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Kai Ruan

TitleResearch Assistant Professor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lobato AG, Ortiz-Vega N, Canic T, Tao X, Bucan N, Ruan K, Rebelo AP, Schule R, Zuchner S, Syed S, Zhai RG. Loss of Fic causes progressive neurodegeneration in a Drosophila model of hereditary spastic paraplegia. Biochim Biophys Acta Mol Basis Dis. 2024 10; 1870(7):167348. PMID: 38986817; PMCID: PMC11549967.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Zhai R, Ruan K, Perez GF, Kubat M, Liu J, Hofacker I, Wuchty S. MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing. Res Sq. 2023 Jul 28. PMID: 37546804; PMCID: PMC10402249.
      Citations:    
    3. Ruan K, Perez GF, Liu J, Kubat M, Hofacker I, Wuchty S, Zhai RG. MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing. bioRxiv. 2023 Jun 28. PMID: 37425843; PMCID: PMC10327045.
      Citations:    
    4. Liu J, Tao X, Zhu Y, Li C, Ruan K, Diaz-Perez Z, Rai P, Wang H, Zhai RG. NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis. Elife. 2021 12 17; 10. PMID: 34919052; PMCID: PMC8683086.
      Citations: 12     Fields:    Translation:AnimalsCells
    5. Ruetenik AL, Ocampo A, Ruan K, Zhu Y, Li C, Zhai RG, Barrientos A. Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging. Microb Cell. 2016 Jul 26; 3(8):338-351. PMID: 28357370; PMCID: PMC5349013.
      Citations: 10     
    6. Ruan K, Zhu Y, Li C, Brazill JM, Zhai RG. Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress. Nat Commun. 2015 Nov 30; 6:10057. PMID: 26616331; PMCID: PMC4674693.
      Citations: 25     Fields:    Translation:AnimalsCells
    7. Zang S, Ali YO, Ruan K, Zhai RG. Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot. EMBO Rep. 2013 Jan; 14(1):87-94. PMID: 23154466; PMCID: PMC3537136.
      Citations: 13     Fields:    Translation:AnimalsCells
    8. Ali YO, Ruan K, Zhai RG. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet. 2012 Jan 15; 21(2):237-50. PMID: 21965302; PMCID: PMC3276290.
      Citations: 55     Fields:    Translation:AnimalsCells
    9. Ali YO, Escala W, Ruan K, Zhai RG. Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration. J Vis Exp. 2011 Mar 11; (49). PMID: 21445036; PMCID: PMC3197301.
      Citations: 92     Fields:    Translation:HumansAnimals
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