"Claudin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.
| Descriptor ID |
D062445
|
| MeSH Number(s) |
D12.776.543.940.200.100
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Claudin-1".
Below are MeSH descriptors whose meaning is more specific than "Claudin-1".
This graph shows the total number of publications written about "Claudin-1" by people in this website by year, and whether "Claudin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Claudin-1" by people in Profiles.
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Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids. PLoS Pathog. 2023 Dec; 19(12):e1011887.
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Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke. J Neurosci. 2019 01 23; 39(4):743-757.
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Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process. Cell Host Microbe. 2018 03 14; 23(3):382-394.e5.
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Endocytosis of tight junction proteins and the regulation of degradation and recycling. Ann N Y Acad Sci. 2017 06; 1397(1):54-65.
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Administration of defined microbiota is protective in a murine Salmonella infection model. Sci Rep. 2015 Nov 04; 5:16094.
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Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82.
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Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells. Am J Rhinol Allergy. 2010 Mar-Apr; 24(2):126-8.
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Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol. 2009 Feb; 83(4):2011-4.
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Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008 Oct; 88(10):1110-20.
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The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95.