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Sangram S. Sisodia

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
Phone+1 (773) 8349186
Email
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    Collapse Overview 
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    Alzheimer’s disease (AD), a prevalent, adult-onset, neurodegenerative disease, is clinically characterized by progressive impairments in cognition and memory. These clinical features are accompanied by characteristic histological changes in the brain, including neuronal loss, extracellular deposition of fibrillogenic Ab peptides in senile plaques and intracellular neurofibrillary tangles. The principal risk factors for AD are age and inheritance of mutant genes, or polymorphic alleles that predispose individuals to late-onset disease.

    Over the past 20 years, my laboratory has focused on examining the cellular and molecular biology of the b-amyloid precursor protein (APP), or presenilins (PS1 and PS2), molecules that are mutated in pedigrees with autosomal dominant, familial forms of Alzheimer's disease (FAD). The function(s) of APP in the central nervous system (CNS) are still not fully understood, but we have demonstrated that APP is subject to rapid anterograde axonal transport and subject to proteolytic processing at, or near, terminal fields. In collaboration with Robert Malinow at UCSD, we have also shown that synaptic activity modulates APP processing and Ab production, and that both axonal and dendritic release of these peptides alter spine dynamics and glutamatergic neurotransmission. Our current efforts are focused on clarifying the dynamics and regulation of APP trafficking and processing cultured neurons and hippocampal slices using recombinant lentiviral-driven APP-GFP chimeras and live cell imaging approaches. In order to assess the normal function of PS, we have used gene targeting strategies; PS1-deficient animals die in late embryogenesis due to defective Notch signaling that is in large part, the result of failed intramembranous, “g-secretase” processing of a membrane-bound Notch substrates. This “g-secretase” activity is also responsible for liberating Ab peptides from membrane-bound APP derivatives. We, and others, have provided genetic and biochemical evidence has revealed that PS associates with nicastrin (NCT), APH-1 and PEN-2 in high molecular weight complexes, and our current efforts are aimed at understanding the temporal assembly of these membrane proteins, the nature of subunit interactions and the enzymatic mechanism(s) by which the complex promotes “g-secretase” processing of Notch, APP and other type 1 membrane proteins.

    A significant effort of our laboratory has been to develop and characterize transgenic animals that express FAD-linked variants of PS1 and APP to clarify the underlying biochemical and pathophysiological alterations that cause AD. We have exploited these animals, as well as animals in which we have conditionally inactivated PS, to clarify issues relevant to axonal trafficking of membrane proteins, neurodegeneration, neuronal vulnerability, gene expression and APP/Ab metabolism. A significant effort in our laboratory is focused on understanding the cell non-autonomous effects of FAD-linked mutant PS1 expression on hippocampal neurogenesis. Our future studies will focus heavily on the mechanisms that are responsible for the observed effects using temporal and system-specific conditional gene inactivation approaches. Extending our demonstration that enriched environments and exercise modulates Ab metabolism and deposition in vivo, our ongoing efforts are focused on the role of polypeptides encoded by genes that are selectively regulated in these settings. Finally, we have been exploring the impact of the microbiome in modulation of amyloid deposition in mouse models of AD.

    In summary, my research program is designed to integrate genetic, neurobiologic, molecular and cellular information to clarify the normal biology of APP and PS and the mechanisms by which mutant genes cause AD. The value of animal models that recapitulate some features of the human disease have, and will be of enormous value for addressing issues relevant to the selective vulnerability of specific CNS systems, the pathophysiological sequelae and ultimately, will provide opportunities to explore mechanism-based therapeutic strategies.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17; 19(1):18. PMID: 38365827; PMCID: PMC10874048.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Saha P, Weigle IQ, Slimmon N, Poli PB, Patel P, Zhang X, Cao Y, Michalkiewicz J, Gomm A, Zhang C, Tanzi RE, Dylla N, Al-Hendy A, Sisodia SS. Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function. Sci Rep. 2024 01 21; 14(1):1827. PMID: 38246956; PMCID: PMC10800351.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Shaik SM, Cao Y, Gogola JV, Dodiya HB, Zhang X, Boutej H, Han W, Kriz J, Sisodia SS. Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome. Mol Neurodegener. 2023 Dec 16; 18(1):95. PMID: 38104136; PMCID: PMC10725591.
      Citations:    Fields:    Translation:AnimalsCells
    4. Sisodia S, Wong PC. Donald Lowell Price, M.D. In memoriam. Mol Neurodegener. 2023 Nov 20; 18(1):88. PMID: 37981690; PMCID: PMC10658964.
      Citations:    Fields:    
    5. Chandra S, Di Meco A, Dodiya HB, Popovic J, Cuddy LK, Weigle IQ, Zhang X, Sadleir K, Sisodia SS, Vassar R. The gut microbiome regulates astrocyte reaction to Aß amyloidosis through microglial dependent and independent mechanisms. Mol Neurodegener. 2023 Jul 06; 18(1):45. PMID: 37415149; PMCID: PMC10324210.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Chandra S, Sisodia SS, Vassar RJ. The gut microbiome in Alzheimer's disease: what we know and what remains to be explored. Mol Neurodegener. 2023 02 01; 18(1):9. PMID: 36721148; PMCID: PMC9889249.
      Citations: 24     Fields:    Translation:HumansAnimals
    7. Seo DO, O'Donnell D, Jain N, Ulrich JD, Herz J, Li Y, Lemieux M, Cheng J, Hu H, Serrano JR, Bao X, Franke E, Karlsson M, Meier M, Deng S, Desai C, Dodiya H, Lelwala-Guruge J, Handley SA, Kipnis J, Sisodia SS, Gordon JI, Holtzman DM. ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science. 2023 01 13; 379(6628):eadd1236. PMID: 36634180; PMCID: PMC9901565.
      Citations: 37     Fields:    Translation:HumansAnimals
    8. Jana A, Wang X, Leasure JW, Magana L, Wang L, Kim YM, Dodiya H, Toth PT, Sisodia SS, Rehman J. Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease. Sci Rep. 2022 10 01; 12(1):16488. PMID: 36182964; PMCID: PMC9526723.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behav Immun Health. 2022 Jul; 22:100462. PMID: 36118272; PMCID: PMC9475126.
