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Yingming Zhao

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Post-translational modifications (PTMs) represent a major vehicle to diversify a cellular proteome, the inventory of all protein species in an organism. PTMs have critical roles in all the major cellular pathways and diseases. A protein can be potentially modified by more than 300 types of post-translational modifications, which are catalyzed by enzymes encoded by more than 5% of the genome in higher eukaryotes. A combination of a dozen PTM sites in a substrate protein could lead to more than a million possible protein structures with potentially different functions. Given the high abundance and diversities of PTMs, they are likely the most complex regulatory mechanisms in cells. Despite their critical roles in cells, little is known about their biology, except several most extensively studied PTMs. Functional characterizations of PTMs at the molecular level have been slow, largely due to a lack of suitable information infrastructure and technology infrastructure.

    Collapse Biography 
    Collapse education and training
    The Rockefeller University, New York cityPhD1997

    Collapse Research 
    Collapse research activities and funding
    R01AR078555     (LIN, HENING ;ZHAO, YINGMING)Jul 1, 2021 - Apr 30, 2026
    NIH
    Histone lactylation pathway in hair cycle: deacylases and their protein targets
    Role: Principal Investigator
    R01CA251677     (BECKER, LEV ;ZHAO, YINGMING)Mar 1, 2021 - Feb 28, 2026
    NIH
    Lactate production by tumor associated macrophages promotes tumorigenesis
    Role: Co-Principal Investigator
    R01GM135504     (ZHAO, YINGMING)Mar 15, 2020 - Feb 29, 2024
    NIH
    Systematic screening for new histone marks and studying their epigenetic function
    Role: Principal Investigator
    R01DK118266     (ZHAO, YINGMING)Jul 1, 2018 - Jun 30, 2022
    NIH
    Biochemistry of the lysine beta-hydroxybutyrylation pathway
    Role: Principal Investigator
    R01GM115961     (ZHAO, YINGMING)Jun 20, 2016 - Mar 31, 2020
    NIH
    Systems-wide analysis of histone lysine 2-hydroxyisobutyrylation pathway
    Role: Principal Investigator
    R01DK107868     (LIN, HENING)Feb 1, 2016 - Jan 31, 2021
    NIH
    SIRT6 and lysine fatty acylation in macrophage inflammation
    Role: Co-Principal Investigator
    R01GM105933     (ZHAO, YINGMING)May 1, 2013 - Feb 28, 2017
    NIH
    Biochemistry of lysine crotonylation pathway
    Role: Principal Investigator
    R01DK082664     (ZHAO, YINGMING)Sep 30, 2008 - Aug 31, 2012
    NIH
    Systematic screening for new histone marks
    Role: Principal Investigator
    R01CA126832     (ZHAO, YINGMING)Jun 1, 2008 - Apr 30, 2013
    NIH
    Global characterization of lysine acetylation in cancer by a proteomics approach
    Role: Principal Investigator
    R33CA107943     (ZHAO, YINGMING)Jun 7, 2004 - Mar 31, 2010
    NIH
    A Novel Proteomics Technology for Protein Farnesylation
    Role: Principal Investigator
    R21CA107943     (ZHAO, YINGMING)Jun 7, 2004 - Mar 31, 2006
    NIH
    A Novel Proteomics Technology for Protein Farnesylation
    Role: Principal Investigator
    U01CA085146     (ZHAO, YINGMING)Sep 30, 1999 - Aug 31, 2005
    NIH
    IDENTIFICATION OF PROSTATE AND OVARIAN CANCER MARKERS
    Role: Principal Investigator
    S10RR013794     (ZHAO, YINGMING)Jun 1, 1999 - May 31, 2000
    NIH
    MALDI/TOF MASS SPECTROMETER SHARED INSTRUMENT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang H, Zhang D, Wang Y, Perez-Neut M, Han Z, Zheng YG, Hao Q, Zhao Y. Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 08 28; 9(1):3374. PMID: 30154464; PMCID: PMC6113264.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    2. Huang H, Tang S, Ji M, Tang Z, Shimada M, Liu X, Qi S, Locasale JW, Roeder RG, Zhao Y, Li X. p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Mol Cell. 2018 06 07; 70(5):984. PMID: 29883613; PMCID: PMC6037533.
      Citations: 18     Fields:    
    3. Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, Dai L, Shimada M, Cross JR, Zhao Y, Roeder RG, Allis CD. Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation. Mol Cell. 2018 02 01; 69(3):533. PMID: 29395068; PMCID: PMC5808432.
      Citations: 31     Fields:    
    4. Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 2018 01; 28(1):111-125. PMID: 29192674; PMCID: PMC5752845.
      Citations: 48     Fields:    Translation:HumansCells
    5. Lombard DB, Zhao Y. ACSF3 and Mal(onate)-Adapted Mitochondria. Cell Chem Biol. 2017 Jun 22; 24(6):649-650. PMID: 28644952.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Sabari BR, Zhang D, Allis CD, Zhao Y. Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol. 2017 02; 18(2):90-101. PMID: 27924077; PMCID: PMC5320945.
      Citations: 389     Fields:    Translation:HumansAnimalsCells
    7. Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine ß-Hydroxybutyrylation. Mol Cell. 2016 04 21; 62(2):194-206. PMID: 27105115; PMCID: PMC5540445.
      Citations: 236     Fields:    Translation:HumansAnimalsCells
    8. Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, Zhao Y. Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. Mol Cell Proteomics. 2015 Nov; 14(11):3056-71. PMID: 26320211; PMCID: PMC4638046.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    9. Huang H, Sabari BR, Garcia BA, Allis CD, Zhao Y. SnapShot: histone modifications. Cell. 2014 Oct 09; 159(2):458-458.e1. PMID: 25303536; PMCID: PMC4324475.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    10. Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y, Mühlhausen C. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014 Apr 01; 19(4):605-17. PMID: 24703693; PMCID: PMC4108075.
      Citations: 342     Fields:    Translation:AnimalsCells
    11. Dai L, Peng C, Lu Z, Chen Y, Ishii H, Jin F, Sabari BR, Deng Z, Allis CD, Ren B, Zhao Y, Montellier E, Debernardi A, Buchou T, Rousseaux S, Khochbin S. Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol. 2014 May; 10(5):365-70. PMID: 24681537.
      Citations: 185     Fields:    Translation:HumansAnimalsCells
    12. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27; 50(6):919-30. PMID: 23806337; PMCID: PMC3769971.
      Citations: 424     Fields:    Translation:AnimalsCells
    13. Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, Buchou T, Cheng Z, Rousseaux S, Rajagopal N, Lu Z, Ye Z, Zhu Q, Wysocka J, Ye Y, Khochbin S, Ren B, Zhao Y. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 2011 Sep 16; 146(6):1016-28. PMID: 21925322; PMCID: PMC3176443.
      Citations: 758     Fields:    Translation:HumansAnimalsCells
    14. Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012658. PMID: 21908771; PMCID: PMC3237090.
      Citations: 333     Fields:    Translation:HumansCells
    15. Chen Y, Chen W, Cobb MH, Zhao Y. PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):761-6. PMID: 19136633; PMCID: PMC2630079.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
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