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Yun Fang

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
Phone+1 (773) 7020940
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    Collapse Overview 
    Collapse overview
    My research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways. Cellular mechanotransduction is instrumental to embryogenesis and physiological control of tissue homeostasis; abnormal cell responses to mechanical forces promote pathologies associated with numerous human diseases. This is especially important in the vasculature, where environmental mechanical stimuli produce cellular responses in endothelial cells at arterial curvatures and bifurcations by locally disturbed blood flow to induce atherosclerosis. A similar cascade appears to be induced in acute lung injury where it is the increased cyclic stretch that is the trigger. My research program at the University of Chicago focuses on the molecular understanding of endothelial homeostasis governed by mechanical forces, with emphasis upon regulation of non-coding genome, transcription factors, G protein signaling, and genetic variance. Another major research goal is to develop innovative nanomedicine-based therapeutic strategies to treat dysregulated mechano-sensing mechanisms causing vascular diseases.

    Key Words: microRNA, non-coding RNA, human genetics, enhancer biology, vascular biology, nanotechnology, nanomedicine, mechanotransduction, atherosclerosis, acute lung injury

    Collapse Biography 
    Collapse education and training
    National Taiwan University, Taiwan BS1999Microbiology & Plant Pathology
    University of Pennsylvania, USAMS2002Biotechnology
    University of Pennsylvania, USAPhD2006Bioengineering
    University of Pennsylvania, USAPostdoctoral Fellow2012Medicine and Engineering
    Collapse awards and honors
    2018Leif B. Sorensen Faculty Research Award, University of Chicago
    2019Young Investigator Award (First Place) , CAAC-ATVB Symposium
    2020B. Lowell Langille Vascular Biology Lectureship , University of Toronto
    2022NHLBI R35 award , National Institutes of Health
    2023Established Investigator Award, American Heart Association
    2023Elected Fellow, The American Institute for Medical and Biological Engineering
    2023Elected Fellow, American Heart Association

    Collapse Research 
    Collapse research activities and funding
    K99HL166870-01A1     (Zhengjie Zhou)Aug 1, 2023 - Jul 31, 2028
    Targeted mRNA therapies treating ARDS
    Role: Sponsor

    Established Investigator Award     (Yun Fang)Apr 1, 2023 - Mar 30, 2028
    American Heart Association
    Endothelial mechanotransduction in vascular diseases and therapeutics
    Role: Principal Investigator

    3-SRA-2023-1364-S-B     (Raghavendra Mirmira)Apr 1, 2023 - Mar 31, 2026
    Juvenile Diabetes Research Foundation
    Engineered nanoparticles for Beta cell-targeted therapeutics
    Role: Co-Investigator

    R01HL159558     (TIRRELL, MATTHEW)Jun 15, 2022 - May 31, 2026
    Targeted Gene Delivery Systems Treating Lung Diseases
    Role: Co-Investigator

    R35HL161244     (FANG, YUN)Jun 1, 2022 - May 31, 2029
    Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms
    Role Description: Principal Investigator

    R35HL161244     (FANG, YUN)Jun 1, 2022 - May 31, 2029
    Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms
    Role: Principal Investigator

    R01HL155909     (HE, CHUAN)Dec 22, 2021 - Nov 30, 2025
    Mechanosensitive M7G epitranscriptome in endothelial health and disease
    Role: Co-Investigator

    R01HL147187     (ROMANOSKI, CASEY E)May 1, 2019 - Apr 30, 2024
    Mechanisms of ERG in Endothelial Activation
    Role: Co-Investigator

    R01HL141120     (LEVITAN, IRENA ;PHILLIPS, SHANE A)Apr 19, 2019 - Mar 31, 2024
    Microvascular endothelial Kir channels in flow-induced dilation and hypertension
    Role: Co-Investigator

    P01HL144454     (PRABHAKAR, NANDURI R)Apr 15, 2019 - Mar 31, 2024
    Integrative Consequences of Intermittent Hypoxia
    Role: Co-Investigator