      Citations: 10     
    10. Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, Zhang CM, Liang Y, Srinath A, Zhang X, Xia J, Olszewski M, Zhang X, Schipma MJ, Chang EB, Tanzi RE, Gilbert JA, Sisodia SS. Gut microbiota-driven brain Aß amyloidosis in mice requires microglia. J Exp Med. 2022 01 03; 219(1). PMID: 34854884; PMCID: PMC8647415.
      Citations: 23     Fields:    Translation:AnimalsCells
    11. Kedia S, Mandal K, Netrakanti PR, Jose M, Sisodia SS, Nair D. Nanoscale organization of Nicastrin, the substrate receptor of the ?-secretase complex, as independent molecular domains. Mol Brain. 2021 10 13; 14(1):158. PMID: 34645511; PMCID: PMC8515736.
      Citations: 3     Fields:    Translation:Cells
    12. Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, Xiang J, Yuan X, Sun B, Sisodia SS, Jiang YH, Cao X, Jing N, Lin A. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience. 2021 Sep 24; 24(9):102942. PMID: 34430820; PMCID: PMC8369003.
      Citations: 13     
    13. Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aß domain promotes Aß production in vitro and deposition in vivo. J Exp Med. 2021 06 07; 218(6). PMID: 33822840; PMCID: PMC8034382.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Kedia S, Ramakrishna P, Netrakanti PR, Singh N, Sisodia SS, Jose M, Kumar S, Mahadevan A, Ramanan N, Nadkarni S, Nair D. Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease. iScience. 2021 Jan 22; 24(1):101924. PMID: 33409475; PMCID: PMC7773964.
      Citations: 10     
    15. Veetil AT, Zou J, Henderson KW, Jani MS, Shaik SM, Sisodia SS, Hale ME, Krishnan Y. DNA-based fluorescent probes of NOS2 activity in live brains. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):14694-14702. PMID: 32554491; PMCID: PMC7334527.
      Citations: 13     Fields:    Translation:AnimalsCells
    16. Cable J, Holtzman DM, Hyman BT, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE, Tansey MG. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Ann N Y Acad Sci. 2020 09; 1475(1):3-14. PMID: 32472577; PMCID: PMC9621603.
      Citations: 4     Fields:    Translation:HumansCells
    17. Dodiya HB, Frith M, Sidebottom A, Cao Y, Koval J, Chang E, Sisodia SS. Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice. Sci Rep. 2020 05 18; 10(1):8183. PMID: 32424118; PMCID: PMC7235236.
      Citations: 35     Fields:    Translation:Animals
    18. Zhang X, Zhang C, Prokopenko D, Liang Y, Han W, Tanzi RE, Sisodia SS. Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. Hum Mol Genet. 2020 04 15; 29(6):955-966. PMID: 31995180.
      Citations: 3     Fields:    Translation:HumansCells
    19. Ortega-Martinez S, Palla N, Zhang X, Lipman E, Sisodia SS. Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion. J Neurosci. 2019 08 21; 39(34):6766-6780. PMID: 31217332; PMCID: PMC6703877.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Dodiya HB, Kuntz T, Shaik SM, Baufeld C, Leibowitz J, Zhang X, Gottel N, Zhang X, Butovsky O, Gilbert JA, Sisodia SS. Sex-specific effects of microbiome perturbations on cerebral Aß amyloidosis and microglia phenotypes. J Exp Med. 2019 07 01; 216(7):1542-1560. PMID: 31097468; PMCID: PMC6605759.
      Citations: 105     Fields:    Translation:AnimalsCells
    21. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. PMID: 28874832; PMCID: PMC5585265.
      Citations: 131     Fields:    Translation:Animals
    22. Veeraraghavalu K, Kohsaka S, Sisodia SS, Füger P, Hefendehl JK, Wendeln AC, Schlosser C, Obermüller U, Wegenast-Braun BM, Neher JJ, Martus P, Thunemann M, Feil R, Skodras A, Jucker M. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci. 2017 Oct; 20(10):1371-1376. PMID: 28846081.
      Citations: 157     Fields:    Translation:AnimalsCells
    23. Veetil AT, Chakraborty K, Xiao K, Minter MR, Sisodia SS, Krishnan Y. Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules. Nat Nanotechnol. 2017 12; 12(12):1183-1189. PMID: 28825714.
      Citations: 28     Fields:    Translation:AnimalsCells
    24. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. PMID: 27443609; PMCID: PMC4956742.
      Citations: 271     Fields:    Translation:Animals
    25. Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity. J Biol Chem. 2016 Mar 25; 291(13):6748-53. PMID: 26887941; PMCID: PMC4807262.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Zhang X, Yu CJ, Sisodia SS. The topology of pen-2, a ?-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain. Mol Neurodegener. 2015 Aug 22; 10:39. PMID: 26296997; PMCID: PMC4546279.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    27. Butkinaree C, Canuel M, Essalmani R, Benjannet S, Asselin MC, Roubtsova A, Marcinkiewicz J, Chamberland A, Guillemot J, Sisodia SS, Prat A, Seidah NG, Poirier S, Hamelin J, Mayer G, Jacob Y. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. J Biol Chem. 2015 Jul 24; 290(30):18609-20. PMID: 26085104; PMCID: PMC4513119.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    28. Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of ?-secretase. J Biol Chem. 2014 Dec 12; 289(50):34851-61. PMID: 25352592; PMCID: PMC4263884.
      Citations: 4     Fields:    Translation:HumansCells
    29. Zhang X, Sisodia SS. Acne inversa caused by missense mutations in NCSTN is not fully compatible with impairments in Notch signaling. J Invest Dermatol. 2015 Feb; 135(2):618-620. PMID: 25211177.
      Citations: 9     Fields:    Translation:HumansCells
    30. DeBoer SR, Dolios G, Wang R, Sisodia SS. Differential release of ß-amyloid from dendrite- versus axon-targeted APP. J Neurosci. 2014 Sep 10; 34(37):12313-27. PMID: 25209273; PMCID: PMC4160770.
      Citations: 22     Fields:    Translation:AnimalsCells
    31. Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1a in activation of ?-secretase and notch signaling in breast cancer. Cell Rep. 2014 Aug 21; 8(4):1077-92. PMID: 25131208; PMCID: PMC4346175.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    32. Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons. J Neurosci. 2014 Mar 05; 34(10):3668-73. PMID: 24599465; PMCID: PMC3942582.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    33. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146; PMCID: PMC3929337.
