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Joanna Gemel

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Hematology and Oncology
AddressChicago IL 60637
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    Collapse education and training
    University of Warsaw, PolandPhD1988Biochemistry
    University of Warsaw, PolandMS1981Biochemistry
    University of Warsaw, PolandBS1980Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gemel J, Zhang J, Mao Y, Lapping-Carr G, Beyer EC. Circulating Small Extracellular Vesicles May Contribute to Vaso-Occlusive Crises in Sickle Cell Disease. J Clin Med. 2022 Feb 03; 11(3). PMID: 35160266.
      View in: PubMed
    2. Lapping-Carr G, Gemel J, Mao Y, Sparks G, Harrington M, Peddinti R, Beyer EC. Insights image for "Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells". Pediatr Res. 2021 03; 89(4):1036. PMID: 33790407.
      View in: PubMed
    3. Gemel J, Mao Y, Lapping-Carr G, Beyer EC. Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome. Int J Mol Sci. 2020 Nov 24; 21(23). PMID: 33255173.
      View in: PubMed
    4. Lapping-Carr G, Gemel J, Mao Y, Beyer EC. Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease. Front Physiol. 2020; 11:1063. PMID: 33013455.
      View in: PubMed
    5. Lapping-Carr G, Gemel J, Mao Y, Sparks G, Harrington M, Peddinti R, Beyer EC. Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells. Pediatr Res. 2021 03; 89(4):776-784. PMID: 32454519.
      View in: PubMed
    6. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164.
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    7. Gemel J, Kilkus J, Dawson G, Beyer EC. Connecting Exosomes and Connexins. Cancers (Basel). 2019 Apr 04; 11(4). PMID: 30987321.
      View in: PubMed
    8. Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 2017 01 17; 18(Suppl 1):7. PMID: 28124622.
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    9. Gemel J, Levy AE, Simon AR, Bennett KB, Ai X, Akhter S, Beyer EC. Connexin40 abnormalities and atrial fibrillation in the human heart. J Mol Cell Cardiol. 2014 Nov; 76:159-68. PMID: 25200600.
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    10. Gemel J, Simon AR, Patel D, Xu Q, Matiukas A, Veenstra RD, Beyer EC. Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated. J Mol Cell Cardiol. 2014 Sep; 74:330-9. PMID: 24973497.
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    11. Patel D, Gemel J, Xu Q, Simon AR, Lin X, Matiukas A, Beyer EC, Veenstra RD. Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties. FEBS Lett. 2014 Apr 17; 588(8):1458-64. PMID: 24457199.
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    12. Rutledge CA, Ng FS, Sulkin MS, Greener ID, Sergeyenko AM, Liu H, Gemel J, Beyer EC, Sovari AA, Efimov IR, Dudley SC. c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction. J Am Coll Cardiol. 2014 Mar 11; 63(9):928-34. PMID: 24361364.
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    13. Gemel J, Nelson TK, Burt JM, Beyer EC. Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer. J Membr Biol. 2012 Jun; 245(5-6):231-41. PMID: 22729648.
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    14. Allen MJ, Gemel J, Beyer EC, Lal R. Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J Biol Chem. 2011 Jun 24; 286(25):22139-46. PMID: 21543330.
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    15. Lin X, Gemel J, Glass A, Zemlin CW, Beyer EC, Veenstra RD. Connexin40 and connexin43 determine gating properties of atrial gap junction channels. J Mol Cell Cardiol. 2010 Jan; 48(1):238-45. PMID: 19486903.
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    16. Gemel J, Lin X, Collins R, Veenstra RD, Beyer EC. Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. Biochem Biophys Res Commun. 2008 May 02; 369(2):388-94. PMID: 18291099.
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    17. Gemel J, Lin X, Veenstra RD, Beyer EC. N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci. 2006 Jun 01; 119(Pt 11):2258-68. PMID: 16723732.
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    18. Wang M, Martínez AD, Berthoud VM, Seul KH, Gemel J, Valiunas V, Kumari S, Brink PR, Beyer EC. Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1185-93. PMID: 15979566.
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    19. Lin X, Gemel J, Beyer EC, Veenstra RD. Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1113-23. PMID: 15513960.
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    20. Gemel J, Valiunas V, Brink PR, Beyer EC. Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci. 2004 May 15; 117(Pt 12):2469-80. PMID: 15128867.
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    21. Musa H, Fenn E, Crye M, Gemel J, Beyer EC, Veenstra RD. Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions. J Physiol. 2004 Jun 15; 557(Pt 3):863-78. PMID: 15107469.
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    22. Valiunas V, Gemel J, Brink PR, Beyer EC. Gap junction channels formed by coexpressed connexin40 and connexin43. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1675-89. PMID: 11557558.
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    23. Luethy MH, Gemel J, Johnston ML, Mooney BP, Miernyk JA, Randall DD. Developmental expression of the mitochondrial pyruvate dehydrogenase complex in pea (Pisum sativum) seedlings. Physiol Plant. 2001 Aug; 112(4):559-566. PMID: 11473717.
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    24. Beyer EC, Gemel J, Martínez A, Berthoud VM, Valiunas V, Moreno AP, Brink PR. Heteromeric mixing of connexins: compatibility of partners and functional consequences. Cell Commun Adhes. 2001; 8(4-6):199-204. PMID: 12064588.
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    25. Beyer EC, Gemel J, Seul KH, Larson DM, Banach K, Brink PR. Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins. Braz J Med Biol Res. 2000 Apr; 33(4):391-7. PMID: 10775303.
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    26. Gemel J, Jacobsen C, MacArthur CA. Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. J Biol Chem. 1999 Feb 26; 274(9):6020-6. PMID: 10026229.
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    27. Gemel J, Gorry M, Ehrlich GD, MacArthur CA. Structure and sequence of human FGF8. Genomics. 1996 Jul 01; 35(1):253-7. PMID: 8661131.
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    28. Moore AL, Gemel J, Randall DD. The Regulation of Pyruvate Dehydrogenase Activity in Pea Leaf Mitochondria (The Effect of Respiration and Oxidative Phosphorylation). Plant Physiol. 1993 Dec; 103(4):1431-1435. PMID: 12232037.
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    29. Schuller KA, Gemel J, Randall DD. Monovalent Cation Activation of Plant Pyruvate Dehydrogenase Kinase. Plant Physiol. 1993 May; 102(1):139-143. PMID: 12231804.
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    30. Gemel J, Randall DD. Light regulation of leaf mitochondrial pyruvate dehydrogenase complex : role of photorespiratory carbon metabolism. Plant Physiol. 1992 Oct; 100(2):908-14. PMID: 16653075.
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    31. Gemel J. [Protein kinases and the photosynthetic activity of chloroplasts]. Postepy Biochem. 1989; 35(3):337-45. PMID: 2561691.
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    32. Gemel J, Kaniuga Z. Comparison of galactolipase activity and free fatty acid levels in chloroplasts of chill-sensitive and chill-resistant plants. Eur J Biochem. 1987 Jul 01; 166(1):229-33. PMID: 3595613.
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    33. Gemel J. [Role of phosphorylation and dephosphorylation of proteins in the regulation of the metabolic activity of chloroplasts]. Postepy Biochem. 1987; 33(1):7-28. PMID: 3313332.
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    34. Zablocki K, Gemel J, Bryla J. The inhibitory effect of octanoate, palmitate and oleate on glucose formation in rabbit kidney tubules. Biochim Biophys Acta. 1983 May 04; 757(1):111-8. PMID: 6838901.
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