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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.
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PubMed
subject areas
A549 Cells
Antiviral Agents
Catalytic Domain
Crystallography, X-Ray
Endoribonucleases
Enzyme Inhibitors
Humans
Ligands
Models, Molecular
Protein Conformation
Pyrrolidines
Thymine
Uridine
Viral Nonstructural Proteins
authors with profiles
Glenn C. Randall
Andrzej Joachimiak