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Wenbin Lin

TitleProfessor
InstitutionUniversity of Chicago
DepartmentChemistry
AddressChicago IL 60637
Email
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    R01CA276307     (WEICHSELBAUM, RALPH R)Jun 1, 2023 - May 31, 2028
    NIH
    Nanoscale Coordination Polymers of Cyclic-di-nucleotides and Peptide Antigens for Effective Therapy of Metastatic Colorectal Cancer
    Role: Co-Principal Investigator
    R01CA279802     (LIN, WENBIN)Mar 1, 2023 - Feb 29, 2028
    NIH
    Tumor-Targeted Multimodality Nanoscale Coordination Polymers for Chemo-Immunotherapy of Metastatic Colorectal Cancer
    Role: Principal Investigator
    R01CA253655     (LIN, WENBIN)Jul 1, 2020 - Jun 30, 2025
    NIH
    Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck Cancers
    Role: Principal Investigator
    R01CA223184     (LIN, WENBIN)Jul 1, 2018 - Jun 30, 2023
    NIH
    Targeted Nanomedicines with Synergistic Chemotherapeutics to Enhance Immunotherapy of Metastatic Colorectal Cancer
    Role: Principal Investigator
    R01CA216436     (LIN, WENBIN)Feb 15, 2018 - Jan 31, 2023
    NIH
    Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian Cancer
    Role: Principal Investigator
    U01CA198989     (LIN, WENBIN)Sep 25, 2015 - Jul 31, 2021
    NIH
    Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck Cancers
    Role: Principal Investigator
    U01CA151455     (LIN, WENBIN)Sep 3, 2010 - Jul 31, 2016
    NIH
    Nanoscale Metal-organic Frameworks for Imaging and Therapy of Pancreatic Cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deng C, Wang Z, Li J, Lin W. Isostructural chiral metal-organic frameworks for enantioselective luminescence sensing of 1-phenyl-1,2-ethanediol. Chem Commun (Camb). 2025 Jul 31; 61(63):11846-11849. PMID: 40635515.
      Citations:    Fields:    
    2. Zhen W, Jiang X, Li E, Germanas T, Lee MJ, Luo T, Ma X, Wang C, Chen Y, Weichselbaum RR, Lin W. Transforming malignant tumors into vulnerable phenotypes via nanoscale coordination polymer mediated cell senescence and photodynamic therapy. Biomaterials. 2025 Nov; 322:123355. PMID: 40279766; PMCID: PMC12140873.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Bian W, Jiang X, Li J, Tillman L, Wang C, Zhen W, Weichselbaum RR, Fromme T, Lin W. Metal-organic layer delivers 3-bromopyruvate to mitochondria for metabolic regulation and cancer radio-immunotherapy. Chem Sci. 2025 Mar 19; 16(12):5234-5240. PMID: 39991561; PMCID: PMC11843481.
      Citations: 1     
    4. Wang Z, Yeary P, Fan Y, Lin W. Anthraquinone-based covalent organic framework as a recyclable direct hydrogen atom transfer photocatalyst for C-H functionalization. Chem Sci. 2024 Mar 27; 15(13):4920-4925. PMID: 38550707; PMCID: PMC10966989.
      Citations: 2     
    5. Jiang X, Liu J, Lee MJ, Peng C, Luo T, Tillman L, Weichselbaum RR, Lin W. Nanoscale coordination polymer synergizes photodynamic therapy and toll-like receptor activation for enhanced antigen presentation and antitumor immunity. Biomaterials. 2023 11; 302:122334. PMID: 37776767; PMCID: PMC10841466.
      Citations: 8     Fields:    Translation:Humans
    6. Li Y, Han W, Gong D, Luo T, Fan Y, Mao J, Qin W, Lin W. A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy. Chem Sci. 2023 May 17; 14(19):5106-5115. PMID: 37206384; PMCID: PMC10189857.
      Citations: 5     
    7. Ni K, Xu Z, Culbert A, Luo T, Guo N, Yang K, Pearson E, Preusser B, Wu T, La Riviere P, Weichselbaum RR, Spiotto MT, Lin W. Author Correction: Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework. Nat Biomed Eng. 2022 Dec; 6(12):1449-1450. PMID: 36369378.
