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Martin Weigert

TitlePROFESSOR
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    R21AI059897     (WEIGERT, MARTIN G)Mar 15, 2004 - Feb 28, 2006
    NIH
    Receptor editing, Autoimmunity and Free Light Chain Pro*
    Role: Principal Investigator

    R01AI043532     (WEIGERT, MARTIN G)Aug 1, 1999 - Mar 31, 2004
    NIH
    GENETIC CONTROL OF AUTOIMMUNITY
    Role: Principal Investigator

    R21AI043532     (WEIGERT, MARTIN G)Apr 1, 1999 - Dec 31, 1999
    NIH
    GENETIC CONTROL OF AUTOIMMUNITY
    Role: Principal Investigator

    U09RG012585     (WEIGERT, MARTIN G)Jul 1, 1984 - Jun 30, 1991
    NIH
    ALLERGY &IMMUNOLOGY STUDY SECTION
    Role: Principal Investigator

    R01GM020964     (WEIGERT, MARTIN G)Jan 1, 1977 - Jul 31, 2012
    NIH
    Genetics and Regulation of Autoantibodies
    Role: Principal Investigator

    R37GM020964     (WEIGERT, MARTIN G)Jan 1, 1977 - Dec 31, 1996
    NIH
    GENETIC CONTROL OF ANTIBODY STRUCTURE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Royer-Chardon C, Costanza M, Cherix S, Piazzon N, Barcena C, Bisig B, Nardi V, Sarro R, Ambrosini G, Spertini O, Blum S, de Leval L, Sarkis R, Burri O, Schyrr F, Blum S, Weigert M, Deplancke B, Seitz A, Naveiras O. MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology. Mod Pathol. 2023 04; 36(4):100088. PMID: 36788087.
      Citations: 1     Fields:    Translation:HumansCells
    2. Wang Y, Liu J, Akatsu C, Zhang R, Zhang H, Zhu H, Liu K, Zhu HY, Min Q, Meng X, Cui C, Tang Y, Yu M, Li Y, Feng X, Wei H, Wen Z, Ji S, Weigert MG, Tsubata T, Wang JY. LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205629119. PMID: 36037365; PMCID: PMC9457450.
      Citations: 4     Fields:    Translation:HumansCells
    3. Kalinina O, Louzoun Y, Wang Y, Utset T, Weigert M. Origins and specificity of auto-antibodies in Sm+ SLE patients. J Autoimmun. 2018 06; 90:94-104. PMID: 29503043.
      Citations: 2     Fields:    Translation:HumansCells
    4. Perera J, Zheng Z, Li S, Gudjonson H, Kalinina O, Benichou JIC, Block KE, Louzoun Y, Yin D, Chong AS, Dinner AR, Weigert M, Huang H. Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Rep. 2016 10 04; 17(2):387-398. PMID: 27705788; PMCID: PMC5091085.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    5. Jennewein M, Bubel M, Metzger W, Weigert M, Pohlemann T, Oberringer M, Guthörl S. Two- and three-dimensional co-culture models of soft tissue healing: pericyte-endothelial cell interaction. Cell Tissue Res. 2016 08; 365(2):279-93. PMID: 27026609.
      Citations: 1     Fields:    Translation:HumansCells
    6. Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell. 2015 Aug 27; 162(5):1066-77. PMID: 26317470.
      Citations: 1179     Fields:    Translation:HumansCells
    7. Royer LA, Weigert M, Maghelli N, Jug F, Günther U, Sbalzarini IF, Myers EW. ClearVolume: open-source live 3D visualization for light-sheet microscopy. Nat Methods. 2015 Jun; 12(6):480-1. PMID: 26020498.
      Citations: 67     Fields:    
    8. Preuss KD, Pfreundschuh M, Weigert M, Fadle N, Regitz E, Kubuschok B. Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor. J Clin Invest. 2015 May; 125(5):2179. PMID: 25932679; PMCID: PMC4463221.
      Citations: 7     Fields:    
    9. Preuss KD, Pfreundschuh M, Weigert M, Fadle N, Regitz E, Kubuschok B. Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor. J Clin Invest. 2015 Jan; 125(1):316-23. PMID: 25485683; PMCID: PMC4382232.
      Citations: 12     Fields:    Translation:HumansCells
    10. Kalinina O, Wang Y, Sia K, Radic M, Weigert M, Cazenave PA. Light chain editors of anti-DNA receptors in human B cells. J Exp Med. 2014 Feb 10; 211(2):357-64. PMID: 24470445; PMCID: PMC3920568.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    11. Radic M, Weigert MG, Khan SN, Han J, Kalinina O, Luning Prak ET. Antibodies that bind complex glycosaminoglycans accumulate in the Golgi. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11958-63. PMID: 23818632; PMCID: PMC3718083.
