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Kay Macleod

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Understanding the role of mitochondria in tissue homeostasis and cancer.
    The Macleod Lab investigates how control of mitochondrial mass, mitochondrial function and mitochondrial signaling affects cellular responses to stress, homeostatic control of tissue maintenance and influences tumor growth and progression to malignancy. We use cutting edge approaches in cell and molecular biology, systems biology, novel mouse models and human patient samples to ask some of the most important questions about how mitochondria control tissue homeostasis, and how mitochondrial dysfunction contributes to cancer progression and metastasis. For example, we examine how BNIP3-dependent mitophagy is essential for proper metabolic zonation in the liver across the hypoxic gradient making up the liver lobule and how loss of BNIP3 promotes hepatic steatosis and liver cancer. This tumor suppressive role of BNIP3 involves coordinated turnover of lipid droplets with mitochondria at the autolysosome in a process we have termed “mitolipophagy”. In addition, we address how the BNIP3-related protein, BNIP3L (or NIX) which is also a mitochondrial cargo receptor, shares mitophagy functions with BNIP3 but we are increasingly focused on the divergent properties of BNIP3 and NIX in cellular growth control, both in the liver and in the pancreas. Our work indicates that while BNIP3 and NIX share functions in mitophagy in various tissues, they also possess unique growth control properties that explain how BNIP3 functions to suppress tumor growth while NIX acts as a tumor promoter. Ongoing work is addressing these functions in hepatocellular carcinoma, pancreatic ductal adenocarcinoma and in muscle atrophy linked to cancer cachexia. In other areas, we are examining how defects in mitophagy can promote tumor responses to chemotherapy and radiotherapy. Finally, we are examining how mitochondrial stress affects other signaling pathways in the cell.

    Collapse Biography 
    Collapse education and training
    University of Edinburgh, ScotlandB.Sc. (Hons)Molecular Biology
    The Beatson Institute for Cancer Research, University of Glasgow, ScotlandPh.D.Cancer Biology
    The Massachusetts Institute of Technology, Cambridge, MAPost-doctoral fellowThe RB tumor suppressor
    Collapse awards and honors
    2002 - 2004Raymond F Zelko Young Investigator, The Cancer Research Foundation, University of Chicago
    2002 - 2004V Foundation Scholar, University of Chicago
    2014 - 2016The Fletcher Scholar Award, The Cancer Research Foundation, University of Chicago
    2016Faculty Marshall, Divisional Academic Ceremony of the Biological Sciences Division, University of Chicago
    2018Scientist of the Month (November 2018), American Women in Science, Chicago Chapter, University of Chicago
    2020Womens Board Senior Scholar, The Cancer Research Foundation, University of Chicago
    2023UCCCC Janet Rowley Discovery Award, University of Chicago

    Collapse Research 
    Collapse research activities and funding
    2R01CA200310-06     (Kay Macleod)Jun 1, 2023 - May 31, 2028
    NIH/NCI
    BNIP3 and BNIP3L (NIX) in lipid homeostasis and growth control in the liver
    Role Description: The proposed research examines the role of BNIP3, BNIP3L (NIX) and mitophagy in control of lipid metabolism in the liver, de-regulation of which has significance for understanding the link between fatty liver disease and hepatocellular carcinoma.
    Role: PI

    R01CA216242     (MACLEOD, KAY F)Mar 15, 2017 - Feb 28, 2022
    NIH
    (PQ5) Consequences of imbalanced mitophagy and mitochondrial biogenesis in cancer
    Role: Principal Investigator

    R01CA162405     (MACLEOD, KAY F)Aug 13, 2012 - Jun 30, 2017
    NIH
    Autophagy in Tumor Progression and Metastasis
    Role: Principal Investigator

    R01CA131188     (MACLEOD, KAY F)Feb 1, 2009 - Dec 31, 2013
    NIH
    Functions of BNIP3 in Mammary Tumorigenesis
    Role: Principal Investigator

    R01HL080262     (MACLEOD, KAY F)Apr 1, 2005 - Mar 31, 2010
    NIH
    Functions of pRb in Stress Erythropoiesis
    Role: Principal Investigator

    T32CA009594     (MACLEOD, KAY F)Sep 22, 1989 - Jun 30, 2024
    NIH
    Multi-Disciplinary Training grant in Cancer Research
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu Y, Carbonetto P, Willwerscheid J, Oakes SA, Macleod KF, Stephens M. DISSECTING TUMOR TRANSCRIPTIONAL HETEROGENEITY FROM SINGLE-CELL RNA-SEQ DATA BY GENERALIZED BINARY COVARIANCE DECOMPOSITION. bioRxiv. 2023 Aug 17. PMID: 37645713; PMCID: PMC10462040.