      Citations: 28     Fields:    Translation:HumansCells
    34. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors. Mol Neurodegener. 2013 Oct 20; 8:41. PMID: 24138759; PMCID: PMC3853710.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    35. Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear ß-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24; 340(6135):924-f. PMID: 23704555.
      Citations: 82     Fields:    Translation:Animals
    36. Veeraraghavalu K, Sisodia SS. Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9148-53. PMID: 23674689; PMCID: PMC3670351.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18; 51(37):7209-11. PMID: 22931393; PMCID: PMC3470910.
      Citations: 50     Fields:    Translation:HumansCells
    38. Zhang X, Garbett K, Veeraraghavalu K, Wilburn B, Gilmore R, Mirnics K, Sisodia SS. A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2. J Neurosci. 2012 Jun 20; 32(25):8633-48. PMID: 22723704; PMCID: PMC3467018.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    39. Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of ?-secretase using synthetic antibodies. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8534-9. PMID: 22586122; PMCID: PMC3365189.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    40. Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med. 2012 May; 2(5):a006270. PMID: 22553493; PMCID: PMC3331683.
      Citations: 468     Fields:    Translation:HumansCells
    41. Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased expression of PS1 is sufficient to elevate the level and activity of ?-secretase in vivo. PLoS One. 2011; 6(11):e28179. PMID: 22140537; PMCID: PMC3226664.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    42. Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res. 2012 Apr; 217(3-4):353-64. PMID: 21960299; PMCID: PMC3670699.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    43. Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci. 2011 Sep 27; 14(10):1227-35. PMID: 21952260.
      Citations: 348     Fields:    Translation:HumansAnimalsCells
    44. Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. J Biol Chem. 2011 Jun 17; 286(24):21440-9. PMID: 21454611; PMCID: PMC3122203.
      Citations: 20     Fields:    Translation:HumansCells
    45. Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21435-40. PMID: 21115843; PMCID: PMC3003001.
      Citations: 93     Fields:    Translation:HumansCells
    46. Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17; 30(46):15677-85. PMID: 21084623; PMCID: PMC3104400.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    47. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. PMID: 20826309; PMCID: PMC2947312.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    48. Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci. 2010 May 19; 30(20):6903-15. PMID: 20484632; PMCID: PMC2879010.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    49. Veeraraghavalu K, Choi SH, Sisodia SS. Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis. Neurodegener Dis. 2010; 7(1-3):46-9. PMID: 20160458.
      Citations: 3     Fields:    Translation:HumansAnimals
    50. Wei W, Nguyen LN, Kessels HW, Hagiwara H, Sisodia S, Malinow R. Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci. 2010 Feb; 13(2):190-6. PMID: 20037574; PMCID: PMC3310198.
      Citations: 190     Fields:    Translation:AnimalsCells
    51. Choi SH, Li Y, Parada LF, Sisodia SS. Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener. 2009 Dec 21; 4:52. PMID: 20025751; PMCID: PMC2806355.
      Citations: 51     Fields:    
    52. Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew Chem Int Ed Engl. 2009; 48(8):1487-9. PMID: 19152390; PMCID: PMC2675571.
      Citations: 11     Fields:    Translation:Animals
    53. Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009 Jan 30; 284(5):2967-2977. PMID: 19036728; PMCID: PMC2631949.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    54. Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, van Leuven F, Walter J, Müller U, Lütjohann D. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci. 2008 Nov 12; 28(46):12097-106. PMID: 19005074; PMCID: PMC6671640.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    55. Norstrom EM, Garbett K, Choi SH, Zhang X, Ebert P, Sisodia SS, Mirnics K. Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. Mol Neurodegener. 2008 Oct 03; 3:14. PMID: 18834536; PMCID: PMC2569036.
      Citations: 13     Fields:    
    56. Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron. 2008 Aug 28; 59(4):568-80. PMID: 18760694; PMCID: PMC3489017.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    57. Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Saido TC, Li YM, Sisodia SS, Thinakaran G, Parent AT. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem. 2008 Jul 11; 283(28):19489-98. PMID: 18456655; PMCID: PMC2443668.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    58. Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW. Biogenesis of gamma-secretase early in the secretory pathway. J Cell Biol. 2007 Dec 03; 179(5):951-63. PMID: 18056412; PMCID: PMC2099203.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    59. Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T. Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease. J Neurosci. 2007 Nov 28; 27(48):13092-7. PMID: 18045903; PMCID: PMC6673391.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    60. Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP. Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis. 2008 Feb; 29(2):316-26. PMID: 17980611; PMCID: PMC2254142.
      Citations: 40     Fields:    Translation:AnimalsCells
    61. Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31; 282(35):25453-63. PMID: 17613531.
      Citations: 66     Fields:    Translation:HumansCells
    62. Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci. 2007 Jun 27; 27(26):7006-10. PMID: 17596449; PMCID: PMC6672232.
      Citations: 66     Fields:    Translation:AnimalsCells
    63. Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci. 2007 Jun 27; 27(26):7011-20. PMID: 17596450; PMCID: PMC2801050.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    64. Peng CY, Yajima H, Burns CE, Zon LI, Sisodia SS, Pfaff SL, Sharma K. Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron. 2007 Mar 15; 53(6):813-27. PMID: 17359917; PMCID: PMC2768132.
      Citations: 75     Fields:    Translation:AnimalsCells
    65. Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 2006 Dec 07; 52(5):831-43. PMID: 17145504; PMCID: PMC1850952.
      Citations: 559     Fields:    Translation:AnimalsCells
    66. Thinakaran G, Sisodia SS. Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci. 2006 Nov; 9(11):1354-5. PMID: 17066063.
      Citations: 15     Fields:    Translation:HumansCells
    67. Kim SH, Tang YP, Sisodia SS. Abeta star: a light onto synaptic dysfunction? Nat Med. 2006 Jul; 12(7):760-1; discussion 761. PMID: 16829934.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    68. Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1936-40. PMID: 16449385; PMCID: PMC1413666.
