FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep; 12(3):201-14.

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subject areas

Apoptosis
Binding Sites
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Humans
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Models, Biological
Multiple Myeloma
Phosphorylation
Receptor, Fibroblast Growth Factor, Type 3
Ribosomal Protein S6 Kinases, 90-kDa
RNA Interference
Tyrosine

authors with profiles

Jing Chen