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Kiang-Teck Jerry Yeo

TitlePROFESSOR
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Yeo is an academic clinical chemist with over 30 years of experience and is board-certified in Clinical Chemistry (1990) & Toxicological Chemistry (1995) by the American Board of Clinical Chemistry. He was the Director of Clinical Chemistry and Endocrinology Laboratories and Dartmouth Reference Laboratory and Professor of Pathology at Dartmouth-Hitchcock Medical Center(1995-2007). Prior to that he was the Scientific Director of Clinical Chemistry and Endocrinology Laboratories and an Assistant Professor at Beth Israel Hospital and Harvard Medical School (1987-1995). Dr. Yeo was past-President of the Commission on Accreditation in Clinical Chemistry (2017-2018), past-Chair of the AACC Personalized Medicine Division (2017-2018), past Treasurer of the AACC Proteomics & Metabolomics Division (2015-2016), past-Chair of Chicago Section of AACC (2014-2015), past-Chair of the AACC Molecular Pathology Division (2008-2010), and past Vice-President of American Board of Clinical Chemistry (2003-2005). His research interests are in emerging angiogenic biomarkers, clinical mass spectrometry and clinical pharmacogenomics applications for precision medicine. He had published more than 100 original articles, book chapters and abstracts in the field of clinical chemistry and pharmacogenomics.


    Collapse Biography 
    Collapse education and training
    University of Washington, Seattle, WASenior Postdoc Fellow1987Clinical Chemistry
    Howard University Cancer Center, Washington, DCResearch Associate1985Cancer research
    SUNY Downstate Medical Center, Brooklyn, NYPhD1983Biochemistry
    University of Malaya, Kuala Lumpur, MalaysiaBSc1977Biochemistry
    Collapse awards and honors
    2017 - 2018President, Commission on Accreditation in Clinical Chemistry
    2017 - 2018Chair, Personalized Medicine Division, American Association for Clinical Chemistry
    2016Albert A. Dietz Service Award, Chicago Section of AACC
    2014Chair, Chicago Section, American Association for Clinical Chemistry
    2013Samuel Natelson Research Award, Chicago Section of American Association for Clinical Chemistry
    2013AACC Outstanding Speaker Award, American Association for Clinical Chemistry
    2005International Travel Fellowship, American Association for Clinical Chemistry
    2003 - 2005Vice-President, American Board of Clinical Chemistry
    1997Fellow, National Academy of Clinical Biochemistry
    1990Diplomate, American Board of Clinical Chemistry

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Research 
    Collapse research activities and funding
         (Rana, Sarosh)Jan 19, 2017 - Dec 31, 2018
    Roche Diagnostics
    Sequential angiogenic factor estimation in intrauterine growth restriction
    Role: Co-Investigator
    1R01HG009938-01A1     (O'Donnell, Peter)Aug 27, 2018 - Jun 30, 2023
    NIH
    Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care
    Role Description: Our goal for this application is to attempt to overcome barriers to clinical implementation of genomic information for prescribing by studying the feasibility and utility of delivering preemptively.
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chan SL, Yi X, Wysocki E, Bridgman R, Gutierrez J, Mikrut K, Leung EK, Yeo KJ, Miller JL. Development of a Nonradioactive Platelet Serotonin Uptake and Release Assay by Micro-Liquid Chromatography Tandem Mass Spectrometry Using Minimal Blood Volume. Am J Clin Pathol. 2019 Nov 04; 152(6):718-724. PMID: 31365739.
      View in: PubMed
    2. Hernandez W, Danahey K, Pei X, Yeo KJ, Leung E, Volchenboum SL, Ratain MJ, Meltzer DO, Stranger BE, Perera MA, O'Donnell PH. Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation. Pharmacogenomics J. 2019 Sep 11. PMID: 31506565.
      View in: PubMed
    3. Truong TM, Apfelbaum J, Shahul S, Anitescu M, Danahey K, Knoebel RW, Liebovitz D, Karrison T, van Wijk XMR, Yeo KJ, Meltzer D, Ratain MJ, O'Donnell PH. The ImPreSS Trial: Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care. Clin Pharmacol Ther. 2019 Dec; 106(6):1179-1183. PMID: 31433489.
