"Genes, bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.
| Descriptor ID |
D019254
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.150
|
| Concept/Terms |
Genes, bcl-2- Genes, bcl-2
- Genes, bcl 2
- bcl-2 Genes
- Gene, bcl-2
- bcl 2 Genes
- bcl-2 Gene
c-bcl-2 Genes- c-bcl-2 Genes
- Gene, c-bcl-2
- Genes, c-bcl-2
- c bcl 2 Genes
- c-bcl-2 Gene
- c-bcl-2 Proto-Oncogenes
- Proto-Oncogene, c-bcl-2
- Proto-Oncogenes, c-bcl-2
- c bcl 2 Proto Oncogenes
- c-bcl-2 Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, bcl-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, bcl-2".
This graph shows the total number of publications written about "Genes, bcl-2" by people in this website by year, and whether "Genes, bcl-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 1 | 0 | 1 |
| 2001 | 1 | 3 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, bcl-2" by people in Profiles.
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BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis. Allergy. 2016 05; 71(5):640-50.
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Impact of oncogene rearrangement patterns on outcomes in patients with double-hit non-Hodgkin lymphoma. Cancer. 2016 Feb 15; 122(4):559-64.
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Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL. Nucleic Acids Res. 2014 May; 42(9):5755-64.
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Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57.
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Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat. BMC Gastroenterol. 2012 Apr 30; 12:41.
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Autophagy evasion in herpesviral latency. Autophagy. 2010 Jan; 6(1):151-2.
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Characterization of cell-death pathways in Punta Toro virus-induced hepatocyte injury. J Gen Virol. 2008 Sep; 89(Pt 9):2175-2181.
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Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat. J Pediatr Gastroenterol Nutr. 2008 Aug; 47(2):115-22.
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Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth. Cancer Res. 2007 Oct 15; 67(20):9685-93.
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Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells. Anticancer Drugs. 2007 Jun; 18(5):535-41.