"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
| Descriptor ID |
D000072200
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| MeSH Number(s) |
D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
|
| Concept/Terms |
Ku Autoantigen- Ku Autoantigen
- Autoantigen, Ku
- Ku Heterodimer
- Heterodimer, Ku
- Ku Protein
- Ku Antigen
- Antigen, Ku
- G22P1 Antigen
- Antigen, G22P1
Ku80 Antigen- Ku80 Antigen
- Antigen, Ku80
- Ku Autoantigen, 80 kDa
- XRCC5 Protein
- X-ray Repair Cross-Complementing Protein 5
- X ray Repair Cross Complementing Protein 5
Ku70 Antigen- Ku70 Antigen
- Antigen, Ku70
- Ku Autoantigen, 70 kDa
- XRCC6 Protein
- X-ray Repair Cross-Complementing Protein 6
- X ray Repair Cross Complementing Protein 6
|
Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".
Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".
This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.
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Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer. Gastroenterology. 2021 07; 161(1):225-238.e15.
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Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751.
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Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks. PLoS One. 2013; 8(4):e60043.
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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol. 2008 Oct; 28(20):6384-401.
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KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Cell Signal. 2008 Nov; 20(11):1978-85.
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Highly proficient gene targeting by homologous recombination in the human pre-B cell line Nalm-6. Methods Mol Biol. 2008; 435:17-29.
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RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res. 2007 Oct 15; 67(20):9658-65.
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53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis. Genes Cells. 2006 Aug; 11(8):935-48.
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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J. 2006 Mar 22; 25(6):1305-14.
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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res. 2005 Dec 15; 65(24):11704-11.