      View in: PubMed
    4. Asif M, Groboske SE, Leung EKY, Yeo KJ, van Wijk XMR. Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding. J Appl Lab Med. 2019 09; 4(2):247-253. PMID: 31639671.
      View in: PubMed
    5. Lopes Perdigao J, Chinthala S, Mueller A, Minhas R, Ramadan H, Nasim R, Naseem H, Young D, Shahul S, Chan SL, Yeo KJ, Rana S. Angiogenic Factor Estimation as a Warning Sign of Preeclampsia-Related Peripartum Morbidity Among Hospitalized Patients. Hypertension. 2019 04; 73(4):868-877. PMID: 30798660.
      View in: PubMed
    6. Leung EKY, Lee CC, Angelos P, Kaplan EL, Grogan RH, Sarracino DA, Krastins B, Lopez MF, Karrison T, Yeo KJ. Analytical Differences in Intraoperative Parathyroid Hormone Assays. J Appl Lab Med. 2019 03; 3(5):788-798. PMID: 31639754.
      View in: PubMed
    7. Minhas R, Young D, Naseem R, Mueller A, Chinthala S, Perdigao JL, Yeo KJ, Chan SL, Tung A, White JB, Shahul S, Rana S. Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension. Pregnancy Hypertens. 2018 Oct; 14:110-114. PMID: 30527096.
      View in: PubMed
    8. Yang Y, Wysocki E, Antwi K, Niederkofler E, Leung EKY, Lazar-Molnar E, Yeo KJ. Development and validation of a targeted affinity-enrichment and LC-MS/MS proteomics approach for the therapeutic monitoring of adalimumab. Clin Chim Acta. 2018 Aug; 483:308-314. PMID: 29752913.
      View in: PubMed
    9. Marin MJ, van Wijk XMR, Yeo KJ. Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies. Clin Chim Acta. 2018 08; 483:239-240. PMID: 29750966.
      View in: PubMed
    10. Yang Y, Yassan L, Leung EKY, Yeo KJ. Smith-Lemli-Opitz Syndrome in a newborn infant with developmental abnormalities and low endogenous cholesterol. Clin Chim Acta. 2018 Apr; 479:208-211. PMID: 29355488.
      View in: PubMed
    11. Chan SL, Rana S, Chinthala S, Salahuddin S, Yeo KJ. Analytical validation of soluble fms-like tyrosine and placental growth factor assays on B·R·A·H·M·S KRYPTOR Compact Plus automated immunoassay platform. Pregnancy Hypertens. 2018 Jan; 11:66-70. PMID: 29523276.
      View in: PubMed
    12. Jerry Yeo KT. Commentary. Clin Chem. 2017 08; 63(8):1329-1330. PMID: 28751321.
      View in: PubMed
    13. Li M, Diamandis EP, Paneth N, Yeo KJ, Vogt H, Master SR. Wellness Initiatives: Benefits and Limitations. Clin Chem. 2017 06; 63(6):1063-1068. PMID: 28432186.
      View in: PubMed
    14. Leung EK, Yi X, Refetoff S, Yeo KT. Diiodothyropropionic acid (DITPA) cross-reacts with thyroid function assays on different immunoassay platforms. Clin Chim Acta. 2016 Jan 30; 453:203-4. PMID: 26683355.
      View in: PubMed
    15. White HD, Brown LA, Gyurik RJ, Manganiello PD, Robinson TD, Hallock LS, Lewis LD, Yeo KT. Treatment of pain in fibromyalgia patients with testosterone gel: Pharmacokinetics and clinical response. Int Immunopharmacol. 2015 Aug; 27(2):249-56. PMID: 26004317.
      View in: PubMed
    16. Alikhan M, Koshy A, Hyjek E, Stenson K, Cohen RN, Yeo KT. Discrepant serum and urine ß-hCG results due to production of ß-hCG by a cribriform-morular variant of thyroid papillary carcinoma. Clin Chim Acta. 2015 Jan 01; 438:181-5. PMID: 25181612.