      Citations: 3     Fields:    Translation:HumansCells
    12. Kishi Y, Higuchi T, Phoon S, Sakamaki Y, Kamiya K, Riemekasten G, Akiyoshi K, Weigert MG, Tsubata T. Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7811-6. PMID: 22547827; PMCID: PMC3356631.
      Citations: 12     Fields:    Translation:AnimalsCells
    13. Schoettler N, Ni D, Weigert M. B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. Mol Immunol. 2012 Jul; 51(3-4):273-82. PMID: 22516082; PMCID: PMC4264353.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    14. Ali Tabei SM, Li Y, Weigert M, Dinner AR. Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV. Vaccine. 2012 Jan 11; 30(3):607-13. PMID: 22119591.
      Citations: 5     Fields:    Translation:Humans
    15. Khan SN, Cox JV, Nishimoto SK, Chen C, Fritzler MJ, Hendershot LM, Weigert M, Radic M. Intra-Golgi formation of IgM-glycosaminoglycan complexes promotes Ig deposition. J Immunol. 2011 Sep 15; 187(6):3198-207. PMID: 21841132.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Meng W, Yunk L, Wang LS, Maganty A, Xue E, Cohen PL, Eisenberg RA, Weigert MG, Mancini SJ, Prak ET. Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol. 2011 Aug 15; 187(4):1835-44. PMID: 21746964; PMCID: PMC3150439.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. Kalinina O, Doyle-Cooper CM, Miksanek J, Meng W, Prak EL, Weigert MG. Alternative mechanisms of receptor editing in autoreactive B cells. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7125-30. PMID: 21471456; PMCID: PMC3084116.
      Citations: 17     Fields:    Translation:AnimalsCells
    18. Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. The Journal of Experimental Medicine. 1993. 177: 999-1008. J Immunol. 2011 Feb 01; 186(3):1303-12. PMID: 21248268.
      Citations: 3     Fields:    Translation:AnimalsCells
    19. Nudelman G, Weigert M, Louzoun Y. In-silico cell surface modeling reveals mechanism for initial steps of B-cell receptor signal transduction. Mol Immunol. 2009 Sep; 46(15):3141-50. PMID: 19631384.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. McKean D, Huppi K, Bell M, Staudt L, Gerhard W, Weigert M. Pillars article: generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA, 81: 3180-3184, May 1984. J Immunol. 2008 May 01; 180(9):5765-9. PMID: 18424692.
      Citations: 2     Fields:    Translation:AnimalsCells
    21. Khan SN, Witsch EJ, Goodman NG, Panigrahi AK, Chen C, Jiang Y, Cline AM, Erikson J, Weigert M, Prak ET, Radic M. Editing and escape from editing in anti-DNA B cells. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3861-6. PMID: 18310318; PMCID: PMC2268806.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    22. Cohn M, Mitchison NA, Paul WE, Silverstein AM, Talmage DW, Weigert M. Reflections on the clonal-selection theory. Nat Rev Immunol. 2007 Oct; 7(10):823-30. PMID: 17893695.
      Citations: 17     Fields:    Translation:HumansAnimals
    23. Hiemann R, Hilger N, Anderer U, Weigert M, Sack U, Michel J, Nitschke J, Böhm A. Automatic analysis of immunofluorescence patterns of HEp-2 cells. Ann N Y Acad Sci. 2007 Aug; 1109:358-71. PMID: 17785325.
      Citations: 14     Fields:    Translation:HumansCells
    24. Liu Y, Li L, Kumar KR, Xie C, Lightfoot S, Zhou XJ, Kearney JF, Weigert M, Mohan C. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. J Immunol. 2007 Jul 15; 179(2):1340-52. PMID: 17617627.
      Citations: 38     Fields:    Translation:AnimalsCells
    25. Doyle CM, Han J, Weigert MG, Prak ET. Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11264-9. PMID: 16847259; PMCID: PMC1544076.
      Citations: 20     Fields:    Translation:AnimalsCells
    26. Witsch EJ, Cao H, Fukuyama H, Weigert M. Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. J Exp Med. 2006 Jul 10; 203(7):1761-72. PMID: 16801398; PMCID: PMC2118344.
