9(441):ra80. PMID: 27531649.
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    19. Makarenko VV, Ahmmed GU, Peng YJ, Khan SA, Nanduri J, Kumar GK, Fox AP, Prabhakar NR. CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia. J Neurophysiol. 2016 Jan 01; 115(1):345-54. PMID: 26561606.
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    20. Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21; 8(373):ra37. PMID: 25900831.
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    21. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J. Peripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. 2015 Apr; 5(2):561-77. PMID: 25880505.
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    22. Nanduri J, Peng YJ, Yuan G, Kumar GK, Prabhakar NR. Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl). 2015 May; 93(5):473-80. PMID: 25772710.
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    23. Kumar GK, Nanduri J, Peng YJ, Prabhakar NR. Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol. 2015 Apr; 209:115-9. PMID: 25583660.
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    24. Kumar GK, Peng YJ, Nanduri J, Prabhakar NR. Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla. Adv Exp Med Biol. 2015; 860:195-9. PMID: 26303481.
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    25. Makarenko VV, Peng YJ, Yuan G, Fox AP, Kumar GK, Nanduri J, Prabhakar NR. CaV3.2 T-type Ca?? channels in H2S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C146-54. PMID: 25377087.
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    26. Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014 Sep 01; 592(17):3841-58. PMID: 24973414.
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    27. Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression. Biochem J. 2014 Mar 01; 458(2):203-11. PMID: 24328859.
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    28. Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1174-9. PMID: 24395806.
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    29. Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NR. Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol. 2013 Nov; 98(11):1620-30. PMID: 23913764.
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    30. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. PMID: 23770311.
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    31. Prabhakar NR, Kumar GK, Peng YJ. Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol (1985). 2012 Oct 15; 113(8):1304-10. PMID: 22723632.
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    32. Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20. PMID: 22232674.
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    33. Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakar NR, Garcia JG. Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):524-31. PMID: 22108299.
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    34. Peng YJ, Nanduri J, Zhang X, Wang N, Raghuraman G, Seagard J, Kumar GK, Prabhakar NR. Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia. J Appl Physiol (1985). 2012 Jan; 112(1):187-96. PMID: 22016368.
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    35. Peng YJ, Raghuraman G, Khan SA, Kumar GK, Prabhakar NR. Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase. J Appl Physiol (1985). 2011 Oct; 111(4):964-70. PMID: 21636565.
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    36. Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3065-70. PMID: 21288809.
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    37. Peng YJ, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10719-24. PMID: 20556885.
      View in: PubMed
    38. Raghuraman G, Rai V, Peng YJ, Prabhakar NR, Kumar GK. Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal. 2009 Aug; 11(8):1777-89. PMID: 19335094.
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    39. Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR. NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci. 2009 Apr 15; 29(15):4903-10. PMID: 19369559.
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    40. Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NR. Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1199-204. PMID: 19147445.
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    41. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J, Di Giulio C, Lahiri S. Long-term regulation of carotid body function: acclimatization and adaptation--invited article. Adv Exp Med Biol. 2009; 648:307-17. PMID: 19536494.
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    42. Pawar A, Peng YJ, Jacono FJ, Prabhakar NR. Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 May; 104(5):1287-94. PMID: 18187605.
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    43. Prabhakar NR, Peng YJ, Kumar GK, Pawar A. Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):148-53. PMID: 17317339.
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    44. Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol. 2006 Dec 01; 577(Pt 2):705-16. PMID: 16973705.
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    45. Peng YJ, Yuan G, Jacono FJ, Kumar GK, Prabhakar NR. 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol. 2006 Oct 01; 576(Pt 1):289-95. PMID: 16887872.
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    46. Jacono FJ, Peng YJ, Nethery D, Faress JA, Lee Z, Kern JA, Prabhakar NR. Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia. J Appl Physiol (1985). 2006 Dec; 101(6):1795-802. PMID: 16888052.
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    47. Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol. 2006 Aug 15; 575(Pt 1):229-39. PMID: 16777938.
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    48. Prabhakar NR, Peng YJ, Yuan G, Kumar GK. Reactive oxygen species facilitate oxygen sensing. Novartis Found Symp. 2006; 272:95-9; discussion 100-5, 131-40. PMID: 16686431.
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    49. Wang J, Peng YJ, Zhu DN. Amino acids modulate the hypotensive effect of angiotensin-(1-7) at the caudal ventrolateral medulla in rats. Regul Pept. 2005 Jul 15; 129(1-3):1-7. PMID: 15927691.
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    50. Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK, Dick TE. Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):447-9. PMID: 15854156.
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    51. Kline DD, Buniel MC, Glazebrook P, Peng YJ, Ramirez-Navarro A, Prabhakar NR, Kunze DL. Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J Neurosci. 2005 Mar 30; 25(13):3389-99. PMID: 15800194.
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    52. Jacono FJ, Peng YJ, Kumar GK, Prabhakar NR. Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor. Respir Physiol Neurobiol. 2005 Feb 15; 145(2-3):135-42. PMID: 15705529.
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    53. Malik MT, Peng YJ, Kline DD, Adhikary G, Prabhakar NR. Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B. Respir Physiol Neurobiol. 2005 Jan 15; 145(1):23-31. PMID: 15652785.
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    54. Peng YJ, Rennison J, Prabhakar NR. Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups. J Appl Physiol (1985). 2004 Nov; 97(5):2020-5. PMID: 15258129.
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    55. Prabhakar NR, Peng YJ, Overholt JL, Kumar GK. Detection of oxygen sensing during intermittent hypoxia. Methods Enzymol. 2004; 381:107-20. PMID: 15063668.
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    56. Prabhakar NR, Peng YJ. Peripheral chemoreceptors in health and disease. J Appl Physiol (1985). 2004 Jan; 96(1):359-66. PMID: 14660497.
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    57. Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985). 2004 Mar; 96(3):1236-42; discussion 1196. PMID: 14660510.
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    58. Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10073-8. PMID: 12907705.
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    59. Peng YJ, Prabhakar NR. Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia. J Appl Physiol (1985). 2003 Jun; 94(6):2342-9. PMID: 12533494.
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    60. Peng Y, Yuan G, Overholt JL, Kumar GK, Prabhakar NR. Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction. Adv Exp Med Biol. 2003; 536:559-64. PMID: 14635713.
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    61. Peng YJ, Wang N, Gong QL, Li P. Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats. Neurosci Lett. 2002 Jun 07; 325(2):134-8. PMID: 12044639.
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    62. Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):821-6. PMID: 11792862.
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    63. Peng Y, Kline DD, Dick TE, Prabhakar NR. Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen. Adv Exp Med Biol. 2001; 499:33-8. PMID: 11729902.
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    64. Shen LL, Peng YJ, Wu GQ, Cao YX, Li P. [The coherence analysis between neuronal discharge in the rostral ventrolateral medulla and the cardiovascular activity in rats]. Sheng Li Xue Bao. 1999 Apr; 51(2):168-74. PMID: 11499011.
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    65. Peng YJ, Gong QL, Li P. GABA(A) receptors in the rostral ventrolateral medulla mediate the depressor response induced by stimulation of the greater splanchnic nerve afferent fibres in rats. Neurosci Lett. 1998 Jun 19; 249(2-3):95-8. PMID: 9682825.
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