      Citations:    
    2. Apiz Saab JJ, Dzierozynski LN, Jonker PB, AminiTabrizi R, Shah H, Menjivar RE, Scott AJ, Nwosu ZC, Zhu Z, Chen RN, Oh M, Sheehan C, Wahl DR, Pasca di Magliano M, Lyssiotis CA, Macleod KF, Weber CR, Muir A. Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis. Elife. 2023 05 31; 12. PMID: 37254839; PMCID: PMC10260022.
      Citations: 5     Fields:    Translation:AnimalsCells
    3. Berardi DE, Bock-Hughes A, Terry AR, Drake LE, Bozek G, Macleod KF. Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner. Sci Adv. 2022 Oct 14; 8(41):eabo2510. PMID: 36223464; PMCID: PMC9555787.
      Citations: 9     Fields:    
    4. Poole LP, Bock-Hughes A, Berardi DE, Macleod KF. ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3. Sci Rep. 2021 10 15; 11(1):20526. PMID: 34654847; PMCID: PMC8519931.
      Citations: 27     Fields:    Translation:HumansCells
    5. Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Karantza V, Kraft C, Ktistakis NT, Kumar S, Macleod KF, Madeo F, Martinez J, Mizushima N, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Colombo MI, Jäättelä M, Johansen T, Juhász G, Kroemer G, Lopez-Otin C, Meléndez A, Münz C. Autophagy in major human diseases. EMBO J. 2021 10 01; 40(19):e108863. PMID: 34459017; PMCID: PMC8488577.
      Citations: 327     Fields:    Translation:HumansAnimalsCells
    6. Poole LP, Macleod KF. Mitophagy in tumorigenesis and metastasis. Cell Mol Life Sci. 2021 Apr; 78(8):3817-3851. PMID: 33580835; PMCID: PMC8259496.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    7. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almasan A, Alonso A, Altan-Bonnet N, Altieri DC, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antebi A, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araya J, Arden C, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Aroca A, Arsov I, Asaro DML, Aschner M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bao Y, Baracca A, Barbati C, Bargiela A, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baumgarner BL, Beale R, Bechara LRG, Beck GR, Beers MF, Begun J, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Bellarosa C, Belleudi F, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bose S, Botana LM, Botas J, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Bultynck G, Burada F, Burgoyne JR, Bustos V, Butturini E, Byrd A, Cadwell K, Cai J, Cai L, Cai Q, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campello S, Campos JC, Canesi L, Caniggia I, Canonico B, Cao B, Caraglia M, Carchman EH, Cardenas C, Cardoso SM, Carew JS, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carosi JM, Carra S, Carrier L, Carroll B, Carter AB, Carvalho AN, Casas J, Cassioli C, Castillo EF, Castillo-Lluva S, Castori M, Castro-Caldas M, Catz SD, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela ML, Cebollada Rica P, Cecarini V, Cechowska-Pasko M, Cenci S, Cervia D, Cetintas VB, Cetrullo S, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chakrabarti O, Chakraborty T, Chakraborty T, Chamilos G, Chan DW, Chan EYW, Chan ED, Chan HYE, Chan HH, Chan H, Chan MTV, Chan YS, Chandra PK, Chang CP, Chang C, Chang HC, Chang K, Chao J, Chapman T, Chatterjee S, Chaube SK, Chaudhary A, Chauhan S, Chaum E, Cheetham ME, Chen CS, Chen GC, Chen JF, Chen LL, Chen L, Chen L, Chen M, Chen MK, Chen N, Chen Q, Chen RH, Chen S, Chen W, Chen W, Chen XM, Chen XW, Chen X, Chen Y, Chen YG, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen ZS, Chen Z, Chen ZH, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751; PMCID: PMC7996087.
