Transcription Factor HES-1
"Transcription Factor HES-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
| Descriptor ID |
D000072056
|
| MeSH Number(s) |
D12.776.260.103.844 D12.776.930.125.844
|
| Concept/Terms |
Transcription Factor HES-1- Transcription Factor HES-1
- HES-1, Transcription Factor
- Transcription Factor HES 1
- Hairy-Like Transcription Factor
- Hairy Like Transcription Factor
- Transcription Factor, Hairy-Like
- Hairy and Enhancer of Split 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor HES-1".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor HES-1".
This graph shows the total number of publications written about "Transcription Factor HES-1" by people in this website by year, and whether "Transcription Factor HES-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transcription Factor HES-1" by people in Profiles.
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Notch Signaling in Inflammation-Induced Preterm Labor. Sci Rep. 2015 Oct 16; 5:15221.
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Ikaros limits basophil development by suppressing C/EBP-a expression. Blood. 2013 Oct 10; 122(15):2572-81.
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Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway. Toxicol Lett. 2013 Jun 20; 220(1):61-9.
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Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. J Clin Invest. 2012 Sep; 122(9):3184-96.
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Ikaros regulates Notch target gene expression in developing thymocytes. J Immunol. 2008 Nov 01; 181(9):6265-74.
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Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation. J Biol Chem. 2008 Apr 18; 283(16):10476-84.
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Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9.
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Lack of requirement for presenilin1 in Notch1 signaling. Curr Biol. 1999 Dec 16-30; 9(24):1493-6.