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Dan Liviu Nicolae

TitleProfessor
InstitutionUniversity of Chicago
DepartmentStatistics
AddressChicago IL 60637
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    Collapse Overview 
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    My group works in the areas of statistical genetics and mathematical statistics. Our investigations are motivated by applications to genetics and genomics studies on common/complex diseases, with a focus on asthma. Statistical genetics problems of interest include developing of statistical methodology for sequencing-based data, microbiome,large-scale data integration, networks and systems biology.

    Collapse Biography 
    Collapse education and training
    University of ChicagoPhD06/1999Statistics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dapas M, Thompson EE, Wentworth-Sheilds W, Clay S, Visness CM, Calatroni A, Sordillo JE, Gold DR, Wood RA, Makhija M, Khurana Hershey GK, Sherenian MG, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Altman MC, Busse WW, Becker PM, Nicolae D, O'Connor GT, Gern JE, Jackson DJ, Ober C. Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings. PLoS Genet. 2023 01; 19(1):e1010594. PMID: 36638096; PMCID: PMC9879483.
      Citations:    Fields:    Translation:HumansCells
    2. Wang K, Moreira A, Grose A, Leahy K, Zhou Y, Clouser FA, Siddiqui M, Leong N, Goodall P, Michalowski M, Ismail M, Christmas M, Schrantz S, Raggi C, Castro C, Moossazadeh D, Ramirez M, Pandey A, Ashi K, Dovgin S, Dixon A, Li X, Begeman I, Heichman S, Lykins J, Wroblewski K, Karrison T, Ross S, Dogra M, Dhamsania V, Graves N, Kirchberg M, Mathur K, Aue A, Boyer K, Heydemann P, Noble AG, Swisher C, Rabiah P, Withers S, Hull T, Su C, Blair M, Latkany P, Mui E, Vasconcelos-Santos DV, Ramirez M, Chittenden C, Wang E, Padrieu G, Nicolae DL, Rzhetsky A, Roizen N, Stillwaggon E, Sawers L, Montoya J, Press C, Ramirez R, Contopoulos-Ioannidis D, Maldonado Y, Liesenfeld O, Gomez C, Wheeler K, Holfels E, Frim D, McLone D, Penn R, Cohen W, Zehar S, McAuley J, Limonne D, Houze S, Abraham S, Piarroux R, Tesic V, Beavis K, Abeleda A, Sautter M, El Mansouri B, El Bachir A, Amarir F, El Bissati K, Meier P, Grigg M, Felín MS, Caballero Z, Norero X, Estripeaut D, Ellis D, Villalobos-Cerrud D, Fabrega L, Montalvo JLS, Mendivil C, Quijada MR, Fernández-Pirla S, de La Guardia V, Wong D, de Guevara ML, Flores C, Borace J, García A, Caballero N, Rengifo-Herrera C, de Saez MTM, Politis M, Restrepo CM, Llanes A, Guzman G, Rebellon A, Villareal A, Perez A, Galvis CAN, Montes MV, Perez NIC, Garcia-López LL, Muñoz-Ortiz J, Rivera-Valdivia N, Bohorquez-Granados MC, de-la-Torre GC, Hernandez JDV, Celis-Giraldo D, Dávila JAA, Torres E, Oquendo MM, Arteaga-Rivera JY, Peyron F, Wallon M, Chapey E, Levigne P, Charter C, De Frias M, de-la-Torre A, Britton G, Motta J, Ortega-Barria E, Romero IL, Gómez-Marín J, Kosagisharaf JR, Llorens XS, Reyes O, McLeod R. Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview. Curr Pediatr Rep. 2022; 10(3):57-92. PMID: 36034212; PMCID: PMC9395898.
      Citations: 1     
    3. Wang K, Moreira A, Grose A, Leahy K, Zhou Y, Clouser FA, Siddiqui M, Leong N, Goodall P, Michalowski M, Ismail M, Christmas M, Schrantz S, Raggi C, Castro C, Moossazadeh D, Ramirez M, Pandey A, Ashi K, Dovgin S, Dixon A, Li X, Begeman I, Heichman S, Lykins J, de La Guardia V, Politis M, Ross S, Dogra M, Dhamsania V, Graves N, Kirchberg M, Mathur K, Aue A, Rebellon A, Boyer K, Heydemann P, Noble AG, Swisher C, Rabiah P, Withers S, Hull T, Frim D, McLone D, Su C, Blair M, Latkany P, Mui E, Vasconcelos-Santos DV, Ramirez M, Chittenden C, Wang E, Padrieu G, Nicolae DL, Rzhetsky A, Roizen N, Stillwaggon E, Sawers L, Levigne P, Montoya J, Press C, Ramirez R, Contopoulos-Ioannidis D, Maldonado Y, Liesenfeld O, Gomez C, Wheeler K, Zehar S, McAuley J, Limonne D, Houze S, Abraham S, Piarroux R, Tesic V, Beavis K, Abeleda A, Sautter M, El Mansouri B, El Bachir A, Amarir F, El Bissati K, Holfels E, Penn R, Cohen W, Ortega-Barria E, Meier P, Grigg M, McLeod R, Felín MS, Caballero Z, Norero X, Estripeaut D, Ellis D, Villalobos-Cerrud D, Fabrega L, Montalvo JLS, Mendivil C, Quijada MR, Fernández-Pirla S, Wong D, de Guevara ML, Flores C, Borace J, García A, Caballero N, Rengifo-Herrera C, de Saez MTM, Restrepo CM, Llanes A, Guzman G, Villareal A, Perez A, Galvis CAN, Montes MV, Perez NIC, Garcia-López LL, Muñoz-Ortiz J, Rivera-Valdivia N, Bohorquez-Granados MC, de-la-Torre GC, Hernandez JDV, Celis-Giraldo D, Dávila JAA, Torres E, Oquendo MM, Arteaga-Rivera JY, Peyron F, Wallon M, Chapey E, Charter C, De Frias M, de-la-Torre A, Britton G, Motta J, Romero IL, Gómez-Marín J, Kosagisharaf JR, Llorens XS, Reyes O. Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village". Curr Pediatr Rep. 2022; 10(3):125-154. PMID: 35991908; PMCID: PMC9379243.
