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Barbara Lynne Kee

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
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    Transcriptional Control of Innate and Adaptive Lymphoid Development and Transformation

    The execution of an effective immune response with minimal immune-mediated disease requires appropriate control of the development and function of adaptive and innate components of the immune system. B and T lymphocytes are the cells that mediate adaptive immunity; they are highly antigen specific but require substantial expansion and activation prior to promoting an effective immune response. In contrast, natural killer (NK) cells, innate-like T lymphocytes, and the recently identified innate lymphoid cells (ILCs) are lymphocytes that function in innate immunity; they acquire their effector properties during their development and are poised to rapidly confront invading pathogens. All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia.

    The E protein class of basic helix-loop-helix (bHLH) transcription factors and their antagonists, the ID proteins, play fundamental roles in the choice between adaptive and innate lymphoid differentiation and they control the precise effector functions exhibited by these cells. Failure to properly control the activity of these proteins leads to immune deficiencies and cancer. The E protein E2A is required for development of B and T lymphocytes due to direct regulation of critical transcriptional networks that specify these lineages from HSCs and multipotent progenitors. Despite a severe T lymphocyte immune deficiency in E2A-deficient mice, the mice develop a disease similar to T lymphocyte acute lymphoblastic leukemia (T-ALL), and the human disease is characterized by recurrent mutations that affect E protein function. We identified a transcriptional cascade involving the transcription factors Notch1 and LEF1 as being critical for leukemia cell survival and we are working toward an understanding of how these transcription factors contribute to both immune deficiency and leukemogenesis.

    ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the targets of the E protein transcription factors control adaptive and innate lymphoid cell differentiation. Our recent studies led to the identification of ETS1 as a critical regulator of ID2 that promotes NK cell and ILC differentiation, and we are working toward an understanding of how ETS1 and ID2 cooperate to control NK cell maturation and effector function.

    Collapse Biography 
    Collapse education and training
    University of Toronto, Toronto, CanadaB.S.06/1989Immunology
    University of Toronto, Toronto, CanadaPh.D. 01/1995Immunology
    The Salk Institute, La Jolla, CAPostdoc03/1996Transcription
    University of California, San Diego, La Jolla, CAPostdoc06/2001Transcription/Immunology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Parriott G, Hegermiller E, Morman RE, Frank C, Saygin C, Stock W, Bartom ET, Kee BL. Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL. Leukemia. 2023 Dec 28. PMID: 38155245.
      Citations:    Fields:    
    2. Morgan RC, Frank C, Greger M, Attaway M, Sigvardsson M, Bartom ET, Kee BL. TGF-ß Promotes the Postselection Thymic Development and Peripheral Function of IFN-?-Producing Invariant NKT cells. J Immunol. 2023 Nov 01; 211(9):1376-1384. PMID: 37702745; PMCID: PMC10592054.
      Citations:    Fields:    Translation:AnimalsCells
    3. Saygin C, Giordano G, Shimamoto K, Eisfelder B, Thomas-Toth A, Venkataraman G, Ananthanarayanan V, Vincent TL, DuVall A, Patel AA, Chen Y, Tan F, Anthony SP, Chen Y, Shen Y, Odenike O, Teachey DT, Kee BL, LaBelle J, Stock W. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023 08 15; 29(16):3151-3161. PMID: 37363966; PMCID: PMC10425730.
      Citations: 1     Fields:    Translation:HumansCells
    4. Chandra A, Yoon S, Michieletto MF, Goldman N, Ferrari EK, Abedi M, Johnson I, Fasolino M, Pham K, Joannas L, Kee BL, Henao-Mejia J, Vahedi G. Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation. Immunity. 2023 07 11; 56(7):1451-1467.e12. PMID: 37263273.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Parriott G, Hegermiller E, Morman RE, Frank C, Saygin C, Stock W, Bartom ET, Kee BL. Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia. bioRxiv. 2023 Apr 25. PMID: 37163059; PMCID: PMC10168235.