      Citations: 821     Fields:    Translation:HumansAnimalsCells
    8. Springer MZ, Poole LP, Drake LE, Bock-Hughes A, Boland ML, Smith AG, Hart J, Chourasia AH, Liu I, Bozek G, Macleod KF. BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver. Autophagy. 2021 11; 17(11):3530-3546. PMID: 33459136; PMCID: PMC8632322.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    9. . Mitophagy and Mitochondrial Dysfunction in Cancer. Annual Review of Cancer Biology. 2020; 4:41 - 60. View Publication.
    10. Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E. Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma. Cancer Lett. 2020 02 28; 471:49-60. PMID: 31830557; PMCID: PMC6980748.
      Citations: 9     Fields:    Translation:Humans
    11. Anderson CM, Macleod KF. Autophagy and cancer cell metabolism. Int Rev Cell Mol Biol. 2019; 347:145-190. PMID: 31451213; PMCID: PMC8211395.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer. Cancer Discov. 2019 09; 9(9):1268-1287. PMID: 31263025; PMCID: PMC6726540.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    13. Smith AG, Macleod KF. Autophagy, cancer stem cells and drug resistance. J Pathol. 2019 04; 247(5):708-718. PMID: 30570140; PMCID: PMC6668344.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    14. Fessenden TB, Beckham Y, Perez-Neut M, Ramirez-San Juan G, Chourasia AH, Macleod KF, Oakes PW, Gardel ML. Dia1-dependent adhesions are required by epithelial tissues to initiate invasion. J Cell Biol. 2018 04 02; 217(4):1485-1502. PMID: 29437785; PMCID: PMC5881494.
      Citations: 15     Fields:    Translation:AnimalsCells
    15. Mowers EE, Sharifi MN, Macleod KF. Functions of autophagy in the tumor microenvironment and cancer metastasis. FEBS J. 2018 05; 285(10):1751-1766. PMID: 29356327; PMCID: PMC5992019.
      Citations: 100     Fields:    Translation:HumansCells
    16. Kathayat RS, Cao Y, Elvira PD, Springer MZ, Drake LE, Macleod KF, Dickinson BC, Sandoz PA, Zaballa ME, van der Goot FG. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018 01 23; 9(1):334. PMID: 29362370; PMCID: PMC5780395.
      Citations: 39     Fields:    Translation:HumansCells
    17. Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Cichowski K, Maertens O. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov. 2017 12; 7(12):1450-1463. PMID: 28963352; PMCID: PMC5718976.
      Citations: 52     Fields:    Translation:HumansCells
    18. Drake LE, Springer MZ, Poole LP, Kim CJ, Macleod KF. Expanding perspectives on the significance of mitophagy in cancer. Semin Cancer Biol. 2017 12; 47:110-124. PMID: 28450176; PMCID: PMC5654704.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    19. Zhou D, Springer MZ, Xu D, Liu D, Hudmon A, Macleod KF, Meroueh SO. Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth. Bioorg Med Chem. 2017 06 15; 25(12):2995-3005. PMID: 28438385; PMCID: PMC6668347.
      Citations: 3     Fields:    Translation:HumansCells
    20. Qiang L, Sample A, Shea CR, Soltani K, Macleod KF, He YY. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy. 2017; 13(12):2086-2103. PMID: 28933598; PMCID: PMC5788558.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    21. Springer MZ, Macleod KF. In Brief: Mitophagy: mechanisms and role in human disease. J Pathol. 2016 11; 240(3):253-255. PMID: 27453450; PMCID: PMC5071152.
      Citations: 62     Fields:    Translation:HumansCells
    22. Mowers EE, Sharifi MN, Macleod KF. Autophagy in cancer metastasis. Oncogene. 2017 03 23; 36(12):1619-1630. PMID: 27593926; PMCID: PMC5337449.
      Citations: 220     Fields:    Translation:HumansAnimalsCells
    23. Mowers EE, Sharifi MN, Macleod KF. Novel insights into how autophagy regulates tumor cell motility. Autophagy. 2016 09; 12(9):1679-80. PMID: 27439889; PMCID: PMC5082768.
      Citations: 15     Fields:    Translation:HumansCells
    24. Sharifi MN, Mowers EE, Macleod KF. Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. Mol Cell Oncol. 2017; 4(2):e1198299. PMID: 28401177; PMCID: PMC5383354.
      Citations: 4     
    25. Sharifi MN, Mowers EE, Drake LE, Collier C, Chen H, Zamora M, Mui S, Macleod KF. Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep. 2016 05 24; 15(8):1660-72. PMID: 27184837; PMCID: PMC4880529.