      Citations: 19     Fields:    Translation:AnimalsCells
    27. Sekiguchi DR, Yunk L, Gary D, Charan D, Srivastava B, Allman D, Weigert MG, Prak ET. Development and selection of edited B cells in B6.56R mice. J Immunol. 2006 Jun 01; 176(11):6879-87. PMID: 16709848.
      Citations: 30     Fields:    Translation:AnimalsCells
    28. Chen C, Li H, Tian Q, Beardall M, Xu Y, Casanova N, Weigert M. Selection of anti-double-stranded DNA B cells in autoimmune MRL-lpr/lpr mice. J Immunol. 2006 May 01; 176(9):5183-90. PMID: 16621982.
      Citations: 21     Fields:    Translation:AnimalsCells
    29. Hiemann R, Hilger N, Sack U, Weigert M. Objective quality evaluation of fluorescence images to optimize automatic image acquisition. Cytometry A. 2006 Mar; 69(3):182-4. PMID: 16496376.
      Citations: 10     Fields:    Translation:HumansCells
    30. Warmflash A, Weigert M, Dinner AR. Control of genotypic allelic inclusion through TCR surface expression. J Immunol. 2005 Nov 15; 175(10):6412-9. PMID: 16272293.
      Citations:    Fields:    Translation:HumansAnimalsCells
    31. Louzoun Y, Vider T, Weigert M. T-cell epitope repertoire as predicted from human and viral genomes. Mol Immunol. 2006 Feb; 43(6):559-69. PMID: 15927255.
      Citations: 15     Fields:    Translation:Humans
    32. Shlomchik MJ, Cooke A, Weigert M. Autoimmunity: The genes and phenotypes of autoimmunity. Curr Opin Immunol. 2004 Dec; 16(6):738-40. PMID: 15511666.
      Citations:    Fields:    Translation:HumansAnimals
    33. Radic MZ, Weigert M. Intricacies of anti-DNA autoantibodies. J Immunol. 2004 Mar 15; 172(6):3367; author reply 3367-8. PMID: 15004132.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Li Y, Louzoun Y, Weigert M. Editing anti-DNA B cells by Vlambdax. J Exp Med. 2004 Feb 02; 199(3):337-46. PMID: 14757741; PMCID: PMC2211795.
      Citations: 24     Fields:    Translation:AnimalsCells
    35. Louzoun Y, Weigert M, Bhanot G. Dynamical analysis of a degenerate primary and secondary humoral immune response. Bull Math Biol. 2003 May; 65(3):535-45. PMID: 12749538.
      Citations: 4     Fields:    Translation:AnimalsCells
    36. Li H, Jiang Y, Cao H, Radic M, Prak EL, Weigert M. Regulation of anti-phosphatidylserine antibodies. Immunity. 2003 Feb; 18(2):185-92. PMID: 12594946.
      Citations: 19     Fields:    Translation:AnimalsCells
    37. Sekiguchi DR, Eisenberg RA, Weigert M. Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells. J Exp Med. 2003 Jan 06; 197(1):27-39. PMID: 12515811; PMCID: PMC2193805.
      Citations: 23     Fields:    Translation:AnimalsCells
    38. Li Y, Li H, Ni D, Weigert M. Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med. 2002 Dec 16; 196(12):1543-52. PMID: 12486097; PMCID: PMC2196070.
      Citations: 37     Fields:    Translation:AnimalsCells
    39. Louzoun Y, Friedman T, Luning Prak E, Litwin S, Weigert M. Analysis of B cell receptor production and rearrangement. Part I. Light chain rearrangement. Semin Immunol. 2002 Jun; 14(3):169-90; discussion 221-22. PMID: 12160645.
      Citations: 10     Fields:    Translation:AnimalsCells
    40. Louzoun Y, Luning Prak E, Litwin S, Weigert M. D is for different-differences between H and L chain rearrangement. Semin Immunol. 2002 Jun; 14(3):239-41. PMID: 12160656.
      Citations: 5     Fields:    Translation:HumansAnimals
    41. Sekiguchi DR, Jainandunsing SM, Fields ML, Maldonado MA, Madaio MP, Erikson J, Weigert M, Eisenberg RA. Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cells. J Immunol. 2002 Apr 15; 168(8):4142-53. PMID: 11937575.
      Citations: 25     Fields:    Translation:AnimalsCells
    42. Li Y, Li H, Weigert M. Autoreactive B cells in the marginal zone that express dual receptors. J Exp Med. 2002 Jan 21; 195(2):181-8. PMID: 11805145; PMCID: PMC2193605.