      Citations: 1     
    4. Wang K, Moreira A, Grose A, Leahy K, Zhou Y, Clouser FA, Siddiqui M, Leong N, Goodall P, Michalowski M, Ismail M, Christmas M, Schrantz S, Raggi C, Castro C, Moossazadeh D, Ramirez M, Pandey A, Ashi K, Dovgin S, Dixon A, Li X, Begeman I, Heichman S, Lykins J, Caballero N, Ross S, Dogra M, Dhamsania V, Graves N, Kirchberg M, Mathur K, Aue A, Boyer K, Heydemann P, Noble AG, Swisher C, Rabiah P, Withers S, Hull T, Frim D, McLone D, Su C, Blair M, Latkany P, Mui E, Vasconcelos-Santos DV, Ramirez M, Chittenden C, Wang E, Hernandez JDV, Nicolae DL, Rzhetsky A, Roizen N, Stillwaggon E, Sawers L, Montoya J, Press C, Ramirez R, Contopoulos-Ioannidis D, Maldonado Y, Liesenfeld O, Gomez C, Wheeler K, Zehar S, McAuley J, Limonne D, Houze S, Abraham S, Piarroux R, Tesic V, Beavis K, Abeleda A, Sautter M, El Mansouri B, El Bachir A, Amarir F, El Bissati K, Holfels E, Penn R, Cohen W, Meier P, Grigg M, Felín MS, Caballero Z, Norero X, Estripeaut D, Ellis D, Rengifo-Herrera C, Villalobos-Cerrud D, Fabrega L, Montalvo JLS, Mendivil C, Quijada MR, Fernández-Pirla S, de La Guardia V, Wong D, de Guevara ML, Flores C, Borace J, García A, de Saez MTM, Politis M, Restrepo CM, Llanes A, Guzman G, Rebellon A, Villareal A, Perez A, Galvis CAN, Montes MV, Perez NIC, Garcia-López LL, Muñoz-Ortiz J, Rivera-Valdivia N, Bohorquez-Granados MC, de-la-Torre GC, Padrieu G, Celis-Giraldo D, Dávila JAA, Torres E, Oquendo MM, Arteaga-Rivera JY, Peyron F, Wallon M, Chapey E, Levigne P, Charter C, De Frias M, de-la-Torre A, Britton G, Motta J, Ortega-Barria E, Romero IL, Gómez-Marín J, Kosagisharaf JR, Llorens XS, Reyes O, McLeod R. Building Programs to Eradicate Toxoplasmosis Part II: Education. Curr Pediatr Rep. 2022 Sep; 10(3):93-108. PMID: 36969368; PMCID: PMC10035399.
      Citations:    
    5. Clay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C. Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55. PMID: 35606880; PMCID: PMC9128203.
      Citations: 1     Fields:    Translation:HumansCells
    6. Soliai MM, Kato A, Helling BA, Stanhope CT, Norton JE, Naughton KA, Klinger AI, Thompson EE, Clay SM, Kim S, Gern JE, Jackson DJ, Altman MC, Kern RC, Tan BK, Schleimer RP, Nicolae DL, Pinto JM, Ober C, Celedón JC. Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. Genome Med. 2021 10 10; 13(1):157. PMID: 34629083; PMCID: PMC8504130.
      Citations: 5     Fields:    Translation:HumansCells
    7. Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 04 01; 203(7):864-870. PMID: 33535024; PMCID: PMC8017591.
      Citations: 6     Fields:    Translation:HumansCells
    8. Helling BA, Hansen GT, Sakabe NJ, Luo K, Billstrand C, Laxman B, Nicolae RI, Nicolae DL, Bochkov YA, Gern JE, Nobrega MA, White SR, Ober C, Sobreira DR. Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma. Commun Biol. 2020 11 13; 3(1):678. PMID: 33188283; PMCID: PMC7666152.
      Citations: 9     Translation:HumansCells
    9. McKennan CG, Pedersen CT, Stokholm J, Chawes BL, Malby Schoos AM, Naughton KA, Thorsen J, Mortensen MS, Vercelli D, Trivedi U, Bisgaard H, Nicolae DL, Ober C, Morin A, Sørensen SJ, Bønnelykke K. Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age. J Allergy Clin Immunol. 2020 12; 146(6):1358-1366. PMID: 32693091; PMCID: PMC7821422.
      Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
    10. Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE, Environmental Influences on Child Health Outcomes-Children's Respiratory Research Workgroup. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020 05; 8(5):482-492. PMID: 32380068; PMCID: PMC7335429.
      Citations: 20     Fields:    Translation:HumansCells
    11. Daya M, Morii W, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Wilson JG, Lange LA, Watson H, Nicolae DL, Meyers DA, Hansel NN, Ford JG, Faruque MU, Bleecker ER, Campbell M, Beaty TH, Ruczinski I, Mathias RA, Taub MA, Ober C, Noguchi E, Barnes KC, CAAPA, Torgerson D, Vince N, Limou S, Geffard E, Douillard V, Walencik A, Gourraud PA. Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma. J Allergy Clin Immunol. 2020 07; 146(1):147-155. PMID: 31981624.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    12. McKennan C, Nicolae D. Accounting for unobserved covariates with varying degrees of estimability in high-dimensional biological data. Biometrika. 2019 Dec; 106(4):823-840. PMID: 31754283; PMCID: PMC6845853.
      Citations: 12     Fields:    
    13. Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Hansel NN, Hernandez RD, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Olopade CO, Olopade O, Qin ZS, Rotimi C, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC, CAAPA, Gourraud PA, Herrera-Paz EF, Jiménez S, Lizee A, Oliveira RR, Vince N. Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019 Sep 04; 10(1):4082. PMID: 31484942; PMCID: PMC6726619.
      Citations: 1     Fields:    
    14. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019 06; 7(6):509-522. PMID: 31036433; PMCID: PMC6534440.
      Citations: 104     Fields:    Translation:HumansCells
    15. Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Hansel NN, Hernandez RD, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Olopade CO, Olopade O, Qin ZS, Rotimi C, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC, CAAPA, Gourraud PA, Herrera-Paz EF, Jiménez S, Lizee A, Oliveira RR, Vince N. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019 02 20; 10(1):880. PMID: 30787307; PMCID: PMC6382865.
      Citations: 39     Fields:    Translation:HumansCells
    16. Sherman RM, Forman J, Antonescu V, Puiu D, Daya M, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Levin AM, Eng C, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Williams LK, Watson H, Ware LB, Olopade CO, Olopade O, Ober C, Nicolae DL, Meyers DA, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker ER, Araujo MI, Campbell M, Foster C, Taub MA, Beaty TH, Ruczinski I, Mathias RA, Barnes KC, Salzberg SL, Oliveira RR, Herrera-Paz EF. Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent. Nat Genet. 2019 02; 51(2):364. PMID: 30647471.
      Citations: 3     Fields:    
    17. Barbeira AN, Pividori M, Zheng J, Wheeler HE, Nicolae DL, Im HK. Integrating predicted transcriptome from multiple tissues improves association detection. PLoS Genet. 2019 01; 15(1):e1007889. PMID: 30668570; PMCID: PMC6358100.