      Citations: 1     Fields:    
    8. Yang K, Han W, Jiang X, Piffko A, Bugno J, Han C, Li S, Liang H, Xu Z, Zheng W, Wang L, Wang J, Huang X, Ting JPY, Fu YX, Lin W, Weichselbaum RR. Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration. Nat Nanotechnol. 2022 12; 17(12):1322-1331. PMID: 36302963.
      Citations: 71     Fields:    Translation:HumansCells
    9. Li Y, Jiang X, Luo T, Xia J, Lee MJ, Weichselbaum RR, Lin W. TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer. Biomaterials. 2022 11; 290:121831. PMID: 36240687.
      Citations: 7     Fields:    Translation:Animals
    10. Ni K, Xu Z, Culbert A, Luo T, Guo N, Yang K, Pearson E, Preusser B, Wu T, La Riviere P, Weichselbaum RR, Spiotto MT, Lin W. Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework. Nat Biomed Eng. 2022 02; 6(2):144-156. PMID: 35190678; PMCID: PMC9462448.
      Citations: 25     Fields:    Translation:Animals
    11. Jiang X, He C, Lin W. Supramolecular metal-based nanoparticles for drug delivery and cancer therapy. Curr Opin Chem Biol. 2021 04; 61:143-153. PMID: 33631394; PMCID: PMC8219202.
      Citations: 18     Fields:    Translation:Cells
    12. Ling X, Han W, Jiang X, Chen X, Rodriguez M, Zhu P, Wu T, Lin W. Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy. Biomaterials. 2021 03; 270:120690. PMID: 33561626; PMCID: PMC8020625.
      Citations: 11     Fields:    Translation:Humans
    13. Ni K, Lan G, Guo N, Culbert A, Luo T, Wu T, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination. Sci Adv. 2020 10; 6(40). PMID: 33008911; PMCID: PMC7852401.
      Citations: 21     Fields:    Translation:HumansPHPublic Health
    14. Ni K, Lan G, Song Y, Hao Z, Lin W. Biomimetic nanoscale metal-organic framework harnesses hypoxia for effective cancer radiotherapy and immunotherapy. Chem Sci. 2020 Apr 20; 11(29):7641-7653. PMID: 34094142; PMCID: PMC8159451.
      Citations: 30     
    15. Chan C, Guo N, Duan X, Han W, Xue L, Bryan D, Wightman SC, Khodarev NN, Weichselbaum RR, Lin W. Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer. Biomaterials. 2019 07; 210:94-104. PMID: 31060867; PMCID: PMC6579118.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Duan X, Chan C, Han W, Guo N, Weichselbaum RR, Lin W. Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat Commun. 2019 04 23; 10(1):1899. PMID: 31015397; PMCID: PMC6478897.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    17. Feng X, Song Y, Chen JS, Li Z, Chen EY, Kaufmann M, Wang C, Lin W. Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes. Chem Sci. 2019 Feb 21; 10(7):2193-2198. PMID: 30881644; PMCID: PMC6385530.
      Citations: 5     
    18. Ni K, Lan G, Veroneau SS, Duan X, Song Y, Lin W. Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy. Nat Commun. 2018 10 17; 9(1):4321. PMID: 30333489; PMCID: PMC6193046.
      Citations: 89     Fields:    Translation:AnimalsCells
    19. Ni K, Lan G, Chan C, Quigley B, Lu K, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun. 2018 06 15; 9(1):2351. PMID: 29907739; PMCID: PMC6003951.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    20. Lu K, He C, Guo N, Chan C, Ni K, Lan G, Tang H, Pelizzari C, Fu YX, Spiotto MT, Weichselbaum RR, Lin W. Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy. Nat Biomed Eng. 2018 08; 2(8):600-610. PMID: 31015630.
      Citations: 159     Fields:    Translation:HumansAnimalsCells
    21. Lin Z, Thacker NC, Sawano T, Drake T, Ji P, Lan G, Cao L, Liu S, Wang C, Lin W. Metal-organic layers stabilize earth-abundant metal-terpyridine diradical complexes for catalytic C-H activation. Chem Sci. 2018 Jan 07; 9(1):143-151. PMID: 29629082; PMCID: PMC5869321.