      View in: PubMed
    17. Leung EK, Yi X, Gloria C, Yeo KT. Clinical evaluation of the QMS® Tacrolimus immunoassay. Clin Chim Acta. 2014 Apr 20; 431:270-5. PMID: 24518359.
      View in: PubMed
    18. Apushkin M, Das A, Joseph C, Leung EK, Yeo KT, Baron JM, Baron BW. Reducing the risk of hyperammonemia from transfusion of stored red blood cells. Transfus Apher Sci. 2013 Dec; 49(3):459-62. PMID: 23725795.
      View in: PubMed
    19. Mandal S, Westra J, Apushkin M, Richa EM, Zibrat SJ, Toney L, Yeo KT, Baron JM, Baron BW. Automated red cell exchange: a simplified formula for how many red cell units to exchange and validity of haemoglobin S levels measured one to two hours later. Blood Transfus. 2014 Jan; 12 Suppl 1:s145-6. PMID: 23736933.
      View in: PubMed
    20. Babic N, Zibrat S, Gordon IO, Lee CC, Yeo KT. Effect of blood collection tubes on the incidence of artifactual hyperkalemia on patient samples from an outreach clinic. Clin Chim Acta. 2012 Oct 09; 413(19-20):1454-8. PMID: 22698439.
      View in: PubMed
    21. Bhardwaj A, Truong QA, Peacock WF, Yeo KT, Storrow A, Thomas S, Curtis KM, Foote RS, Lee HK, Miller KF, Januzzi JL. A multicenter comparison of established and emerging cardiac biomarkers for the diagnostic evaluation of chest pain in the emergency department. Am Heart J. 2011 Aug; 162(2):276-282.e1. PMID: 21835288.
      View in: PubMed
    22. Manolopoulos VG, Dechairo B, Huriez A, Kühn A, Llerena A, van Schaik RH, Yeo KT, Ragia G, Siest G. Pharmacogenomics and personalized medicine in clinical practice. Pharmacogenomics. 2011 May; 12(5):597-610. PMID: 21619425.
      View in: PubMed
    23. Lee CC, McMillin GA, Babic N, Melis R, Yeo KT. Evaluation of a CYP2C19 genotype panel on the GenMark eSensor® platform and the comparison to the Autogenomics Infiniti™ and Luminex CYP2C19 panels. Clin Chim Acta. 2011 May 12; 412(11-12):1133-7. PMID: 21385571.
      View in: PubMed
    24. Pratt VM, Zehnbauer B, Wilson JA, Baak R, Babic N, Bettinotti M, Buller A, Butz K, Campbell M, Civalier C, El-Badry A, Farkas DH, Lyon E, Mandal S, McKinney J, Muralidharan K, Noll L, Sander T, Shabbeer J, Smith C, Telatar M, Toji L, Vairavan A, Vance C, Weck KE, Wu AH, Yeo KT, Zeller M, Kalman L. Characterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1: a GeT-RM and Association for Molecular Pathology collaborative project. J Mol Diagn. 2010 Nov; 12(6):835-46. PMID: 20889555.
      View in: PubMed
    25. Wong SH, Happy C, Blinka D, Gock S, Jentzen JM, Donald Hon J, Coleman H, Jortani SA, Lucire Y, Morris-Kukoski CL, Neuman MG, Orsulak PJ, Sander T, Wagner MA, Wynn JR, Wu AH, Yeo KT. From personalized medicine to personalized justice: the promises of translational pharmacogenomics in the justice system. Pharmacogenomics. 2010 Jun; 11(6):731-7. PMID: 20504247.
      View in: PubMed
    26. Babic N, Haverfield EV, Burrus JA, Lozada A, Das S, Yeo KT. Comparison of performance of three commercial platforms for warfarin sensitivity genotyping. Clin Chim Acta. 2009 Aug; 406(1-2):143-7. PMID: 19545555.
