Immunoglobulin Joining Region
"Immunoglobulin Joining Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
| Descriptor ID |
D007133
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| MeSH Number(s) |
D12.644.541.500.650.500.590 D12.776.124.486.485.680.650.500.590 D12.776.124.486.485.797.590 D12.776.124.790.651.680.650.500.590 D12.776.124.790.651.797.590 D12.776.377.715.548.680.650.500.590 D12.776.377.715.548.797.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Joining Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Joining Region".
This graph shows the total number of publications written about "Immunoglobulin Joining Region" by people in this website by year, and whether "Immunoglobulin Joining Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Joining Region" by people in Profiles.
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Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. J Immunol. 2013 Dec 15; 191(12):5973-83.
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High-throughput sequencing of the zebrafish antibody repertoire. Science. 2009 May 08; 324(5928):807-10.
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A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell. 2005 Aug 05; 19(3):357-66.
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A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity. 2002 Feb; 16(2):245-55.
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Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement. J Exp Med. 2001 Mar 19; 193(6):699-712.
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Revising B cell receptors. J Exp Med. 2000 Jun 05; 191(11):1813-7.
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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript. J Exp Med. 1998 Aug 17; 188(4):689-98.
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Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5262-6.
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Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 1993 May; 7(1):38-46.
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B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med. 1993 Apr 01; 177(4):1165-73.