      Citations: 17     
    22. Thacker NC, Ji P, Lin Z, Urban A, Lin W. Phenanthroline-based metal-organic frameworks for Fe-catalyzed Csp3-H amination. Faraday Discuss. 2017 09 08; 201:303-315. PMID: 28627532.
      Citations: 1     Fields:    
    23. Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron KB, Posner MC, Lin W, Khodarev NN, Weichselbaum RR. In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases. Mol Ther. 2017 07 05; 25(7):1588-1595. PMID: 28457664; PMCID: PMC5498809.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    24. Kong XJ, Lin Z, Zhang ZM, Zhang T, Lin W. Hierarchical Integration of Photosensitizing Metal-Organic Frameworks and Nickel-Containing Polyoxometalates for Efficient Visible-Light-Driven Hydrogen Evolution. Angew Chem Int Ed Engl. 2016 05 23; 55(22):6411-6. PMID: 27094346.
      Citations: 13     Fields:    
    25. Zhang ZM, Duan X, Yao S, Wang Z, Lin Z, Li YG, Long LS, Wang EB, Lin W. Cation-mediated optical resolution and anticancer activity of chiral polyoxometalates built from entirely achiral building blocks. Chem Sci. 2016 Jul 01; 7(7):4220-4229. PMID: 30155068; PMCID: PMC6013930.
      Citations: 9     
    26. Cao L, Lin Z, Peng F, Wang W, Huang R, Wang C, Yan J, Liang J, Zhang Z, Zhang T, Long L, Sun J, Lin W. Self-Supporting Metal-Organic Layers as Single-Site Solid Catalysts. Angew Chem Int Ed Engl. 2016 Apr 11; 55(16):4962-6. PMID: 26954885.
      Citations: 43     Fields:    
    27. Lin X, Hong Y, Zhang C, Huang R, Wang C, Lin W. Pre-concentration and energy transfer enable the efficient luminescence sensing of transition metal ions by metal-organic frameworks. Chem Commun (Camb). 2015 Dec 11; 51(95):16996-9. PMID: 26445903.
      Citations: 6     Fields:    
    28. He C, Lu J, Lin W. Hybrid nanoparticles for combination therapy of cancer. J Control Release. 2015 Dec 10; 219:224-236. PMID: 26387745; PMCID: PMC4656047.
      Citations: 53     Fields:    Translation:HumansAnimals
    29. Sawano T, Ji P, McIsaac AR, Lin Z, Abney CW, Lin W. The first chiral diene-based metal-organic frameworks for highly enantioselective carbon-carbon bond formation reactions. Chem Sci. 2015 Dec 01; 6(12):7163-7168. PMID: 29861953; PMCID: PMC5951194.
      Citations: 5     
    30. Poon C, He C, Liu D, Lu K, Lin W. Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer. J Control Release. 2015 Mar 10; 201:90-9. PMID: 25620067; PMCID: PMC4624312.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    31. Liu D, He C, Poon C, Lin W. Theranostic nanoscale coordination polymers for magnetic resonance imaging and bisphosphonate delivery. J Mater Chem B. 2014 Dec 14; 2(46):8249-8255. PMID: 32262098.
      Citations: 11     Fields:    
    32. He C, Liu D, Lin W. Self-assembled nanoscale coordination polymers carrying siRNAs and cisplatin for effective treatment of resistant ovarian cancer. Biomaterials. 2015 Jan; 36:124-33. PMID: 25315138; PMCID: PMC4252980.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    33. Zhang T, Lin W. Metal-organic frameworks for artificial photosynthesis and photocatalysis. Chem Soc Rev. 2014 Aug 21; 43(16):5982-93. PMID: 24769551.
      Citations: 178     Fields:    
    34. Rocca JD, Werner ME, Kramer SA, Huxford-Phillips RC, Sukumar R, Cummings ND, Vivero-Escoto JL, Wang AZ, Lin W. Polysilsesquioxane nanoparticles for triggered release of cisplatin and effective cancer chemoradiotherapy. Nanomedicine. 2015 Jan; 11(1):31-8. PMID: 25038495; PMCID: PMC4280316.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
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