    R01HL136765     (FANG, YUN)Aug 10, 2017 - May 31, 2022
    Coronary artery disease locus 1p32.2 and miR92a-PPAP2B signaling in endothelial mechanobiology
    Role: Principal Investigator

    R01HL138223     (FANG, YUN)Aug 1, 2017 - Jul 31, 2022
    Spatial Delivery of MicroRNA Inhibitor via Targeted Polyelectrolyte Complex Micelles to Treat Atherosclerosis.
    Role: Principal Investigator

    R01HL119577     (DI RIENZO, ANNA)Apr 1, 2014 - Feb 28, 2025
    Functional Genomics of Tibetan Adaptations
    Role: Co-Investigator

    R00HL103789     (FANG, YUN)Apr 18, 2013 - Mar 31, 2017
    miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
    Role: Principal Investigator

    K99HL103789     (FANG, YUN)Apr 1, 2011 - Mar 31, 2013
    miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
    Role: Principal Investigator

    T32HL007605     (MUTLU, GOKHAN M.)Jun 1, 1985 - Jun 30, 2025
    Research training in respiratory biology
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Volpatti LR, de Matos SN, Borjas G, Reda J, Watkins EA, Zhou Z, Nguyen M, Solanki A, Fang Y, Hubbell JA. LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice. bioRxiv. 2024 Mar 06. PMID: 38496521; PMCID: PMC10942346.
    2. Li J, Zhu J, Gray O, Sobreira DR, Wu D, Huang RT, Miao B, Sakabe NJ, Krause MD, Kaikkonen MU, Romanoski CE, Nobrega MA, Fang Y. Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells. J Cell Biol. 2024 03 04; 223(3). PMID: 38231044; PMCID: PMC10794123.
      Citations:    Fields:    Translation:HumansCells
    3. Reed EB, Orbeta S, Miao BA, Sitikov A, Chen B, Levitan I, Solway J, Mutlu GM, Fang Y, Mongin AA, Dulin NO. Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2024 01 01; 326(1):L111-L123. PMID: 38084409.
      Citations:    Fields:    Translation:HumansCells
    4. Reed EB, Orbeta S, Sitikov A, Levitan I, Mutlu GM, Dulin NO, Miao BA, Chen B, Solway J, Fang Y, Mongin AA. Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation. bioRxiv. 2023 Nov 09. PMID: 37333255; PMCID: PMC10274757.
    5. Cetin-Atalay R, Meliton AY, Ozcan C, Woods PS, Sun KA, Fang Y, Hamanaka RB, Mutlu GM. Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice. PLoS One. 2023; 18(10):e0292990. PMID: 37844118; PMCID: PMC10578579.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Huang X, Zhang X, Machireddy N, Evans CE, Trewartha SD, Hu G, Fang Y, Mutlu GM, Wu D, Zhao YY. Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury. Sci Transl Med. 2023 08 16; 15(709):eabm5755. PMID: 37585502; PMCID: PMC10894510.
      Citations: 5     Fields:    Translation:Animals
    7. Pan T, Cao G, Tang E, Zhao Y, Penaloza-MacMaster P, Fang Y, Huang J. A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections. Front Genet. 2023; 14:1105673. PMID: 36992700; PMCID: PMC10040851.
      Citations: 1     
    8. Gray OA, Yoo J, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Di Rienzo A, Sobreira DR, Nobréga MA. A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942. PMID: 36417539; PMCID: PMC9683707.
      Citations: 7     Fields:    
    9. Cetin-Atalay R, Meliton AY, Sun KA, Glass ME, Woods PS, Peng YJ, Fang Y, Hamanaka RB, Prabhakar NR, Mutlu GM. Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells. Sci Rep. 2022 10 13; 12(1):17167. PMID: 36229484; PMCID: PMC9561121.
      Citations: 3     Fields:    Translation:HumansCells
    10. Zhou Z, Yeh CF, Mellas M, Oh MJ, Zhu J, Li J, Huang RT, Harrison DL, Shentu TP, Wu D, Lueckheide M, Carver L, Chung EJ, Leon L, Yang KC, Tirrell MV, Fang Y. Targeted polyelectrolyte complex micelles treat vascular complications in vivo. Proc Natl Acad Sci U S A. 2021 12 14; 118(50). PMID: 34880134; PMCID: PMC8685925.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Li J, Fang Y, Wu D. Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes. Curr Top Membr. 2021; 87:199-253. PMID: 34696886; PMCID: PMC8639155.
      Citations: 6     Fields:    Translation:Cells