      Citations:    
    6. Kee BL, Anderson MK, Sigvardsson M, Zúñiga-Pflücker JC. Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function. Front Immunol. 2022; 13:1062734. PMID: 36405705; PMCID: PMC9672664.
      Citations:    Fields:    
    7. Morgan RC, Kee BL. Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development. J Immunol. 2022 07 15; 209(2):208-216. PMID: 35821098.
      Citations: 5     Fields:    Translation:Cells
    8. Parriott G, Kee BL. E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia. Front Immunol. 2022; 13:885144. PMID: 35514954; PMCID: PMC9065262.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Carr T, McGregor S, Dias S, Verykokakis M, Le Beau MM, Xue HH, Sigvardsson M, Bartom ET, Kee BL. Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia. Front Immunol. 2022; 13:845488. PMID: 35371057; PMCID: PMC8971981.
      Citations: 4     Fields:    Translation:Animals
    10. Li ZY, Morman RE, Hegermiller E, Sun M, Bartom ET, Maienschein-Cline M, Kee BL, Sigvardsson M. The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. J Exp Med. 2021 06 07; 218(6). PMID: 33857289; PMCID: PMC8056751.
      Citations: 8     Fields:    Translation:AnimalsCells
    11. Kee BL. It's a Phase That EBF1 Is Going Through. Immunity. 2020 12 15; 53(6):1123-1125. PMID: 33326760.
      Citations: 1     Fields:    Translation:Cells
    12. McCarter AC, Della Gatta G, Melnick A, Kim E, Sha C, Wang Q, Nalamolu JK, Liu Y, Keeley TM, Yan R, Sun M, Kodgule R, Kunnath N, Ambesi-Impiombato A, Kuick R, Rao A, Ryan RJH, Kee BL, Samuelson LC, Ostrowski MC, Ferrando AA, Chiang MY. Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia. Blood Cancer Discov. 2020 09; 1(2):178-197. PMID: 32924017; PMCID: PMC7482717.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Gioulbasani M, Galaras A, Grammenoudi S, Moulos P, Dent AL, Hatzis P, Kee BL, Verykokakis M, Sigvardsson M. The transcription factor BCL-6 controls early development of innate-like T cells. Nat Immunol. 2020 09; 21(9):1058-1069. PMID: 32719520; PMCID: PMC7442690.
      Citations: 10     Fields:    Translation:AnimalsCells
    14. Kee BL, Morman RE, Sun M. Transcriptional regulation of natural killer cell development and maturation. Adv Immunol. 2020; 146:1-28. PMID: 32327150.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Jacobsen JA, Bartom ET, Sigvardsson M, Kee BL. Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate. J Immunol. 2020 04 01; 204(7):1760-1769. PMID: 32094206; PMCID: PMC7344269.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Pham D, Moseley CE, Gao M, Savic D, Winstead CJ, Sun M, Kee BL, Myers RM, Weaver CT, Hatton RD. Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf. Cell Rep. 2019 10 29; 29(5):1203-1220.e7. PMID: 31665634; PMCID: PMC7182170.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    17. Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Grajales-Reyes GE, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM, Briseño CG, Wöhner M. Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019 09; 20(9):1161-1173. PMID: 31406378; PMCID: PMC6707878.
      Citations: 46     Fields:    Translation:AnimalsCells
    18. Dias S, Chowdhury M, Bartom ET, Okoreeh MK, Sigvardsson M, Kee BL, de Pooter RF. Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. J Immunol. 2019 05 15; 202(10):2837-2842. PMID: 30962294; PMCID: PMC6504590.
      Citations: 3     Fields:    Translation:AnimalsCells
    19. Zook EC, Li ZY, Xu Y, Verykokakis M, Beaulieu A, Lasorella A, Maienschein-Cline M, Sun JC, Sigvardsson M, Kee BL, de Pooter RF. Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development. Sci Immunol. 2018 04 27; 3(22). PMID: 29703840; PMCID: PMC6750718.