      Citations: 56     Fields:    Translation:AnimalsCells
    69. Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1941-6. PMID: 16449386; PMCID: PMC1413665.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    70. Lazarov O, Peterson LD, Peterson DA, Sisodia SS. Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex. J Neurosci. 2006 Jan 11; 26(2):429-34. PMID: 16407539; PMCID: PMC6674394.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    71. Unger T, Korade Z, Lazarov O, Terrano D, Schor NF, Sisodia SS, Mirnics K. Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice. Am J Geriatr Psychiatry. 2005 Dec; 13(12):1041-51. PMID: 16319296.
      Citations: 7     Fields:    Translation:HumansAnimals
    72. Perez SE, Lazarov O, Koprich JB, Chen EY, Rodriguez-Menendez V, Lipton JW, Sisodia SS, Mufson EJ. Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice. J Neurosci. 2005 Nov 02; 25(44):10220-9. PMID: 16267229; PMCID: PMC6725777.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    73. Unger T, Korade Z, Lazarov O, Terrano D, Sisodia SS, Mirnics K. True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice. Methods. 2005 Nov; 37(3):261-73. PMID: 16308155.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    74. Kim SH, Sisodia SS. Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. J Biol Chem. 2005 Dec 23; 280(51):41953-66. PMID: 16234243.
      Citations: 43     Fields:    Translation:HumansCells
    75. Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF. P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis. 2005 Dec; 20(3):969-85. PMID: 16006137.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    76. Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Sisodia SS, Thinakaran G, Parent AT. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem. 2005 Jul 08; 280(27):25892-900. PMID: 15886206; PMCID: PMC1201532.
      Citations: 116     Fields:    Translation:AnimalsCells
    77. Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 2005 Mar 11; 120(5):701-13. PMID: 15766532.
      Citations: 303     Fields:    Translation:AnimalsCells
    78. Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci. 2005 Mar 02; 25(9):2386-95. PMID: 15745965; PMCID: PMC6726084.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    79. Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS, Mirnics K. Presenilin-1-dependent transcriptome changes. J Neurosci. 2005 Feb 09; 25(6):1571-8. PMID: 15703411; PMCID: PMC6726008.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    80. Barnes NY, Taniguchi Y, Thinakaran G, Sisodia SS, Parent AT. Presenilin attenuates receptor-mediated signaling and synaptic function. J Neurosci. 2005 Feb 09; 25(6):1540-9. PMID: 15703408; PMCID: PMC6725985.
      Citations: 34     Fields:    Translation:AnimalsCells
    81. Kim SH, Sisodia SS. A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. J Biol Chem. 2005 Jan 21; 280(3):1992-2001. PMID: 15537629.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    82. Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. J Biol Chem. 2004 Nov 19; 279(47):48615-9. PMID: 15456788.
      Citations: 25     Fields:    Translation:HumansCells
    83. Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Herms J, Müller U. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 2004 Oct 13; 23(20):4106-15. PMID: 15385965; PMCID: PMC524337.
      Citations: 164     Fields:    Translation:HumansAnimals
    84. Louvi A, Sisodia SS, Grove EA. Presenilin 1 in migration and morphogenesis in the central nervous system. Development. 2004 Jul; 131(13):3093-105. PMID: 15163631.
      Citations: 16     Fields:    Translation:AnimalsCells
    85. Mirnics ZK, Mirnics K, Terrano D, Lewis DA, Sisodia SS, Schor NF. DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes. Mol Psychiatry. 2003 Oct; 8(10):863-78. PMID: 14515137.
      Citations: 10     Fields:    Translation:AnimalsCells
    86. Taniguchi Y, Kim SH, Sisodia SS. Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC). J Biol Chem. 2003 Aug 15; 278(33):30425-8. PMID: 12840034.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    87. Kim SH, Ikeuchi T, Yu C, Sisodia SS. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates. J Biol Chem. 2003 Sep 05; 278(36):33992-4002. PMID: 12821663.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    88. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 2003 Mar 27; 37(6):925-37. PMID: 12670422.
      Citations: 743     Fields:    Translation:HumansAnimalsCells
    89. Ikeuchi T, Sisodia SS. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem. 2003 Mar 07; 278(10):7751-4. PMID: 12551931.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    90. Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase". J Biol Chem. 2003 Feb 28; 278(9):7010-8. PMID: 12493731.
      Citations: 20     Fields:    Translation:AnimalsCells
    91. Lazarov O, Lee M, Peterson DA, Sisodia SS, Lazarov O, Lee M, Peterson DA, Sisodia SS. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci. 2002 Nov 15; 22(22):9785-93. PMID: 12427834; PMCID: PMC6757836.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    92. Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H, Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003 Jan 31; 278(5):3446-54. PMID: 12435726.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    93. Sisodia SS, St George-Hyslop PH, Sisodia SS, St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci. 2002 Apr; 3(4):281-90. PMID: 11967558.
      Citations: 191     Fields:    Translation:HumansAnimals
    94. Borchelt DR, Lee MK, Gonzales V, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice. Neurobiol Aging. 2002 Mar-Apr; 23(2):171-7. PMID: 11804700.
      Citations: 4     Fields:    Translation:HumansAnimals
    95. Sisodia SS, Sisodia SS. Biomedicine. A cargo receptor mystery APParently solved? Science. 2002 Feb 01; 295(5556):805-7. PMID: 11823626.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    96. Kalback W, Watson MD, Kokjohn TA, Kuo YM, Weiss N, Luehrs DC, Lopez J, Brune D, Sisodia SS, Staufenbiel M, Emmerling M, Roher AE. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry. 2002 Jan 22; 41(3):922-8. PMID: 11790115.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    97. Mirinics ZK, Calafat J, Udby L, Lovelock J, Kjeldsen L, Rothermund K, Sisodia SS, Borregaard N, Corey SJ. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Blood Cells Mol Dis. 2002 Jan-Feb; 28(1):28-38. PMID: 11987239.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    98. Ikeuchi T, Sisodia SS. Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities. Neuromolecular Med. 2002; 1(1):43-54. PMID: 12025815.
      Citations: 3     Fields:    Translation:AnimalsCells
    99. Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. 2001 Dec 06; 32(5):911-26. PMID: 11738035.
      Citations: 142     Fields:    Translation:AnimalsCells
    100. Kim SH, Creemers JW, Chu S, Thinakaran G, Sisodia SS. Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides. J Biol Chem. 2002 Jan 18; 277(3):1872-7. PMID: 11709554.