      View in: PubMed
    27. Wu AH, Babic N, Yeo KJ. Implementation of pharmacogenomics into the clinical practice of therapeutics: issues for the clinician and the laboratorian. Per Med. 2009 May; 6(3):315-327. PMID: 29783510.
      View in: PubMed
    28. Lee HK, Brough TJ, Curtis MB, Polito FA, Yeo KT. Pseudohyperkalemia--is serum or whole blood a better specimen type than plasma? Clin Chim Acta. 2008 Oct; 396(1-2):95-6. PMID: 18638465.
      View in: PubMed
    29. Lee HK, Lewis LD, Tsongalis GJ, Schur BC, Jannetto PJ, Wong SH, Yeo KT. Validation of a CYP2D6 genotyping panel on the NanoChip Molecular Biology Workstation. Clin Chem. 2007 May; 53(5):823-8. PMID: 17363417.
      View in: PubMed
    30. Wise S, Chien J, Yeo K, Richardson C. Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system. Diabet Med. 2006 May; 23(5):510-5. PMID: 16681559.
      View in: PubMed
    31. Lee HK, Lewis LD, Tsongalis GJ, McMullin M, Schur BC, Wong SH, Yeo KT. Negative urine opioid screening caused by rifampin-mediated induction of oxycodone hepatic metabolism. Clin Chim Acta. 2006 May; 367(1-2):196-200. PMID: 16414038.
      View in: PubMed
    32. Yeo KT, Lee HK, Wong KC, Foote RS. Can exercise-induced changes in B-type natriuretic peptides be used to detect cardiac ischemia? J Card Fail. 2005 Jun; 11(5 Suppl):S59-64. PMID: 15948103.
      View in: PubMed
    33. Yeo KT, Dumont KE, Brough T. Elecsys NT-ProBNP and BNP assays: are there analytically and clinically relevant differences? J Card Fail. 2005 Jun; 11(5 Suppl):S84-8. PMID: 15948108.
      View in: PubMed
    34. Foote RS, Pearlman JD, Siegel AH, Yeo KT. Detection of exercise-induced ischemia by changes in B-type natriuretic peptides. J Am Coll Cardiol. 2004 Nov 16; 44(10):1980-7. PMID: 15542280.
      View in: PubMed
    35. Reynolds AM, Yeo K, Lee C. Anisotropy of acceleration in turbulent flows. Phys Rev E Stat Nonlin Soft Matter Phys. 2004; 70(1 Pt 2):017302. PMID: 15324209.
      View in: PubMed
    36. Morgan TM, Crawford L, Stoller A, Toth D, Yeo KT, Baron JA. Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers. Metabolism. 2004 May; 53(5):578-82. PMID: 15131760.
      View in: PubMed
    37. Panteghini M, Pagani F, Yeo KT, Apple FS, Christenson RH, Dati F, Mair J, Ravkilde J, Wu AH. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem. 2004 Feb; 50(2):327-32. PMID: 14656904.
      View in: PubMed
    38. Yeo KT, Wu AH, Apple FS, Kroll MH, Christenson RH, Lewandrowski KB, Sedor FA, Butch AW. Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. Clin Chim Acta. 2003 Dec; 338(1-2):107-15. PMID: 14637274.
      View in: PubMed
    39. Hoefner DM, Yeo KT. Lot-to-lot inconsistency of anticardiolipin reagents. Clin Chem. 2002 Sep; 48(9):1625-6; author reply 1626. PMID: 12194956.
      View in: PubMed
    40. Fillinger MP, Rassias AJ, Guyre PM, Sanders JH, Beach M, Pahl J, Watson RB, Whalen PK, Yeo KT, Yeager MP. Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgery. J Cardiothorac Vasc Anesth. 2002 Apr; 16(2):163-9. PMID: 11957164.
      View in: PubMed
    41. Beelen AP, Yeo KT, Lewis LD. Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone. Hum Exp Toxicol. 2001 Apr; 20(4):215-9. PMID: 11393275.