      Citations: 100     Fields:    Translation:AnimalsCells
    43. Li H, Jiang Y, Prak EL, Radic M, Weigert M. Editors and editing of anti-DNA receptors. Immunity. 2001 Dec; 15(6):947-57. PMID: 11754816.
      Citations: 86     Fields:    Translation:AnimalsCells
    44. Cocca BA, Seal SN, D'Agnillo P, Mueller YM, Katsikis PD, Rauch J, Weigert M, Radic MZ. Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13826-31. PMID: 11717440; PMCID: PMC61126.
      Citations: 32     Fields:    Translation:HumansCells
    45. Nemazee D, Weigert M. Revising B cell receptors. J Exp Med. 2000 Jun 05; 191(11):1813-7. PMID: 10839798; PMCID: PMC2213535.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    46. Brard F, Shannon M, Prak EL, Litwin S, Weigert M. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med. 1999 Sep 06; 190(5):691-704. PMID: 10477553; PMCID: PMC2195620.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    47. Xu H, Li H, Suri-Payer E, Hardy RR, Weigert M. Regulation of anti-DNA B cells in recombination-activating gene-deficient mice. J Exp Med. 1998 Oct 05; 188(7):1247-54. PMID: 9763604; PMCID: PMC2212494.
      Citations: 24     Fields:    Translation:AnimalsCells
    48. Shannon M, Weigert M. Fixing mismatches. Science. 1998 Feb 20; 279(5354):1159-60. PMID: 9508690.
      Citations: 3     Fields:    Translation:AnimalsCells
    49. Shlomchik MJ, Watts P, Weigert MG, Litwin S. Clone: a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection. Curr Top Microbiol Immunol. 1998; 229:173-97. PMID: 9479855.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    50. Stewart JJ, Lee CY, Ibrahim S, Watts P, Shlomchik M, Weigert M, Litwin S. A Shannon entropy analysis of immunoglobulin and T cell receptor. Mol Immunol. 1997 Oct; 34(15):1067-82. PMID: 9519765.
      Citations: 83     Fields:    Translation:AnimalsCells
    51. Stewart JJ, Agosto H, Litwin S, Welsh JD, Shlomchik M, Weigert M, Seiden PE. A solution to the rheumatoid factor paradox: pathologic rheumatoid factors can be tolerized by competition with natural rheumatoid factors. J Immunol. 1997 Aug 15; 159(4):1728-38. PMID: 9257834.
      Citations: 10     Fields:    Translation:Animals
    52. Chen C, Prak EL, Weigert M. Editing disease-associated autoantibodies. Immunity. 1997 Jan; 6(1):97-105. PMID: 9052841.
      Citations: 62     Fields:    Translation:AnimalsCells
    53. Hannum LG, Ni D, Haberman AM, Weigert MG, Shlomchik MJ. A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J Exp Med. 1996 Oct 01; 184(4):1269-78. PMID: 8879198; PMCID: PMC2192833.
      Citations: 49     Fields:    Translation:AnimalsCells
    54. Chen C, Nagy Z, Prak EL, Weigert M. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity. 1995 Dec; 3(6):747-55. PMID: 8777720.
      Citations: 116     Fields:    Translation:AnimalsCells
    55. Radic MZ, Weigert M. Origins of anti-DNA antibodies and their implications for B-cell tolerance. Ann N Y Acad Sci. 1995 Sep 29; 764:384-96. PMID: 7486552.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    56. Radic MZ, Ibrahim SM, Rauch J, Camper SA, Weigert M. Constitutive secretion of transgene-encoded IgG2b autoantibodies leads to symptoms of autoimmune disease. J Immunol. 1995 Sep 15; 155(6):3213-22. PMID: 7673734.
      Citations: 6     Fields:    Translation:AnimalsCells
    57. Ibrahim SM, Weigert M, Basu C, Erikson J, Radic MZ. Light chain contribution to specificity in anti-DNA antibodies. J Immunol. 1995 Sep 15; 155(6):3223-33. PMID: 7673735.
      Citations: 44     Fields:    Translation:AnimalsCells
    58. Prak EL, Weigert M. Light chain replacement: a new model for antibody gene rearrangement. J Exp Med. 1995 Aug 01; 182(2):541-8. PMID: 7629511; PMCID: PMC2192124.
      Citations: 71     Fields:    Translation:AnimalsCells
    59. Chen C, Nagy Z, Radic MZ, Hardy RR, Huszar D, Camper SA, Weigert M. The site and stage of anti-DNA B-cell deletion. Nature. 1995 Jan 19; 373(6511):252-5. PMID: 7816141.
