A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity. Bioorg Med Chem. 2015 May 01; 23(9):2247-60.

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subject areas

Aminopyridines
Animals
Cell Cycle Proteins
Cell Line, Tumor
Cell Proliferation
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Drug Stability
Humans
Male
Microsomes, Liver
Models, Molecular
Molecular Structure
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Rats
Rats, Sprague-Dawley
Solubility
Structure-Activity Relationship
Tissue Distribution

authors with profiles

Yusuke Nakamura