      Citations: 125     Fields:    Translation:HumansCells
    18. Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C. Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree. Commun Biol. 2019; 2:28. PMID: 30675526; PMCID: PMC6338666.
      Citations: 14     Translation:Humans
    19. Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C. Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree. Commun Biol. 2019 Jan 18; 2(1):28. PMID: 31924898.
      Citations:    
    20. Sherman RM, Forman J, Antonescu V, Puiu D, Daya M, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Levin AM, Eng C, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Williams LK, Watson H, Ware LB, Olopade CO, Olopade O, Ober C, Nicolae DL, Meyers DA, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker ER, Araujo MI, Campbell M, Foster C, Taub MA, Beaty TH, Ruczinski I, Mathias RA, Barnes KC, Salzberg SL, Oliveira RR, Herrera-Paz EF. Assembly of a pan-genome from deep sequencing of 910 humans of African descent. Nat Genet. 2019 01; 51(1):30-35. PMID: 30455414; PMCID: PMC6309586.
      Citations: 139     Fields:    Translation:Humans
    21. Croteau-Chonka DC, Chen Z, Barnes KC, Gauderman WJ, Gilliland FD, Krishnan JA, Liu AH, London SJ, Martinez FD, Millstein J, Naureckas ET, Nicolae DL, White SR, Ober C, Weiss ST, Raby BA, Barraza-Villarreal A, Celedón JC. Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma. Obesity (Silver Spring). 2018 12; 26(12):1938-1948. PMID: 30358166; PMCID: PMC6262830.
      Citations: 5     Fields:    Translation:Humans
    22. Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C. Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions. PLoS One. 2018; 13(9):e0203906. PMID: 30204804; PMCID: PMC6133383.
      Citations: 4     Fields:    Translation:HumansCells
    23. Gignoux CR, Torgerson DG, Pino-Yanes M, Uricchio LH, Galanter J, Roth LA, Eng C, Hu D, Nguyen EA, Huntsman S, Mathias RA, Kumar R, Rodriguez-Santana J, Thakur N, Oh SS, McGarry M, Moreno-Estrada A, Sandoval K, Winkler CA, Seibold MA, Padhukasahasram B, Conti DV, Farber HJ, Avila P, Brigino-Buenaventura E, Lenoir M, Meade K, Serebrisky D, Borrell LN, Rodriguez-Cintron W, Thyne S, Joubert BR, Romieu I, Levin AM, Sienra-Monge JJ, Del Rio-Navarro BE, Gan W, Raby BA, Weiss ST, Bleecker E, Meyers DA, Martinez FJ, Gauderman WJ, Gilliland F, London SJ, Bustamante CD, Nicolae DL, Ober C, Sen S, Barnes K, Williams LK, Hernandez RD, Burchard EG. An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos. J Allergy Clin Immunol. 2019 03; 143(3):957-969. PMID: 30201514; PMCID: PMC6927816.
      Citations: 21     Fields:    Translation:HumansCells
    24. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 09; 50(9):1343. PMID: 30116036.
      Citations: 1     Fields:    
    25. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 08; 50(8):1072-1080. PMID: 30013184; PMCID: PMC7068780.
      Citations: 38     Fields:    Translation:Humans
    26. Gamazon ER, van de Bunt M, Wen X, Xi HS, Hormozdiari F, Ongen H, Konkashbaev A, Derks EM, Quan J, GTEx Consortium, Nicolae DL, Eskin E, Kellis M, Getz G, McCarthy MI, Dermitzakis ET, Cox NJ, Ardlie KG, Segrè AV, Aguet F. Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation. Nat Genet. 2018 07; 50(7):956-967. PMID: 29955180; PMCID: PMC6248311.
      Citations: 202     Fields:    Translation:Humans
    27. Barbeira AN, Dickinson SP, Bonazzola R, Zheng J, Wheeler HE, Torres JM, Torstenson ES, Shah KP, Garcia T, Edwards TL, Stahl EA, Huckins LM, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun. 2018 05 08; 9(1):1825. PMID: 29739930; PMCID: PMC5940825.
      Citations: 404     Fields:    Translation:Humans
    28. Kothari PH, Qiu W, Croteau-Chonka DC, Martinez FD, Liu AH, Lemanske RF, Ober C, Krishnan JA, Nicolae DL, Barnes KC, London SJ, Barraza-Villarreal A, White SR, Naureckas ET, Millstein J, Gauderman WJ, Gilliland FD, Carey VJ, Weiss ST, Raby BA, Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium. Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus. J Allergy Clin Immunol. 2018 06; 141(6):2282-2286.e6. PMID: 29374573; PMCID: PMC5994185.
      Citations: 12     Fields:    Translation:HumansCells
    29. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Washington C, Nicolae D, Ober C, Morin A, Bønnelykke K. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018 09; 142(3):749-764.e3. PMID: 29307657; PMCID: PMC6172038.
      Citations: 70     Fields:    Translation:HumansCells
    30. Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Curran JE, Peralta J, Akolkar B, Bell GI, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Nicolae DL, Lehman D, Park T, Won S, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Blangero J, Cingolani P, Mazur A, Zöllner S, Burtt NP, Dupuis J, Sladek R, Abecasis GR. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):379-384. PMID: 29279374; PMCID: PMC5777025.
      Citations: 21     Fields:    Translation:Humans
    31. Barnes KC, Cookson WOC, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Boomsma DI, Brightling CE, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Meyers D, Michel S, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Smith LJ, Solodilova M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Torgerson DG, Tsunoda T, van der Valk RJP, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL, Demenais F, Margaritte-Jeannin P, Altmüller J, Bønnelykke K, Bouzigon E, Brossard M, Heliövaara M, Kähönen M, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Marenholz I, Melén E, Mohamdi H, Pershagen G, Schlünssen V, Siroux V, Standl M, Tiesler CMT, Uitterlinden AG, Vaysse A, Widén E. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 01; 50(1):42-53. PMID: 29273806; PMCID: PMC5901974.
      Citations: 200     Fields:    Translation:HumansCells
    32. Igartua C, Mozaffari SV, Nicolae DL, Ober C. Rare non-coding variants are associated with plasma lipid traits in a founder population. Sci Rep. 2017 11 27; 7(1):16415. PMID: 29180722; PMCID: PMC5704019.
      Citations: 12     Fields:    Translation:Humans
    33. Igartua C, Davenport ER, Gilad Y, Nicolae DL, Pinto J, Ober C. Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome. 2017 02 01; 5(1):16. PMID: 28143570; PMCID: PMC5286564.