      Citations: 29     Fields:    Translation:AnimalsCells
    20. Verykokakis M, Kee BL. Transcriptional and epigenetic regulation of innate-like T lymphocyte development. Curr Opin Immunol. 2018 04; 51:39-45. PMID: 29452898; PMCID: PMC5943139.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. Sun M, Kee BL. Lnc'ing Id2 to ILC1. Immunity. 2017 09 19; 47(3):389-390. PMID: 28930650.
      Citations: 1     Fields:    Translation:HumansCells
    22. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. J Immunol. 2017 06 15; 198(12):4682-4691. PMID: 28490575; PMCID: PMC5527689.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Gabrielli S, Sun M, Bell A, Zook EC, de Pooter RF, Zamai L, Kee BL. Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. Eur J Immunol. 2017 05; 47(5):800-805. PMID: 28276053; PMCID: PMC5662841.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Verykokakis M, Kee BL. Applying the TOR(C)QUE in iNKT cells: A new twist in an old tale. Eur J Immunol. 2017 03; 47(3):454-457. PMID: 28295259; PMCID: PMC5582540.
      Citations: 1     Fields:    Translation:AnimalsCells
    25. Zook EC, Kee BL. Development of innate lymphoid cells. Nat Immunol. 2016 06 21; 17(7):775-82. PMID: 27328007.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    26. Zook EC, Ramirez K, Guo X, van der Voort G, Svensson EC, Fu YX, Kee BL, Sigvardsson M. The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2. J Exp Med. 2016 05 02; 213(5):687-96. PMID: 27069114; PMCID: PMC4854726.
      Citations: 47     Fields:    Translation:AnimalsCells
    27. Block KE, Zheng Z, Dent AL, Kee BL, Huang H. Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells. J Immunol. 2016 Feb 15; 196(4):1550-7. PMID: 26783341; PMCID: PMC4744513.
      Citations: 45     Fields:    Translation:AnimalsCells
    28. Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL. Correction: Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the notch signaling pathway. J Immunol. 2015 Jun 15; 194(12):6191. PMID: 26048968; PMCID: PMC4891201.
      Citations: 1     Fields:    
    29. Xu Y, Evaristo C, Alegre ML, Gurbuxani S, Kee BL. Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. PLoS One. 2015; 10(4):e0125211. PMID: 25923440; PMCID: PMC4414598.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Immunity. 2015 Apr 21; 42(4):731-43. PMID: 25902484; PMCID: PMC4725053.
      Citations: 61     Fields:    Translation:AnimalsCells
    31. Carr T, Krishnamoorthy V, Yu S, Xue HH, Kee BL, Verykokakis M. The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. J Exp Med. 2015 May 04; 212(5):793-807. PMID: 25897173; PMCID: PMC4419352.
      Citations: 36     Fields:    Translation:AnimalsCells
    32. Xu W, Lopez-Lastra S, Motomura Y, Kee B, Brady H, Coles MC, Vosshenrich C, Kubo M, Di Santo JP, Domingues RG, Fonseca-Pereira D, Ferreira M, Ribeiro H, Moreira-Santos L, Bihl F, Braud V, Veiga-Fernandes H. NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Rep. 2015 Mar 31; 10(12):2043-54. PMID: 25801035.
      Citations: 100     Fields:    Translation:AnimalsCells
    33. Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Akinola EO, Gounari F, Kee BL. Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. J Immunol. 2015 Apr 01; 194(7):3191-200. PMID: 25710912; PMCID: PMC4369417.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Verykokakis M, Zook EC, Kee BL. ID'ing innate and innate-like lymphoid cells. Immunol Rev. 2014 Sep; 261(1):177-97. PMID: 25123285; PMCID: PMC4159719.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    35. Kee BL. Sox4 B-lymphocyte progenitors. Blood. 2014 Jun 26; 123(26):4009-10. PMID: 24970928.
