Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo. Clin Cancer Res. 2005 Aug 15; 11(16):6002-11.
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Animals
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Antineoplastic Agents
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Apoptosis
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Binding Sites
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Binding, Competitive
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Blotting, Western
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Cell Cycle Proteins
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Cell Division
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Cell Line
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Cell Line, Tumor
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Cell Survival
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Colchicine
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Diterpenes
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Dose-Response Relationship, Drug
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Drugs, Chinese Herbal
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G2 Phase
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HeLa Cells
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Humans
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Liver Neoplasms
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Microscopy, Fluorescence
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Microtubules
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Molecular Structure
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Time Factors
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Treatment Outcome
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Tubulin
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Xenograft Model Antitumor Assays