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He, Chuan

One or more keywords matched the following properties of He, Chuan

Property	Value
keywords	DNA methylation
overview	Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

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Value

keywords

DNA methylation

overview

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item Type	Name
Concept	DNA Damage
Concept	DNA Transposable Elements
Concept	DNA-Binding Proteins
Concept	DNA, Mitochondrial
Concept	DNA Repair
Concept	DNA, Bacterial
Concept	DNA
Concept	DNA (Cytosine-5-)-Methyltransferases
Concept	DNA-Directed RNA Polymerases
Concept	Site-Specific DNA-Methyltransferase (Adenine-Specific)
Concept	DNA Adducts
Concept	DNA Probes
Concept	Sequence Analysis, DNA
Concept	DNA Repair Enzymes
Concept	DNA, Algal
Concept	Thymine DNA Glycosylase
Concept	DNA Footprinting
Concept	DNA Methylation
Concept	O(6)-Methylguanine-DNA Methyltransferase
Concept	DNA Helicases
Concept	DNA, Single-Stranded
Concept	DNA-Cytosine Methylases
Academic Article	The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article	Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
Academic Article	Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article	The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article	The structure of the human AGT protein bound to DNA and its implications for damage detection.
Academic Article	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article	Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article	Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article	N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article	Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article	Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article	The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.
Academic Article	Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.
Academic Article	Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
Academic Article	A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).
Academic Article	Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Academic Article	An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.
Academic Article	Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article	Grand challenge commentary: RNA epigenetics?
Academic Article	Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article	A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
Academic Article	Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Academic Article	Potential functional roles of DNA demethylation intermediates.
Academic Article	Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response.
Academic Article	Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article	Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article	Engineering a uranyl-specific binding protein from NikR.
Academic Article	Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
Academic Article	Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.
Academic Article	Design of an emission ratiometric biosensor from MerR family proteins: a sensitive and selective sensor for Hg2+.
Academic Article	N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article	The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article	Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
Academic Article	The tightly regulated copper window in yeast.
Academic Article	Chemical methods to study protein-nucleic acid interactions.
Academic Article	How do DNA repair proteins locate potential base lesions? a chemical crosslinking method to investigate O6-alkylguanine-DNA alkyltransferases.
Academic Article	Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
Academic Article	Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking.
Academic Article	Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article	A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article	Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions.
Academic Article	Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Academic Article	Cancer: Damage prevention targeted.
Academic Article	Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
Academic Article	A general strategy to convert the MerR family proteins into highly sensitive and selective fluorescent biosensors for metal ions.
Academic Article	Nucleic acid modifications with epigenetic significance.
Academic Article	Mapping recently identified nucleotide variants in the genome and transcriptome.
Academic Article	Selective recognition of metal ions by metalloregulatory proteins.
Academic Article	Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage ß-glucosyltransferase.
Academic Article	Direct reversal of DNA alkylation damage.
Academic Article	Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article	Nucleic acid oxidation in DNA damage repair and epigenetics.
Academic Article	Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2.
Academic Article	In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.
Academic Article	Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article	Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor.
Academic Article	Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Academic Article	Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article	Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
Academic Article	Decoding the transcriptome and DNA methylome of human primordial germ cells.
Academic Article	High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
Academic Article	DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Academic Article	Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing.
Academic Article	Detecting hepatocellular carcinoma in blood.
Academic Article	Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability.
Academic Article	Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article	Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article	Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article	A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article	Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Academic Article	Synthesis of DNA oligos containing 2'-deoxy-2'-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor.
Academic Article	DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article	Epigenetics: Making your mark on DNA.
Academic Article	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Grant	Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Academic Article	Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
Academic Article	Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.
Academic Article	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article	Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma.
Academic Article	5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article	DNA 5-Methylcytosine-Specific Amplification and Sequencing.
Academic Article	N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article	Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
Academic Article	Author Correction: Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
Academic Article	LEAD-m6 A-seq for Locus-Specific Detection of N6 -Methyladenosine and Quantification of Differential Methylation.
Academic Article	A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article	Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.
Academic Article	METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article	KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal-assisted labeling.
Academic Article	Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review.
Academic Article	spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity.
Academic Article	Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma.
Academic Article	N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
Academic Article	Mammalian DNA N6-methyladenosine: Challenges and new insights.
Concept	Circulating Tumor DNA
Grant	Discovering the epigenetics of RNA modifications
Grant	RNA methylation and regulatory T cells
Grant	Direct Oxidative Nucleic Acids Demethylation
Grant	Labeling and sequencing of 5hmC and 5mC in DNA-Renewal
Grant	Base-resolution sequencing of m6A in RNA
Grant	Direct Oxidative Nucleic Acids Demethylation
Academic Article	Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Academic Article	Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease.
Academic Article	Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Academic Article	Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Academic Article	Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA.
Academic Article	Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.
Academic Article	Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
Academic Article	5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.

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