Methylenetetrahydrofolate Dehydrogenase (NADP)
"Methylenetetrahydrofolate Dehydrogenase (NADP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
| Descriptor ID |
D008754
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| MeSH Number(s) |
D08.811.682.662.253
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
Below are MeSH descriptors whose meaning is more specific than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
This graph shows the total number of publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in this website by year, and whether "Methylenetetrahydrofolate Dehydrogenase (NADP)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in Profiles.
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KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells. Mol Cancer Ther. 2014 Jun; 13(6):1611-24.
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Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1270-8.