      Citations: 32     Fields:    Translation:HumansCells
    34. Croteau-Chonka DC, Qiu W, Martinez FD, Strunk RC, Lemanske RF, Liu AH, Gilliland FD, Millstein J, Gauderman WJ, Ober C, Krishnan JA, White SR, Naureckas ET, Nicolae DL, Barnes KC, London SJ, Carey VJ, Weiss ST, Raby BA, Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium, Barraza-Villarreal A. Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188. PMID: 27494826; PMCID: PMC5394783.
      Citations: 31     Fields:    Translation:HumansCells
    35. Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight. 2016 12 08; 1(20):e90151. PMID: 27942592; PMCID: PMC5139904.
      Citations: 68     Fields:    Translation:HumansCells
    36. Wheeler HE, Shah KP, Brenner J, Garcia T, Aquino-Michaels K, GTEx Consortium, Cox NJ, Nicolae DL, Im HK. Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues. PLoS Genet. 2016 Nov; 12(11):e1006423. PMID: 27835642; PMCID: PMC5106030.
      Citations: 74     Fields:    Translation:Humans
    37. Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, CAAPA, Barnes KC, Oliveira R. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun. 2016 10 11; 7:12522. PMID: 27725671; PMCID: PMC5062574.
      Citations: 73     Fields:    Translation:HumansCells
    38. Nicolae DL. Association Tests for Rare Variants. Annu Rev Genomics Hum Genet. 2016 08 31; 17:117-30. PMID: 27147090.
      Citations: 20     Fields:    Translation:Humans
    39. Wang J, Gamazon ER, Pierce BL, Stranger BE, Im HK, Gibbons RD, Cox NJ, Nicolae DL, Chen LS. Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx. Am J Hum Genet. 2016 Apr 07; 98(4):697-708. PMID: 27040689; PMCID: PMC4833292.
      Citations: 21     Fields:    Translation:HumansCells
    40. Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S104-5. PMID: 27027945; PMCID: PMC5015745.
      Citations: 5     Fields:    
    41. Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C. Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):376-85. PMID: 26474238; PMCID: PMC4803084.
      Citations: 51     Fields:    Translation:HumansCells
    42. Loisel DA, Du G, Tisler CJ, Evans MD, Myers RA, Gangnon RE, Jackson DJ, Lemanske RF, Nicolae DL, Gern JE, Ober C, Ahluwalia TS, Kreiner-Møller E, Bønnelykke K, Bisgaard H. Genetic associations with viral respiratory illnesses and asthma control in children. Clin Exp Allergy. 2016 Jan; 46(1):112-24. PMID: 26399222; PMCID: PMC4715666.
      Citations: 15     Fields:    Translation:Humans
    43. Liu Q, Chen LS, Nicolae DL, Pierce BL. A unified set-based test with adaptive filtering for gene-environment interaction analyses. Biometrics. 2016 06; 72(2):629-38. PMID: 26496228; PMCID: PMC4842175.
      Citations: 8     Fields:    
    44. Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, GTEx Consortium, Nicolae DL, Cox NJ, Im HK. A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015 Sep; 47(9):1091-8. PMID: 26258848; PMCID: PMC4552594.
      Citations: 739     Fields:    Translation:Humans
    45. Brehm JM, Ramratnam SK, Tse SM, Croteau-Chonka DC, Pino-Yanes M, Rosas-Salazar C, Litonjua AA, Raby BA, Boutaoui N, Han YY, Chen W, Forno E, Marsland AL, Nugent NR, Eng C, Spear ML, Martinez FD, Weiss ST, Ober C, Nicolae DL, Barnes KC, Lemanske RF, Strunk RC, Liu A, London SJ, Gilliland F, Sleiman P, March M, Hakonarson H, Duan QL, Kolls JK, Fritz GK, Hu D, Fani N, Stevens JS, Almli LM, Burchard EG, Shin J, McQuaid EL, Ressler K, Canino G, Colón-Semidey A, Alvarez M, Acosta-Pérez E, Avila L, Soto-Quiros M, Celedón JC. Stress and Bronchodilator Response in Children with Asthma. Am J Respir Crit Care Med. 2015 Jul 01; 192(1):47-56. PMID: 25918834; PMCID: PMC4511425.
      Citations: 49     Fields:    Translation:HumansCells
    46. Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. Am J Respir Crit Care Med. 2015 May 15; 191(10):1116-25. PMID: 25763605; PMCID: PMC4451618.
      Citations: 36     Fields:    Translation:HumansCells
    47. Kim KW, Myers RA, Lee JH, Igartua C, Lee KE, Kim YH, Kim EJ, Yoon D, Lee JS, Hirota T, Tamari M, Takahashi A, Kubo M, Choi JM, Kim KE, Nicolae DL, Ober C, Sohn MH. Genome-wide association study of recalcitrant atopic dermatitis in Korean children. J Allergy Clin Immunol. 2015 Sep; 136(3):678-684.e4. PMID: 25935106; PMCID: PMC4562879.
      Citations: 13     Fields:    Translation:HumansCells
    48. Livne OE, Han L, Alkorta-Aranburu G, Wentworth-Sheilds W, Abney M, Ober C, Nicolae DL. PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population. PLoS Comput Biol. 2015 Mar; 11(3):e1004139. PMID: 25735005; PMCID: PMC4348507.
      Citations: 21     Fields:    Translation:Humans
    49. Igartua C, Myers RA, Mathias RA, Pino-Yanes M, Eng C, Graves PE, Levin AM, Del-Rio-Navarro BE, Jackson DJ, Livne OE, Rafaels N, Edlund CK, Yang JJ, Huntsman S, Salam MT, Romieu I, Mourad R, Gern JE, Lemanske RF, Wyss A, Hoppin JA, Barnes KC, Burchard EG, Gauderman WJ, Martinez FD, Raby BA, Weiss ST, Williams LK, London SJ, Gilliland FD, Nicolae DL, Ober C. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. Nat Commun. 2015 Jan 16; 6:5965. PMID: 25591454; PMCID: PMC4309441.
      Citations: 40     Fields:    Translation:Humans
    50. Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Chapela R, Ford JG, Lenoir MA, Thyne SM, Brigino-Buenaventura E, Borrell LN, Rodriguez-Cintron W, Sen S, Kumar R, Bustamante CD, Martinez FD, Raby BA, Weiss ST, Nicolae DL, Ober C, Meyers DA, Bleecker ER, Mack SJ, Hernandez RD, Eichler EE, Barnes KC, Williams LK, Torgerson DG, Burchard EG, Rodriguez-Santana JR. Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol. 2015 Jun; 135(6):1502-10. PMID: 25488688; PMCID: PMC4458233.