      Citations: 80     Fields:    Translation:AnimalsCells
    60. Shan H, Shlomchik MJ, Marshak-Rothstein A, Pisetsky DS, Litwin S, Weigert MG. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J Immunol. 1994 Dec 01; 153(11):5104-20. PMID: 7525723.
      Citations: 14     Fields:    Translation:AnimalsCells
    61. Prak EL, Trounstine M, Huszar D, Weigert M. Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance. J Exp Med. 1994 Nov 01; 180(5):1805-15. PMID: 7964462; PMCID: PMC2191736.
      Citations: 37     Fields:    Translation:AnimalsCells
    62. Jacobson BA, Sharon J, Shan H, Shlomchik M, Weigert MG, Marshak-Rothstein A. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. J Immunol. 1994 May 01; 152(9):4489-99. PMID: 8157964.
      Citations: 9     Fields:    Translation:AnimalsCells
    63. Chen C, Radic MZ, Erikson J, Camper SA, Litwin S, Hardy RR, Weigert M. Deletion and editing of B cells that express antibodies to DNA. J Immunol. 1994 Feb 15; 152(4):1970-82. PMID: 8120401.
      Citations: 59     Fields:    Translation:AnimalsCells
    64. Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol. 1994; 12:487-520. PMID: 8011289.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    65. Shlomchik MJ, Zharhary D, Saunders T, Camper SA, Weigert MG. A rheumatoid factor transgenic mouse model of autoantibody regulation. Int Immunol. 1993 Oct; 5(10):1329-41. PMID: 8268138.
      Citations: 55     Fields:    Translation:AnimalsCells
    66. Radic MZ, Mackle J, Erikson J, Mol C, Anderson WF, Weigert M. Residues that mediate DNA binding of autoimmune antibodies. J Immunol. 1993 Jun 01; 150(11):4966-77. PMID: 8496598.
      Citations: 97     Fields:    Translation:HumansCells
    67. Radic MZ, Erikson J, Litwin S, Weigert M. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med. 1993 Apr 01; 177(4):1165-73. PMID: 8459210; PMCID: PMC2190988.
      Citations: 131     Fields:    Translation:AnimalsCells
    68. Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med. 1993 Apr 01; 177(4):999-1008. PMID: 8459227; PMCID: PMC2190958.
      Citations: 295     Fields:    Translation:AnimalsCells
    69. Weigert M, Schwartz RS. Consideration of the transgenic and other approaches to studying DNA antibodies and their idiotypes. Lupus. 1992 Oct; 1(5):333-4. PMID: 1284636.
      Citations:    Fields:    Translation:AnimalsCells
    70. Berney T, Fulpius T, Shibata T, Reininger L, Van Snick J, Shan H, Weigert M, Marshak-Rothstein A, Izui S. Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass. Int Immunol. 1992 Jan; 4(1):93-9. PMID: 1540551.
      Citations: 16     Fields:    Translation:Animals
    71. Carmack CE, Camper SA, Mackle JJ, Gerhard WU, Weigert MG. Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus. J Immunol. 1991 Sep 15; 147(6):2024-33. PMID: 1909739.
      Citations: 17     Fields:    Translation:AnimalsCells
    72. Erikson J, Radic MZ, Camper SA, Hardy RR, Carmack C, Weigert M. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 1991 Jan 24; 349(6307):331-4. PMID: 1898987.
      Citations: 154     Fields:    Translation:AnimalsCells
    73. Radic MZ, Mascelli MA, Erikson J, Shan H, Weigert M. Ig H and L chain contributions to autoimmune specificities. J Immunol. 1991 Jan 01; 146(1):176-82. PMID: 1898596.
      Citations: 69     Fields:    Translation:AnimalsCells
    74. Shlomchik M, Weigert M. Is the hypothesis alive that IgM anti-IgG1 rheumatoid factor specificity is determined by framework regions? Eur J Immunol. 1990 Nov; 20(11):2529-31. PMID: 2253689.
      Citations:    Fields:    Translation:Humans
    75. Clarke S, Rickert R, Wloch MK, Staudt L, Gerhard W, Weigert M. The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations. J Immunol. 1990 Oct 01; 145(7):2286-96. PMID: 2398280.
      Citations: 25     Fields:    Translation:AnimalsCells
    76. Shan H, Shlomchik M, Weigert M. Heavy-chain class switch does not terminate somatic mutation. J Exp Med. 1990 Aug 01; 172(2):531-6. PMID: 2115570; PMCID: PMC2188341.
