"Single-Chain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
| Descriptor ID |
D057127
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| MeSH Number(s) |
D12.644.541.500.650.500.800 D12.776.124.486.485.114.224.785 D12.776.124.486.485.680.650.500.800 D12.776.124.790.651.680.650.500.800 D12.776.377.715.548.680.650.500.795
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| Concept/Terms |
Single-Chain Antibodies- Single-Chain Antibodies
- Antibodies, Single-Chain
- Single Chain Antibodies
- ScFv Antibodies
- Antibodies, ScFv
- Single-Chain Fv
- Fv, Single-Chain
- Single Chain Fv
- Single-Chain Fv Antibody
- Antibody, Single-Chain Fv
- Fv Antibody, Single-Chain
- Single Chain Fv Antibody
- Single-Chain Variable Fragment
- Fragment, Single-Chain Variable
- Single Chain Variable Fragment
- Variable Fragment, Single-Chain
- Single-Chain Variable Fragment Antibodies
- Single Chain Variable Fragment Antibodies
- Single-Chain Variable Fragment Antibody
- Single Chain Variable Fragment Antibody
- Single-Chain Variable Fragments
- Fragments, Single-Chain Variable
- Single Chain Variable Fragments
- Variable Fragments, Single-Chain
- Fv Antibody Fragments, Single-Chain
- Fv Antibody Fragments, Single Chain
- Single-Chain Fv Antibody Fragments
- Single Chain Fv Antibody Fragments
|
Below are MeSH descriptors whose meaning is more general than "Single-Chain Antibodies".
Below are MeSH descriptors whose meaning is more specific than "Single-Chain Antibodies".
This graph shows the total number of publications written about "Single-Chain Antibodies" by people in this website by year, and whether "Single-Chain Antibodies" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 2 | 4 |
| 2015 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Single-Chain Antibodies" by people in Profiles.
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Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice. Neurobiol Dis. 2019 01; 121:131-137.
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A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. Clin Cancer Res. 2018 08 01; 24(15):3611-3631.
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A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis. Nat Nanotechnol. 2017 12; 12(12):1190-1198.
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A novel single-chain antibody redirects adenovirus to IL13Ra2-expressing brain tumors. Sci Rep. 2015 Dec 14; 5:18133.
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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal. 2015 Jan 15; 13:1.
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Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy. Bioconjug Chem. 2014 Dec 17; 25(12):2205-11.
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A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of ?-secretase. J Biol Chem. 2014 Dec 12; 289(50):34851-61.
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Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations. J Neuroimmunol. 2014 Jul 15; 272(1-2):67-75.
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Recombinant antibody mediated delivery of organelle-specific DNA pH sensors along endocytic pathways. Nanoscale. 2014 Jan 21; 6(2):1144-52.
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Recombinant antibodies to histone post-translational modifications. Nat Methods. 2013 Oct; 10(10):992-5.