      Citations: 27     Fields:    Translation:HumansCells
    51. Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A, Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias RA, Beaty TH, Li X, Graves P, Romieu I, Navarro Bdel R, Salam MT, Vora H, Nicolae DL, Ober C, Martinez FD, Bleecker ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG, Barnes KC, Williams LK, London SJ, Zhang B, Raby BA, Weiss ST. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. BMC Med Genomics. 2014 Aug 02; 7:48. PMID: 25085501; PMCID: PMC4127082.
      Citations: 30     Fields:    Translation:HumansCells
    52. Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, Nystad W, Ober C, Nicolae D, Barnes KC, Martinez F, Liu A, Lemanske R, Strunk R, Weiss S, London S, Gilliland F, Raby B, Asthma BRIDGE consortium, Håberg SE. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. PLoS One. 2014; 9(6):e99716. PMID: 24964093; PMCID: PMC4070909.
      Citations: 59     Fields:    Translation:HumansCells
    53. Sharma S, Zhou X, Thibault DM, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF, Barraza-Villareal A, Lemanske RF, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K, London SJ, Martinez F, Ober C, Carey VJ, Weiss ST, Raby BA, Avila L, Soto-Quiros M, Celedón JC. A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. J Allergy Clin Immunol. 2014 Nov; 134(5):1153-62. PMID: 24934276; PMCID: PMC4253878.
      Citations: 30     Fields:    Translation:HumansCells
    54. King CR, Nicolae DL. GWAS to Sequencing: Divergence in Study Design and Analysis. Genes (Basel). 2014 May 28; 5(2):460-76. PMID: 24879455; PMCID: PMC4094943.
      Citations: 6     Fields:    
    55. Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL, GRAAD, del Rio Navarro B. Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014 Oct 01; 23(19):5251-9. PMID: 24824216; PMCID: PMC4159149.
      Citations: 39     Fields:    Translation:Humans
    56. Ahsan H, Halpern J, Kibriya MG, Pierce BL, Tong L, Gamazon E, McGuire V, Felberg A, Shi J, Jasmine F, Roy S, Brutus R, Argos M, Melkonian S, Chang-Claude J, Andrulis I, Hopper JL, John EM, Malone K, Ursin G, Gammon MD, Thomas DC, Seminara D, Casey G, Knight JA, Southey MC, Giles GG, Santella RM, Lee E, Conti D, Duggan D, Gallinger S, Haile R, Jenkins M, Lindor NM, Newcomb P, Michailidou K, Apicella C, Park DJ, Peto J, Fletcher O, dos Santos Silva I, Lathrop M, Hunter DJ, Chanock SJ, Meindl A, Schmutzler RK, Lochmann M, Beckmann L, Hein R, Makalic E, Schmidt DF, Bui QM, Stone J, Flesch-Janys D, Dahmen N, Nevanlinna H, Blomqvist C, Hall P, Czene K, Irwanto A, Liu J, Rahman N, Turnbull C, Familial Breast Cancer Study, Dunning AM, Pharoah P, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Nicolae D, Easton DF, Cox NJ, Whittemore AS, Müller-Myhsok B, Aittomäki K. A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. PMID: 24493630; PMCID: PMC3990360.
      Citations: 48     Fields:    Translation:Humans
    57. Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, White KP, Rzhetsky A, Brunak S. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013 Sep 26; 155(1):70-80. PMID: 24074861; PMCID: PMC3844554.
      Citations: 127     Fields:    Translation:Humans
    58. Hernandez W, Gamazon ER, Aquino-Michaels K, Patel S, O'Brien TJ, Harralson AF, Kittles RA, Barbour A, Tuck M, McIntosh SD, Douglas JN, Nicolae D, Cavallari LH, Perera MA. Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans. Pharmacogenomics J. 2014 Jun; 14(3):223-8. PMID: 24018621; PMCID: PMC4016191.
      Citations: 36     Fields:    Translation:Humans
    59. Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE, Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM, Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL, Abney M, Ober C. Genome-wide association study of lung function phenotypes in a founder population. J Allergy Clin Immunol. 2014 Jan; 133(1):248-55.e1-10. PMID: 23932459; PMCID: PMC4270121.
      Citations: 38     Fields:    Translation:Humans
    60. Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, Broderick SM, Wade MS, Hysi P, Scuirba J, Richards TJ, Juan-Guardela BM, Vij R, Han MK, Martinez FJ, Kossen K, Seiwert SD, Christie JD, Nicolae D, Kaminski N, Garcia JGN. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med. 2013 Jun; 1(4):309-317. PMID: 24429156; PMCID: PMC3894577.
      Citations: 268     Fields:    Translation:Humans
    61. Granell R, Kogevinas M, Strachan D, Gonzalez JR, Wjst M, Jarvis D, Ege M, Genuneit J, Horak E, Bouzigon E, Demenais F, Kauffmann F, Siroux V, Michel S, von Berg A, Heinzmann A, Kabesch M, Probst-Hensch NM, Curjuric I, Imboden M, Rochat T, Henderson J, Sterne JA, McArdle WL, Hui J, James AL, William Musk A, Palmer LJ, Becker A, Kozyrskyj AL, Chan-Young M, Park JE, Leung A, Daley D, Freidin MB, Deev IA, Ogorodova LM, Puzyrev VP, Brehm JM, Cloutier MM, Canino G, Soto-Quiros M, Avila L, Magnusson J, Kull I, Scholtens S, Marike Boezen H, Koppelman GH, Wijga AH, Marenholz I, Esparza-Gordillo J, Lau S, Lee YA, Standl M, Tiesler CM, Flexeder C, Heinrich J, Myers RA, Ober C, Nicolae DL, Farrall M, Kumar A, Moffatt MF, Cookson WO, Lasky-Su J, Melén E, Braun-Fahrländer C, Celedón JC, Acosta-Pérez E, Bergström A, Söderhäll C. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy. 2013 Apr; 43(4):463-74. PMID: 23517042; PMCID: PMC3608930.
      Citations: 32     Fields:    Translation:Humans
    62. Caliskan M, Bochkov YA, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF, Nicolae DL, Ober C, Kreiner-Møller E, Bønnelykke K. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013 Apr 11; 368(15):1398-407. PMID: 23534543; PMCID: PMC3755952.
      Citations: 229     Fields:    Translation:HumansCells
    63. Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C. Maternal asthma and microRNA regulation of soluble HLA-G in the airway. J Allergy Clin Immunol. 2013 Jun; 131(6):1496-503. PMID: 23534973; PMCID: PMC3779062.
      Citations: 26     Fields:    Translation:HumansPHPublic Health
    64. Liu Q, Nicolae DL, Chen LS. Marbled inflation from population structure in gene-based association studies with rare variants. Genet Epidemiol. 2013 Apr; 37(3):286-92. PMID: 23468125; PMCID: PMC3716585.
