"Integrin alpha5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
| Descriptor ID |
D039482
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.500
|
| Concept/Terms |
Integrin alpha5- Integrin alpha5
- alpha5, Integrin
- alpha(5) Integrin
- alpha5 Integrin
- Integrin, alpha5
- VLA-5 alpha Chain
- VLA 5 alpha Chain
- alpha Chain, VLA-5
- CD49e Antigens
- Platelet Glycoprotein Ic
- Glycoprotein Ic, Platelet
- Ic, Platelet Glycoprotein
- Integrin alphaF
- alphaF, Integrin
- CD49e Antigen
- Antigen, CD49e
- Antigens, CD49e
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5".
This graph shows the total number of publications written about "Integrin alpha5" by people in this website by year, and whether "Integrin alpha5" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha5" by people in Profiles.
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Enhancement of ovarian tumor detection with avß3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer. Int J Gynecol Cancer. 2014 Jan; 24(1):19-28.
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miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression. Am J Pathol. 2013 May; 182(5):1876-89.
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Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation. Endocrinology. 2009 Sep; 150(9):4306-15.
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Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res. 2008 Apr 01; 68(7):2329-39.