      Citations: 15     Fields:    Translation:AnimalsCells
    77. Clarke SH, Staudt LM, Kavaler J, Schwartz D, Gerhard WU, Weigert MG. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J Immunol. 1990 Apr 01; 144(7):2795-801. PMID: 2108213.
      Citations: 38     Fields:    Translation:AnimalsCells
    78. Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990 Jan 01; 171(1):265-92. PMID: 2104919; PMCID: PMC2187662.
      Citations: 215     Fields:    Translation:AnimalsCells
    79. Kleinfield RW, Weigert MG. Analysis of VH gene replacement events in a B cell lymphoma. J Immunol. 1989 Jun 15; 142(12):4475-82. PMID: 2498430.
      Citations: 18     Fields:    Translation:AnimalsCells
    80. Kleinfield RW, Weigert MG. Interspersion of the VHQ52 and VH7183 gene families in the NFS/N mouse. J Immunol. 1989 Jun 15; 142(12):4483-92. PMID: 2498431.
      Citations: 2     Fields:    Translation:AnimalsCells
    81. Radic MZ, Mascelli MA, Erikson J, Shan H, Shlomchik M, Weigert M. Structural patterns in anti-DNA antibodies from MRL/lpr mice. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:933-46. PMID: 2640629.
      Citations: 26     Fields:    Translation:AnimalsCells
    82. Shapiro MA, Weigert M. How immunoglobulin V kappa genes rearrange. J Immunol. 1987 Dec 01; 139(11):3834-9. PMID: 3119721.
      Citations: 30     Fields:    Translation:AnimalsCells
    83. Shlomchik MJ, Aucoin AH, Pisetsky DS, Weigert MG. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9150-4. PMID: 3480535; PMCID: PMC299710.
      Citations: 147     Fields:    Translation:AnimalsCells
    84. Shapiro MA, Weigert M. A complex translocation at the murine kappa light-chain locus. Mol Cell Biol. 1987 Nov; 7(11):4130-3. PMID: 3123918; PMCID: PMC368086.
      Citations: 2     Fields:    Translation:AnimalsCells
    85. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG. The role of clonal selection and somatic mutation in autoimmunity. Nature. 1987 Aug 27-Sep 2; 328(6133):805-11. PMID: 3498121.
      Citations: 214     Fields:    Translation:AnimalsCells
    86. Shlomchik M, Nemazee D, van Snick J, Weigert M. Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization. J Exp Med. 1987 Apr 01; 165(4):970-87. PMID: 3494096; PMCID: PMC2188567.
      Citations: 33     Fields:    Translation:AnimalsCells
    87. Shlomchik MJ, Nemazee DA, Sato VL, Van Snick J, Carson DA, Weigert MG. Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells. J Exp Med. 1986 Aug 01; 164(2):407-27. PMID: 3088205; PMCID: PMC2188225.
      Citations: 45     Fields:    Translation:AnimalsCells
    88. Kleinfield R, Hardy RR, Tarlinton D, Dangl J, Herzenberg LA, Weigert M. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature. 1986 Aug 28-Sep 3; 322(6082):843-6. PMID: 3092106.
      Citations: 103     Fields:    Translation:AnimalsCells
    89. Clarke SH, Huppi K, Ruezinsky D, Staudt L, Gerhard W, Weigert M. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med. 1985 Apr 01; 161(4):687-704. PMID: 3920342; PMCID: PMC2189056.
      Citations: 109     Fields:    Translation:AnimalsCells
    90. Huppi K, Jouvin-Marche E, Scott C, Potter M, Weigert M. Genetic polymorphism at the kappa chain locus in mice: comparisons of restriction enzyme hybridization fragments of variable and constant region genes. Immunogenetics. 1985; 21(5):445-57. PMID: 2987114.
      Citations: 26     Fields:    Translation:AnimalsCells
    91. McKean D, Huppi K, Bell M, Staudt L, Gerhard W, Weigert M. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci U S A. 1984 May; 81(10):3180-4. PMID: 6203114; PMCID: PMC345245.
      Citations: 203     Fields:    Translation:AnimalsCells
    92. Huppi K, Julius M, Staudt L, Gerhard W, Weigert M. The idiotypes of V kappa 21 light chains. Ann Immunol (Paris). 1984 Jan-Feb; 135C(1):181-5. PMID: 6424552.