      Citations: 25     Fields:    Translation:HumansCells
    101. Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never more enigmatic. Trends Neurosci. 2001 Nov; 24(11 Suppl):S2-6. PMID: 11881741.
      Citations: 13     Fields:    Translation:Humans
    102. Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS, Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. J Biol Chem. 2001 Nov 23; 276(47):43756-60. PMID: 11583985.
      Citations: 66     Fields:    Translation:Cells
    103. Kim SH, Leem JY, Lah JJ, Slunt HH, Levey AI, Thinakaran G, Sisodia SS. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. J Biol Chem. 2001 Nov 16; 276(46):43343-50. PMID: 11564743.
      Citations: 28     Fields:    Translation:AnimalsCells
    104. Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Seidah NG, Benjannet S, Chrétien M. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J Biol Chem. 2001 Apr 06; 276(14):10879-87. PMID: 11152688.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    105. Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2000 Dec; 2(12):863-70. PMID: 11146649.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    106. Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, Sklar J, Nye J, Sisodia SS. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J Mol Neurosci. 2000 Dec; 15(3):189-204. PMID: 11303783.
      Citations: 13     Fields:    Translation:AnimalsCells
    107. Takahashi M, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH, Doré S. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 2000 Nov; 28(2):461-73. PMID: 11144356.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    108. Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Rülicke T, Müller U. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J Neurosci. 2000 Nov 01; 20(21):7951-63. PMID: 11050115; PMCID: PMC6772747.
      Citations: 194     Fields:    Translation:AnimalsCells
    109. Sisodia SS. Neuroscience. An accomplice for gamma-secretase brought into focus. Science. 2000 Sep 29; 289(5488):2296-7. PMID: 11041797.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    110. Kim SH, Lah JJ, Thinakaran G, Levey A, Sisodia SS. Subcellular localization of presenilins: association with a unique membrane pool in cultured cells. Neurobiol Dis. 2000 Apr; 7(2):99-117. PMID: 10783294.
      Citations: 16     Fields:    Translation:AnimalsCells
    111. Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiol Dis. 2000 Feb; 7(1):54-63. PMID: 10671322.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    112. Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, Lynn DG, Meredith SC, Sisodia SS, Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, Lynn DG, Meredith SC, Sisodia SS. Familial British dementia: expression and metabolism of BRI. Ann N Y Acad Sci. 2000; 920:93-9. PMID: 11193182.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    113. Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR, Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW, Sisodia SS, Borchelt DR. The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci. 2000; 920:179-91. PMID: 11193148.
      Citations: 19     Fields:    Translation:HumansAnimals
    114. Berechid BE, Thinakaran G, Wong PC, Sisodia SS, Nye JS. Lack of requirement for presenilin1 in Notch1 signaling. Curr Biol. 1999 Dec 16-30; 9(24):1493-6. PMID: 10607593.
      Citations: 11     Fields:    Translation:AnimalsCells
    115. Sisodia SS. Alzheimer's disease: perspectives for the new millennium. J Clin Invest. 1999 Nov; 104(9):1169-70. PMID: 10545514; PMCID: PMC409829.
      Citations: 30     Fields:    Translation:Humans
    116. Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Lynn DG, Thinakaran G, Meredith SC, Sisodia SS. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat Neurosci. 1999 Nov; 2(11):984-8. PMID: 10526337.
      Citations: 47     Fields:    Translation:AnimalsCells
    117. Li XF, Thinakaran G, Sisodia SS, Yu FS. Amyloid precursor-like protein 2 promotes cell migration toward fibronectin and collagen IV. J Biol Chem. 1999 Sep 17; 274(38):27249-56. PMID: 10480944.
      Citations: 20     Fields:    Translation:AnimalsCells
    118. Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat Neurosci. 1999 Aug; 2(8):695-7. PMID: 10412057.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    119. Sisodia SS, Kim SH, Thinakaran G. Function and dysfunction of the presenilins. Am J Hum Genet. 1999 Jul; 65(1):7-12. PMID: 10364510; PMCID: PMC1378068.
      Citations: 19     Fields:    Translation:HumansAnimals
    120. Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci. 1999 Jun 01; 19(11):4229-37. PMID: 10341227; PMCID: PMC6782616.
      Citations: 62     Fields:    Translation:AnimalsCells
    121. Parent A, Linden DJ, Sisodia SS, Borchelt DR. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol Dis. 1999 Feb; 6(1):56-62. PMID: 10078973.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    122. Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):742-7. PMID: 9892704; PMCID: PMC15207.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    123. Buxbaum JD, Thinakaran G, Koliatsos V, O'Callahan J, Slunt HH, Price DL, Sisodia SS. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J Neurosci. 1998 Dec 01; 18(23):9629-37. PMID: 9822724; PMCID: PMC6793291.
      Citations: 111     Fields:    Translation:AnimalsCells
    124. Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: the human illness and transgenic models. Science. 1998 Nov 06; 282(5391):1079-83. PMID: 9804539.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    125. Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 1998 Nov; 21(5):1213-21. PMID: 9856475.
      Citations: 92     Fields:    Translation:AnimalsCells
    126. Sisodia SS, Gallagher M. A role for the beta-amyloid precursor protein in memory? Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12074-6. PMID: 9770440; PMCID: PMC33903.
      Citations: 8     Fields:    Translation:HumansAnimals
    127. Sisodia SS. Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial? Cell. 1998 Oct 02; 95(1):1-4. PMID: 9778239.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    128. Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathol. 1998 Oct; 8(4):735-57. PMID: 9804381; PMCID: PMC8098285.
      Citations: 6     Fields:    Translation:HumansAnimals
    129. Tam A, Nouvet FJ, Fujimura-Kamada K, Slunt H, Sisodia SS, Michaelis S. Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. J Cell Biol. 1998 Aug 10; 142(3):635-49. PMID: 9700155; PMCID: PMC2148179.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    130. Price DL, Sisodia SS, Borchelt DR. Alzheimer disease--when and why? Nat Genet. 1998 Aug; 19(4):314-6. PMID: 9697686.
      Citations: 12     Fields:    Translation:Humans
    131. Borchelt DR, Wong PC, Becher MW, Pardo CA, Lee MK, Xu ZS, Thinakaran G, Jenkins NA, Copeland NG, Sisodia SS, Cleveland DW, Price DL, Hoffman PN. Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiol Dis. 1998 Jul; 5(1):27-35. PMID: 9702785.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    132. Confaloni AM, Thinakaran G, Sisodia SS, Moya KL, Lyckman AW. Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. J Biol Chem. 1998 May 01; 273(18):11100-6. PMID: 9556595.