      Citations: 2     Fields:    Translation:AnimalsCells
    36. Verykokakis M, Krishnamoorthy V, Iavarone A, Lasorella A, Sigvardsson M, Kee BL. Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. J Immunol. 2013 Dec 15; 191(12):5973-83. PMID: 24244015; PMCID: PMC3864619.
      Citations: 38     Fields:    Translation:AnimalsCells
    37. Gounari F, Kee BL. Fingerprinting ikaros. Nat Immunol. 2013 Oct; 14(10):1034-5. PMID: 24048134; PMCID: PMC4197131.
      Citations: 1     Fields:    Translation:Animals
    38. Xu W, Carr T, Ramirez K, McGregor S, Sigvardsson M, Kee BL. E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment. Blood. 2013 Feb 28; 121(9):1534-42. PMID: 23297135; PMCID: PMC3587319.
      Citations: 41     Fields:    Translation:AnimalsCells
    39. Berthault C, Granato A, Dias S, Ramond C, Kee BL, Cumano A, Vieira P, Pereira de Sousa A. Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors. J Immunol. 2012 Oct 15; 189(8):3822-30. PMID: 22972921.
      Citations: 11     Fields:    Translation:AnimalsCells
    40. Ramirez K, Chandler KJ, Spaulding C, Zandi S, Sigvardsson M, Graves BJ, Kee BL. Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1. Immunity. 2012 Jun 29; 36(6):921-32. PMID: 22608498; PMCID: PMC3389314.
      Citations: 73     Fields:    Translation:AnimalsCells
    41. Mandal M, Powers SE, Maienschein-Cline M, Bartom ET, Hamel KM, Kee BL, Dinner AR, Clark MR. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011 Oct 30; 12(12):1212-20. PMID: 22037603; PMCID: PMC3233979.
      Citations: 114     Fields:    Translation:AnimalsCells
    42. Kee BL. A comprehensive transcriptional landscape of human hematopoiesis. Cell Stem Cell. 2011 Feb 04; 8(2):122-4. PMID: 21295265.
      Citations: 3     Fields:    
    43. Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K, Gómez-del Arco P. Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity. 2010 Nov 24; 33(5):685-98. PMID: 21093322; PMCID: PMC3072037.
      Citations: 60     Fields:    Translation:AnimalsCells
    44. Kee BL, de Pooter RF. E proteins and the regulation of early lymphocyte development. Immunol Rev. 2010 Nov; 238(1):93-109. PMID: 20969587; PMCID: PMC2992984.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    45. De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA, Cavé H. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010 Nov; 16(11):1321-7. PMID: 20972433; PMCID: PMC2974790.
      Citations: 83     Fields:    Translation:AnimalsCells
    46. Tran AH, Berger A, Wu GE, Kee BL, Paige CJ. Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes. J Neuroimmunol. 2011 Mar; 232(1-2):41-50. PMID: 20965576.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Verykokakis M, Boos MD, Bendelac A, Kee BL. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity. 2010 Aug 27; 33(2):203-15. PMID: 20674402; PMCID: PMC2933745.
      Citations: 79     Fields:    Translation:AnimalsCells
    48. Ramirez K, Kee BL. Multiple hats for natural killers. Curr Opin Immunol. 2010 Apr; 22(2):193-8. PMID: 20335012; PMCID: PMC3388277.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    49. Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One. 2010 Feb 19; 5(2):e9303. PMID: 20174563; PMCID: PMC2824806.
      Citations: 53     Fields:    Translation:AnimalsCells
    50. Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nat Immunol. 2009 Oct; 10(10):1110-7. PMID: 19734904; PMCID: PMC3057509.
      Citations: 67     Fields:    Translation:AnimalsCells
    51. Gao J, Graves S, Koch U, Liu S, Jankovic V, Buonamici S, El Andaloussi A, Nimer SD, Kee BL, Taichman R, Radtke F, Aifantis I. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell. 2009 Jun 05; 4(6):548-58. PMID: 19497283; PMCID: PMC2914688.