      Citations: 21     Fields:    Translation:Humans
    65. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179. PMID: 23457522; PMCID: PMC3572953.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    66. Chen LS, Hsu L, Gamazon ER, Cox NJ, Nicolae DL. An exponential combination procedure for set-based association tests in sequencing studies. Am J Hum Genet. 2012 Dec 07; 91(6):977-86. PMID: 23159251; PMCID: PMC3516612.
      Citations: 22     Fields:    Translation:Humans
    67. Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. PMID: 23146381; PMCID: PMC3596497.
      Citations: 32     Fields:    Translation:Humans
    68. Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Galanter JM, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C, Celedón JC. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. PMID: 23040885; PMCID: PMC3666859.
      Citations: 13     Fields:    Translation:HumansCells
    69. Ding D, Scott NM, Thompson EE, Chaiworapongsa T, Torres R, Billstrand C, Murray K, Dexheimer PJ, Ismail M, Kay H, Levy S, Romero R, Lindheimer MD, Nicolae DL, Ober C. Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia. Reprod Sci. 2012 Dec; 19(12):1343-51. PMID: 22902742; PMCID: PMC4046444.
      Citations: 7     Fields:    Translation:HumansCells
    70. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012 Oct; 130(4):861-8.e7. PMID: 22694930; PMCID: PMC3579216.
      Citations: 65     Fields:    Translation:Humans
    71. Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Avila PC, Ford JG, Barnes KC, Burchard EG, Howard TD, Bleecker ER, Meyers DA, Cox NJ, Ober C, Nicolae DL, Rodríguez-Santana JR, Rodríguez-Cintrón W. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012 Sep; 130(3):622-629.e9. PMID: 22607992; PMCID: PMC3503456.
      Citations: 20     Fields:    Translation:HumansCells
    72. Grassi MA, Tikhomirov A, Ramalingam S, Lee KE, Hosseini SM, Klein BE, Klein R, Lussier YA, Cox NJ, Nicolae DL. Replication analysis for severe diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012 Apr 30; 53(4):2377-81. PMID: 22427569; PMCID: PMC3777289.
      Citations: 23     Fields:    Translation:Humans
    73. Uricchio LH, Chong JX, Ross KD, Ober C, Nicolae DL. Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals. Genet Epidemiol. 2012 May; 36(4):312-9. PMID: 22460724; PMCID: PMC3794468.
      Citations: 15     Fields:    Translation:Humans
    74. Im HK, Gamazon ER, Nicolae DL, Cox NJ. On sharing quantitative trait GWAS results in an era of multiple-omics data and the limits of genomic privacy. Am J Hum Genet. 2012 Apr 06; 90(4):591-8. PMID: 22463877; PMCID: PMC3322234.
      Citations: 42     Fields:    Translation:HumansCells
    75. Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012 Feb 10; 90(2):273-81. PMID: 22325360; PMCID: PMC3276672.
      Citations: 36     Fields:    Translation:Humans
    76. Ionita-Laza I, Makarov V, Yoon S, Raby B, Buxbaum J, Nicolae DL, Lin X. Finding disease variants in Mendelian disorders by using sequence data: methods and applications. Am J Hum Genet. 2011 Dec 09; 89(6):701-12. PMID: 22137099; PMCID: PMC3234377.
      Citations: 32     Fields:    Translation:Humans
    77. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ, Mexico City Childhood Asthma Study (MCAAS), Gilliland FD, Children's Health Study (CHS) and HARBORS study, Burchard EG, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Lat, Martinez FD, Childhood Asthma Research and Education (CARE) Network, Weiss ST, Childhood Asthma Management Program (CAMP), Williams LK, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes KC, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober C, Nicolae DL, Celedón JC. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31; 43(9):887-92. PMID: 21804549; PMCID: PMC3445408.
      Citations: 396     Fields:    Translation:Humans
    78. Wegmann D, Kessner DE, Veeramah KR, Mathias RA, Nicolae DL, Yanek LR, Sun YV, Torgerson DG, Rafaels N, Mosley T, Becker LC, Ruczinski I, Beaty TH, Kardia SL, Meyers DA, Barnes KC, Becker DM, Freimer NB, Novembre J. Recombination rates in admixed individuals identified by ancestry-based inference. Nat Genet. 2011 Jul 20; 43(9):847-53. PMID: 21775992; PMCID: PMC8582322.
      Citations: 57     Fields:    Translation:Humans
    79. Below JE, Gamazon ER, Morrison JV, Konkashbaev A, Pluzhnikov A, McKeigue PM, Parra EJ, Elbein SC, Hallman DM, Nicolae DL, Bell GI, Cruz M, Cox NJ, Hanis CL. Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Diabetologia. 2011 Aug; 54(8):2047-55. PMID: 21647700; PMCID: PMC3761075.
      Citations: 67     Fields:    Translation:Humans
    80. Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ, Nicolae DL. Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet. 2011 Jun 15; 20(12):2472-81. PMID: 21441570; PMCID: PMC3098732.
      Citations: 78     Fields:    Translation:Humans
    81. Gamazon ER, Nicolae DL, Cox NJ. A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. PLoS Genet. 2011 Feb 03; 7(2):e1001292. PMID: 21304891; PMCID: PMC3033384.
      Citations: 38     Fields:    Translation:Humans
    82. Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA, Nicolae D, Cox NJ. The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans. Clin Pharmacol Ther. 2011 Mar; 89(3):408-15. PMID: 21270790; PMCID: PMC3625373.
      Citations: 56     Fields:    Translation:HumansCells
    83. Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C, Çaliskan M. Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13. Hum Mol Genet. 2011 Apr 01; 20(7):1285-9. PMID: 21212097; PMCID: PMC3115579.
      Citations: 48     Fields:    Translation:HumansCells
    84. King CR, Rathouz PJ, Nicolae DL. An evolutionary framework for association testing in resequencing studies. PLoS Genet. 2010 Nov 11; 6(11):e1001202. PMID: 21085648; PMCID: PMC2978703.
      Citations: 35     Fields:    Translation:Humans
    85. Reimherr M, Nicolae DL. You've gotta be lucky: Coverage and the elusive gene-gene interaction. Ann Hum Genet. 2011 Jan; 75(1):105-11. PMID: 20977438; PMCID: PMC3005128.
      Citations: 5     Fields:    Translation:Humans
    86. Ratnam S, Bozek G, Nicolae D, Storb U. The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol. 2010 Oct; 47(16):2611-8. PMID: 20691478; PMCID: PMC3038623.
      Citations: 2     Fields:    Translation:AnimalsCells
    87. Pluzhnikov A, Below JE, Konkashbaev A, Tikhomirov A, Kistner-Griffin E, Roe CA, Nicolae DL, Cox NJ. Spoiling the whole bunch: quality control aimed at preserving the integrity of high-throughput genotyping. Am J Hum Genet. 2010 Jul 09; 87(1):123-8. PMID: 20598280; PMCID: PMC2896766.