      View in: PubMed
    42. Beisswenger PJ, Szwergold BS, Yeo KT. Glycated proteins in diabetes. Clin Lab Med. 2001 Mar; 21(1):53-78, vi. PMID: 11321937.
      View in: PubMed
    43. Yeo KT, Storm CA, Li Y, Jayne JE, Brough T, Quinn-Hall KS, Fitzmaurice TF. Performance of the enhanced Abbott AxSYM cardiac troponin I reagent in patients with heterophilic antibodies. Clin Chim Acta. 2000 Feb 25; 292(1-2):13-23. PMID: 10686273.
      View in: PubMed
    44. Fitzmaurice TF, Brown C, Rifai N, Wu AH, Yeo KT. False increase of cardiac troponin I with heterophilic antibodies. Clin Chem. 1998 Oct; 44(10):2212-4. PMID: 9761264.
      View in: PubMed
    45. Krasnow JS, Berga SL, Guzick DS, Zeleznik AJ, Yeo KT. Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report. Fertil Steril. 1996 Mar; 65(3):552-5. PMID: 8774285.
      View in: PubMed
    46. Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, Dvorak HF. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res. 1996 Jan 01; 56(1):172-81. PMID: 8548760.
      View in: PubMed
    47. Baker PN, Krasnow J, Roberts JM, Yeo KT. Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia. Obstet Gynecol. 1995 Nov; 86(5):815-21. PMID: 7566855.
      View in: PubMed
    48. Brown LF, Yeo KT, Berse B, Morgentaler A, Dvorak HF, Rosen S. Vascular permeability factor (vascular endothelial growth factor) is strongly expressed in the normal male genital tract and is present in substantial quantities in semen. J Urol. 1995 Aug; 154(2 Pt 1):576-9. PMID: 7609140.
      View in: PubMed
    49. Detmar M, Yeo KT, Nagy JA, Van de Water L, Brown LF, Berse B, Elicker BM, Ledbetter S, Dvorak HF. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol. 1995 Jul; 105(1):44-50. PMID: 7615975.
      View in: PubMed
    50. Brown LF, Harrist TJ, Yeo KT, Ståhle-Bäckdahl M, Jackman RW, Berse B, Tognazzi K, Dvorak HF, Detmar M. Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. J Invest Dermatol. 1995 May; 104(5):744-9. PMID: 7738351.
      View in: PubMed
    51. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK, Yeo KT. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994 Oct 15; 118(4):445-50. PMID: 7943121.
      View in: PubMed
    52. Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jackman RW, Berse B, Dvorak HF. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med. 1994 Sep 01; 180(3):1141-6. PMID: 8064230.
      View in: PubMed
    53. Dvorak HF, Nagy JA, Berse B, Brown LF, Yeo KT, Yeo TK, Dvorak AM, van de Water L, Sioussat TM, Senger DR. Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma formation. Ann N Y Acad Sci. 1992 Dec 04; 667:101-11. PMID: 1309029.
      View in: PubMed
    54. Yeo KT, Sioussat TM, Faix JD, Senger DR, Yeo TK. Development of time-resolved immunofluorometric assay of vascular permeability factor. Clin Chem. 1992 Jan; 38(1):71-5. PMID: 1733610.
      View in: PubMed
    55. Khoo DH, Tan KT, Yeo KT, Chew W, Yong V, Tan YT. Diabetic retinopathy--results of a two year screening programme in two medical units in Singapore. Ann Acad Med Singapore. 1990 Jul; 19(4):484-8. PMID: 2221808.
      View in: PubMed
    56. Kharasch ED, Yeo KT, Kenny MA, Amory DW. Influence of hypothermic cardiopulmonary bypass on atrial natriuretic factor levels. Can J Anaesth. 1989 Sep; 36(5):545-53. PMID: 2529049.
      View in: PubMed
    57. Yeo KT, Traverse W, Horowitz GL. Clinical performance of the EMIT vancomycin assay. Clin Chem. 1989 Jul; 35(7):1504-7. PMID: 2667803.
      View in: PubMed
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