      Citations: 100     Fields:    Translation:AnimalsCells
    52. Kee BL, Dias S. A s-myly route toward lymphoid differentiation. Immunity. 2009 Apr 17; 30(4):474-6. PMID: 19371711.
      Citations:    Fields:    Translation:Cells
    53. Kee BL. E and ID proteins branch out. Nat Rev Immunol. 2009 Mar; 9(3):175-84. PMID: 19240756.
      Citations: 181     Fields:    Translation:HumansAnimalsCells
    54. Dias S, Xu W, McGregor S, Kee B. Transcriptional regulation of lymphocyte development. Curr Opin Genet Dev. 2008 Oct; 18(5):441-8. PMID: 18775782; PMCID: PMC2743889.
      Citations: 15     Fields:    Translation:Cells
    55. Dias S, Gurbuxani S, Sigvardsson M, Kee BL, Månsson R. E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity. 2008 Aug 15; 29(2):217-27. PMID: 18674933; PMCID: PMC2600583.
      Citations: 114     Fields:    Translation:AnimalsCells
    56. Bhalla S, Spaulding C, Brumbaugh RL, Zagort DE, Massari ME, Murre C, Kee BL. differential roles for the E2A activation domains in B lymphocytes and macrophages. J Immunol. 2008 Feb 01; 180(3):1694-703. PMID: 18209066.
      Citations: 18     Fields:    Translation:AnimalsCells
    57. Boos MD, Ramirez K, Kee BL. Extrinsic and intrinsic regulation of early natural killer cell development. Immunol Res. 2008; 40(3):193-207. PMID: 18266115.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    58. Molinero LL, Zhou P, Wang Y, Harlin H, Kee B, Abraham C, Alegre ML. Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells. Am J Transplant. 2008 Jan; 8(1):21-31. PMID: 18021281; PMCID: PMC2829624.
      Citations: 11     Fields:    Translation:AnimalsCells
    59. Spaulding C, Reschly EJ, Zagort DE, Yashiro-Ohtani Y, Beverly LJ, Capobianco A, Pear WS, Kee BL. Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 2007 Oct 01; 110(7):2650-8. PMID: 17585052.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    60. Nutt SL, Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity. 2007 Jun; 26(6):715-25. PMID: 17582344.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    61. Boos MD, Yokota Y, Eberl G, Kee BL. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med. 2007 May 14; 204(5):1119-30. PMID: 17452521; PMCID: PMC2118569.
      Citations: 195     Fields:    Translation:AnimalsCells
    62. Welner RS, Pelayo R, Garrett KP, Chen X, Perry SS, Sun XH, Kee BL, Kincade PW. Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors. Blood. 2007 Jun 01; 109(11):4825-931. PMID: 17317852; PMCID: PMC1885519.
      Citations: 34     Fields:    Translation:AnimalsCells
    63. Xu W, Kee BL. Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas. Blood. 2007 May 15; 109(10):4406-14. PMID: 17272506.
      Citations: 29     Fields:    Translation:HumansCells
    64. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I, Thompson B. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007 Jan; 13(1):70-7. PMID: 17173050.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    65. Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 2006 May 15; 107(10):4115-21. PMID: 16449526; PMCID: PMC1895288.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    66. Kee BL. Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors. J Immunol. 2005 Oct 01; 175(7):4518-27. PMID: 16177095.
      Citations: 14     Fields:    Translation:AnimalsCells
    67. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. PMID: 16172133.
      Citations: 14     Fields:    Translation:AnimalsCells
    68. Nick McElhinny SA, Havener JM, Garcia-Diaz M, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA, Juárez R. A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell. 2005 Aug 05; 19(3):357-66. PMID: 16061182.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    69. Osborne BA, Kee BL. Lymphoid development: it's not 'all Greek to us' any more. Nat Immunol. 2005 Feb; 6(2):119-23. PMID: 15662436.
