Item Type | Name |
Concept
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Protein Denaturation
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Concept
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Protein Methyltransferases
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Concept
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Protein Precursors
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Protein Processing, Post-Translational
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Concept
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Protein Structure, Quaternary
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Concept
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Protein Structure, Tertiary
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Concept
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Ubiquitin-Protein Ligase Complexes
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Concept
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Amyloid beta-Protein Precursor
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Concept
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GTP-Binding Protein alpha Subunits, Gs
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Concept
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GTP-Binding Protein alpha Subunits, Gi-Go
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Concept
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Protein Transport
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Concept
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Protein Structure, Secondary
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Concept
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Protein Folding
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Concept
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Receptors, G-Protein-Coupled
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Concept
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G-Protein-Coupled Receptor Kinase 1
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Concept
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Focal Adhesion Protein-Tyrosine Kinases
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Protein Interaction Domains and Motifs
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Concept
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Protein Multimerization
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Concept
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Sequence Analysis, Protein
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Concept
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Structural Homology, Protein
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Concept
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AMP-Activated Protein Kinases
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Concept
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Protein Stability
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Concept
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Protein Isoforms
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Academic Article
|
Variability of conformations at crystal contacts in BPTI represent true low-energy structures: correspondence among lattice packing and molecular dynamics structures.
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Academic Article
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Structural consequences of mutation.
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Academic Article
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Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
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Academic Article
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Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures.
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Academic Article
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Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor.
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Academic Article
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Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
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Academic Article
|
Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.
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Academic Article
|
Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
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Academic Article
|
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
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Academic Article
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Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes.
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Academic Article
|
Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity.
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Academic Article
|
Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin.
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Academic Article
|
Structural basis for cytokine hormone-receptor recognition and receptor activation.
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Academic Article
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Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
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Academic Article
|
The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
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Academic Article
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Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
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Academic Article
|
The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
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Academic Article
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Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis.
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Academic Article
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Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.
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Academic Article
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Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.
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Academic Article
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The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
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Academic Article
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Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
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Academic Article
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Crystals of the complex between human growth hormone and the extracellular domain of its receptor.
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Academic Article
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Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.
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Academic Article
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Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
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Academic Article
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The first semi-synthetic serine protease made by native chemical ligation.
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Academic Article
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The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold.
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Academic Article
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Structure of bistramide A-actin complex at a 1.35 angstroms resolution.
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Academic Article
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Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
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Academic Article
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Crystal structure and site 1 binding energetics of human placental lactogen.
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Academic Article
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X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers.
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Academic Article
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The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.
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Academic Article
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Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.
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Academic Article
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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
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Academic Article
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Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide.
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Academic Article
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Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
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Academic Article
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X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
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Academic Article
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Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
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Academic Article
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The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.
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Academic Article
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Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization.
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Academic Article
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Exploring and designing protein function with restricted diversity.
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Academic Article
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Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
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Academic Article
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Mechanism of activation gating in the full-length KcsA K+ channel.
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Academic Article
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Hydroxyl hydrogen conformations in trypsin determined by the neutron diffraction solvent difference map method: relative importance of steric and electrostatic factors in defining hydrogen-bonding geometries.
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Academic Article
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Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces.
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Academic Article
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Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
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Academic Article
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Tertiary structure is a principal determinant to protein deamidation.
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Academic Article
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Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin.
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Academic Article
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Structure of bovine trypsinogen at 1.9 A resolution.
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Academic Article
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X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.
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Academic Article
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Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
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Academic Article
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The X-ray structure of a growth hormone-prolactin receptor complex.
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Academic Article
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Crystal structure of full-length KcsA in its closed conformation.
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Academic Article
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A method of solvent structure analysis for proteins using D2O-H2O neutron difference maps.
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Academic Article
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Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
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Academic Article
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X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
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Academic Article
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The crystal structure of affinity-matured human growth hormone at 2 A resolution.
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Academic Article
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Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.
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Academic Article
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Protein dynamics investigated by neutron diffraction.
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Academic Article
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Automated peak fitting procedure for processing data from an area detector and its application to the neutron structure of trypsin.
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Academic Article
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Neutron protein crystallography: advances in methods and applications.
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Academic Article
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Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
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Academic Article
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Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis.
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Academic Article
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Molecular recognition in biological systems: from activation to inhibition.
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Academic Article
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High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
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Academic Article
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The production and X-ray structure determination of perdeuterated Staphylococcal nuclease.
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Academic Article
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Effect of protein packing structure on side-chain methyl rotor conformations.
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Academic Article
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Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods.
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Academic Article
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The use of neutrons to show how proteins work.
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Academic Article
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Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin.
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Academic Article
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Mechanisms of zymogen activation.
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Academic Article
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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
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Academic Article
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The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
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Academic Article
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The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
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Academic Article
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Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold.
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Academic Article
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Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions.
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Academic Article
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An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells.
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Academic Article
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Characterization of engineered actin binding proteins that control filament assembly and structure.
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Academic Article
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The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
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Academic Article
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The application of neutron crystallography to the study of dynamic and and hydration properties of proteins.
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Academic Article
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Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique.
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Academic Article
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Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
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Academic Article
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Visualization of arrestin recruitment by a G-protein-coupled receptor.
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Academic Article
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Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.
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Academic Article
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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.
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Academic Article
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Nuclear pores. Architecture of the nuclear pore complex coat.
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Academic Article
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Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
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Academic Article
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Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
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Academic Article
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Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
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Academic Article
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Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
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Academic Article
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A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction.
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Academic Article
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A YidC-like Protein in the Archaeal Plasma Membrane.
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Academic Article
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A High Through-put Platform for Recombinant Antibodies to Folded Proteins.
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Academic Article
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Architecture of the fungal nuclear pore inner ring complex.
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Academic Article
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Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
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Academic Article
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A polar ring endows improved specificity to an antibody fragment.
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Academic Article
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Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
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Academic Article
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The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
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Academic Article
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Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.
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Academic Article
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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
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Academic Article
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Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
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Academic Article
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Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
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Academic Article
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Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics.
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Academic Article
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Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
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Academic Article
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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
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Academic Article
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The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.
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Academic Article
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Structural basis for activation of voltage sensor domains in an ion channel TPC1.
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Academic Article
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Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
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Academic Article
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An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.
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Academic Article
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Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
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Award or Honor Receipt
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Christian Anfinsen Award
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Award or Honor Receipt
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Director Department of Protein Engineering
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Academic Article
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Structure and mechanism of the ER-based glucosyltransferase ALG6.
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Academic Article
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Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
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Academic Article
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Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment.
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Academic Article
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Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
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Academic Article
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Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
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Academic Article
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Structures of ABCB4 provide insight into phosphatidylcholine translocation.
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Academic Article
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Structure of an AMPK complex in an inactive, ATP-bound state.
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Academic Article
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Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
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Academic Article
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Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
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Academic Article
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Architecture of the cytoplasmic face of the nuclear pore.
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Academic Article
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A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
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Academic Article
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Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
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Academic Article
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Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
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Academic Article
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Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
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Concept
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Protein Domains
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Concept
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Protein Conformation, alpha-Helical
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Concept
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Protein Conformation, beta-Strand
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Grant
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Chaperone Assisted Crystallography
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Grant
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Chaperone-Enabled studies of epigenetic regulation enzymes
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Grant
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Recombinant Antibody Network
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Grant
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Energetics of cytokine-induced receptor signaling
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Academic Article
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Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum.
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Academic Article
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Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
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Academic Article
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Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.
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