      Citations: 153     Fields:    Translation:AnimalsCells
    26. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Akematsu T, Akporiaye ET, Al-Rubeai M, Albanese C, Albani D, Albert ML, Aldudo J, Alirezaei M, Alloza I, Almasan A, Alnemri ES, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bao H, Barrachina MD, Barreiro E, Bartel B, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beck GR, Beckham JD, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernassola F, Bertolotti A, Bess AS, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bingol B, Bird SW, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Bonaldo P, Bordi M, Boulton ME, Bouret SG, Bozhkov PV, Brady N, Braga VM, Brancolini C, Brennan LA, Bresnick EH, Brest P, Bridges D, Brini M, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burke RE, Burmeister M, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Campanella M, Campbell GR, Campbell M, Campello S, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carroll B, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Cervia D, Cetrullo S, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clarke PG, Clarke R, Clementi E, Cnop M, Cocco T, Cohen EE, Colecchia D, Coletto L, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977.
      Citations: 2804     Fields:    Translation:HumansAnimals
    27. Chourasia AH, Tracy K, Frankenberger C, Boland ML, Sharifi MN, Drake LE, Sachleben JR, Asara JM, Locasale JW, Karczmar GS, Macleod KF. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep. 2015 Sep; 16(9):1145-63. PMID: 26232272; PMCID: PMC4576983.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    28. Fan X, Macleod K, Mustafi D, Conzen SD, Markiewicz E, Zamora M, Vosicky J, Mueller J, Karczmar GS. Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers. PLoS One. 2015; 10(7):e0129212. PMID: 26208092; PMCID: PMC4514815.
      Citations: 3     Fields:    Translation:Animals
    29. Chourasia AH, Boland ML, Macleod KF. Mitophagy and cancer. Cancer Metab. 2015; 3:4. PMID: 25810907; PMCID: PMC4373087.
      Citations: 114     
    30. Sharifi MN, Mowers EE, Drake LE, Macleod KF. Measuring autophagy in stressed cells. Methods Mol Biol. 2015; 1292:129-50. PMID: 25804753; PMCID: PMC4460991.
      Citations: 40     Fields:    Translation:HumansAnimals
    31. Chourasia AH, Macleod KF. Tumor suppressor functions of BNIP3 and mitophagy. Autophagy. 2015; 11(10):1937-8. PMID: 26315353; PMCID: PMC4824596.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    32. Fan X, Mustafi D, Markiewicz E, Zamora M, Vosicky J, Leinroth A, Mueller J, Macleod K, Conzen SD, Karczmar GS. Mammary cancer initiation and progression studied with magnetic resonance imaging. Breast Cancer Res. 2014 Dec 16; 16(6):495. PMID: 25510596; PMCID: PMC4303211.
      Citations: 7     Fields:    Translation:Animals
    33. Markiewicz E, Fan X, Mustafi D, Zamora M, Roman BB, Jansen SA, Macleod K, Conzen SD, Karczmar GS. High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media. Magn Reson Imaging. 2015 Jan; 33(1):161-5. PMID: 25179139; PMCID: PMC4267960.
      Citations: 5     Fields:    Translation:Animals
    34. Kuo WL, Sharifi MN, Lingen MW, Ahmed O, Liu J, Nagilla M, Macleod KF, Cohen EE. p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors. PLoS One. 2014; 9(3):e90171. PMID: 24599075; PMCID: PMC3943907.
      Citations: 16     Fields:    Translation:HumansCells
    35. Drake LE, Macleod KF. Tumour suppressor gene function in carcinoma-associated fibroblasts: from tumour cells via EMT and back again? J Pathol. 2014 Feb; 232(3):283-8. PMID: 24254977; PMCID: PMC6664431.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    36. Boland ML, Chourasia AH, Macleod KF. Mitochondrial dysfunction in cancer. Front Oncol. 2013 Dec 02; 3:292. PMID: 24350057; PMCID: PMC3844930.
      Citations: 209     
    37. Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW, Brady MJ, Macleod KF. BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol. 2012 Jul; 32(13):2570-84. PMID: 22547685; PMCID: PMC3434502.