      Citations:    Fields:    Translation:HumansAnimalsCells
    70. Kee BL. Helix-loop-helix proteins in lymphocyte lineage determination. Curr Top Microbiol Immunol. 2005; 290:15-27. PMID: 16480037.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    71. Seet CS, Brumbaugh RL, Kee BL. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med. 2004 Jun 21; 199(12):1689-700. PMID: 15210745; PMCID: PMC2212815.
      Citations: 61     Fields:    Translation:AnimalsCells
    72. Perkins EJ, Kee BL, Ramsden DA. Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition. Nucleic Acids Res. 2004; 32(6):1942-7. PMID: 15051812; PMCID: PMC390374.
      Citations: 18     Fields:    Translation:AnimalsCells
    73. Kee BL, Bain G, Murre C. IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors. EMBO J. 2002 Jan 15; 21(1-2):103-13. PMID: 11782430; PMCID: PMC125811.
      Citations: 22     Fields:    Translation:AnimalsCells
    74. Kee BL, Murre C. Transcription factor regulation of B lineage commitment. Curr Opin Immunol. 2001 Apr; 13(2):180-5. PMID: 11228411.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    75. Kee BL, Rivera RR, Murre C. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta. Nat Immunol. 2001 Mar; 2(3):242-7. PMID: 11224524.
      Citations: 61     Fields:    Translation:AnimalsCells
    76. Kee BL, Quong MW, Murre C. E2A proteins: essential regulators at multiple stages of B-cell development. Immunol Rev. 2000 Jun; 175:138-49. PMID: 10933599.
      Citations: 41     Fields:    Translation:AnimalsCells
    77. Kee BL, Murre C. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med. 1998 Aug 17; 188(4):699-713. PMID: 9705952; PMCID: PMC2213347.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    78. Kee BL, Paige CJ. In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors. Curr Biol. 1996 Sep 01; 6(9):1159-69. PMID: 8805368.
      Citations: 3     Fields:    Translation:AnimalsCells
    79. Kee BL, Arias J, Montminy MR. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. J Biol Chem. 1996 Feb 02; 271(5):2373-5. PMID: 8576192.
      Citations: 69     Fields:    Translation:HumansCells
    80. Marshall AJ, Kee BL, Paige CJ, Wu GE. Analysis of immunoglobulin gene rearrangement in fetal B-cell progenitors developing in vivo or in vitro. Ann N Y Acad Sci. 1995 Sep 29; 764:222-3. PMID: 7486527.
      Citations:    Fields:    Translation:AnimalsCells
    81. Kee BL, Paige CJ. In-vitro models of B-lineage commitment. Semin Immunol. 1995 Jun; 7(3):143-54. PMID: 7579201.
      Citations:    Fields:    Translation:HumansAnimalsCells
    82. Kee BL, Paige CJ. Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes. Int Rev Cytol. 1995; 157:129-79. PMID: 7706019.
      Citations: 6     Fields:    Translation:AnimalsCells
    83. Kee BL, Cumano A, Iscove NN, Paige CJ. Stromal cell independent growth of bipotent B cell--macrophage precursors from murine fetal liver. Int Immunol. 1994 Mar; 6(3):401-7. PMID: 7514441.
      Citations: 6     Fields:    Translation:AnimalsCells
    84. Cumano A, Kee BL, Ramsden DA, Marshall A, Paige CJ, Wu GE. Development of B lymphocytes from lymphoid committed and uncommitted progenitors. Immunol Rev. 1994 Feb; 137:5-33. PMID: 8034337.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    85. Kee BL, Paige CJ, Letarte M. Characterization of murine CD10, an endopeptidase expressed on bone marrow adherent cells. Int Immunol. 1992 Sep; 4(9):1041-7. PMID: 1390435.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    86. Kee BL, Dadi HK, Tran-Paterson R, Quackenbush EJ, Andrulis IL, Letarte M. CD10 and CD44 genes of leukemic cells and malignant cell lines show no evidence of transformation-related alterations. J Cell Physiol. 1991 Sep; 148(3):414-20. PMID: 1833412.
      Citations: 3     Fields:    Translation:HumansCells
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