Nuclear Receptor Co-Repressor 2
"Nuclear Receptor Co-Repressor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear co-repressor protein that shows specificity for RETINOIC ACID RECEPTORS and THYROID HORMONE RECEPTORS. The dissociation of this co-repressor from nuclear receptors is generally ligand-dependent, but can also occur by way of its phosphorylation by members of the MAP KINASE SIGNALING SYSTEM. The protein contains two nuclear receptor interaction domains and four repressor domains and is closely-related in structure to NUCLEAR RECEPTOR CO-REPRESSOR 1.
| Descriptor ID |
D056985
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| MeSH Number(s) |
D12.776.930.780.625.400
|
| Concept/Terms |
Nuclear Receptor Co-Repressor 2- Nuclear Receptor Co-Repressor 2
- Nuclear Receptor Co Repressor 2
- TRAC Co-repressor
- Co-repressor, TRAC
- TRAC Co repressor
- SMRT Co-repressor
- Co-repressor, SMRT
- SMRT Co repressor
- Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor
- T3 Receptor-associating Factor
- Receptor-associating Factor, T3
- T3 Receptor associating Factor
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Co-Repressor 2".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Co-Repressor 2".
This graph shows the total number of publications written about "Nuclear Receptor Co-Repressor 2" by people in this website by year, and whether "Nuclear Receptor Co-Repressor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Nuclear Receptor Co-Repressor 2" by people in Profiles.
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SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10).
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HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 07 01; 34(13-14):973-988.
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Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717.
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Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015 May 15; 407:52-6.
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NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65.
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The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010 Jun 11; 285(24):18485-95.
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Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma). J Biol Chem. 2010 Apr 30; 285(18):13517-24.
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Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity (Silver Spring). 2009 May; 17(5):965-72.
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SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2007 Mar 15; 267(1-2):138-43.
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SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2006 Oct 19; 259(1-2):43-9.