      Citations: 130     Fields:    Translation:AnimalsCells
    38. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bourquin JP, Boya P, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, Ghosh P, Giammarioli AM, Giatromanolaki AN, Gibson SB, Gilkerson RW, Ginger ML, Ginsberg HN, Golab J, Goligorsky MS, Golstein P, Gomez-Manzano C, Goncu E, Gonzalez CD, Gonzalez R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      Citations: 1819     Fields:    Translation:HumansAnimals
    39. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K, Maertens O. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929; PMCID: PMC3233475.
      Citations: 144     Fields:    Translation:AnimalsCells
    40. Szmulewitz RZ, Clark R, Lotan T, Otto K, Taylor Veneris J, Macleod K, Rinker-Schaeffer C. MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression. Int J Cancer. 2012 Feb 01; 130(3):509-20. PMID: 21351092; PMCID: PMC3465713.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Macleod KF. The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? J Clin Invest. 2010 Dec; 120(12):4179-82. PMID: 21099103; PMCID: PMC2993607.
      Citations: 16     Fields:    Translation:Humans
    42. Barth S, Glick D, Macleod KF. Autophagy: assays and artifacts. J Pathol. 2010 Jun; 221(2):117-24. PMID: 20225337; PMCID: PMC2989884.
      Citations: 378     Fields:    Translation:HumansAnimalsCells
    43. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010 May; 221(1):3-12. PMID: 20225336; PMCID: PMC2990190.
      Citations: 1422     Fields:    Translation:HumansAnimalsCells
    44. Liu H, Knabb JR, Spike BT, Macleod KF. Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. Mol Cancer Res. 2009 Jul; 7(7):1099-109. PMID: 19584263; PMCID: PMC2994938.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    45. Macleod KF. The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat Rev Cancer. 2008 Oct; 8(10):769-81. PMID: 18800074; PMCID: PMC2989879.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    46. Taylor JL, Szmulewitz RZ, Lotan T, Hickson J, Griend DV, Yamada SD, Macleod K, Rinker-Schaeffer CW. New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells. Cancer Lett. 2008 Dec 08; 272(1):12-22. PMID: 18572308.
      Citations: 16     Fields:    Translation:Humans
    47. Lotan T, Hickson J, Souris J, Huo D, Taylor J, Li T, Otto K, Yamada SD, Macleod K, Rinker-Schaeffer CW. c-Jun NH2-terminal kinase activating kinase 1/mitogen-activated protein kinase kinase 4-mediated inhibition of SKOV3ip.1 ovarian cancer metastasis involves growth arrest and p21 up-regulation. Cancer Res. 2008 Apr 01; 68(7):2166-75. PMID: 18381422; PMCID: PMC3484373.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    48. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Cleveland JL, Codogno P, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Finley KD, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gorski S, Gottlieb RA, He YW, Heidenreich K, Hill JA, Hu X, Huang WP, Iwasaki A, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL, Clavé C, Colombo MI, Dröge W, Fésüs L, Fuentes JM, González-Estévez C, Häussinger D, Høyer-Hansen M, Jäättelä M, Kovács AL, López-Otín C, Meléndez A, Münz C, Nürnberg B, Rohrer B, Sass M, Tallóczy Z, Uzcátegui NL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. PMID: 18188003; PMCID: PMC2654259.
      Citations: 1203     Fields:    Translation:HumansAnimalsCells
    49. Dirlam A, Spike BT, Macleod KF. Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007 Dec; 27(24):8713-28. PMID: 17923680; PMCID: PMC2169398.
      Citations: 39     Fields:    Translation:AnimalsCells
    50. Tracy K, Macleod KF. Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy. 2007 Nov-Dec; 3(6):616-9. PMID: 17786027; PMCID: PMC2989881.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    51. Spike BT, Macleod KF. Effects of hypoxia on heterotypic macrophage interactions. Cell Cycle. 2007 Nov 01; 6(21):2620-4. PMID: 17873523; PMCID: PMC2989883.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    52. Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007 Sep; 27(17):6229-42. PMID: 17576813; PMCID: PMC1952167.
      Citations: 212     Fields:    Translation:HumansAnimalsCells
    53. Spike BT, Dibling BC, Macleod KF. Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse. Blood. 2007 Sep 15; 110(6):2173-81. PMID: 17557897; PMCID: PMC1976369.
      Citations: 18     Fields:    Translation:AnimalsCells
    54. Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6794-9. PMID: 17420462; PMCID: PMC1849960.
