ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).

Descriptor ID	D000075924
MeSH Number(s)	D08.811.399.340.375
Concept/Terms	X-linked Nuclear Protein X-linked Nuclear Protein Nuclear Protein, X-linked X linked Nuclear Protein RAD54 Homolog Protein Homolog Protein, RAD54 ATRX Protein

Below are MeSH descriptors whose meaning is more general than "X-linked Nuclear Protein".

Below are MeSH descriptors whose meaning is related to "X-linked Nuclear Protein".

Below are MeSH descriptors whose meaning is more specific than "X-linked Nuclear Protein".