Nedd4 Ubiquitin Protein Ligases
"Nedd4 Ubiquitin Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
| Descriptor ID |
D000075702
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| MeSH Number(s) |
D05.500.199.500 D08.811.464.938.750.257 D12.776.543.990.493.500
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| Concept/Terms |
Nedd4 Ubiquitin Protein Ligases- Nedd4 Ubiquitin Protein Ligases
- Nedd4 Proteins
- Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
- Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
|
Below are MeSH descriptors whose meaning is more general than "Nedd4 Ubiquitin Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Nedd4 Ubiquitin Protein Ligases".
This graph shows the total number of publications written about "Nedd4 Ubiquitin Protein Ligases" by people in this website by year, and whether "Nedd4 Ubiquitin Protein Ligases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nedd4 Ubiquitin Protein Ligases" by people in Profiles.
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Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
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DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation. 2020 02 25; 141(8):655-666.
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Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One. 2014; 9(8):e104396.
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Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics. J Hypertens. 2013 Apr; 31(4):698-704.
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Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol. 2011 Sep; 22(9):1707-19.
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Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production. Proc Jpn Acad Ser B Phys Biol Sci. 2011; 87(8):563-73.
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Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. Am J Physiol Cell Physiol. 2009 Mar; 296(3):C544-57.
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Association of NEDD4L ubiquitin ligase with essential hypertension. Hypertension. 2005 Sep; 46(3):488-91.