      Citations: 30     Fields:    Translation:Humans
    88. Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet. 2010 Apr 01; 6(4):e1000888. PMID: 20369019; PMCID: PMC2848547.
      Citations: 739     Fields:    Translation:Humans
    89. De la Cruz O, Wen X, Ke B, Song M, Nicolae DL. Gene, region and pathway level analyses in whole-genome studies. Genet Epidemiol. 2010 Apr; 34(3):222-231. PMID: 20013942; PMCID: PMC4061611.
      Citations: 31     Fields:    Translation:Humans
    90. Thompson EE, Sun Y, Nicolae D, Ober C. Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans. Genet Epidemiol. 2010 Feb; 34(2):133-9. PMID: 19697328; PMCID: PMC4238926.
      Citations: 5     Fields:    Translation:Humans
    91. Thompson EE, Haller G, Pinto JM, Sun Y, Zelano B, Jacob S, McClintock MK, Nicolae DL, Ober C. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. Hum Immunol. 2010 Jan; 71(1):100-3. PMID: 19833159; PMCID: PMC3631539.
      Citations: 5     Fields:    Translation:HumansCells
    92. Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, Nicolae DL, Dolan ME, Cox NJ. SCAN: SNP and copy number annotation. Bioinformatics. 2010 Jan 15; 26(2):259-62. PMID: 19933162; PMCID: PMC2852202.
      Citations: 171     Fields:    
    93. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Western Regional Alliance for Pediatric IBD, Silber G, Wrobel I, Quiros A, International IBD Genetics Consortium, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Hakonarson H, Libioulle C, Van Gossum A. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec; 41(12):1335-40. PMID: 19915574; PMCID: PMC3267927.
      Citations: 229     Fields:    Translation:Humans
    94. Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Re. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes. 2010 Feb; 59(2):539-49. PMID: 19875614; PMCID: PMC2809960.
      Citations: 61     Fields:    Translation:Humans
    95. Storb U, Shen HM, Nicolae D. Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils. Cell Cycle. 2009 Oct 01; 8(19):3097-101. PMID: 19738437.
      Citations: 19     Fields:    Translation:AnimalsCells
    96. Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res. 2009 Sep 15; 15(18):5714-23. PMID: 19723643; PMCID: PMC2767337.
      Citations: 96     Fields:    Translation:Humans
    97. Song M, Nicolae DL. Restricted parameter space models for testing gene-gene interaction. Genet Epidemiol. 2009 Jul; 33(5):386-93. PMID: 19058263; PMCID: PMC4077544.
      Citations: 11     Fields:    Translation:Humans
    98. Nicolae DL, Ober C. (Too) great expectations: the challenges in replicating asthma disease genes. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1078-9. PMID: 19498061; PMCID: PMC4263324.
      Citations: 5     Fields:    Translation:HumansCells
    99. Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J Lipid Res. 2009 May; 50(5):798-806. PMID: 19124843; PMCID: PMC2666166.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    100. Hristea A, Nicolae D, Luka AI, Constantinescu RM, Arama V, Tanasescu R. Invasive pneumococcal infections: Austrian syndrome. Rom J Intern Med. 2009; 47(1):93-6. PMID: 19886075.
      Citations: 2     Fields:    Translation:Humans
    101. De la Cruz O, Blekhman R, Zhang X, Nicolae D, Firestein S, Gilad Y. A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes. Mol Biol Evol. 2009 Mar; 26(3):491-4. PMID: 19103638; PMCID: PMC2767087.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    102. Grassi MA, Mazzulla DA, Knudtson MD, Huang WW, Lee KE, Klein BE, Nicolae DL, Klein R. Patient self-report of prior laser treatment reliably indicates presence of severe diabetic retinopathy. Am J Ophthalmol. 2009 Mar; 147(3):501-4. PMID: 19054495; PMCID: PMC2758026.
      Citations: 13     Fields:    Translation:Humans
    103. Ma SF, Flores C, Wade MS, Dudek SM, Nicolae DL, Ober C, Garcia JG. A common cortactin gene variation confers differential susceptibility to severe asthma. Genet Epidemiol. 2008 Dec; 32(8):757-66. PMID: 18521921; PMCID: PMC3774307.
      Citations: 11     Fields:    Translation:HumansCells
    104. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Libioulle C, Van Gossum A. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008 Aug; 40(8):955-62. PMID: 18587394; PMCID: PMC2574810.
      Citations: 1225     Fields:    Translation:Humans
    105. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med. 2008 Apr 17; 358(16):1682-91. PMID: 18403759; PMCID: PMC2629486.
      Citations: 227     Fields:    Translation:Humans
    106. Wen X, Nicolae DL. Association studies for untyped markers with TUNA. Bioinformatics. 2008 Feb 01; 24(3):435-7. PMID: 18057020; PMCID: PMC4051297.
      Citations: 11     Fields:    
    107. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet. 2007 Oct; 81(4):829-34. PMID: 17847008; PMCID: PMC2227932.
      Citations: 169     Fields:    Translation:HumansCells
    108. Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF, Nicolae DL, Ober C. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007 Jun; 119(6):1423-9. PMID: 17556058.
      Citations: 11     Fields:    Translation:Humans
    109. Tuvlin JA, Raza SS, Bracamonte S, Julian C, Hanauer SB, Nicolae DL, King AC, Cho JH. Smoking and inflammatory bowel disease: trends in familial and sporadic cohorts. Inflamm Bowel Dis. 2007 May; 13(5):573-9. PMID: 17345609.
      Citations: 19     Fields:    Translation:Humans
    110. Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR, Rioux JD. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007 May; 39(5):596-604. PMID: 17435756; PMCID: PMC2757939.
      Citations: 802     Fields:    Translation:HumansAnimalsCells
    111. Nicolae DL. Quantifying the amount of missing information in genetic association studies. Genet Epidemiol. 2006 Dec; 30(8):703-17. PMID: 16986163.
      Citations: 15     Fields:    Translation:Humans
    112. Nicolae DL. Testing untyped alleles (TUNA)-applications to genome-wide association studies. Genet Epidemiol. 2006 Dec; 30(8):718-27. PMID: 16986160.
      Citations: 57     Fields:    Translation:Humans
    113. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006 Dec 01; 314(5804):1461-3. PMID: 17068223; PMCID: PMC4410764.
      Citations: 1166     Fields:    Translation:HumansCells
    114. Shen HM, Tanaka A, Bozek G, Nicolae D, Storb U. Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J Immunol. 2006 Oct 15; 177(8):5386-92. PMID: 17015724.