      Citations: 2     Fields:    Translation:AnimalsCells
    93. VanNess BG, Shapiro M, Kelley DE, Perry RP, Weigert M, D'Eustachio P, Ruddle F. Aberrant rearrangement of the kappa light-chain locus involving the heavy-chain locus and chromosome 15 in a mouse plasmacytoma. Nature. 1983 Feb 03; 301(5899):425-7. PMID: 6401845.
      Citations: 12     Fields:    Translation:AnimalsCells
    94. Scott CL, Mushinski JF, Huppi K, Weigert M, Potter M. Amplification of immunoglobulin lambda constant genes in populations of wild mice. Nature. 1982 Dec 23; 300(5894):757-60. PMID: 6817142.
      Citations: 12     Fields:    Translation:Animals
    95. Bocchieri MH, Cooke A, Smith JB, Weigert M, Riblet RJ. Independent segregation of NZB immune abnormalities in NZB x C58 recombinant inbred mice. Eur J Immunol. 1982 Apr; 12(4):349-54. PMID: 7094992.
      Citations: 16     Fields:    Translation:AnimalsCells
    96. Van Ness BG, Coleclough C, Perry RP, Weigert M. DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):262-6. PMID: 6804938; PMCID: PMC345706.
      Citations: 52     Fields:    Translation:AnimalsCells
    97. Van Ness BG, Weigert M, Coleclough C, Mather EL, Kelley DE, Perry RP. Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene. Cell. 1981 Dec; 27(3 Pt 2):593-602. PMID: 6101210.
      Citations: 64     Fields:    Translation:AnimalsCells
    98. Sakano H, Kurosawa Y, Weigert M, Tonegawa S. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature. 1981 Apr 16; 290(5807):562-5. PMID: 6783961.
      Citations: 101     Fields:    Translation:AnimalsCells
    99. Coleclough C, Perry RP, Karjalainen K, Weigert M. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature. 1981 Apr 02; 290(5805):372-8. PMID: 6783959.
      Citations: 107     Fields:    Translation:AnimalsCells
    100. Perry RP, Coleclough C, Weigert M. Reorganization and expression of immunoglobulin genes: status of allelic elements. Cold Spring Harb Symp Quant Biol. 1981; 45 Pt 2:925-33. PMID: 6790224.
      Citations: 8     Fields:    Translation:AnimalsCells
    101. Julius MA, McKean DJ, Potter M, Feldmann RJ, Weigert M. The structural basis of antigenic determinants on V kappa 21 light chains. Mol Immunol. 1981 Jan; 18(1):1-9. PMID: 6167848.
      Citations: 2     Fields:    Translation:AnimalsCells
    102. Julius MA, McKean DJ, Potter M, Weigert M. Expression of kappa chains of the V kappa 21 group in Mus musculus and related species. Mol Immunol. 1981 Jan; 18(1):11-7. PMID: 6167849.
      Citations: 4     Fields:    Translation:AnimalsCells
    103. Perry RP, Kelley DE, Coleclough C, Seidman JG, Leder P, Tonegawa S, Matthyssens G, Weigert M. Transcription of mouse kappa chain genes: implications for allelic exclusion. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):1937-41. PMID: 6769117; PMCID: PMC348624.
      Citations: 65     Fields:    Translation:Cells
    104. Riblet R, Claflin L, Gibson DM, Mathieson BJ, Weigert M. Antibody gene linkage studies in (NZB X C58) recombinant-inbred lines. J Immunol. 1980 Feb; 124(2):787-9. PMID: 6766165.
      Citations: 13     Fields:    Translation:AnimalsCells
    105. Weigert M, Perry R, Kelley D, Hunkapiller T, Schilling J, Hood L. The joining of V and J gene segments creates antibody diversity. Nature. 1980 Jan 31; 283(5746):497-9. PMID: 6766210.
      Citations: 45     Fields:    Translation:AnimalsCells
    106. Loh E, Black B, Riblet R, Weigert M, Hood JM, Hood L. Myeloma proteins from NZB and BALB/c mice: structural and functional differences. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1395-9. PMID: 108679; PMCID: PMC383258.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    107. Kaartinen M, Karjalainen K, Morse HC, Weigert M, Potter M, Mäkela O. A search for hapten-binding mouse plasmacytoma proteins. Eur J Immunol. 1979 Feb; 9(2):125-9. PMID: 436927.
      Citations:    Fields:    Translation:AnimalsCells
    108. Loh E, Hood JM, Riblet R, Weigert M, Hood L. Comparisons of myeloma proteins from NZB and BALB/c mice: structural and functional differences of heavy chains. J Immunol. 1979 Jan; 122(1):44-8. PMID: 105043.