      Citations: 30     Fields:    Translation:AnimalsCells
    133. Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med. 1998 Apr; 4(4):447-51. PMID: 9546791.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    134. Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol Dis. 1998 Apr; 4(6):438-53. PMID: 9666482.
      Citations: 43     Fields:    Translation:AnimalsCells
    135. Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 1998 Mar; 20(3):603-9. PMID: 9539132.
      Citations: 38     Fields:    Translation:HumansAnimals
    136. Guo J, Thinakaran G, Guo Y, Sisodia SS, Yu FX. A role for amyloid precursor-like protein 2 in corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 1998 Feb; 39(2):292-300. PMID: 9477985.
      Citations: 20     Fields:    Translation:AnimalsCells
    137. Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci. 1998; 21:479-505. PMID: 9530504.
      Citations: 172     Fields:    Translation:HumansAnimals
    138. Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Adv Exp Med Biol. 1998; 446:145-59. PMID: 10079842.
      Citations: 2     Fields:    Translation:HumansAnimals
    139. Price DL, Tanzi RE, Borchelt DR, Sisodia SS. Alzheimer's disease: genetic studies and transgenic models. Annu Rev Genet. 1998; 32:461-93. PMID: 9928488.
      Citations: 118     Fields:    Translation:HumansAnimals
    140. Bergin A, Kim G, Price DL, Sisodia SS, Lee MK, Rabin BA. Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron. Gene. 1997 Dec 19; 204(1-2):47-53. PMID: 9434164.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    141. Thinakaran G, Harris CL, Ratovitski T, Davenport F, Slunt HH, Price DL, Borchelt DR, Sisodia SS. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J Biol Chem. 1997 Nov 07; 272(45):28415-22. PMID: 9353300.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    142. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997 Nov-Dec; 18(6):661-9. PMID: 9461064.
      Citations: 129     Fields:    Translation:Animals
    143. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 1997 Oct; 19(4):939-45. PMID: 9354339.
      Citations: 370     Fields:    Translation:HumansAnimals
    144. Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR. Endoproteolytic processing and stabilization of wild-type and mutant presenilin. J Biol Chem. 1997 Sep 26; 272(39):24536-41. PMID: 9305918.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    145. Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Rev Neurol (Paris). 1997 Sep; 153(8-9):484-95. PMID: 9683997.
      Citations: 3     Fields:    Translation:HumansAnimals
    146. Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Mol Genet. 1997 Sep; 6(9):1535-41. PMID: 9285791.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    147. Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat Med. 1997 Jul; 3(7):756-60. PMID: 9212102.
      Citations: 52     Fields:    Translation:HumansAnimals
    148. Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature. 1997 May 15; 387(6630):288-92. PMID: 9153393.
      Citations: 185     Fields:    Translation:Animals
    149. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5090-4. PMID: 9144195; PMCID: PMC24636.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    150. Hendriks L, Thinakaran G, Harris CL, De Jonghe C, Martin JJ, Sisodia SS, Van Broeckhoven C. Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls. Neuroreport. 1997 May 06; 8(7):1717-21. PMID: 9189920.
      Citations: 4     Fields:    Translation:Humans
    151. Li HL, Roch JM, Sundsmo M, Otero D, Sisodia S, Thomas R, Saitoh T. Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease. J Neurobiol. 1997 May; 32(5):469-80. PMID: 9110259.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    152. Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3748-52. PMID: 9108049; PMCID: PMC20512.
      Citations: 99     Fields:    Translation:HumansCells
    153. Zhao B, Chrest FJ, Horton WE, Sisodia SS, Kusiak JW. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. J Neurosci Res. 1997 Feb 01; 47(3):253-63. PMID: 9039647.
      Citations: 17     Fields:    Translation:AnimalsCells
    154. Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 1997 Feb; 18(2):327-38. PMID: 9052802.
      Citations: 461     Fields:    Translation:HumansAnimalsCells
    155. Walter J, Capell A, Hung AY, Langen H, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C, Schnölzer M. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. J Biol Chem. 1997 Jan 17; 272(3):1896-903. PMID: 8999878.
      Citations: 21     Fields:    Translation:HumansCells
    156. Marquez-Sterling NR, Lo AC, Sisodia SS, Koo EH. Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J Neurosci. 1997 Jan 01; 17(1):140-51. PMID: 8987743; PMCID: PMC6793693.
      Citations: 43     Fields:    Translation:AnimalsCells
    157. Wang R, Sweeney D, Gandy SE, Sisodia SS. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem. 1996 Dec 13; 271(50):31894-902. PMID: 8943233.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    158. Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14940-4. PMID: 8962160; PMCID: PMC26241.
      Citations: 75     Fields:    Translation:HumansAnimals
    159. Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, Price DL. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal. 1996 Dec; 13(6):159-63. PMID: 9117892.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    160. Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J Neurosci. 1996 Dec 01; 16(23):7513-25. PMID: 8922407; PMCID: PMC6579112.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    161. Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 1996 Nov; 17(5):1005-13. PMID: 8938131.
      Citations: 446     Fields:    Translation:HumansAnimalsCells
    162. Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 1996 Nov; 17(5):1023-30. PMID: 8938133.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    163. Lee MK, Borchelt DR, Wong PC, Sisodia SS, Price DL. Transgenic models of neurodegenerative diseases. Curr Opin Neurobiol. 1996 Oct; 6(5):651-60. PMID: 8937830.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    164. Crain BJ, Hu W, Sze CI, Slunt HH, Koo EH, Price DL, Thinakaran G, Sisodia SS. Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain. Am J Pathol. 1996 Oct; 149(4):1087-95. PMID: 8863657; PMCID: PMC1865173.
      Citations: 6     Fields:    Translation:Humans
    165. Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL. Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology. 1996 Oct; 47(4 Suppl 2):S54-61; discussion S61-2. PMID: 8858052.
      Citations: 14     Fields:    Translation:Animals
    166. Price DL, Becher MW, Wong PC, Borchelt DR, Lee MK, Sisodia SS. Inherited neurodegenerative diseases and transgenic models. Brain Pathol. 1996 Oct; 6(4):467-80. PMID: 8944317.