    12. Harrison D, Wu D, Huang J, Fang Y. Single-cell lactate production rate as a measure of glycolysis in endothelial cells. STAR Protoc. 2021 09 17; 2(3):100807. PMID: 34527962; PMCID: PMC8433287.
      Citations: 2     Fields:    Translation:HumansCells
    13. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Fang Y, Mutlu GM. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111; PMCID: PMC8399572.
      Citations: 3     Fields:    Translation:HumansCells
    14. Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM. Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995. PMID: 34322038; PMCID: PMC8311436.
      Citations: 3     
    15. Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JJK, Wu R. Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021; 9:691801. PMID: 34179020; PMCID: PMC8222825.
      Citations: 3     
    16. Wu D, Harrison DL, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Huang J, Fang Y, Mutlu GM. Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 05; 3(5):714-727. PMID: 34031595; PMCID: PMC8362837.
      Citations: 24     Fields:    Translation:HumansCells
    17. Fang Y. Preface. Curr Top Membr. 2021; 87:xiii-xv. PMID: 34696891.
      Citations:    Fields:    
    18. Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. Nano Lett. 2020 05 13; 20(5):3852-3857. PMID: 32208712; PMCID: PMC7227009.
      Citations: 3     Fields:    
    19. Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. The guidance receptor plexin D1 is a mechanosensor in endothelial cells. Nature. 2020 02; 578(7794):290-295. PMID: 32025034; PMCID: PMC7025890.
      Citations: 65     Fields:    Translation:AnimalsCells
    20. Harrison DL, Fang Y, Huang J. T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation. Front Phys. 2019 Apr; 7. PMID: 32601597; PMCID: PMC7323161.
      Citations: 27     
    21. Fang Y, Wu D, Birukov KG. Mechanosensing and Mechanoregulation of Endothelial Cell Functions. Compr Physiol. 2019 03 15; 9(2):873-904. PMID: 30873580; PMCID: PMC6697421.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    22. Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11349-E11358. PMID: 30429326; PMCID: PMC6275533.
      Citations: 39     Fields:    Translation:HumansCells
    23. Allon M, Litovsky SH, Tey JCS, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT. Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease. J Vasc Access. 2019 Jan; 20(1):31-40. PMID: 29742957; PMCID: PMC6212345.
      Citations: 5     Fields:    Translation:Humans
    24. Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC. Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circ Res. 2018 04 13; 122(8):1052-1068. PMID: 29535165; PMCID: PMC5899016.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    25. Fancher IS, Ahn SJ, Adamos C, Osborn C, Oh MJ, Fang Y, Reardon CA, Getz GS, Phillips SA, Levitan I. Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K+ Channels. J Am Heart Assoc. 2018 03 03; 7(5). PMID: 29502106; PMCID: PMC5866319.
      Citations: 21     Fields:    Translation:AnimalsCells
    26. Wu D, Hamanaka RB, Fang Y, Mutlu GM. Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1a Drives Endothelial Dysfunction at Atheroprone Sites". Arterioscler Thromb Vasc Biol. 2017 12; 37(12):e197-e198. PMID: 29162600; PMCID: PMC5777320.
      Citations:    Fields:    Translation:Humans
    27. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML, Aragón RL. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620. PMID: 29158473; PMCID: PMC5696341.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    28. Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I. Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):64-75. PMID: 29025707; PMCID: PMC5746473.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    29. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282. PMID: 29302619; PMCID: PMC5749269.
      Citations: 13     Fields:    
    30. Fang Y, Davis IC. The Runt of the Litter-Stronger than We Thought? Am J Respir Cell Mol Biol. 2017 08; 57(2):139-140. PMID: 28762769.