      Citations: 86     Fields:    Translation:AnimalsCells
    55. Liu HP, Thompson AM, Macleod KF. A novel form of pRb expressed during normal myelopoiesis and in tumour-associated macrophages. Cell Prolif. 2005 Feb; 38(1):13-24. PMID: 15679863; PMCID: PMC6495145.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    56. Spike BT, Macleod KF. The Rb tumor suppressor in stress responses and hematopoietic homeostasis. Cell Cycle. 2005 Jan; 4(1):42-5. PMID: 15611658.
      Citations: 15     Fields:    Translation:HumansAnimals
    57. Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T, Macleod KF. The Rb tumor suppressor is required for stress erythropoiesis. EMBO J. 2004 Oct 27; 23(21):4319-29. PMID: 15457215; PMCID: PMC524396.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    58. Liu H, Dibling B, Spike B, Dirlam A, Macleod K. New roles for the RB tumor suppressor protein. Curr Opin Genet Dev. 2004 Feb; 14(1):55-64. PMID: 15108806.
      Citations: 20     Fields:    Translation:Humans
    59. Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J. 2001 Jul 02; 20(13):3402-13. PMID: 11432828; PMCID: PMC125524.
      Citations: 33     Fields:    Translation:AnimalsCells
    60. Macleod KF, Jacks T. Insights into cancer from transgenic mouse models. J Pathol. 1999 Jan; 187(1):43-60. PMID: 10341706.
      Citations: 23     Fields:    Translation:Animals
    61. Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell. 1998 Sep; 2(3):293-304. PMID: 9774968.
      Citations: 123     Fields:    Translation:AnimalsCells
    62. Macleod KF, Hu Y, Jacks T. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 1996 Nov 15; 15(22):6178-88. PMID: 8947040; PMCID: PMC452439.
      Citations: 99     Fields:    Translation:AnimalsCells
    63. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 1995 Apr 15; 9(8):935-44. PMID: 7774811.
      Citations: 320     Fields:    Translation:AnimalsCells
    64. Plaza S, Grevin D, MacLeod K, Stehelin D, Saule S. Pax-QNR/Pax-6, a paired- and homeobox-containing protein, recognizes Ets binding sites and can alter the transactivating properties of Ets transcription factors. Gene Expr. 1994; 4(1-2):43-52. PMID: 7841787; PMCID: PMC6134372.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    65. Macleod K, Leprince D, Stehelin D. The ets gene family. Trends Biochem Sci. 1992 Jul; 17(7):251-6. PMID: 1502727.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    66. Macleod K, Plumb M. Derepression of mouse beta-major-globin gene transcription during erythroid differentiation. Mol Cell Biol. 1991 Sep; 11(9):4324-32. PMID: 1875923; PMCID: PMC361293.
      Citations: 10     Fields:    Translation:AnimalsCells
    67. Harrison PR, Plumb M, Frampton J, Thiele B, Macleod K, Chester J, Chambers I, Fleming J, O'Prey J, Walker M, et al. Regulation of erythroid-specific gene expression. Biomed Biochim Acta. 1990; 49(2-3):S5-10. PMID: 2117451.
      Citations:    Fields:    Translation:AnimalsCells
    68. Plumb M, Frampton J, Wainwright H, Walker M, Macleod K, Goodwin G, Harrison P. GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression. Nucleic Acids Res. 1989 Jan 11; 17(1):73-92. PMID: 2911489; PMCID: PMC331536.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    69. Harrison PR, Plumb M, Frampton J, Llewellyn D, Chester J, Chambers I, MacLeod K, Fleming J, O'Prey J, Walker M, et al. Regulation of erythroid cell-specific gene expression during erythropoiesis. Br J Cancer Suppl. 1988 Dec; 9:46-51. PMID: 3151147; PMCID: PMC2149114.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    70. Isamat M, Macleod KF, King A, McEwan C, Melton DW. Characterization, evolutionary relationships, and chromosome location of processed mouse HPRT pseudogene. Somat Cell Mol Genet. 1988 Jul; 14(4):359-69. PMID: 2899912.
      Citations: 4     Fields:    Translation:AnimalsCells
    71. Harrison PR, Plumb M, Frampton J, Chambers I, Llewellyn D, Chester J, Macleod K, Fleming J, O'Prey J, Walker M, et al. cis and trans control of erythroid cell-specific gene expression during erythropoiesis. J Cell Sci Suppl. 1988; 10:145-55. PMID: 3152055.
      Citations:    Fields:    Translation:Animals
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