      Citations: 63     Fields:    Translation:AnimalsCells
    115. Nicolae DL, Wu X, Miyake K, Cox NJ. GEL: a novel genotype calling algorithm using empirical likelihood. Bioinformatics. 2006 Aug 15; 22(16):1942-7. PMID: 16809396.
      Citations: 8     Fields:    
    116. Nicolae DL, Wen X, Voight BF, Cox NJ. Coverage and characteristics of the Affymetrix GeneChip Human Mapping 100K SNP set. PLoS Genet. 2006 May; 2(5):e67. PMID: 16680197; PMCID: PMC1456318.
      Citations: 19     Fields:    Translation:Humans
    117. Achkar JP, Dassopoulos T, Silverberg MS, Tuvlin JA, Duerr RH, Brant SR, Siminovitch K, Reddy D, Datta LW, Bayless TM, Zhang L, Barmada MM, Rioux JD, Steinhart AH, McLeod RS, Griffiths AM, Cohen Z, Yang H, Bromfield GP, Schumm P, Hanauer SB, Cho JH, Nicolae DL. Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. Am J Gastroenterol. 2006 Mar; 101(3):572-80. PMID: 16542294.
      Citations: 8     Fields:    Translation:Humans
    118. Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2006 Jun; 290(6):G1157-63. PMID: 16439468.
      Citations: 84     Fields:    Translation:Humans
    119. Longerich S, Tanaka A, Bozek G, Nicolae D, Storb U. The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med. 2005 Nov 21; 202(10):1443-54. PMID: 16301749; PMCID: PMC2212980.
      Citations: 30     Fields:    Translation:AnimalsCells
    120. Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel DB, Steiner L, Walker K, Shult P, Gangnon RE, Gern JE, Martinez FD, Lemanske RF, Ober C. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet. 2005 Apr; 76(4):696-704. PMID: 15726497; PMCID: PMC1199307.
      Citations: 25     Fields:    Translation:Humans
    121. Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 Feb; 76(2):349-57. PMID: 15611928; PMCID: PMC1196380.
      Citations: 80     Fields:    Translation:HumansCells
    122. Barmada MM, Brant SR, Nicolae DL, Achkar JP, Panhuysen CI, Bayless TM, Cho JH, Duerr RH. A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis. 2004 Sep; 10(5):513-20. PMID: 15472510.
      Citations: 23     Fields:    Translation:HumansCells
    123. Li J, Moran T, Swanson E, Julian C, Harris J, Bonen DK, Hedl M, Nicolae DL, Abraham C, Cho JH. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet. 2004 Aug 15; 13(16):1715-25. PMID: 15198989.
      Citations: 104     Fields:    Translation:HumansCells
    124. Nicolae DL, Kong A. Measuring the relative information in allele-sharing linkage studies. Biometrics. 2004 Jun; 60(2):368-75. PMID: 15180662.
      Citations: 3     Fields:    Translation:Humans
    125. Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004 Mar; 113(3):511-8. PMID: 15007355.
      Citations: 24     Fields:    Translation:Humans
    126. Barmada MM, Brant SR, Nicolae DL, Achkar JP, Panhuysen CI, Bayless TM, Cho JH, Duerr RH. A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis. 2004 Jan; 10(1):15-22. PMID: 15058521.
      Citations: 8     Fields:    Translation:Humans
    127. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res. 2003; 4:14. PMID: 14748924; PMCID: PMC314398.
      Citations: 49     Fields:    Translation:Humans
    128. Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Bleecker ER, Lange EM, Rich SS, Meyers DA, Ober C, Cox NJ, Collaborative Study for the Genetics of Asthma. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol. 2003 Apr; 111(4):840-6. PMID: 12704367.
      Citations: 43     Fields:    Translation:HumansPHPublic Health
    129. Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, Tanabe T, Chen FF, Foster SJ, Duerr RH, Brant SR, Cho JH, Nuñez G. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology. 2003 Jan; 124(1):140-6. PMID: 12512038.
      Citations: 141     Fields:    Translation:HumansCells
    130. Gu Z, Nicolae D, Lu HH, Li WH, Gu Z, Nicolae D, Lu HH, Li WH. Rapid divergence in expression between duplicate genes inferred from microarray data. Trends Genet. 2002 Dec; 18(12):609-13. PMID: 12446139.
      Citations: 142     Fields:    Translation:Animals
    131. Michael N, Martin TE, Nicolae D, Kim N, Padjen K, Zhan P, Nguyen H, Pinkert C, Storb U, Michael N, Martin TE, Nicolae D, Kim N, Padjen K, Zhan P, Nguyen H, Pinkert C, Storb U. Effects of sequence and structure on the hypermutability of immunoglobulin genes. Immunity. 2002 Jan; 16(1):123-34. PMID: 11825571.
      Citations: 28     Fields:    Translation:Animals
    132. Nicolae DL, Cox NJ. MERLIN...and the geneticist's stone? Nat Genet. 2002 Jan; 30(1):3-4. PMID: 11753377.
      Citations: 2     Fields:    Translation:HumansAnimals
    133. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Cho JH, Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Cho JH. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001 May 31; 411(6837):603-6. PMID: 11385577.
      Citations: 1479     Fields:    Translation:HumansCells
    134. Kong A, Nicolae DL. On a randomization procedure. Am J Hum Genet. 2000 Nov; 67(5):1352-6. PMID: 11032791; PMCID: PMC1288579.
      Citations:    Fields:    Translation:Humans
    135. Cho JH, Nicolae DL, Ramos R, Fields CT, Rabenau K, Corradino S, Brant SR, Espinosa R, LeBeau M, Hanauer SB, Bodzin J, Bonen DK. Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease. Hum Mol Genet. 2000 May 22; 9(9):1425-32. PMID: 10814724.
      Citations: 15     Fields:    Translation:HumansCells
    136. Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet. 1999 Feb; 21(2):213-5. PMID: 9988276.
      Citations: 105     Fields:    Translation:HumansCells
    137. Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, Pickles MR, Qin L, Fu Y, Mann JS, Kirschner BS, Jabs EW, Weber J, Hanauer SB, Bayless TM, Brant SR. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7502-7. PMID: 9636179; PMCID: PMC22666.
      Citations: 87     Fields:    Translation:HumansCells
    138. Sweeney PJ, Nicolae D, Ignacio L, Chen L, Roach M, Wara W, Marcus KC, Vijayakumar S. Effect of subcutaneous recombinant human erythropoietin in cancer patients receiving radiotherapy: final report of a randomized, open-labelled, phase II trial. Br J Cancer. 1998 Jun; 77(11):1996-2002. PMID: 9667681; PMCID: PMC2150364.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
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