      Citations:    Fields:    Translation:HumansAnimalsCells
    167. Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM. cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Hum Mol Genet. 1996 Oct; 5(10):1589-98. PMID: 8894693.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    168. Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol. 1996 Sep; 149(3):1063-71. PMID: 8780408; PMCID: PMC1865137.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    169. Borchelt DR, Sisodia SS. Loss of functional prion protein: a role in prion disorders? Chem Biol. 1996 Aug; 3(8):619-21. PMID: 8807894.
      Citations: 6     Fields:    Translation:HumansAnimals
    170. Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 1996 Jul; 17(1):181-90. PMID: 8755489.
      Citations: 299     Fields:    Translation:HumansAnimalsCells
    171. Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J Biol Chem. 1996 Apr 19; 271(16):9390-7. PMID: 8621605.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    172. Sisodia SS, Thinakaran G, Slunt HH, Kitt CA, Von Koch CS, Reed RR, Zheng H, Price DL. Studies on the metabolism and biological function of APLP2. Ann N Y Acad Sci. 1996 Jan 17; 777:77-81. PMID: 8624130.
      Citations: 4     Fields:    Translation:AnimalsCells
    173. Zheng H, Jiang M, Trumbauer ME, Hopkins R, Sirinathsinghji DJ, Stevens KA, Conner MW, Slunt HH, Sisodia SS, Chen HY, Van der Ploeg LH. Mice deficient for the amyloid precursor protein gene. Ann N Y Acad Sci. 1996 Jan 17; 777:421-6. PMID: 8624124.
      Citations: 21     Fields:    Translation:Animals
    174. Price DL, Koliatsos VE, Wong PC, Pardo CA, Borchelt DR, Lee MK, Cleveland DW, Griffin JW, Hoffman PN, Cork LC, Sisodia SS. Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Found Symp. 1996; 196:3-13; discussion 13-7. PMID: 8866125.
      Citations: 1     Fields:    Translation:HumansAnimals
    175. Price DL, Borchelt DR, Wong PC, Pardo CA, Thinakaran G, Lee MK, Cleveland DW, Sisodia SS. Neurodegenerative diseases and model systems. Cold Spring Harb Symp Quant Biol. 1996; 61:725-38. PMID: 9246498.
      Citations: 1     Fields:    Translation:HumansAnimals
    176. von Koch CS, Lahiri DK, Mammen AL, Copeland NG, Gilbert DJ, Jenkins NA, Sisodia S. The mouse APLP2 gene. Chromosomal localization and promoter characterization. J Biol Chem. 1995 Oct 27; 270(43):25475-80. PMID: 7592716.
      Citations: 3     Fields:    Translation:AnimalsCells
    177. Reeves RH, Irving NG, Moran TH, Wohn A, Kitt C, Sisodia SS, Schmidt C, Bronson RT, Davisson MT. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet. 1995 Oct; 11(2):177-84. PMID: 7550346.
      Citations: 364     Fields:    Translation:HumansAnimalsCells
    178. Price DL, Sisodia SS, Gandy SE. Amyloid beta amyloidosis in Alzheimer's disease. Curr Opin Neurol. 1995 Aug; 8(4):268-74. PMID: 7582041.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    179. Thinakaran G, Slunt HH, Sisodia SS. Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2. J Biol Chem. 1995 Jul 14; 270(28):16522-5. PMID: 7622456.
      Citations: 11     Fields:    Translation:HumansCells
    180. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 Jun; 14(6):1105-16. PMID: 7605627.
      Citations: 446     Fields:    Translation:HumansAnimalsCells
    181. Lo AC, Thinakaran G, Slunt HH, Sisodia SS. Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain. J Biol Chem. 1995 May 26; 270(21):12641-5. PMID: 7759513.
      Citations: 9     Fields:    Translation:AnimalsCells
    182. Rabizadeh S, Gralla EB, Borchelt DR, Gwinn R, Valentine JS, Sisodia S, Wong P, Lee M, Hahn H, Bredesen DE. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):3024-8. PMID: 7708768; PMCID: PMC42351.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    183. Sisodia SS, Price DL. Role of the beta-amyloid protein in Alzheimer's disease. FASEB J. 1995 Mar; 9(5):366-70. PMID: 7896005.
      Citations: 69     Fields:    Translation:Humans
    184. Lai A, Sisodia SS, Trowbridge IS. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. J Biol Chem. 1995 Feb 24; 270(8):3565-73. PMID: 7876092.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    185. Borchelt DR, Guarnieri M, Wong PC, Lee MK, Slunt HS, Xu ZS, Sisodia SS, Price DL, Cleveland DW. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. J Biol Chem. 1995 Feb 17; 270(7):3234-8. PMID: 7852409.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    186. Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):954-8. PMID: 7862672; PMCID: PMC42615.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    187. Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL. Cellular and molecular biology of Alzheimer's disease and animal models. Neuroimaging Clin N Am. 1995 Feb; 5(1):59-68. PMID: 7743085.
      Citations: 2     Fields:    Translation:HumansAnimals
    188. Zhao B, Sisodia SS, Kusiak JW. Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells. J Neurosci Res. 1995 Feb 01; 40(2):261-8. PMID: 7745619.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    189. Van Nostrand WE, Schmaier AH, Neiditch BR, Siegel RS, Raschke WC, Sisodia SS, Wagner SL. Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2. Biochim Biophys Acta. 1994 Dec 14; 1209(2):165-70. PMID: 7811686.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    190. Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. J Biol Chem. 1994 Dec 09; 269(49):30966-73. PMID: 7983032.
      Citations: 15     Fields:    Translation:AnimalsCells
    191. Thinakaran G, Sisodia SS. Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site. J Biol Chem. 1994 Sep 02; 269(35):22099-104. PMID: 8071334.
      Citations: 18     Fields:    Translation:AnimalsCells
    192. Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8292-6. PMID: 8058797; PMCID: PMC44592.
      Citations: 191     Fields:    Translation:HumansCells
    193. Borchelt DR, Koliatsos VE, Guarnieri M, Pardo CA, Sisodia SS, Price DL. Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems. J Biol Chem. 1994 May 20; 269(20):14711-4. PMID: 7514179.
