"Integrin alpha4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
| Descriptor ID |
D039441
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.450
|
| Concept/Terms |
Integrin alpha4- Integrin alpha4
- CD49d Antigens
- Antigens, CD49d
- CD49d Antigen
- alpha4 Integrin
- Integrin, alpha4
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4".
This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha4" by people in Profiles.
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Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia. Haematologica. 2016 Apr; 101(4):458-65.
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Mucosal healing is associated with improved long-term outcome of maintenance therapy with natalizumab in Crohn's disease. Inflamm Bowel Dis. 2013 Nov; 19(12):2577-83.
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Integrins a4 and aM, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. Pediatr Res. 2013 Mar; 73(3):332-6.
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Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol. 2011 Apr; 106(4):644-59, quiz 660.
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Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts. J Biol Chem. 2008 Mar 14; 283(11):6997-7006.
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Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab. Inflamm Bowel Dis. 2007 Jan; 13(1):2-11.
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Increased CD4+ T cells during acute attack of Ménière's disease. Acta Otolaryngol. 2002 Dec; 122(8):857-60.
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A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem. 2002 Jun 07; 277(23):20887-94.