      Citations:    Fields:    Translation:AnimalsCells
    109. Valbuena O, Marcu KB, Weigert M, Perry RP. Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity. Nature. 1978 Dec 21-28; 276(5690):780-4. PMID: 103002.
      Citations: 26     Fields:    Translation:AnimalsCells
    110. Weigert M, Gatmaitan L, Loh E, Schilling J, Hood L. Rearrangement of genetic information may produce immunoglobulin diversity. Nature. 1978 Dec 21-28; 276(5690):785-90. PMID: 103003.
      Citations: 58     Fields:    Translation:AnimalsCells
    111. Morse HC, Riblet R, Asofsky R, Weigert M. Plasmacytomas of the NZB mouse. J Immunol. 1978 Nov; 121(5):1969-72. PMID: 712074.
      Citations: 5     Fields:    Translation:AnimalsCells
    112. Barstad P, Hubert J, Hunkapiller M, Goetze A, Schilling J, Black B, Eaton B, Richards J, Weigert M, Hood L. Immunoglobulins with hapten-binding activity: structure-function correlations and genetic implications. Eur J Immunol. 1978 Jul; 8(7):497-503. PMID: 689076.
      Citations: 12     Fields:    Translation:AnimalsCells
    113. Valbuena O, Marcu KB, Croce CM, Huebner K, Weigert M, Perry RP. Chromosomal locations of mouse immunoglobulin genes. Proc Natl Acad Sci U S A. 1978 Jun; 75(6):2883-7. PMID: 96442; PMCID: PMC392669.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    114. Weigert M, Riblet R. Genetic control of antibody variable regions. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:837-46. PMID: 408080.
      Citations: 33     Fields:    Translation:AnimalsCells
    115. Riblet R, Blomberg B, Weigert M, Lieberman R, Taylor BA, Potter M. Genetics of mouse antibodies. I. Linkage of the dextran response locus, VH-DEX, to allotype. Eur J Immunol. 1975 Nov; 5(11):775-7. PMID: 829901.
      Citations: 28     Fields:    Translation:AnimalsCells
    116. Riblet R, Weigert M, Mäkelä O. Genetics of mouse antibodies. II. Recombination between VH genes and allotype. Eur J Immunol. 1975 Nov; 5(11):778-81. PMID: 829902.
      Citations: 11     Fields:    Translation:AnimalsCells
    117. Taylor BA, Bailey DW, Cherry M, Riblet R, Weigert M. Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21; 256(5519):644-6. PMID: 807855.
      Citations: 61     Fields:    Translation:Animals
    118. Barstad P, Farnsworth V, Weigert M, Cohn M, Hood L. Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):4096-100. PMID: 4215076; PMCID: PMC434335.
      Citations: 15     Fields:    Translation:AnimalsCells
    119. Weigert M, Raschke WC, Carson D, Cohn M. Immunochemical analysis of the idiotypes of mouse myeloma proteins with specificity for levan or dextran. J Exp Med. 1974 Jan 01; 139(1):137-47. PMID: 4128444; PMCID: PMC2139518.
      Citations: 15     Fields:    Translation:AnimalsCells
    120. Cesari IM, Weigert M. Mouse lambda-chain sequences. Proc Natl Acad Sci U S A. 1973 Jul; 70(7):2112-6. PMID: 4516208; PMCID: PMC433677.
      Citations: 21     Fields:    Translation:AnimalsCells
    121. Carson D, Weigert M. Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. Proc Natl Acad Sci U S A. 1973 Jan; 70(1):235-9. PMID: 4119224; PMCID: PMC433222.
      Citations: 39     Fields:    Translation:AnimalsCells
    122. Blomberg B, Geckeler WR, Weigert M. Genetics of the antibody response to dextran in mice. Science. 1972 Jul 14; 177(4044):178-80. PMID: 4114394.
      Citations: 102     Fields:    Translation:AnimalsCellsPHPublic Health
    123. Lundblad A, Steller R, Kabat EA, Hirst JW, Weigert MG, Cohn M. Immunochemical studies on mouse myeloma proteins with specificity for dextran or for levan. Immunochemistry. 1972 May; 9(5):535-44. PMID: 5036150.
      Citations: 18     Fields:    Translation:AnimalsCells
    124. Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. Variability in the lambda light chain sequences of mouse antibody. Nature. 1970 Dec 12; 228(5276):1045-7. PMID: 5483159.
      Citations: 151     Fields:    Translation:AnimalsCells
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