"ADAM17 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
| Descriptor ID |
D000072198
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.375 D09.400.430.500.375 D12.776.395.033.375
|
| Concept/Terms |
ADAM17 Protein- ADAM17 Protein
- TACE (Enzyme)
- TNF-alpha Converting Enzyme
- TNF alpha Converting Enzyme
- Tumor Necrosis Factor Alpha Convertase
- ADAM-17
- Tumor Necrosis Factor-alpha Converting Enzyme
- Tumor Necrosis Factor alpha Converting Enzyme
- TNF-alpha Convertase
- Convertase, TNF-alpha
- TNF alpha Convertase
- CD156b Antigen
- Antigen, CD156b
- ADAM-17 Protein
- ADAM 17 Protein
- Disintegrin and Metalloproteinase Domain-Containing Protein 17
- Disintegrin and Metalloproteinase Domain Containing Protein 17
- TACA (Enzyme)
- Tumor Necrosis Factor-alpha Convertase
|
Below are MeSH descriptors whose meaning is more general than "ADAM17 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM17 Protein".
This graph shows the total number of publications written about "ADAM17 Protein" by people in this website by year, and whether "ADAM17 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "ADAM17 Protein" by people in Profiles.
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Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer. FASEB J. 2020 10; 34(10):13935-13948.
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A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. Sci Transl Med. 2018 08 15; 10(454).
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ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):549-561.
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ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells. PLoS One. 2015; 10(7):e0132661.
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Epithelial innate immune response to Acinetobacter baumannii challenge. Infect Immun. 2014 Nov; 82(11):4458-65.
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ALCAM/CD166 is a TGF-ß-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res. 2014 Mar 01; 74(5):1404-15.
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ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. PLoS One. 2012; 7(12):e50791.
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TIMP-3 ameliorates hepatic ischemia/reperfusion injury through inhibition of tumor necrosis factor-alpha-converting enzyme activity in rats. Transplantation. 2006 Dec 15; 82(11):1518-23.