      Citations: 30     Fields:    Translation:AnimalsCells
    194. Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS. Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem. 1994 Jan 28; 269(4):2637-44. PMID: 8300594.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    195. Sisodia SS. Cellular and molecular genetic approaches in Alzheimer's disease. Neurobiol Aging. 1994; 15 Suppl 2:S135-7. PMID: 7700438.
      Citations: 1     Fields:    Translation:Humans
    196. Price DL, Sisodia SS. Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med. 1994; 45:435-46. PMID: 8198393.
      Citations: 42     Fields:    Translation:HumansAnimals
    197. da Cruz e Silva OA, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran TV, Suzuki T, Sisodia SS, Gandy S, Greengard P. Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail. Neuroscience. 1993 Dec; 57(4):873-7. PMID: 8309547.
      Citations: 21     Fields:    Translation:Cells
    198. Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet. 1993 Sep; 5(1):22-30. PMID: 8220418.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    199. Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet. 1993 Sep; 5(1):95-100. PMID: 8220435.
      Citations: 106     Fields:    Translation:HumansCells
    200. Price DL, Borchelt DR, Sisodia SS. Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6381-4. PMID: 8101988; PMCID: PMC46935.
      Citations: 18     Fields:    Translation:Humans
    201. Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J Neurosci. 1993 Jul; 13(7):3136-42. PMID: 8331390; PMCID: PMC6576678.
      Citations: 80     Fields:    Translation:AnimalsCells
    202. Sisodia SS. Secretion of the beta-amyloid precursor protein. Ann N Y Acad Sci. 1992 Dec 31; 674:53-7. PMID: 1288370.
      Citations: 7     Fields:    Translation:Animals
    203. Price DL, Martin LJ, Clatterbuck RE, Koliatsos VE, Sisodia SS, Walker LC, Cork LC. Neuronal degeneration in human diseases and animal models. J Neurobiol. 1992 Nov; 23(9):1277-94. PMID: 1469388.
      Citations: 4     Fields:    Translation:HumansAnimals
    204. Price DL, Walker LC, Martin LJ, Sisodia SS. Amyloidosis in aging and Alzheimer's disease. Am J Pathol. 1992 Oct; 141(4):767-72. PMID: 1415474; PMCID: PMC1886638.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    205. Sisodia SS, Price DL. Amyloidogenesis in Alzheimer's disease: basic biology and animal models. Curr Opin Neurobiol. 1992 Oct; 2(5):648-52. PMID: 1422121.
      Citations: 4     Fields:    Translation:HumansAnimals
    206. Price DL, Borchelt DR, Walker LC, Sisodia SS. Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease. Neurobiol Aging. 1992 Sep-Oct; 13(5):623-5. PMID: 1461354.
      Citations: 10     Fields:    Translation:HumansAnimals
    207. Sisodia SS. Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):6075-9. PMID: 1631093; PMCID: PMC49440.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    208. Price DL, Martin LJ, Sisodia SS, Walker LC, Cork LC. Alzheimer's disease-type brain abnormalities in animal models. Prog Clin Biol Res. 1992; 379:271-87. PMID: 1409750.
      Citations: 1     Fields:    Translation:Animals
    209. Goedert M, Sisodia SS, Price DL. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Curr Opin Neurobiol. 1991 Oct; 1(3):441-7. PMID: 1821689.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    210. Wang R, Meschia JF, Cotter RJ, Sisodia SS. Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells. J Biol Chem. 1991 Sep 05; 266(25):16960-4. PMID: 1909332.
      Citations: 38     Fields:    Translation:AnimalsCells
    211. Price DL, Martin LJ, Sisodia SS, Wagster MV, Koo EH, Walker LC, Koliatsos VE, Cork LC. Aged non-human primates: an animal model of age-associated neurodegenerative disease. Brain Pathol. 1991 Jul; 1(4):287-96. PMID: 1688300.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    212. Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1461-5. PMID: 1899927; PMCID: PMC51038.
      Citations: 38     Fields:    Translation:AnimalsCells
    213. Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Ann N Y Acad Sci. 1991; 640:161-5. PMID: 1776735.
      Citations:    Fields:    Translation:HumansCells
    214. Price DL, Koliatsos VE, Sisodia SS, Koo EH, Martin LJ, Walker LC, Appelgate MD, Cork LC. Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models. Clin Neuropharmacol. 1991; 14 Suppl 1:S9-14. PMID: 1913711.
      Citations: 4     Fields:    Translation:AnimalsCells
    215. Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science. 1990 Apr 27; 248(4954):492-5. PMID: 1691865.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    216. Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Fischer P, Masters CL, Price DL. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1561-5. PMID: 1689489; PMCID: PMC53515.
      Citations: 190     Fields:    Translation:HumansAnimalsCells
    217. Koo EH, Sisodia SS, Cork LC, Unterbeck A, Bayney RM, Price DL. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron. 1990 Jan; 4(1):97-104. PMID: 2106906.
      Citations: 21     Fields:    Translation:HumansAnimals
    218. Sisodia SS, Gay DA, Cleveland DW. In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol. 1990 Jan; 2(1):66-76. PMID: 2078553.
      Citations: 6     Fields:    Translation:AnimalsCells
    219. Price DL, Koo EH, Sisodia SS, Martin LJ, Koliatsos VE, Muma NA, Walker LC, Cork LC. Neuronal responses to injury and aging: lessons from animal models. Prog Brain Res. 1990; 86:297-308. PMID: 2087560.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    220. Price DL, Sisodia SS, Koo EH, Muma NA, Kitt CA, Walker LC, Martin LJ, Troncoso JC, Griffin JW, Hoffman PN, et al. Neuronal disorders: studies of animal models and human diseases. Toxicol Pathol. 1990; 18(1 Pt 2):128-37. PMID: 2195633.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    221. Gay DA, Sisodia SS, Cleveland DW. Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5763-7. PMID: 2762294; PMCID: PMC297710.
      Citations: 53     Fields:    Translation:AnimalsCells
    222. Gabriel A, Sisodia SS, Cleveland DW. Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J Biol Chem. 1987 Nov 25; 262(33):16192-9. PMID: 3680249.
      Citations: 8     Fields:    Translation:AnimalsCells
    223. Sisodia SS, Sollner-Webb B, Cleveland DW. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol. 1987 Oct; 7(10):3602-12. PMID: 3683396; PMCID: PMC368014.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
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