      Citations:    Fields:    Translation:Humans
    31. Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 05 30; 6. PMID: 28556776; PMCID: PMC5495571.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    32. Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Fang Y, Mutlu GM. Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Am J Respir Crit Care Med. 2017 03 01; 195(5):639-651. PMID: 27855271; PMCID: PMC5363977.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    33. Oh MJ, Zhang C, LeMaster E, Adamos C, Berdyshev E, Bogachkov Y, Kohler EE, Baruah J, Fang Y, Schraufnagel DE, Wary KK, Levitan I. Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation. J Lipid Res. 2016 05; 57(5):791-808. PMID: 26989083; PMCID: PMC4847627.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    34. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. PMID: 26034042; PMCID: PMC4522239.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    35. Kuo CH, Leon L, Chung EJ, Huang RT, Sontag TJ, Reardon CA, Getz GS, Tirrell M, Fang Y. Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles. J Mater Chem B. 2014 Dec 14; 2(46):8142-8153. PMID: 25685357; PMCID: PMC4322949.
      Citations: 30     Fields:    
    36. Chung EJ, Mlinar LB, Nord K, Sugimoto MJ, Wonder E, Alenghat FJ, Fang Y, Tirrell M. Monocyte-targeting supramolecular micellar assemblies: a molecular diagnostic tool for atherosclerosis. Adv Healthc Mater. 2015 Feb 18; 4(3):367-76. PMID: 25156590; PMCID: PMC4336846.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Davies PF, Civelek M, Fang Y, Fleming I. The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovasc Res. 2013 Jul 15; 99(2):315-27. PMID: 23619421; PMCID: PMC3695748.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    38. Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):979-87. PMID: 22267480; PMCID: PMC3306477.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    39. Fang Y, Shi C, Manduchi E, Civelek M, Davies PF. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13450-5. PMID: 20624982; PMCID: PMC2922125.
      Citations: 216     Fields:    Translation:HumansAnimalsCells
    40. Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo. Semin Thromb Hemost. 2010 Apr; 36(3):265-75. PMID: 20533180; PMCID: PMC3817717.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    41. Levitan I, Fang Y, Rosenhouse-Dantsker A, Romanenko V. Cholesterol and ion channels. Subcell Biochem. 2010; 51:509-49. PMID: 20213557; PMCID: PMC2895485.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    42. Mohler ER, Fang Y, Shaffer RG, Moore J, Wilensky RL, Parmacek M, Levitan I. Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):317-24. PMID: 17482574; PMCID: PMC2703014.
      Citations: 17     Fields:    Translation:AnimalsCells
    43. Byfield FJ, Hoffman BD, Romanenko VG, Fang Y, Crocker JC, Levitan I. Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. Acta Physiol (Oxf). 2006 May-Jun; 187(1-2):285-94. PMID: 16734765.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    44. Fang Y, Mohler ER, Hsieh E, Osman H, Hashemi SM, Davies PF, Rothblat GH, Wilensky RL, Levitan I. Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circ Res. 2006 Apr 28; 98(8):1064-71. PMID: 16556870.
      Citations: 48     Fields:    Translation:HumansAnimals
    45. Fang W, Chen JY, Fang Y, Huang JL. Epinephrine overdose-associated hypokalemia and rhabdomyolysis in a newborn. Pharmacotherapy. 2005 Sep; 25(9):1266-70. PMID: 16164400.
      Citations: 4     Fields:    Translation:Humans
    46. Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1134-44. PMID: 15958527.
      Citations: 33     Fields:    Translation:HumansCells
    47. Romanenko VG, Fang Y, Byfield F, Travis AJ, Vandenberg CA, Rothblat GH, Levitan I. Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J. 2004 Dec; 87(6):3850-61. PMID: 15465867; PMCID: PMC1304896.
      Citations: 102     Fields:    Translation:AnimalsCells
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